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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TIMELESS |
 Gene summary |
| Gene information | Gene symbol | TIMELESS | Gene ID | 8914 |
| Gene name | timeless circadian regulator | |
| Synonyms | TIM|TIM1|hTIM | |
| Cytomap | 12q13.3 | |
| Type of gene | protein-coding | |
| Description | protein timeless homologTof1 homologtimeless circadian clock 1timeless homolog | |
| Modification date | 20180523 | |
| UniProtAcc | Q9UNS1 | |
| Context | PubMed: TIMELESS [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TIMELESS | GO:0045892 | negative regulation of transcription, DNA-templated | 9856465 |
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Exon skipping events across known transcript of Ensembl for TIMELESS from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TIMELESS |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TIMELESS |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_93684 | 12 | 56811690:56811792:56811917:56812143:56814352:56814471 | 56811917:56812143 | ENSG00000111602.7 | ENST00000553532.1,ENST00000557589.1,ENST00000229201.4,ENST00000554616.1 |
| exon_skip_93687 | 12 | 56814746:56814918:56815134:56815277:56815510:56815593 | 56815134:56815277 | ENSG00000111602.7 | ENST00000553532.1,ENST00000229201.4,ENST00000554616.1 |
| exon_skip_93689 | 12 | 56815889:56815975:56816630:56816776:56817057:56817259 | 56816630:56816776 | ENSG00000111602.7 | ENST00000553532.1,ENST00000557589.1,ENST00000229201.4 |
| exon_skip_93692 | 12 | 56822019:56822189:56822332:56822436:56822666:56822884 | 56822332:56822436 | ENSG00000111602.7 | ENST00000553532.1,ENST00000229201.4 |
| exon_skip_93694 | 12 | 56822666:56822884:56823888:56824065:56824664:56824752 | 56823888:56824065 | ENSG00000111602.7 | ENST00000553532.1,ENST00000229201.4 |
| exon_skip_93695 | 12 | 56825254:56825388:56826152:56826305:56826809:56826911 | 56826152:56826305 | ENSG00000111602.7 | ENST00000229201.4 |
| exon_skip_93696 | 12 | 56825254:56825388:56826152:56826308:56826809:56826911 | 56826152:56826308 | ENSG00000111602.7 | ENST00000553532.1,ENST00000554616.1 |
| exon_skip_93697 | 12 | 56826152:56826308:56826809:56826911:56827164:56827227 | 56826809:56826911 | ENSG00000111602.7 | ENST00000553532.1,ENST00000554616.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TIMELESS |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_93684 | 12 | 56811690:56811792:56811917:56812143:56814352:56814471 | 56811917:56812143 | ENSG00000111602.7 | ENST00000229201.4,ENST00000553532.1,ENST00000557589.1,ENST00000554616.1 |
| exon_skip_93687 | 12 | 56814746:56814918:56815134:56815277:56815510:56815593 | 56815134:56815277 | ENSG00000111602.7 | ENST00000229201.4,ENST00000553532.1,ENST00000554616.1 |
| exon_skip_93689 | 12 | 56815889:56815975:56816630:56816776:56817057:56817259 | 56816630:56816776 | ENSG00000111602.7 | ENST00000229201.4,ENST00000553532.1,ENST00000557589.1 |
| exon_skip_93692 | 12 | 56822019:56822189:56822332:56822436:56822666:56822884 | 56822332:56822436 | ENSG00000111602.7 | ENST00000229201.4,ENST00000553532.1 |
| exon_skip_93694 | 12 | 56822666:56822884:56823888:56824065:56824664:56824752 | 56823888:56824065 | ENSG00000111602.7 | ENST00000229201.4,ENST00000553532.1 |
| exon_skip_93695 | 12 | 56825254:56825388:56826152:56826305:56826809:56826911 | 56826152:56826305 | ENSG00000111602.7 | ENST00000229201.4 |
| exon_skip_93696 | 12 | 56825254:56825388:56826152:56826308:56826809:56826911 | 56826152:56826308 | ENSG00000111602.7 | ENST00000553532.1,ENST00000554616.1 |
| exon_skip_93697 | 12 | 56826152:56826308:56826809:56826911:56827164:56827227 | 56826809:56826911 | ENSG00000111602.7 | ENST00000553532.1,ENST00000554616.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TIMELESS |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000553532 | 56811917 | 56812143 | Frame-shift |
| ENST00000553532 | 56815134 | 56815277 | Frame-shift |
| ENST00000553532 | 56816630 | 56816776 | Frame-shift |
| ENST00000553532 | 56822332 | 56822436 | Frame-shift |
| ENST00000553532 | 56823888 | 56824065 | In-frame |
| ENST00000553532 | 56826152 | 56826308 | In-frame |
| ENST00000553532 | 56826809 | 56826911 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000553532 | 56811917 | 56812143 | Frame-shift |
| ENST00000553532 | 56815134 | 56815277 | Frame-shift |
| ENST00000553532 | 56816630 | 56816776 | Frame-shift |
| ENST00000553532 | 56822332 | 56822436 | Frame-shift |
| ENST00000553532 | 56823888 | 56824065 | In-frame |
| ENST00000553532 | 56826152 | 56826308 | In-frame |
| ENST00000553532 | 56826809 | 56826911 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TIMELESS |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000553532 | 4388 | 1208 | 56826809 | 56826911 | 581 | 682 | 143 | 177 |
| ENST00000553532 | 4388 | 1208 | 56826152 | 56826308 | 683 | 838 | 177 | 229 |
| ENST00000553532 | 4388 | 1208 | 56823888 | 56824065 | 1061 | 1237 | 303 | 362 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000553532 | 4388 | 1208 | 56826809 | 56826911 | 581 | 682 | 143 | 177 |
| ENST00000553532 | 4388 | 1208 | 56826152 | 56826308 | 683 | 838 | 177 | 229 |
| ENST00000553532 | 4388 | 1208 | 56823888 | 56824065 | 1061 | 1237 | 303 | 362 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UNS1 | 143 | 177 | 177 | 177 | Alternative sequence | ID=VSP_051693;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9856465;Dbxref=PMID:15489334,PMID:9856465 |
| Q9UNS1 | 143 | 177 | 1 | 1208 | Chain | ID=PRO_0000072538;Note=Protein timeless homolog |
| Q9UNS1 | 143 | 177 | 145 | 147 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI |
| Q9UNS1 | 143 | 177 | 150 | 168 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI |
| Q9UNS1 | 143 | 177 | 1 | 309 | Region | Note=Required for homodimerization and for interaction with CRY1 and CHEK1;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9UNS1 | 177 | 229 | 177 | 177 | Alternative sequence | ID=VSP_051693;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9856465;Dbxref=PMID:15489334,PMID:9856465 |
| Q9UNS1 | 177 | 229 | 1 | 1208 | Chain | ID=PRO_0000072538;Note=Protein timeless homolog |
| Q9UNS1 | 177 | 229 | 184 | 195 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI |
| Q9UNS1 | 177 | 229 | 198 | 207 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI |
| Q9UNS1 | 177 | 229 | 209 | 214 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI |
| Q9UNS1 | 177 | 229 | 215 | 225 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI |
| Q9UNS1 | 177 | 229 | 1 | 309 | Region | Note=Required for homodimerization and for interaction with CRY1 and CHEK1;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9UNS1 | 177 | 229 | 226 | 228 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI |
| Q9UNS1 | 303 | 362 | 1 | 1208 | Chain | ID=PRO_0000072538;Note=Protein timeless homolog |
| Q9UNS1 | 303 | 362 | 336 | 352 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI |
| Q9UNS1 | 303 | 362 | 354 | 367 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI |
| Q9UNS1 | 303 | 362 | 1 | 309 | Region | Note=Required for homodimerization and for interaction with CRY1 and CHEK1;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UNS1 | 143 | 177 | 177 | 177 | Alternative sequence | ID=VSP_051693;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9856465;Dbxref=PMID:15489334,PMID:9856465 |
| Q9UNS1 | 143 | 177 | 1 | 1208 | Chain | ID=PRO_0000072538;Note=Protein timeless homolog |
| Q9UNS1 | 143 | 177 | 145 | 147 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI |
| Q9UNS1 | 143 | 177 | 150 | 168 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI |
| Q9UNS1 | 143 | 177 | 1 | 309 | Region | Note=Required for homodimerization and for interaction with CRY1 and CHEK1;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9UNS1 | 177 | 229 | 177 | 177 | Alternative sequence | ID=VSP_051693;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:9856465;Dbxref=PMID:15489334,PMID:9856465 |
| Q9UNS1 | 177 | 229 | 1 | 1208 | Chain | ID=PRO_0000072538;Note=Protein timeless homolog |
| Q9UNS1 | 177 | 229 | 184 | 195 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI |
| Q9UNS1 | 177 | 229 | 198 | 207 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI |
| Q9UNS1 | 177 | 229 | 209 | 214 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI |
| Q9UNS1 | 177 | 229 | 215 | 225 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI |
| Q9UNS1 | 177 | 229 | 1 | 309 | Region | Note=Required for homodimerization and for interaction with CRY1 and CHEK1;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
| Q9UNS1 | 177 | 229 | 226 | 228 | Turn | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI |
| Q9UNS1 | 303 | 362 | 1 | 1208 | Chain | ID=PRO_0000072538;Note=Protein timeless homolog |
| Q9UNS1 | 303 | 362 | 336 | 352 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI |
| Q9UNS1 | 303 | 362 | 354 | 367 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5MQI |
| Q9UNS1 | 303 | 362 | 1 | 309 | Region | Note=Required for homodimerization and for interaction with CRY1 and CHEK1;Ontology_term=ECO:0000250;evidence=ECO:0000250 |
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SNVs in the skipped exons for TIMELESS |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_93687 | 56815135 | 56815277 | 56815154 | 56815154 | Frame_Shift_Del | T | - | p.K949fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_93689 | 56816631 | 56816776 | 56816735 | 56816735 | Frame_Shift_Del | A | - | p.F777fs |
| LUAD | TCGA-44-2656-01 | exon_skip_93684 | 56811918 | 56812143 | 56811918 | 56811918 | Nonsense_Mutation | C | A | p.E1152* |
| HNSC | TCGA-CN-4728-01 | exon_skip_93687 | 56815135 | 56815277 | 56815188 | 56815188 | Nonsense_Mutation | C | A | p.E938* |
| HNSC | TCGA-CN-4728-01 | exon_skip_93687 | 56815135 | 56815277 | 56815188 | 56815188 | Nonsense_Mutation | C | A | p.E939* |
| CESC | TCGA-DR-A0ZM-01 | exon_skip_93687 | 56815135 | 56815277 | 56815235 | 56815235 | Nonsense_Mutation | G | C | p.S922* |
| CESC | TCGA-DR-A0ZM-01 | exon_skip_93687 | 56815135 | 56815277 | 56815235 | 56815235 | Nonsense_Mutation | G | C | p.S923* |
| BLCA | TCGA-GV-A6ZA-01 | exon_skip_93697 | 56826810 | 56826911 | 56826818 | 56826818 | Nonsense_Mutation | G | A | p.Q175* |
| STAD | TCGA-BR-6452-01 | exon_skip_93692 | 56822333 | 56822436 | 56822332 | 56822332 | Splice_Site | C | T | . |
| STAD | TCGA-BR-6452-01 | exon_skip_93692 | 56822333 | 56822436 | 56822332 | 56822332 | Splice_Site | C | T | p.N470_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| IGR1_SKIN | 56811918 | 56812143 | 56811975 | 56811975 | Missense_Mutation | C | G | p.A1133P |
| OVCA433_OVARY | 56811918 | 56812143 | 56811975 | 56811975 | Missense_Mutation | C | G | p.A1133P |
| AMO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 56811918 | 56812143 | 56811977 | 56811977 | Missense_Mutation | T | C | p.Q1132R |
| SW1463_LARGE_INTESTINE | 56811918 | 56812143 | 56812005 | 56812005 | Missense_Mutation | C | T | p.E1123K |
| HEC151_ENDOMETRIUM | 56811918 | 56812143 | 56812025 | 56812025 | Missense_Mutation | G | T | p.P1116H |
| TT_OESOPHAGUS | 56815135 | 56815277 | 56815182 | 56815182 | Missense_Mutation | G | A | p.R941W |
| ALLSIL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 56816631 | 56816776 | 56816640 | 56816640 | Missense_Mutation | A | G | p.L810P |
| SNU1076_UPPER_AERODIGESTIVE_TRACT | 56823889 | 56824065 | 56823896 | 56823896 | Missense_Mutation | G | A | p.S360L |
| HCC2998_LARGE_INTESTINE | 56823889 | 56824065 | 56824044 | 56824044 | Missense_Mutation | A | C | p.L311V |
| QIMRWIL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 56826153 | 56826305 | 56826289 | 56826289 | Missense_Mutation | C | G | p.S184T |
| QIMRWIL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 56826153 | 56826308 | 56826289 | 56826289 | Missense_Mutation | C | G | p.S184T |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 56823889 | 56824065 | 56823889 | 56823890 | Splice_Site | - | T | p.K362fs |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TIMELESS |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TIMELESS |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TIMELESS |
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RelatedDrugs for TIMELESS |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TIMELESS |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TIMELESS | C0005586 | Bipolar Disorder | 5 | PSYGENET |
| TIMELESS | C0011570 | Mental Depression | 2 | PSYGENET |
| TIMELESS | C0011581 | Depressive disorder | 2 | PSYGENET |
| TIMELESS | C0525045 | Mood Disorders | 2 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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