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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for PEX11A |
 Gene summary |
| Gene information | Gene symbol | PEX11A | Gene ID | 8800 |
| Gene name | peroxisomal biogenesis factor 11 alpha | |
| Synonyms | PEX11-ALPHA|PMP28|hsPEX11p | |
| Cytomap | 15q26.1 | |
| Type of gene | protein-coding | |
| Description | peroxisomal membrane protein 11A28 kDa peroxisomal integral membrane proteinperoxin-11Aperoxisomal biogenesis factor 11Aprotein PEX11 homolog alpha | |
| Modification date | 20180523 | |
| UniProtAcc | O75192 | |
| Context | PubMed: PEX11A [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| PEX11A | GO:0016559 | peroxisome fission | 20826455 |
| PEX11A | GO:0044375 | regulation of peroxisome size | 20826455 |
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Exon skipping events across known transcript of Ensembl for PEX11A from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for PEX11A |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for PEX11A |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_130838 | 15 | 90224535:90224771:90229661:90229777:90233807:90233893 | 90229661:90229777 | ENSG00000166821.4 | ENST00000561224.1 |
| exon_skip_130839 | 15 | 90226310:90227086:90229661:90229777:90233807:90233893 | 90229661:90229777 | ENSG00000166821.4 | ENST00000561257.1 |
| exon_skip_130840 | 15 | 90226481:90227179:90229661:90229777:90233807:90233893 | 90229661:90229777 | ENSG00000166821.4 | ENST00000300056.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for PEX11A |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_130838 | 15 | 90224535:90224771:90229661:90229777:90233807:90233893 | 90229661:90229777 | ENSG00000166821.4 | ENST00000561224.1 |
| exon_skip_130839 | 15 | 90226310:90227086:90229661:90229777:90233807:90233893 | 90229661:90229777 | ENSG00000166821.4 | ENST00000561257.1 |
| exon_skip_130840 | 15 | 90226481:90227179:90229661:90229777:90233807:90233893 | 90229661:90229777 | ENSG00000166821.4 | ENST00000300056.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for PEX11A |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000300056 | 90229661 | 90229777 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000300056 | 90229661 | 90229777 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for PEX11A |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for PEX11A |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HNSC | TCGA-CN-4729-01 | exon_skip_130839 exon_skip_130840 exon_skip_130838 | 90229662 | 90229777 | 90229778 | 90229778 | Splice_Site | C | G | p.R19_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for PEX11A |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PEX11A |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for PEX11A |
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RelatedDrugs for PEX11A |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PEX11A |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| PEX11A | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
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