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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for DDO |
 Gene summary |
| Gene information | Gene symbol | DDO | Gene ID | 8528 |
| Gene name | D-aspartate oxidase | |
| Synonyms | DASOX|DDO-1|DDO-2 | |
| Cytomap | 6q21 | |
| Type of gene | protein-coding | |
| Description | D-aspartate oxidaseD-aspartate oxidase, DDOaspartic oxidase | |
| Modification date | 20180522 | |
| UniProtAcc | Q99489 | |
| Context | PubMed: DDO [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| DDO | GO:0019478 | D-amino acid catabolic process | 20603179 |
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Exon skipping events across known transcript of Ensembl for DDO from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for DDO |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for DDO |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_461784 | 6 | 110712973:110714545:110725976:110726153:110729536:110729645 | 110725976:110726153 | ENSG00000203797.5 | ENST00000368924.3 |
| exon_skip_461787 | 6 | 110725976:110726153:110729536:110729645:110734493:110734669 | 110729536:110729645 | ENSG00000203797.5 | ENST00000368924.3 |
| exon_skip_461790 | 6 | 110729536:110729645:110734493:110734669:110736669:110736765 | 110734493:110734669 | ENSG00000203797.5 | ENST00000368923.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for DDO |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_461784 | 6 | 110712973:110714545:110725976:110726153:110729536:110729645 | 110725976:110726153 | ENSG00000203797.5 | ENST00000368924.3 |
| exon_skip_461790 | 6 | 110729536:110729645:110734493:110734669:110736669:110736765 | 110734493:110734669 | ENSG00000203797.5 | ENST00000368923.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for DDO |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for DDO |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for DDO |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_461784 | 110725977 | 110726153 | 110726023 | 110726023 | Frame_Shift_Del | T | - | p.T166fs |
| UCEC | TCGA-B5-A0K9-01 | exon_skip_461784 | 110725977 | 110726153 | 110726027 | 110726027 | Frame_Shift_Del | A | - | p.F164fs |
| UCEC | TCGA-BK-A0C9-01 | exon_skip_461784 | 110725977 | 110726153 | 110726050 | 110726050 | Frame_Shift_Del | G | - | p.Q157fs |
| BLCA | TCGA-DK-A6AW-01 | exon_skip_461784 | 110725977 | 110726153 | 110726086 | 110726086 | Nonsense_Mutation | G | A | p.R145* |
| SKCM | TCGA-EB-A5UL-06 | exon_skip_461784 | 110725977 | 110726153 | 110726086 | 110726086 | Nonsense_Mutation | G | A | p.R145* |
| SKCM | TCGA-EB-A5UL-06 | exon_skip_461784 | 110725977 | 110726153 | 110726086 | 110726086 | Nonsense_Mutation | G | A | p.R145X |
| UCEC | TCGA-AX-A0J0-01 | exon_skip_461787 | 110729537 | 110729645 | 110729610 | 110729610 | Nonsense_Mutation | C | A | p.E98* |
| THYM | TCGA-XU-A930-01 | exon_skip_461787 | 110729537 | 110729645 | 110729536 | 110729536 | Splice_Site | C | T | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| CAPAN1_PANCREAS | 110725977 | 110726153 | 110726032 | 110726041 | Frame_Shift_Del | CCTGACCAAA | - | p.FGQA160fs |
| NCIH929_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 110734494 | 110734669 | 110734549 | 110734553 | Frame_Shift_Del | AGTAA | - | p.FT66fs |
| MFE319_ENDOMETRIUM | 110725977 | 110726153 | 110726047 | 110726047 | Missense_Mutation | A | G | p.Y158H |
| RERFLCMS_LUNG | 110725977 | 110726153 | 110726085 | 110726085 | Missense_Mutation | C | T | p.R145Q |
| RAMOS2G64C10_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 110725977 | 110726153 | 110726110 | 110726110 | Missense_Mutation | A | G | p.W137R |
| HCC2218_BREAST | 110725977 | 110726153 | 110726111 | 110726111 | Missense_Mutation | G | C | p.F136L |
| SCC9_UPPER_AERODIGESTIVE_TRACT | 110734494 | 110734669 | 110734506 | 110734506 | Missense_Mutation | G | T | p.H82N |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 110734494 | 110734669 | 110734523 | 110734523 | Missense_Mutation | G | A | p.A76V |
| HSC3_UPPER_AERODIGESTIVE_TRACT | 110734494 | 110734669 | 110734560 | 110734560 | Missense_Mutation | C | A | p.D64Y |
| OV90_OVARY | 110734494 | 110734669 | 110734563 | 110734563 | Missense_Mutation | A | C | p.S63A |
| GP5D_LARGE_INTESTINE | 110734494 | 110734669 | 110734604 | 110734604 | Missense_Mutation | C | T | p.C49Y |
| TC138_BONE | 110725977 | 110726153 | 110726086 | 110726086 | Nonsense_Mutation | G | A | p.R145* |
| CAPAN1_PANCREAS | 110725977 | 110726153 | 110725978 | 110725978 | Splice_Site | T | - | p.R181fs |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DDO |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DDO |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DDO |
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RelatedDrugs for DDO |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DDO |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| DDO | C0036341 | Schizophrenia | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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