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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for NOP14 |
 Gene summary |
| Gene information | Gene symbol | NOP14 | Gene ID | 8602 |
| Gene name | NOP14 nucleolar protein | |
| Synonyms | C4orf9|NOL14|RES4-25|RES425|UTP2 | |
| Cytomap | 4p16.3 | |
| Type of gene | protein-coding | |
| Description | nucleolar protein 14NOP14 nucleolar protein homologprobable nucleolar complex protein 14 | |
| Modification date | 20180523 | |
| UniProtAcc | P78316 | |
| Context | PubMed: NOP14 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for NOP14 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for NOP14 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for NOP14 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_428221 | 4 | 2941016:2941070:2941253:2941372:2943308:2943443 | 2941253:2941372 | ENSG00000087269.11 | ENST00000416614.2,ENST00000314262.6 |
| exon_skip_428222 | 4 | 2952840:2952972:2954001:2954124:2955237:2955372 | 2954001:2954124 | ENSG00000087269.11 | ENST00000398071.4,ENST00000416614.2,ENST00000502735.1,ENST00000314262.6 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for NOP14 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_428221 | 4 | 2941016:2941070:2941253:2941372:2943308:2943443 | 2941253:2941372 | ENSG00000087269.11 | ENST00000416614.2,ENST00000314262.6 |
| exon_skip_428222 | 4 | 2952840:2952972:2954001:2954124:2955237:2955372 | 2954001:2954124 | ENSG00000087269.11 | ENST00000416614.2,ENST00000314262.6,ENST00000502735.1,ENST00000398071.4 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for NOP14 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000314262 | 2941253 | 2941372 | Frame-shift |
| ENST00000416614 | 2941253 | 2941372 | Frame-shift |
| ENST00000314262 | 2954001 | 2954124 | In-frame |
| ENST00000416614 | 2954001 | 2954124 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000314262 | 2941253 | 2941372 | Frame-shift |
| ENST00000416614 | 2941253 | 2941372 | Frame-shift |
| ENST00000314262 | 2954001 | 2954124 | In-frame |
| ENST00000416614 | 2954001 | 2954124 | In-frame |
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Infer the effects of exon skipping event on protein functional features for NOP14 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000314262 | 2906 | 857 | 2954001 | 2954124 | 797 | 919 | 249 | 290 |
| ENST00000416614 | 3555 | 857 | 2954001 | 2954124 | 814 | 936 | 249 | 290 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000314262 | 2906 | 857 | 2954001 | 2954124 | 797 | 919 | 249 | 290 |
| ENST00000416614 | 3555 | 857 | 2954001 | 2954124 | 814 | 936 | 249 | 290 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P78316 | 249 | 290 | 1 | 857 | Chain | ID=PRO_0000137155;Note=Nucleolar protein 14 |
| P78316 | 249 | 290 | 1 | 857 | Chain | ID=PRO_0000137155;Note=Nucleolar protein 14 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P78316 | 249 | 290 | 1 | 857 | Chain | ID=PRO_0000137155;Note=Nucleolar protein 14 |
| P78316 | 249 | 290 | 1 | 857 | Chain | ID=PRO_0000137155;Note=Nucleolar protein 14 |
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SNVs in the skipped exons for NOP14 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BLCA | TCGA-FJ-A3ZE-01 | exon_skip_428221 | 2941254 | 2941372 | 2941321 | 2941327 | Frame_Shift_Del | GGCAGAG | - | p.L749fs |
| BLCA | TCGA-FJ-A3ZE-01 | exon_skip_428221 | 2941254 | 2941372 | 2941321 | 2941327 | Frame_Shift_Del | GGCAGAG | - | p.LCR749fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_428221 | 2941254 | 2941372 | 2941339 | 2941339 | Frame_Shift_Del | T | - | p.S745fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_428221 | 2941254 | 2941372 | 2941345 | 2941345 | Frame_Shift_Del | T | - | p.M743fs |
| BLCA | TCGA-GC-A3BM-01 | exon_skip_428222 | 2954002 | 2954124 | 2954005 | 2954006 | Frame_Shift_Ins | - | A | p.L289fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| OCILY12_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 2941254 | 2941372 | 2941359 | 2941359 | Missense_Mutation | C | T | p.S738N |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NOP14 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NOP14 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NOP14 |
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RelatedDrugs for NOP14 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NOP14 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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