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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for DCTN5 |
 Gene summary |
| Gene information | Gene symbol | DCTN5 | Gene ID | 84516 |
| Gene name | dynactin subunit 5 | |
| Synonyms | - | |
| Cytomap | 16p12.2 | |
| Type of gene | protein-coding | |
| Description | dynactin subunit 5dynactin 4dynactin 5 (p25)dynactin subunit p25 | |
| Modification date | 20180519 | |
| UniProtAcc | Q9BTE1 | |
| Context | PubMed: DCTN5 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for DCTN5 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for DCTN5 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for DCTN5 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_134729 | 16 | 23652849:23652911:23654275:23654344:23669827:23669946 | 23654275:23654344 | ENSG00000166847.5 | ENST00000563998.1,ENST00000568589.1 |
| exon_skip_134730 | 16 | 23654275:23654344:23668806:23668907:23669827:23669946 | 23668806:23668907 | ENSG00000166847.5 | ENST00000563188.1 |
| exon_skip_134731 | 16 | 23654275:23654344:23669827:23669946:23672490:23672602 | 23669827:23669946 | ENSG00000166847.5 | ENST00000563998.1,ENST00000300087.2,ENST00000568589.1,ENST00000566298.1 |
| exon_skip_134733 | 16 | 23654275:23654344:23672490:23672602:23676946:23677014 | 23672490:23672602 | ENSG00000166847.5 | ENST00000566053.1 |
| exon_skip_134735 | 16 | 23669827:23669946:23672490:23672602:23676946:23677014 | 23672490:23672602 | ENSG00000166847.5 | ENST00000563998.1,ENST00000300087.2,ENST00000568589.1,ENST00000563188.1,ENST00000566298.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for DCTN5 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_134729 | 16 | 23652849:23652911:23654275:23654344:23669827:23669946 | 23654275:23654344 | ENSG00000166847.5 | ENST00000563998.1,ENST00000568589.1 |
| exon_skip_134730 | 16 | 23654275:23654344:23668806:23668907:23669827:23669946 | 23668806:23668907 | ENSG00000166847.5 | ENST00000563188.1 |
| exon_skip_134731 | 16 | 23654275:23654344:23669827:23669946:23672490:23672602 | 23669827:23669946 | ENSG00000166847.5 | ENST00000300087.2,ENST00000563998.1,ENST00000568589.1,ENST00000566298.1 |
| exon_skip_134733 | 16 | 23654275:23654344:23672490:23672602:23676946:23677014 | 23672490:23672602 | ENSG00000166847.5 | ENST00000566053.1 |
| exon_skip_134735 | 16 | 23669827:23669946:23672490:23672602:23676946:23677014 | 23672490:23672602 | ENSG00000166847.5 | ENST00000300087.2,ENST00000563998.1,ENST00000568589.1,ENST00000563188.1,ENST00000566298.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for DCTN5 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000300087 | 23669827 | 23669946 | Frame-shift |
| ENST00000300087 | 23672490 | 23672602 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000300087 | 23669827 | 23669946 | Frame-shift |
| ENST00000300087 | 23672490 | 23672602 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for DCTN5 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for DCTN5 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| ESCA | TCGA-L5-A8NQ-01 | exon_skip_134733 exon_skip_134735 | 23672491 | 23672602 | 23672534 | 23672534 | Nonsense_Mutation | G | T | p.E94X |
| UCS | TCGA-NA-A4R0-01 | exon_skip_134729 | 23654276 | 23654344 | 23654275 | 23654275 | Splice_Site | G | C | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| JHUEM1_ENDOMETRIUM | 23654276 | 23654344 | 23654298 | 23654298 | Missense_Mutation | G | A | p.R24H |
| YH13_CENTRAL_NERVOUS_SYSTEM | 23669828 | 23669946 | 23669853 | 23669853 | Missense_Mutation | T | A | p.I48N |
| MZ1PC_PANCREAS | 23669828 | 23669946 | 23669856 | 23669856 | Missense_Mutation | G | T | p.R49L |
| HCC2108_LUNG | 23672491 | 23672602 | 23672593 | 23672593 | Missense_Mutation | C | G | p.N113K |
| WSUNHL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 23669828 | 23669946 | 23669828 | 23669828 | Splice_Site | A | C | p.T40P |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DCTN5 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DCTN5 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DCTN5 |
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RelatedDrugs for DCTN5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DCTN5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| DCTN5 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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