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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for KIAA1841 |
 Gene summary |
| Gene information | Gene symbol | KIAA1841 | Gene ID | 84542 |
| Gene name | KIAA1841 | |
| Synonyms | - | |
| Cytomap | 2p15 | |
| Type of gene | protein-coding | |
| Description | uncharacterized protein KIAA1841 | |
| Modification date | 20180519 | |
| UniProtAcc | Q6NSI8 | |
| Context | PubMed: KIAA1841 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for KIAA1841 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for KIAA1841 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for KIAA1841 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_325805 | 2 | 61295983:61296120:61296786:61296833:61297476:61297635 | 61296786:61296833 | ENSG00000162929.9 | ENST00000482513.1 |
| exon_skip_325807 | 2 | 61297476:61297635:61298740:61298927:61300592:61300686 | 61298740:61298927 | ENSG00000162929.9 | ENST00000453873.1,ENST00000482513.1,ENST00000356719.2,ENST00000295031.5,ENST00000402291.1 |
| exon_skip_325808 | 2 | 61298792:61298927:61300592:61300686:61304054:61304293 | 61300592:61300686 | ENSG00000162929.9 | ENST00000453873.1,ENST00000482513.1,ENST00000356719.2,ENST00000295031.5,ENST00000402291.1 |
| exon_skip_325812 | 2 | 61298792:61298927:61304054:61304293:61308586:61308645 | 61304054:61304293 | ENSG00000162929.9 | ENST00000453186.1 |
| exon_skip_325815 | 2 | 61300592:61300686:61304054:61304293:61308586:61308645 | 61304054:61304293 | ENSG00000162929.9 | ENST00000453873.1,ENST00000482513.1,ENST00000356719.2,ENST00000295031.5,ENST00000402291.1 |
| exon_skip_325816 | 2 | 61304054:61304293:61308586:61308645:61310288:61310449 | 61308586:61308645 | ENSG00000162929.9 | ENST00000453873.1,ENST00000482513.1,ENST00000356719.2,ENST00000295031.5,ENST00000453186.1,ENST00000402291.1 |
| exon_skip_325823 | 2 | 61308586:61308645:61310288:61310449:61315293:61315380 | 61310288:61310449 | ENSG00000162929.9 | ENST00000453873.1,ENST00000482513.1,ENST00000356719.2,ENST00000295031.5,ENST00000453186.1,ENST00000402291.1 |
| exon_skip_325827 | 2 | 61315492:61315603:61319598:61319722:61324834:61324987 | 61319598:61319722 | ENSG00000162929.9 | ENST00000453873.1,ENST00000356719.2,ENST00000295031.5,ENST00000453186.1,ENST00000402291.1 |
| exon_skip_325830 | 2 | 61319598:61319722:61324834:61324987:61330987:61331088 | 61324834:61324987 | ENSG00000162929.9 | ENST00000453873.1,ENST00000356719.2,ENST00000295031.5,ENST00000453186.1,ENST00000402291.1 |
| exon_skip_325834 | 2 | 61324834:61324987:61330987:61331133:61333697:61333797 | 61330987:61331133 | ENSG00000162929.9 | ENST00000453873.1,ENST00000356719.2,ENST00000295031.5,ENST00000453186.1,ENST00000402291.1 |
| exon_skip_325836 | 2 | 61343113:61343205:61344491:61344520:61344601:61344675 | 61344491:61344520 | ENSG00000162929.9 | ENST00000453873.1,ENST00000356719.2,ENST00000295031.5,ENST00000453186.1,ENST00000488322.1,ENST00000402291.1,ENST00000462959.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for KIAA1841 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_325805 | 2 | 61295983:61296120:61296786:61296833:61297476:61297635 | 61296786:61296833 | ENSG00000162929.9 | ENST00000482513.1 |
| exon_skip_325807 | 2 | 61297476:61297635:61298740:61298927:61300592:61300686 | 61298740:61298927 | ENSG00000162929.9 | ENST00000482513.1,ENST00000402291.1,ENST00000295031.5,ENST00000356719.2,ENST00000453873.1 |
| exon_skip_325808 | 2 | 61298792:61298927:61300592:61300686:61304054:61304293 | 61300592:61300686 | ENSG00000162929.9 | ENST00000482513.1,ENST00000402291.1,ENST00000295031.5,ENST00000356719.2,ENST00000453873.1 |
| exon_skip_325812 | 2 | 61298792:61298927:61304054:61304293:61308586:61308645 | 61304054:61304293 | ENSG00000162929.9 | ENST00000453186.1 |
| exon_skip_325815 | 2 | 61300592:61300686:61304054:61304293:61308586:61308645 | 61304054:61304293 | ENSG00000162929.9 | ENST00000482513.1,ENST00000402291.1,ENST00000295031.5,ENST00000356719.2,ENST00000453873.1 |
| exon_skip_325816 | 2 | 61304054:61304293:61308586:61308645:61310288:61310449 | 61308586:61308645 | ENSG00000162929.9 | ENST00000482513.1,ENST00000453186.1,ENST00000402291.1,ENST00000295031.5,ENST00000356719.2,ENST00000453873.1 |
| exon_skip_325823 | 2 | 61308586:61308645:61310288:61310449:61315293:61315380 | 61310288:61310449 | ENSG00000162929.9 | ENST00000482513.1,ENST00000453186.1,ENST00000402291.1,ENST00000295031.5,ENST00000356719.2,ENST00000453873.1 |
| exon_skip_325827 | 2 | 61315492:61315603:61319598:61319722:61324834:61324987 | 61319598:61319722 | ENSG00000162929.9 | ENST00000453186.1,ENST00000402291.1,ENST00000295031.5,ENST00000356719.2,ENST00000453873.1 |
| exon_skip_325830 | 2 | 61319598:61319722:61324834:61324987:61330987:61331088 | 61324834:61324987 | ENSG00000162929.9 | ENST00000453186.1,ENST00000402291.1,ENST00000295031.5,ENST00000356719.2,ENST00000453873.1 |
| exon_skip_325834 | 2 | 61324834:61324987:61330987:61331133:61333697:61333797 | 61330987:61331133 | ENSG00000162929.9 | ENST00000453186.1,ENST00000402291.1,ENST00000295031.5,ENST00000356719.2,ENST00000453873.1 |
| exon_skip_325836 | 2 | 61343113:61343205:61344491:61344520:61344601:61344675 | 61344491:61344520 | ENSG00000162929.9 | ENST00000453186.1,ENST00000402291.1,ENST00000295031.5,ENST00000356719.2,ENST00000453873.1,ENST00000462959.1,ENST00000488322.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for KIAA1841 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000402291 | 61298740 | 61298927 | Frame-shift |
| ENST00000453873 | 61298740 | 61298927 | Frame-shift |
| ENST00000402291 | 61300592 | 61300686 | Frame-shift |
| ENST00000453873 | 61300592 | 61300686 | Frame-shift |
| ENST00000402291 | 61304054 | 61304293 | Frame-shift |
| ENST00000453873 | 61304054 | 61304293 | Frame-shift |
| ENST00000402291 | 61308586 | 61308645 | Frame-shift |
| ENST00000453873 | 61308586 | 61308645 | Frame-shift |
| ENST00000402291 | 61310288 | 61310449 | Frame-shift |
| ENST00000453873 | 61310288 | 61310449 | Frame-shift |
| ENST00000402291 | 61319598 | 61319722 | Frame-shift |
| ENST00000453873 | 61319598 | 61319722 | Frame-shift |
| ENST00000402291 | 61330987 | 61331133 | Frame-shift |
| ENST00000453873 | 61330987 | 61331133 | Frame-shift |
| ENST00000402291 | 61344491 | 61344520 | Frame-shift |
| ENST00000453873 | 61344491 | 61344520 | Frame-shift |
| ENST00000402291 | 61324834 | 61324987 | In-frame |
| ENST00000453873 | 61324834 | 61324987 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000402291 | 61298740 | 61298927 | Frame-shift |
| ENST00000453873 | 61298740 | 61298927 | Frame-shift |
| ENST00000402291 | 61300592 | 61300686 | Frame-shift |
| ENST00000453873 | 61300592 | 61300686 | Frame-shift |
| ENST00000402291 | 61304054 | 61304293 | Frame-shift |
| ENST00000453873 | 61304054 | 61304293 | Frame-shift |
| ENST00000402291 | 61308586 | 61308645 | Frame-shift |
| ENST00000453873 | 61308586 | 61308645 | Frame-shift |
| ENST00000402291 | 61310288 | 61310449 | Frame-shift |
| ENST00000453873 | 61310288 | 61310449 | Frame-shift |
| ENST00000402291 | 61319598 | 61319722 | Frame-shift |
| ENST00000453873 | 61319598 | 61319722 | Frame-shift |
| ENST00000402291 | 61330987 | 61331133 | Frame-shift |
| ENST00000453873 | 61330987 | 61331133 | Frame-shift |
| ENST00000402291 | 61344491 | 61344520 | Frame-shift |
| ENST00000453873 | 61344491 | 61344520 | Frame-shift |
| ENST00000402291 | 61324834 | 61324987 | In-frame |
| ENST00000453873 | 61324834 | 61324987 | In-frame |
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Infer the effects of exon skipping event on protein functional features for KIAA1841 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000402291 | 4533 | 718 | 61324834 | 61324987 | 1454 | 1606 | 404 | 455 |
| ENST00000453873 | 4311 | 718 | 61324834 | 61324987 | 1238 | 1390 | 404 | 455 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000402291 | 4533 | 718 | 61324834 | 61324987 | 1454 | 1606 | 404 | 455 |
| ENST00000453873 | 4311 | 718 | 61324834 | 61324987 | 1238 | 1390 | 404 | 455 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6NSI8 | 404 | 455 | 380 | 718 | Alternative sequence | ID=VSP_032301;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q6NSI8 | 404 | 455 | 380 | 718 | Alternative sequence | ID=VSP_032301;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q6NSI8 | 404 | 455 | 1 | 718 | Chain | ID=PRO_0000324598;Note=Uncharacterized protein KIAA1841 |
| Q6NSI8 | 404 | 455 | 1 | 718 | Chain | ID=PRO_0000324598;Note=Uncharacterized protein KIAA1841 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6NSI8 | 404 | 455 | 380 | 718 | Alternative sequence | ID=VSP_032301;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q6NSI8 | 404 | 455 | 380 | 718 | Alternative sequence | ID=VSP_032301;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q6NSI8 | 404 | 455 | 1 | 718 | Chain | ID=PRO_0000324598;Note=Uncharacterized protein KIAA1841 |
| Q6NSI8 | 404 | 455 | 1 | 718 | Chain | ID=PRO_0000324598;Note=Uncharacterized protein KIAA1841 |
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SNVs in the skipped exons for KIAA1841 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_325808 | 61300593 | 61300686 | 61300638 | 61300638 | Frame_Shift_Del | A | - | p.E128fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_325812 exon_skip_325815 | 61304055 | 61304293 | 61304106 | 61304106 | Frame_Shift_Del | T | - | p.D161fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_325812 exon_skip_325815 | 61304055 | 61304293 | 61304106 | 61304106 | Frame_Shift_Del | T | - | p.D161fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_325812 exon_skip_325815 | 61304055 | 61304293 | 61304238 | 61304238 | Frame_Shift_Del | A | - | p.I205fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_325812 exon_skip_325815 | 61304055 | 61304293 | 61304248 | 61304248 | Frame_Shift_Del | A | - | p.K209fs |
| LUAD | TCGA-05-4424-01 | exon_skip_325812 exon_skip_325815 | 61304055 | 61304293 | 61304276 | 61304276 | Frame_Shift_Del | G | - | p.C218fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_325816 | 61308587 | 61308645 | 61308630 | 61308630 | Frame_Shift_Del | A | - | p.L238fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_325816 | 61308587 | 61308645 | 61308630 | 61308630 | Frame_Shift_Del | A | - | p.L238fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_325816 | 61308587 | 61308645 | 61308630 | 61308630 | Frame_Shift_Del | A | - | p.L238fs |
| STAD | TCGA-HU-A4H4-01 | exon_skip_325823 | 61310289 | 61310449 | 61310316 | 61310316 | Frame_Shift_Del | A | - | p.H252fs |
| STAD | TCGA-FP-8211-01 | exon_skip_325830 | 61324835 | 61324987 | 61324903 | 61324913 | Frame_Shift_Del | AAGTTCATTGA | - | p.427_430del |
| STAD | TCGA-FP-8211-01 | exon_skip_325830 | 61324835 | 61324987 | 61324903 | 61324913 | Frame_Shift_Del | AAGTTCATTGA | - | p.A427fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_325830 | 61324835 | 61324987 | 61324950 | 61324950 | Frame_Shift_Del | A | - | p.Q443fs |
| LIHC | TCGA-CC-A7IE-01 | exon_skip_325807 | 61298741 | 61298927 | 61298747 | 61298747 | Nonsense_Mutation | A | T | p.K53X |
| LUAD | TCGA-17-Z045-01 | exon_skip_325812 exon_skip_325815 | 61304055 | 61304293 | 61304155 | 61304155 | Nonsense_Mutation | G | T | p.E178* |
| BLCA | TCGA-SY-A9G5-01 | exon_skip_325816 | 61308587 | 61308645 | 61308605 | 61308605 | Nonsense_Mutation | C | G | p.S230* |
| CHOL | TCGA-ZH-A8Y8-01 | exon_skip_325827 | 61319599 | 61319722 | 61319611 | 61319611 | Nonsense_Mutation | G | A | p.W367X |
| UCEC | TCGA-B5-A11E-01 | exon_skip_325827 | 61319599 | 61319722 | 61319611 | 61319611 | Nonsense_Mutation | G | A | p.W367* |
| COAD | TCGA-A6-5661-01 | exon_skip_325812 exon_skip_325815 | 61304055 | 61304293 | 61304295 | 61304296 | Splice_Site | - | A | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| EN_ENDOMETRIUM | 61298741 | 61298927 | 61298745 | 61298746 | Frame_Shift_Ins | - | A | p.AK52fs |
| SNUC5_LARGE_INTESTINE | 61298741 | 61298927 | 61298745 | 61298745 | Missense_Mutation | C | T | p.A52V |
| GIMEN_AUTONOMIC_GANGLIA | 61298741 | 61298927 | 61298847 | 61298847 | Missense_Mutation | C | G | p.T86R |
| SNU1040_LARGE_INTESTINE | 61298741 | 61298927 | 61298858 | 61298858 | Missense_Mutation | T | C | p.S90P |
| HT29_LARGE_INTESTINE | 61304055 | 61304293 | 61304070 | 61304071 | Missense_Mutation | CC | TT | p.H150Y |
| HT29_LARGE_INTESTINE | 61304055 | 61304293 | 61304071 | 61304071 | Missense_Mutation | C | T | p.H150Y |
| L428_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 61304055 | 61304293 | 61304102 | 61304102 | Missense_Mutation | A | T | p.E160V |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 61304055 | 61304293 | 61304111 | 61304111 | Missense_Mutation | C | T | p.T163I |
| SKGT2_STOMACH | 61304055 | 61304293 | 61304263 | 61304263 | Missense_Mutation | G | A | p.E214K |
| NCIH929_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 61304055 | 61304293 | 61304284 | 61304284 | Missense_Mutation | C | T | p.P221S |
| SKUT1_SOFT_TISSUE | 61310289 | 61310449 | 61310293 | 61310293 | Missense_Mutation | A | G | p.E245G |
| HCC202_BREAST | 61310289 | 61310449 | 61310305 | 61310305 | Missense_Mutation | A | C | p.Q249P |
| EB2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 61310289 | 61310449 | 61310371 | 61310371 | Missense_Mutation | A | G | p.N271S |
| EB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 61310289 | 61310449 | 61310371 | 61310371 | Missense_Mutation | A | G | p.N271S |
| YD38_UPPER_AERODIGESTIVE_TRACT | 61310289 | 61310449 | 61310429 | 61310429 | Missense_Mutation | C | A | p.D290E |
| HEC108_ENDOMETRIUM | 61319599 | 61319722 | 61319613 | 61319613 | Missense_Mutation | A | G | p.D368G |
| KMRC3_KIDNEY | 61319599 | 61319722 | 61319664 | 61319664 | Missense_Mutation | A | G | p.D385G |
| OAW42_OVARY | 61324835 | 61324987 | 61324946 | 61324946 | Missense_Mutation | A | G | p.N442D |
| CW2_LARGE_INTESTINE | 61324835 | 61324987 | 61324953 | 61324953 | Missense_Mutation | A | C | p.K444T |
| K2_SKIN | 61330988 | 61331133 | 61331021 | 61331021 | Missense_Mutation | C | T | p.R467C |
| SNU81_LARGE_INTESTINE | 61330988 | 61331133 | 61331021 | 61331021 | Missense_Mutation | C | T | p.R467C |
| TASK1_CENTRAL_NERVOUS_SYSTEM | 61330988 | 61331133 | 61331112 | 61331112 | Missense_Mutation | C | G | p.P497R |
| HCC2998_LARGE_INTESTINE | 61310289 | 61310449 | 61310290 | 61310290 | Splice_Site | T | C | p.V244A |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for KIAA1841 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for KIAA1841 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for KIAA1841 |
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RelatedDrugs for KIAA1841 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KIAA1841 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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