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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for HOPX |
 Gene summary |
| Gene information | Gene symbol | HOPX | Gene ID | 84525 |
| Gene name | HOP homeobox | |
| Synonyms | CAMEO|HOD|HOP|LAGY|NECC1|OB1|SMAP31|TOTO | |
| Cytomap | 4q12 | |
| Type of gene | protein-coding | |
| Description | homeodomain-only proteinlung cancer-associated Y proteinnot expressed in choriocarcinoma clone 1odd homeobox protein 1 | |
| Modification date | 20180523 | |
| UniProtAcc | Q9BPY8 | |
| Context | PubMed: HOPX [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| HOPX | GO:0001829 | trophectodermal cell differentiation | 17576768 |
| HOPX | GO:0045596 | negative regulation of cell differentiation | 17576768 |
| HOPX | GO:0051131 | chaperone-mediated protein complex assembly | 10811660 |
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Exon skipping events across known transcript of Ensembl for HOPX from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for HOPX |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for HOPX |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENSG00000171476.17 | ENST00000554144.1,ENST00000381260.3 |
| exon_skip_429674 | 4 | 57514163:57514963:57522022:57522178:57547420:57547460 | 57522022:57522178 | ENSG00000171476.17 | ENST00000337881.7 |
| exon_skip_429702 | 4 | 57522024:57522178:57523940:57524065:57547420:57547460 | 57523940:57524065 | ENSG00000171476.17 | ENST00000557328.1,ENST00000554144.1 |
| exon_skip_429712 | 4 | 57522024:57522178:57542664:57542732:57547420:57547460 | 57542664:57542732 | ENSG00000171476.17 | ENST00000556376.2 |
| exon_skip_429723 | 4 | 57525458:57525704:57538820:57538967:57547420:57547460 | 57538820:57538967 | ENSG00000171476.17 | ENST00000605395.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for HOPX |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENSG00000171476.17 | ENST00000554144.1,ENST00000381260.3 |
| exon_skip_429674 | 4 | 57514163:57514963:57522022:57522178:57547420:57547460 | 57522022:57522178 | ENSG00000171476.17 | ENST00000337881.7 |
| exon_skip_429702 | 4 | 57522024:57522178:57523940:57524065:57547420:57547460 | 57523940:57524065 | ENSG00000171476.17 | ENST00000554144.1,ENST00000557328.1 |
| exon_skip_429712 | 4 | 57522024:57522178:57542664:57542732:57547420:57547460 | 57542664:57542732 | ENSG00000171476.17 | ENST00000556376.2 |
| exon_skip_429723 | 4 | 57525458:57525704:57538820:57538967:57547420:57547460 | 57538820:57538967 | ENSG00000171476.17 | ENST00000605395.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for HOPX |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000337881 | 57522022 | 57522178 | 3UTR-3CDS |
| ENST00000556376 | 57542664 | 57542732 | 3UTR-3UTR |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000337881 | 57522022 | 57522178 | 3UTR-3CDS |
| ENST00000556376 | 57542664 | 57542732 | 3UTR-3UTR |
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Infer the effects of exon skipping event on protein functional features for HOPX |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for HOPX |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NCIH1105_LUNG | 57522023 | 57522178 | 57522060 | 57522060 | Missense_Mutation | A | G | p.I36T |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for HOPX |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENST00000554144.1,ENST00000381260.3 | GBM | rs4371677 | chr4:57516896 | G/A | 2.71e-05 |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENST00000554144.1,ENST00000381260.3 | BLCA | rs4371677 | chr4:57516896 | G/A | 1.30e-06 |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENST00000554144.1,ENST00000381260.3 | ESCA | rs4371677 | chr4:57516896 | G/A | 4.40e-05 |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENST00000554144.1,ENST00000381260.3 | HNSC | rs4371677 | chr4:57516896 | G/A | 3.43e-09 |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENST00000554144.1,ENST00000381260.3 | BRCA | rs4371677 | chr4:57516896 | G/A | 7.04e-07 |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENST00000554144.1,ENST00000381260.3 | LGG | rs4371677 | chr4:57516896 | G/A | 6.42e-11 |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENST00000554144.1,ENST00000381260.3 | LGG | rs4371677 | chr4:57516896 | G/A | 3.45e-08 |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENST00000554144.1,ENST00000381260.3 | LGG | rs4371677 | chr4:57516896 | G/A | 1.27e-06 |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENST00000554144.1,ENST00000381260.3 | KIRC | rs4371677 | chr4:57516896 | G/A | 7.20e-06 |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENST00000554144.1,ENST00000381260.3 | KIRC | rs4371677 | chr4:57516896 | G/A | 7.18e-05 |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENST00000554144.1,ENST00000381260.3 | LUAD | rs4371677 | chr4:57516896 | G/A | 1.55e-08 |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENST00000554144.1,ENST00000381260.3 | LUSC | rs4371677 | chr4:57516896 | G/A | 1.79e-06 |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENST00000554144.1,ENST00000381260.3 | LUSC | rs4371677 | chr4:57516896 | G/A | 8.88e-05 |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENST00000554144.1,ENST00000381260.3 | OV | rs4371677 | chr4:57516896 | G/A | 5.93e-04 |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENST00000554144.1,ENST00000381260.3 | PRAD | rs4371677 | chr4:57516896 | G/A | 4.59e-06 |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENST00000554144.1,ENST00000381260.3 | PRAD | rs4371677 | chr4:57516896 | G/A | 3.21e-03 |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENST00000554144.1,ENST00000381260.3 | STAD | rs4371677 | chr4:57516896 | G/A | 2.53e-05 |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENST00000554144.1,ENST00000381260.3 | THCA | rs4371677 | chr4:57516896 | G/A | 7.24e-22 |
| exon_skip_429672 | 4 | 57514163:57514963:57516848:57516978:57522022:57522171 | 57516848:57516978 | ENST00000554144.1,ENST00000381260.3 | THCA | rs4371677 | chr4:57516896 | G/A | 1.10e-03 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for HOPX |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for HOPX |
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RelatedDrugs for HOPX |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for HOPX |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| HOPX | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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