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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ST3GAL5 |
 Gene summary |
| Gene information | Gene symbol | ST3GAL5 | Gene ID | 8869 |
| Gene name | ST3 beta-galactoside alpha-2,3-sialyltransferase 5 | |
| Synonyms | SATI|SIAT9|SIATGM3S|SPDRS|ST3Gal V|ST3GalV | |
| Cytomap | 2p11.2 | |
| Type of gene | protein-coding | |
| Description | lactosylceramide alpha-2,3-sialyltransferaseCMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferaseST3 beta-galactoside alpha-23-sialyltransferase 5alpha 2,3-sialyltransferase Vganglioside GM3 synthasesialyltransferase 9 (CMP-NeuAc:lactosylceramide al | |
| Modification date | 20180523 | |
| UniProtAcc | Q9UNP4 | |
| Context | PubMed: ST3GAL5 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ST3GAL5 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ST3GAL5 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ST3GAL5 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_341435 | 2 | 86067087:86067515:86071518:86071677:86073499:86073547 | 86071518:86071677 | ENSG00000115525.12 | ENST00000461206.1,ENST00000393805.1,ENST00000377332.3,ENST00000393808.3 |
| exon_skip_341440 | 2 | 86071518:86071677:86073499:86073686:86074983:86075327 | 86073499:86073686 | ENSG00000115525.12 | ENST00000393805.1,ENST00000377332.3,ENST00000393808.3 |
| exon_skip_341442 | 2 | 86073616:86073686:86074504:86074685:86074983:86075107 | 86074504:86074685 | ENSG00000115525.12 | ENST00000461206.1 |
| exon_skip_341443 | 2 | 86073616:86073686:86074983:86075327:86088303:86088415 | 86074983:86075327 | ENSG00000115525.12 | ENST00000393805.1,ENST00000377332.3,ENST00000393808.3 |
| exon_skip_341444 | 2 | 86073616:86073686:86074983:86075504:86088303:86088415 | 86074983:86075504 | ENSG00000115525.12 | ENST00000306262.5 |
| exon_skip_341468 | 2 | 86075273:86075327:86088303:86088415:86090484:86090608 | 86088303:86088415 | ENSG00000115525.12 | ENST00000455892.1,ENST00000393805.1,ENST00000377332.3,ENST00000433665.1,ENST00000393808.3 |
| exon_skip_341483 | 2 | 86078630:86078826:86079982:86080214:86088303:86088415 | 86079982:86080214 | ENSG00000115525.12 | ENST00000525834.2 |
| exon_skip_341487 | 2 | 86090484:86090608:86097194:86097381:86115946:86116000 | 86097194:86097381 | ENSG00000115525.12 | ENST00000433665.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ST3GAL5 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_341435 | 2 | 86067087:86067515:86071518:86071677:86073499:86073547 | 86071518:86071677 | ENSG00000115525.12 | ENST00000393808.3,ENST00000393805.1,ENST00000377332.3,ENST00000461206.1 |
| exon_skip_341440 | 2 | 86071518:86071677:86073499:86073686:86074983:86075327 | 86073499:86073686 | ENSG00000115525.12 | ENST00000393808.3,ENST00000393805.1,ENST00000377332.3 |
| exon_skip_341442 | 2 | 86073616:86073686:86074504:86074685:86074983:86075107 | 86074504:86074685 | ENSG00000115525.12 | ENST00000461206.1 |
| exon_skip_341443 | 2 | 86073616:86073686:86074983:86075327:86088303:86088415 | 86074983:86075327 | ENSG00000115525.12 | ENST00000393808.3,ENST00000393805.1,ENST00000377332.3 |
| exon_skip_341444 | 2 | 86073616:86073686:86074983:86075504:86088303:86088415 | 86074983:86075504 | ENSG00000115525.12 | ENST00000306262.5 |
| exon_skip_341468 | 2 | 86075273:86075327:86088303:86088415:86090484:86090608 | 86088303:86088415 | ENSG00000115525.12 | ENST00000393808.3,ENST00000393805.1,ENST00000377332.3,ENST00000455892.1,ENST00000433665.1 |
| exon_skip_341483 | 2 | 86078630:86078826:86079982:86080214:86088303:86088415 | 86079982:86080214 | ENSG00000115525.12 | ENST00000525834.2 |
| exon_skip_341487 | 2 | 86090484:86090608:86097194:86097381:86115946:86116000 | 86097194:86097381 | ENSG00000115525.12 | ENST00000433665.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ST3GAL5 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for ST3GAL5 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for ST3GAL5 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_341435 | 86071519 | 86071677 | 86071632 | 86071632 | Frame_Shift_Del | T | - | p.I299fs |
| LIHC | TCGA-DD-A1EG-01 | 86073500 | 86073686 | 86073637 | 86073637 | Frame_Shift_Del | T | - | p.T239fs | |
| LIHC | TCGA-DD-A39Y-01 | 86073500 | 86073686 | 86073637 | 86073637 | Frame_Shift_Del | T | - | p.T239fs | |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_341443 | 86074984 | 86075327 | 86075118 | 86075118 | Frame_Shift_Del | T | - | p.E176fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_341444 | 86074984 | 86075504 | 86075118 | 86075118 | Frame_Shift_Del | T | - | p.E176fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_341443 | 86074984 | 86075327 | 86075199 | 86075199 | Frame_Shift_Del | G | - | p.P149fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_341444 | 86074984 | 86075504 | 86075199 | 86075199 | Frame_Shift_Del | G | - | p.P149fs |
| LUAD | TCGA-86-8358-01 | exon_skip_341443 | 86074984 | 86075327 | 86075204 | 86075204 | Frame_Shift_Del | C | - | p.A148fs |
| LUAD | TCGA-86-8358-01 | exon_skip_341444 | 86074984 | 86075504 | 86075204 | 86075204 | Frame_Shift_Del | C | - | p.A148fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_341483 | 86079983 | 86080214 | 86080065 | 86080065 | Frame_Shift_Del | G | - | p.P156fs |
| HNSC | TCGA-CV-7253-01 | exon_skip_341443 | 86074984 | 86075327 | 86075251 | 86075251 | Nonsense_Mutation | A | T | p.L132* |
| HNSC | TCGA-CV-7253-01 | exon_skip_341444 | 86074984 | 86075504 | 86075251 | 86075251 | Nonsense_Mutation | A | T | p.L132* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LS180_LARGE_INTESTINE | 86088304 | 86088415 | 86088332 | 86088333 | Frame_Shift_Ins | - | T | p.M97fs |
| HCT15_LARGE_INTESTINE | 86071519 | 86071677 | 86071595 | 86071595 | Missense_Mutation | G | A | p.P311L |
| ISHIKAWAHERAKLIO02ER_ENDOMETRIUM | 86073500 | 86073686 | 86073543 | 86073543 | Missense_Mutation | A | T | p.V269D |
| HCC2998_LARGE_INTESTINE | 86073500 | 86073686 | 86073545 | 86073545 | Missense_Mutation | A | C | p.S268R |
| SKMEL31_SKIN | 86073500 | 86073686 | 86073546 | 86073546 | Missense_Mutation | C | G | p.S268T |
| NCIH630_LARGE_INTESTINE | 86073500 | 86073686 | 86073551 | 86073551 | Missense_Mutation | A | T | p.F266L |
| BEN_LUNG | 86074984 | 86075327 | 86075081 | 86075081 | Missense_Mutation | C | A | p.A189S |
| BEN_LUNG | 86074984 | 86075504 | 86075081 | 86075081 | Missense_Mutation | C | A | p.A189S |
| SNUC2A_LARGE_INTESTINE | 86074984 | 86075327 | 86075173 | 86075173 | Missense_Mutation | T | C | p.Y158C |
| SNUC2A_LARGE_INTESTINE | 86074984 | 86075504 | 86075173 | 86075173 | Missense_Mutation | T | C | p.Y158C |
| SNUC2B_LARGE_INTESTINE | 86074984 | 86075327 | 86075173 | 86075173 | Missense_Mutation | T | C | p.Y158C |
| SNUC2B_LARGE_INTESTINE | 86074984 | 86075504 | 86075173 | 86075173 | Missense_Mutation | T | C | p.Y158C |
| BEN_LUNG | 86088304 | 86088415 | 86088340 | 86088340 | Missense_Mutation | C | G | p.M94I |
| DSH1_URINARY_TRACT | 86088304 | 86088415 | 86088402 | 86088402 | Missense_Mutation | C | T | p.V74M |
| JHH5_LIVER | 86071519 | 86071677 | 86071531 | 86071531 | Nonsense_Mutation | C | T | p.W332* |
| NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 86071519 | 86071677 | 86071665 | 86071665 | Nonsense_Mutation | G | A | p.R288* |
| SNU1040_LARGE_INTESTINE | 86071519 | 86071677 | 86071665 | 86071665 | Nonsense_Mutation | G | A | p.R288* |
| LS411N_LARGE_INTESTINE | 86071519 | 86071677 | 86071677 | 86071677 | Splice_Site | G | A | p.P284S |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ST3GAL5 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_341468 | 2 | 86075273:86075327:86088303:86088415:86090484:86090608 | 86088303:86088415 | ENST00000455892.1,ENST00000393805.1,ENST00000377332.3,ENST00000433665.1,ENST00000393808.3 | BRCA | rs1138484 | chr2:86088311 | T/C | 6.72e-05 |
| exon_skip_341468 | 2 | 86075273:86075327:86088303:86088415:86090484:86090608 | 86088303:86088415 | ENST00000455892.1,ENST00000393805.1,ENST00000377332.3,ENST00000433665.1,ENST00000393808.3 | BRCA | rs1138484 | chr2:86088311 | T/C | 6.73e-05 |
| exon_skip_341468 | 2 | 86075273:86075327:86088303:86088415:86090484:86090608 | 86088303:86088415 | ENST00000455892.1,ENST00000393805.1,ENST00000377332.3,ENST00000433665.1,ENST00000393808.3 | LGG | rs1138484 | chr2:86088311 | T/C | 4.10e-05 |
| exon_skip_341468 | 2 | 86075273:86075327:86088303:86088415:86090484:86090608 | 86088303:86088415 | ENST00000455892.1,ENST00000393805.1,ENST00000377332.3,ENST00000433665.1,ENST00000393808.3 | LGG | rs1138484 | chr2:86088311 | T/C | 4.10e-05 |
| exon_skip_341468 | 2 | 86075273:86075327:86088303:86088415:86090484:86090608 | 86088303:86088415 | ENST00000455892.1,ENST00000393805.1,ENST00000377332.3,ENST00000433665.1,ENST00000393808.3 | KIRC | rs1138484 | chr2:86088311 | T/C | 3.87e-04 |
| exon_skip_341468 | 2 | 86075273:86075327:86088303:86088415:86090484:86090608 | 86088303:86088415 | ENST00000455892.1,ENST00000393805.1,ENST00000377332.3,ENST00000433665.1,ENST00000393808.3 | KIRC | rs1138484 | chr2:86088311 | T/C | 3.87e-04 |
| exon_skip_341468 | 2 | 86075273:86075327:86088303:86088415:86090484:86090608 | 86088303:86088415 | ENST00000455892.1,ENST00000393805.1,ENST00000377332.3,ENST00000433665.1,ENST00000393808.3 | LUAD | rs1138484 | chr2:86088311 | T/C | 6.50e-04 |
| exon_skip_341468 | 2 | 86075273:86075327:86088303:86088415:86090484:86090608 | 86088303:86088415 | ENST00000455892.1,ENST00000393805.1,ENST00000377332.3,ENST00000433665.1,ENST00000393808.3 | LUAD | rs1138484 | chr2:86088311 | T/C | 6.52e-04 |
| exon_skip_341468 | 2 | 86075273:86075327:86088303:86088415:86090484:86090608 | 86088303:86088415 | ENST00000455892.1,ENST00000393805.1,ENST00000377332.3,ENST00000433665.1,ENST00000393808.3 | THCA | rs1138484 | chr2:86088311 | T/C | 2.74e-06 |
| exon_skip_341468 | 2 | 86075273:86075327:86088303:86088415:86090484:86090608 | 86088303:86088415 | ENST00000455892.1,ENST00000393805.1,ENST00000377332.3,ENST00000433665.1,ENST00000393808.3 | THCA | rs1138484 | chr2:86088311 | T/C | 2.75e-06 |
| exon_skip_341442 | 2 | 86073616:86073686:86074504:86074685:86074983:86075107 | 86074504:86074685 | ENST00000461206.1 | BLCA | rs13020072 | chr2:86074512 | A/G | 5.31e-04 |
| exon_skip_341442 | 2 | 86073616:86073686:86074504:86074685:86074983:86075107 | 86074504:86074685 | ENST00000461206.1 | BLCA | rs13020072 | chr2:86074512 | A/G | 5.32e-04 |
| exon_skip_341442 | 2 | 86073616:86073686:86074504:86074685:86074983:86075107 | 86074504:86074685 | ENST00000461206.1 | BRCA | rs13020072 | chr2:86074512 | A/G | 8.42e-05 |
| exon_skip_341442 | 2 | 86073616:86073686:86074504:86074685:86074983:86075107 | 86074504:86074685 | ENST00000461206.1 | BRCA | rs13020072 | chr2:86074512 | A/G | 8.42e-05 |
| exon_skip_341442 | 2 | 86073616:86073686:86074504:86074685:86074983:86075107 | 86074504:86074685 | ENST00000461206.1 | LGG | rs13020072 | chr2:86074512 | A/G | 1.67e-04 |
| exon_skip_341442 | 2 | 86073616:86073686:86074504:86074685:86074983:86075107 | 86074504:86074685 | ENST00000461206.1 | LGG | rs13020072 | chr2:86074512 | A/G | 1.67e-04 |
| exon_skip_341442 | 2 | 86073616:86073686:86074504:86074685:86074983:86075107 | 86074504:86074685 | ENST00000461206.1 | LGG | rs13020072 | chr2:86074512 | A/G | 9.61e-04 |
| exon_skip_341442 | 2 | 86073616:86073686:86074504:86074685:86074983:86075107 | 86074504:86074685 | ENST00000461206.1 | KIRC | rs13020072 | chr2:86074512 | A/G | 2.55e-04 |
| exon_skip_341442 | 2 | 86073616:86073686:86074504:86074685:86074983:86075107 | 86074504:86074685 | ENST00000461206.1 | KIRC | rs13020072 | chr2:86074512 | A/G | 2.55e-04 |
| exon_skip_341442 | 2 | 86073616:86073686:86074504:86074685:86074983:86075107 | 86074504:86074685 | ENST00000461206.1 | PRAD | rs13020072 | chr2:86074512 | A/G | 9.81e-04 |
| exon_skip_341442 | 2 | 86073616:86073686:86074504:86074685:86074983:86075107 | 86074504:86074685 | ENST00000461206.1 | PRAD | rs13020072 | chr2:86074512 | A/G | 9.83e-04 |
| exon_skip_341442 | 2 | 86073616:86073686:86074504:86074685:86074983:86075107 | 86074504:86074685 | ENST00000461206.1 | THCA | rs13020072 | chr2:86074512 | A/G | 1.44e-05 |
| exon_skip_341442 | 2 | 86073616:86073686:86074504:86074685:86074983:86075107 | 86074504:86074685 | ENST00000461206.1 | THCA | rs13020072 | chr2:86074512 | A/G | 6.50e-05 |
| exon_skip_341442 | 2 | 86073616:86073686:86074504:86074685:86074983:86075107 | 86074504:86074685 | ENST00000461206.1 | THCA | rs13020072 | chr2:86074512 | A/G | 6.52e-05 |
| exon_skip_341442 | 2 | 86073616:86073686:86074504:86074685:86074983:86075107 | 86074504:86074685 | ENST00000461206.1 | THCA | rs13020072 | chr2:86074512 | A/G | 2.45e-03 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ST3GAL5 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ST3GAL5 |
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RelatedDrugs for ST3GAL5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ST3GAL5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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