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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for NTNG2 |
 Gene summary |
| Gene information | Gene symbol | NTNG2 | Gene ID | 84628 |
| Gene name | netrin G2 | |
| Synonyms | LHLL9381|Lmnt2|NTNG1|bA479K20.1 | |
| Cytomap | 9q34.13 | |
| Type of gene | protein-coding | |
| Description | netrin-G2bA479K20.1 (novel protein)laminet 2netrin G1 | |
| Modification date | 20180522 | |
| UniProtAcc | Q96CW9 | |
| Context | PubMed: NTNG2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for NTNG2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for NTNG2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for NTNG2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_500626 | 9 | 135037333:135037626:135041735:135042431:135073352:135073996 | 135041735:135042431 | ENSG00000196358.6 | ENST00000393228.4,ENST00000360670.3,ENST00000372179.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for NTNG2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_500626 | 9 | 135037333:135037626:135041735:135042431:135073352:135073996 | 135041735:135042431 | ENSG00000196358.6 | ENST00000360670.3,ENST00000393228.4,ENST00000372179.3 |
| exon_skip_500633 | 9 | 135102235:135102408:135105958:135105982:135114490:135114658 | 135105958:135105982 | ENSG00000196358.6 | ENST00000393229.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for NTNG2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000393229 | 135105958 | 135105982 | In-frame |
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Infer the effects of exon skipping event on protein functional features for NTNG2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for NTNG2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_500626 | 135041736 | 135042431 | 135042267 | 135042267 | Frame_Shift_Del | G | - | p.G17fs |
| BLCA | TCGA-K4-A83P-01 | exon_skip_500626 | 135041736 | 135042431 | 135042359 | 135042359 | Frame_Shift_Del | G | - | p.K47fs |
| COAD | TCGA-AD-6895-01 | exon_skip_500626 | 135041736 | 135042431 | 135042407 | 135042407 | Frame_Shift_Del | C | - | p.D63fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_500626 | 135041736 | 135042431 | 135042407 | 135042407 | Frame_Shift_Del | C | - | p.D63fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_500626 | 135041736 | 135042431 | 135042407 | 135042407 | Frame_Shift_Del | C | - | p.D63fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HCT15_LARGE_INTESTINE | 135041736 | 135042431 | 135042406 | 135042407 | Frame_Shift_Ins | - | C | p.DP63fs |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 135041736 | 135042431 | 135042262 | 135042262 | Missense_Mutation | C | T | p.A15V |
| SW1783_CENTRAL_NERVOUS_SYSTEM | 135041736 | 135042431 | 135042298 | 135042298 | Missense_Mutation | C | T | p.T27I |
| NCIH3122_LUNG | 135041736 | 135042431 | 135042351 | 135042351 | Missense_Mutation | C | T | p.R45C |
| SNU81_LARGE_INTESTINE | 135041736 | 135042431 | 135042416 | 135042416 | Missense_Mutation | G | T | p.E66D |
| EN_ENDOMETRIUM | 135041736 | 135042431 | 135042420 | 135042420 | Missense_Mutation | T | C | p.F68L |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for NTNG2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NTNG2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for NTNG2 |
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RelatedDrugs for NTNG2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for NTNG2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| NTNG2 | C0005586 | Bipolar Disorder | 2 | CTD_human;PSYGENET |
| NTNG2 | C0036341 | Schizophrenia | 1 | CTD_human |
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