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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MAP4K3 |
 Gene summary |
| Gene information | Gene symbol | MAP4K3 | Gene ID | 8491 |
| Gene name | mitogen-activated protein kinase kinase kinase kinase 3 | |
| Synonyms | GLK|MAPKKKK3|MEKKK 3|MEKKK3|RAB8IPL1 | |
| Cytomap | 2p22.1 | |
| Type of gene | protein-coding | |
| Description | mitogen-activated protein kinase kinase kinase kinase 3MAPK/ERK kinase kinase kinase 3MEK kinase kinase 3germinal center kinase-like kinasegerminal center kinase-related protein kinase | |
| Modification date | 20180523 | |
| UniProtAcc | Q8IVH8 | |
| Context | PubMed: MAP4K3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MAP4K3 | GO:0006468 | protein phosphorylation | 9275185 |
| MAP4K3 | GO:0009411 | response to UV | 9275185 |
| MAP4K3 | GO:0034612 | response to tumor necrosis factor | 9275185 |
| MAP4K3 | GO:0035556 | intracellular signal transduction | 9275185 |
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Exon skipping events across known transcript of Ensembl for MAP4K3 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MAP4K3 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MAP4K3 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_338513 | 2 | 39477233:39477846:39478970:39479026:39481590:39481661 | 39478970:39479026 | ENSG00000011566.10 | ENST00000341681.5,ENST00000536018.1,ENST00000437545.1,ENST00000263881.3 |
| exon_skip_338514 | 2 | 39478970:39479026:39481590:39481661:39485488:39485581 | 39481590:39481661 | ENSG00000011566.10 | ENST00000341681.5,ENST00000536018.1,ENST00000437545.1,ENST00000263881.3 |
| exon_skip_338516 | 2 | 39485488:39485581:39485659:39485728:39487746:39487918 | 39485659:39485728 | ENSG00000011566.10 | ENST00000341681.5,ENST00000536018.1,ENST00000437545.1,ENST00000263881.3 |
| exon_skip_338520 | 2 | 39492343:39492447:39494329:39494388:39499423:39499541 | 39494329:39494388 | ENSG00000011566.10 | ENST00000341681.5,ENST00000536018.1,ENST00000437545.1,ENST00000263881.3 |
| exon_skip_338523 | 2 | 39499423:39499541:39499622:39499683:39505547:39505560 | 39499622:39499683 | ENSG00000011566.10 | ENST00000495648.3,ENST00000341681.5,ENST00000536018.1,ENST00000437545.1,ENST00000263881.3 |
| exon_skip_338524 | 2 | 39505547:39505627:39507412:39507497:39509653:39509692 | 39507412:39507497 | ENSG00000011566.10 | ENST00000341681.5,ENST00000536018.1,ENST00000437545.1,ENST00000263881.3 |
| exon_skip_338526 | 2 | 39507412:39507497:39509653:39509695:39513992:39514105 | 39509653:39509695 | ENSG00000011566.10 | ENST00000341681.5,ENST00000536018.1,ENST00000437545.1,ENST00000263881.3 |
| exon_skip_338529 | 2 | 39513992:39514105:39515261:39515421:39517432:39517475 | 39515261:39515421 | ENSG00000011566.10 | ENST00000341681.5,ENST00000536018.1,ENST00000437545.1,ENST00000263881.3 |
| exon_skip_338530 | 2 | 39526883:39526942:39530214:39530258:39535083:39535146 | 39530214:39530258 | ENSG00000011566.10 | ENST00000414968.1,ENST00000536018.1 |
| exon_skip_338532 | 2 | 39526883:39526942:39535083:39535146:39536601:39536660 | 39535083:39535146 | ENSG00000011566.10 | ENST00000263881.3 |
| exon_skip_338533 | 2 | 39530214:39530258:39535083:39535146:39536601:39536660 | 39535083:39535146 | ENSG00000011566.10 | ENST00000414968.1,ENST00000536018.1 |
| exon_skip_338534 | 2 | 39542450:39542529:39552658:39552769:39552870:39552952 | 39552658:39552769 | ENSG00000011566.10 | ENST00000341681.5,ENST00000414968.1,ENST00000536018.1,ENST00000437545.1,ENST00000263881.3 |
| exon_skip_338535 | 2 | 39560672:39560715:39564060:39564108:39564666:39564722 | 39564060:39564108 | ENSG00000011566.10 | ENST00000341681.5,ENST00000437545.1,ENST00000263881.3 |
| exon_skip_338538 | 2 | 39570528:39570593:39583389:39583480:39605206:39605264 | 39583389:39583480 | ENSG00000011566.10 | ENST00000341681.5,ENST00000437545.1,ENST00000263881.3,ENST00000429397.1 |
| exon_skip_338539 | 2 | 39583389:39583480:39605206:39605264:39664032:39664089 | 39605206:39605264 | ENSG00000011566.10 | ENST00000341681.5,ENST00000429397.1,ENST00000484274.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MAP4K3 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_338513 | 2 | 39477233:39477846:39478970:39479026:39481590:39481661 | 39478970:39479026 | ENSG00000011566.10 | ENST00000263881.3,ENST00000437545.1,ENST00000341681.5,ENST00000536018.1 |
| exon_skip_338514 | 2 | 39478970:39479026:39481590:39481661:39485488:39485581 | 39481590:39481661 | ENSG00000011566.10 | ENST00000263881.3,ENST00000437545.1,ENST00000341681.5,ENST00000536018.1 |
| exon_skip_338516 | 2 | 39485488:39485581:39485659:39485728:39487746:39487918 | 39485659:39485728 | ENSG00000011566.10 | ENST00000263881.3,ENST00000437545.1,ENST00000341681.5,ENST00000536018.1 |
| exon_skip_338520 | 2 | 39492343:39492447:39494329:39494388:39499423:39499541 | 39494329:39494388 | ENSG00000011566.10 | ENST00000263881.3,ENST00000437545.1,ENST00000341681.5,ENST00000536018.1 |
| exon_skip_338523 | 2 | 39499423:39499541:39499622:39499683:39505547:39505560 | 39499622:39499683 | ENSG00000011566.10 | ENST00000263881.3,ENST00000437545.1,ENST00000341681.5,ENST00000536018.1,ENST00000495648.3 |
| exon_skip_338524 | 2 | 39505547:39505627:39507412:39507497:39509653:39509692 | 39507412:39507497 | ENSG00000011566.10 | ENST00000263881.3,ENST00000437545.1,ENST00000341681.5,ENST00000536018.1 |
| exon_skip_338526 | 2 | 39507412:39507497:39509653:39509695:39513992:39514105 | 39509653:39509695 | ENSG00000011566.10 | ENST00000263881.3,ENST00000437545.1,ENST00000341681.5,ENST00000536018.1 |
| exon_skip_338529 | 2 | 39513992:39514105:39515261:39515421:39517432:39517475 | 39515261:39515421 | ENSG00000011566.10 | ENST00000263881.3,ENST00000437545.1,ENST00000341681.5,ENST00000536018.1 |
| exon_skip_338530 | 2 | 39526883:39526942:39530214:39530258:39535083:39535146 | 39530214:39530258 | ENSG00000011566.10 | ENST00000536018.1,ENST00000414968.1 |
| exon_skip_338532 | 2 | 39526883:39526942:39535083:39535146:39536601:39536660 | 39535083:39535146 | ENSG00000011566.10 | ENST00000263881.3 |
| exon_skip_338533 | 2 | 39530214:39530258:39535083:39535146:39536601:39536660 | 39535083:39535146 | ENSG00000011566.10 | ENST00000536018.1,ENST00000414968.1 |
| exon_skip_338534 | 2 | 39542450:39542529:39552658:39552769:39552870:39552952 | 39552658:39552769 | ENSG00000011566.10 | ENST00000263881.3,ENST00000437545.1,ENST00000341681.5,ENST00000536018.1,ENST00000414968.1 |
| exon_skip_338535 | 2 | 39560672:39560715:39564060:39564108:39564666:39564722 | 39564060:39564108 | ENSG00000011566.10 | ENST00000263881.3,ENST00000437545.1,ENST00000341681.5 |
| exon_skip_338538 | 2 | 39570528:39570593:39583389:39583480:39605206:39605264 | 39583389:39583480 | ENSG00000011566.10 | ENST00000263881.3,ENST00000437545.1,ENST00000341681.5,ENST00000429397.1 |
| exon_skip_338539 | 2 | 39583389:39583480:39605206:39605264:39664032:39664089 | 39605206:39605264 | ENSG00000011566.10 | ENST00000341681.5,ENST00000429397.1,ENST00000484274.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MAP4K3 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000263881 | 39478970 | 39479026 | Frame-shift |
| ENST00000263881 | 39481590 | 39481661 | Frame-shift |
| ENST00000263881 | 39494329 | 39494388 | Frame-shift |
| ENST00000263881 | 39499622 | 39499683 | Frame-shift |
| ENST00000263881 | 39507412 | 39507497 | Frame-shift |
| ENST00000263881 | 39515261 | 39515421 | Frame-shift |
| ENST00000263881 | 39583389 | 39583480 | Frame-shift |
| ENST00000263881 | 39485659 | 39485728 | In-frame |
| ENST00000263881 | 39509653 | 39509695 | In-frame |
| ENST00000263881 | 39535083 | 39535146 | In-frame |
| ENST00000263881 | 39552658 | 39552769 | In-frame |
| ENST00000263881 | 39564060 | 39564108 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000263881 | 39478970 | 39479026 | Frame-shift |
| ENST00000263881 | 39481590 | 39481661 | Frame-shift |
| ENST00000263881 | 39494329 | 39494388 | Frame-shift |
| ENST00000263881 | 39499622 | 39499683 | Frame-shift |
| ENST00000263881 | 39507412 | 39507497 | Frame-shift |
| ENST00000263881 | 39515261 | 39515421 | Frame-shift |
| ENST00000263881 | 39583389 | 39583480 | Frame-shift |
| ENST00000263881 | 39485659 | 39485728 | In-frame |
| ENST00000263881 | 39509653 | 39509695 | In-frame |
| ENST00000263881 | 39535083 | 39535146 | In-frame |
| ENST00000263881 | 39552658 | 39552769 | In-frame |
| ENST00000263881 | 39564060 | 39564108 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MAP4K3 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000263881 | 4379 | 894 | 39564060 | 39564108 | 692 | 739 | 122 | 138 |
| ENST00000263881 | 4379 | 894 | 39552658 | 39552769 | 1133 | 1243 | 269 | 306 |
| ENST00000263881 | 4379 | 894 | 39535083 | 39535146 | 1382 | 1444 | 352 | 373 |
| ENST00000263881 | 4379 | 894 | 39509653 | 39509695 | 1913 | 1954 | 529 | 543 |
| ENST00000263881 | 4379 | 894 | 39485659 | 39485728 | 2634 | 2702 | 769 | 792 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000263881 | 4379 | 894 | 39564060 | 39564108 | 692 | 739 | 122 | 138 |
| ENST00000263881 | 4379 | 894 | 39552658 | 39552769 | 1133 | 1243 | 269 | 306 |
| ENST00000263881 | 4379 | 894 | 39535083 | 39535146 | 1382 | 1444 | 352 | 373 |
| ENST00000263881 | 4379 | 894 | 39509653 | 39509695 | 1913 | 1954 | 529 | 543 |
| ENST00000263881 | 4379 | 894 | 39485659 | 39485728 | 2634 | 2702 | 769 | 792 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8IVH8 | 122 | 138 | 136 | 136 | Active site | Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q8IVH8 | 122 | 138 | 1 | 894 | Chain | ID=PRO_0000086277;Note=Mitogen-activated protein kinase kinase kinase kinase 3 |
| Q8IVH8 | 122 | 138 | 16 | 273 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q8IVH8 | 122 | 138 | 110 | 129 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5T |
| Q8IVH8 | 269 | 306 | 1 | 894 | Chain | ID=PRO_0000086277;Note=Mitogen-activated protein kinase kinase kinase kinase 3 |
| Q8IVH8 | 269 | 306 | 16 | 273 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q8IVH8 | 269 | 306 | 271 | 274 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5T |
| Q8IVH8 | 269 | 306 | 280 | 289 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5T |
| Q8IVH8 | 352 | 373 | 352 | 372 | Alternative sequence | ID=VSP_007053;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q8IVH8 | 352 | 373 | 1 | 894 | Chain | ID=PRO_0000086277;Note=Mitogen-activated protein kinase kinase kinase kinase 3 |
| Q8IVH8 | 529 | 543 | 1 | 894 | Chain | ID=PRO_0000086277;Note=Mitogen-activated protein kinase kinase kinase kinase 3 |
| Q8IVH8 | 769 | 792 | 1 | 894 | Chain | ID=PRO_0000086277;Note=Mitogen-activated protein kinase kinase kinase kinase 3 |
| Q8IVH8 | 769 | 792 | 556 | 867 | Domain | Note=CNH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00795 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8IVH8 | 122 | 138 | 136 | 136 | Active site | Note=Proton acceptor;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q8IVH8 | 122 | 138 | 1 | 894 | Chain | ID=PRO_0000086277;Note=Mitogen-activated protein kinase kinase kinase kinase 3 |
| Q8IVH8 | 122 | 138 | 16 | 273 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q8IVH8 | 122 | 138 | 110 | 129 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5T |
| Q8IVH8 | 269 | 306 | 1 | 894 | Chain | ID=PRO_0000086277;Note=Mitogen-activated protein kinase kinase kinase kinase 3 |
| Q8IVH8 | 269 | 306 | 16 | 273 | Domain | Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Q8IVH8 | 269 | 306 | 271 | 274 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5T |
| Q8IVH8 | 269 | 306 | 280 | 289 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:5J5T |
| Q8IVH8 | 352 | 373 | 352 | 372 | Alternative sequence | ID=VSP_007053;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 |
| Q8IVH8 | 352 | 373 | 1 | 894 | Chain | ID=PRO_0000086277;Note=Mitogen-activated protein kinase kinase kinase kinase 3 |
| Q8IVH8 | 529 | 543 | 1 | 894 | Chain | ID=PRO_0000086277;Note=Mitogen-activated protein kinase kinase kinase kinase 3 |
| Q8IVH8 | 769 | 792 | 1 | 894 | Chain | ID=PRO_0000086277;Note=Mitogen-activated protein kinase kinase kinase kinase 3 |
| Q8IVH8 | 769 | 792 | 556 | 867 | Domain | Note=CNH;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00795 |
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SNVs in the skipped exons for MAP4K3 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_338513 | 39478971 | 39479026 | 39479011 | 39479011 | Frame_Shift_Del | A | - | p.S853fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_338524 | 39507413 | 39507497 | 39507471 | 39507471 | Frame_Shift_Del | A | - | p.F552fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_338529 | 39515262 | 39515421 | 39515372 | 39515372 | Frame_Shift_Del | T | - | p.N455fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_338538 | 39583390 | 39583480 | 39583449 | 39583449 | Frame_Shift_Del | A | - | p.I63fs |
| UCEC | TCGA-AX-A060-01 | exon_skip_338514 | 39481591 | 39481661 | 39481629 | 39481629 | Nonsense_Mutation | T | A | p.K835* |
| BLCA | TCGA-DK-A2I6-01 | exon_skip_338523 | 39499623 | 39499683 | 39499674 | 39499674 | Nonsense_Mutation | G | A | p.R602* |
| LUAD | TCGA-86-8278-01 | exon_skip_338529 | 39515262 | 39515421 | 39515342 | 39515342 | Nonsense_Mutation | G | C | p.S465* |
| GBM | TCGA-76-4934-01 | exon_skip_338529 | 39515262 | 39515421 | 39515367 | 39515367 | Nonsense_Mutation | C | A | p.G457* |
| LUSC | TCGA-63-5131-01 | exon_skip_338516 | 39485660 | 39485728 | 39485729 | 39485729 | Splice_Site | C | T | p.D770_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 39478971 | 39479026 | 39479004 | 39479004 | Missense_Mutation | C | T | p.S855N |
| SNUC5_LARGE_INTESTINE | 39481591 | 39481661 | 39481644 | 39481644 | Missense_Mutation | C | T | p.V830M |
| COGE352_BONE | 39485660 | 39485728 | 39485698 | 39485698 | Missense_Mutation | G | T | p.T780N |
| HCT15_LARGE_INTESTINE | 39494330 | 39494388 | 39494365 | 39494365 | Missense_Mutation | A | T | p.I666N |
| JHUEM7_ENDOMETRIUM | 39494330 | 39494388 | 39494381 | 39494381 | Missense_Mutation | A | C | p.S661A |
| SNU81_LARGE_INTESTINE | 39499623 | 39499683 | 39499673 | 39499673 | Missense_Mutation | C | T | p.R602Q |
| HCC2998_LARGE_INTESTINE | 39507413 | 39507497 | 39507488 | 39507488 | Missense_Mutation | A | C | p.C547G |
| ES2_OVARY | 39515262 | 39515421 | 39515330 | 39515330 | Missense_Mutation | G | T | p.A469E |
| MDAMB436_BREAST | 39515262 | 39515421 | 39515353 | 39515353 | Missense_Mutation | T | G | p.R461S |
| BT474_BREAST | 39515262 | 39515421 | 39515384 | 39515384 | Missense_Mutation | G | A | p.T451I |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 39535084 | 39535146 | 39535126 | 39535126 | Missense_Mutation | C | G | p.L359F |
| OCIAML5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 39535084 | 39535146 | 39535126 | 39535126 | Missense_Mutation | C | G | p.L359F |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 39535084 | 39535146 | 39535126 | 39535126 | Missense_Mutation | C | G | p.L359F |
| OCILY3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 39535084 | 39535146 | 39535133 | 39535133 | Missense_Mutation | C | T | p.G357D |
| SW684_SOFT_TISSUE | 39552659 | 39552769 | 39552663 | 39552663 | Missense_Mutation | G | A | p.P305L |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 39481591 | 39481661 | 39481660 | 39481660 | Splice_Site | C | A | p.V824V |
| HCC827GR5_LUNG | 39507413 | 39507497 | 39507393 | 39507413 | Splice_Site | ATAAAAACACACAATACTACC | - | p.G572del |
| MCF7_BREAST | 39583390 | 39583480 | 39583478 | 39583480 | Splice_Site | CTC | - | p.G52del |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAP4K3 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_338538 | 2 | 39570528:39570593:39583389:39583480:39605206:39605264 | 39583389:39583480 | ENST00000341681.5,ENST00000437545.1,ENST00000263881.3,ENST00000429397.1 | PAAD | rs8545 | chr2:39583446 | A/G | 3.53e-04 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAP4K3 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAP4K3 |
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RelatedDrugs for MAP4K3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Q8IVH8 | DB12010 | Fostamatinib | Mitogen-activated protein kinase kinase kinase kinase 3 | small molecule | approved|investigational |
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RelatedDiseases for MAP4K3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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