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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for RECK |
 Gene summary |
| Gene information | Gene symbol | RECK | Gene ID | 8434 |
| Gene name | reversion inducing cysteine rich protein with kazal motifs | |
| Synonyms | ST15 | |
| Cytomap | 9p13.3 | |
| Type of gene | protein-coding | |
| Description | reversion-inducing cysteine-rich protein with Kazal motifsmembrane-anchored glycoprotein (metastasis and invasion)suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs)suppression of tumorigenicity 5 (reversion-in | |
| Modification date | 20180523 | |
| UniProtAcc | O95980 | |
| Context | PubMed: RECK [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for RECK from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for RECK |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for RECK |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_495847 | 9 | 36052261:36052320:36056976:36057010:36058823:36058898 | 36056976:36057010 | ENSG00000122707.7 | ENST00000475774.1 |
| exon_skip_495848 | 9 | 36058823:36058898:36060115:36060152:36063791:36063877 | 36060115:36060152 | ENSG00000122707.7 | ENST00000475774.1,ENST00000479053.1,ENST00000377966.3 |
| exon_skip_495852 | 9 | 36060115:36060152:36063791:36063877:36065573:36065621 | 36063791:36063877 | ENSG00000122707.7 | ENST00000475774.1,ENST00000479053.1,ENST00000377966.3 |
| exon_skip_495853 | 9 | 36065573:36065621:36066765:36066867:36080601:36080635 | 36066765:36066867 | ENSG00000122707.7 | ENST00000475774.1 |
| exon_skip_495854 | 9 | 36065573:36065621:36080601:36080635:36083361:36083559 | 36080601:36080635 | ENSG00000122707.7 | ENST00000479053.1,ENST00000377966.3 |
| exon_skip_495856 | 9 | 36083361:36083559:36087690:36087958:36091160:36091340 | 36087690:36087958 | ENSG00000122707.7 | ENST00000377966.3 |
| exon_skip_495857 | 9 | 36091160:36091340:36100327:36100540:36102090:36102227 | 36100327:36100540 | ENSG00000122707.7 | ENST00000377966.3 |
| exon_skip_495858 | 9 | 36105139:36105280:36107972:36108161:36109953:36110076 | 36107972:36108161 | ENSG00000122707.7 | ENST00000377966.3 |
| exon_skip_495860 | 9 | 36109953:36110076:36112301:36112473:36116981:36117174 | 36112301:36112473 | ENSG00000122707.7 | ENST00000377966.3 |
| exon_skip_495861 | 9 | 36112301:36112473:36116981:36117174:36118753:36118964 | 36116981:36117174 | ENSG00000122707.7 | ENST00000377966.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for RECK |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_495847 | 9 | 36052261:36052320:36056976:36057010:36058823:36058898 | 36056976:36057010 | ENSG00000122707.7 | ENST00000475774.1 |
| exon_skip_495848 | 9 | 36058823:36058898:36060115:36060152:36063791:36063877 | 36060115:36060152 | ENSG00000122707.7 | ENST00000377966.3,ENST00000475774.1,ENST00000479053.1 |
| exon_skip_495852 | 9 | 36060115:36060152:36063791:36063877:36065573:36065621 | 36063791:36063877 | ENSG00000122707.7 | ENST00000377966.3,ENST00000475774.1,ENST00000479053.1 |
| exon_skip_495853 | 9 | 36065573:36065621:36066765:36066867:36080601:36080635 | 36066765:36066867 | ENSG00000122707.7 | ENST00000475774.1 |
| exon_skip_495854 | 9 | 36065573:36065621:36080601:36080635:36083361:36083559 | 36080601:36080635 | ENSG00000122707.7 | ENST00000377966.3,ENST00000479053.1 |
| exon_skip_495856 | 9 | 36083361:36083559:36087690:36087958:36091160:36091340 | 36087690:36087958 | ENSG00000122707.7 | ENST00000377966.3 |
| exon_skip_495857 | 9 | 36091160:36091340:36100327:36100540:36102090:36102227 | 36100327:36100540 | ENSG00000122707.7 | ENST00000377966.3 |
| exon_skip_495858 | 9 | 36105139:36105280:36107972:36108161:36109953:36110076 | 36107972:36108161 | ENSG00000122707.7 | ENST00000377966.3 |
| exon_skip_495860 | 9 | 36109953:36110076:36112301:36112473:36116981:36117174 | 36112301:36112473 | ENSG00000122707.7 | ENST00000377966.3 |
| exon_skip_495861 | 9 | 36112301:36112473:36116981:36117174:36118753:36118964 | 36116981:36117174 | ENSG00000122707.7 | ENST00000377966.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for RECK |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000377966 | 36060115 | 36060152 | Frame-shift |
| ENST00000377966 | 36063791 | 36063877 | Frame-shift |
| ENST00000377966 | 36080601 | 36080635 | Frame-shift |
| ENST00000377966 | 36087690 | 36087958 | Frame-shift |
| ENST00000377966 | 36112301 | 36112473 | Frame-shift |
| ENST00000377966 | 36116981 | 36117174 | Frame-shift |
| ENST00000377966 | 36100327 | 36100540 | In-frame |
| ENST00000377966 | 36107972 | 36108161 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000377966 | 36060115 | 36060152 | Frame-shift |
| ENST00000377966 | 36063791 | 36063877 | Frame-shift |
| ENST00000377966 | 36080601 | 36080635 | Frame-shift |
| ENST00000377966 | 36087690 | 36087958 | Frame-shift |
| ENST00000377966 | 36112301 | 36112473 | Frame-shift |
| ENST00000377966 | 36116981 | 36117174 | Frame-shift |
| ENST00000377966 | 36100327 | 36100540 | In-frame |
| ENST00000377966 | 36107972 | 36108161 | In-frame |
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Infer the effects of exon skipping event on protein functional features for RECK |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000377966 | 4905 | 971 | 36100327 | 36100540 | 1652 | 1864 | 362 | 432 |
| ENST00000377966 | 4905 | 971 | 36107972 | 36108161 | 2143 | 2331 | 525 | 588 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000377966 | 4905 | 971 | 36100327 | 36100540 | 1652 | 1864 | 362 | 432 |
| ENST00000377966 | 4905 | 971 | 36107972 | 36108161 | 2143 | 2331 | 525 | 588 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O95980 | 362 | 432 | 23 | 942 | Chain | ID=PRO_0000016583;Note=Reversion-inducing cysteine-rich protein with Kazal motifs |
| O95980 | 525 | 588 | 23 | 942 | Chain | ID=PRO_0000016583;Note=Reversion-inducing cysteine-rich protein with Kazal motifs |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O95980 | 362 | 432 | 23 | 942 | Chain | ID=PRO_0000016583;Note=Reversion-inducing cysteine-rich protein with Kazal motifs |
| O95980 | 525 | 588 | 23 | 942 | Chain | ID=PRO_0000016583;Note=Reversion-inducing cysteine-rich protein with Kazal motifs |
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SNVs in the skipped exons for RECK |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_495856 | 36087691 | 36087958 | 36087762 | 36087762 | Frame_Shift_Del | A | - | p.K237fs |
| LUAD | TCGA-78-7155-01 | exon_skip_495856 | 36087691 | 36087958 | 36087832 | 36087833 | Frame_Shift_Del | TT | - | p.L260fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_495856 | 36087691 | 36087958 | 36087842 | 36087842 | Frame_Shift_Del | T | - | p.C263fs |
| COAD | TCGA-AU-6004-01 | exon_skip_495860 | 36112302 | 36112473 | 36112461 | 36112461 | Frame_Shift_Del | A | - | p.Q683fs |
| ESCA | TCGA-L5-A4OI-01 | exon_skip_495860 | 36112302 | 36112473 | 36112461 | 36112461 | Frame_Shift_Del | A | - | p.N685fs |
| ESCA | TCGA-L5-A4OI-01 | exon_skip_495860 | 36112302 | 36112473 | 36112461 | 36112461 | Frame_Shift_Del | A | - | p.Q683fs |
| STAD | TCGA-BR-8487-01 | exon_skip_495860 | 36112302 | 36112473 | 36112461 | 36112461 | Frame_Shift_Del | A | - | p.Q683fs |
| KIRC | TCGA-G6-A8L6-01 | exon_skip_495861 | 36116982 | 36117174 | 36117089 | 36117089 | Frame_Shift_Del | T | - | p.V723fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_495861 | 36116982 | 36117174 | 36117144 | 36117144 | Frame_Shift_Del | A | - | p.G741fs |
| LUAD | TCGA-67-3774-01 | exon_skip_495860 | 36112302 | 36112473 | 36112460 | 36112461 | Frame_Shift_Ins | - | A | p.K683fs |
| STAD | TCGA-BR-8382-01 | exon_skip_495860 | 36112302 | 36112473 | 36112460 | 36112461 | Frame_Shift_Ins | - | A | p.Q683fs |
| STAD | TCGA-MX-A5UJ-01 | exon_skip_495860 | 36112302 | 36112473 | 36112460 | 36112461 | Frame_Shift_Ins | - | A | p.K683fs |
| STAD | TCGA-MX-A5UJ-01 | exon_skip_495860 | 36112302 | 36112473 | 36112460 | 36112461 | Frame_Shift_Ins | - | A | p.Q683fs |
| UCEC | TCGA-D1-A163-01 | exon_skip_495860 | 36112302 | 36112473 | 36112460 | 36112461 | Frame_Shift_Ins | - | A | p.Q683fs |
| STAD | TCGA-BR-8382-01 | exon_skip_495860 | 36112302 | 36112473 | 36112461 | 36112462 | Frame_Shift_Ins | - | A | p.Q683fs |
| LIHC | TCGA-ES-A2HT-01 | exon_skip_495852 | 36063792 | 36063877 | 36063817 | 36063817 | Nonsense_Mutation | G | A | p.W99X |
| BRCA | TCGA-C8-A1HE-01 | exon_skip_495852 | 36063792 | 36063877 | 36063860 | 36063860 | Nonsense_Mutation | C | T | p.R114* |
| READ | TCGA-AG-A002-01 | exon_skip_495857 | 36100328 | 36100540 | 36100335 | 36100335 | Nonsense_Mutation | G | T | p.E365X |
| THYM | TCGA-ZC-AAAF-01 | exon_skip_495857 | 36100328 | 36100540 | 36100398 | 36100398 | Nonsense_Mutation | G | T | p.E386X |
| SKCM | TCGA-EE-A29M-06 | exon_skip_495854 | 36080602 | 36080635 | 36080601 | 36080601 | Splice_Site | G | A | . |
| LUSC | TCGA-66-2787-01 | exon_skip_495857 | 36100328 | 36100540 | 36100327 | 36100327 | Splice_Site | G | T | p.R362_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| TOV21G_OVARY | 36112302 | 36112473 | 36112460 | 36112461 | Frame_Shift_Ins | - | A | p.Q683fs |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 36060116 | 36060152 | 36060129 | 36060129 | Missense_Mutation | A | G | p.N83S |
| DG75_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 36063792 | 36063877 | 36063836 | 36063836 | Missense_Mutation | G | A | p.E106K |
| BICR31_UPPER_AERODIGESTIVE_TRACT | 36063792 | 36063877 | 36063845 | 36063845 | Missense_Mutation | A | C | p.I109L |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 36063792 | 36063877 | 36063849 | 36063849 | Missense_Mutation | C | G | p.A110G |
| SCABER_URINARY_TRACT | 36080602 | 36080635 | 36080632 | 36080632 | Missense_Mutation | G | A | p.E146K |
| PEDS005TPFAD_KIDNEY | 36087691 | 36087958 | 36087766 | 36087766 | Missense_Mutation | C | T | p.T238M |
| NCIH513_PLEURA | 36087691 | 36087958 | 36087766 | 36087766 | Missense_Mutation | C | A | p.T238K |
| JHUEM7_ENDOMETRIUM | 36087691 | 36087958 | 36087846 | 36087846 | Missense_Mutation | C | T | p.L265F |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 36087691 | 36087958 | 36087853 | 36087853 | Missense_Mutation | G | T | p.S267I |
| AGS_STOMACH | 36100328 | 36100540 | 36100402 | 36100402 | Missense_Mutation | A | C | p.K387T |
| SARC9371_BONE | 36100328 | 36100540 | 36100422 | 36100422 | Missense_Mutation | T | C | p.F394L |
| COLO794_SKIN | 36107973 | 36108161 | 36108054 | 36108054 | Missense_Mutation | G | T | p.G553V |
| PCM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 36107973 | 36108161 | 36108112 | 36108112 | Missense_Mutation | G | A | p.M572I |
| KYSE270_OESOPHAGUS | 36107973 | 36108161 | 36108122 | 36108122 | Missense_Mutation | G | A | p.D576N |
| 127399_SOFT_TISSUE | 36107973 | 36108161 | 36108150 | 36108150 | Missense_Mutation | G | A | p.G585E |
| D341MED_CENTRAL_NERVOUS_SYSTEM | 36107973 | 36108161 | 36108150 | 36108150 | Missense_Mutation | G | A | p.G585E |
| HCC515_LUNG | 36107973 | 36108161 | 36108150 | 36108150 | Missense_Mutation | G | A | p.G585E |
| NCIH3122_LUNG | 36107973 | 36108161 | 36108150 | 36108150 | Missense_Mutation | G | A | p.G585E |
| D341MED_CENTRAL_NERVOUS_SYSTEM | 36107973 | 36108161 | 36108156 | 36108156 | Missense_Mutation | G | A | p.R587K |
| NCIH3122_LUNG | 36107973 | 36108161 | 36108156 | 36108156 | Missense_Mutation | G | A | p.R587K |
| KMM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 36107973 | 36108161 | 36108156 | 36108156 | Missense_Mutation | G | T | p.R587I |
| NALM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 36112302 | 36112473 | 36112353 | 36112353 | Missense_Mutation | G | T | p.G647V |
| NCIH358_LUNG | 36112302 | 36112473 | 36112373 | 36112373 | Missense_Mutation | T | A | p.C654S |
| IM95_STOMACH | 36112302 | 36112473 | 36112415 | 36112415 | Missense_Mutation | T | C | p.F668L |
| SW684_SOFT_TISSUE | 36112302 | 36112473 | 36112454 | 36112454 | Missense_Mutation | C | T | p.P681S |
| MFE319_ENDOMETRIUM | 36112302 | 36112473 | 36112467 | 36112467 | Missense_Mutation | A | C | p.N685T |
| HEC59_ENDOMETRIUM | 36116982 | 36117174 | 36117023 | 36117023 | Missense_Mutation | A | G | p.K701R |
| HEC1_ENDOMETRIUM | 36116982 | 36117174 | 36117059 | 36117059 | Missense_Mutation | A | G | p.Q713R |
| HEC1B_ENDOMETRIUM | 36116982 | 36117174 | 36117059 | 36117059 | Missense_Mutation | A | G | p.Q713R |
| REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 36116982 | 36117174 | 36117065 | 36117065 | Missense_Mutation | C | T | p.A715V |
| SW48_LARGE_INTESTINE | 36116982 | 36117174 | 36117075 | 36117075 | Missense_Mutation | G | T | p.Q718H |
| SNU1040_LARGE_INTESTINE | 36116982 | 36117174 | 36117125 | 36117125 | Missense_Mutation | G | A | p.C735Y |
| SNU81_LARGE_INTESTINE | 36100328 | 36100540 | 36100335 | 36100335 | Nonsense_Mutation | G | T | p.E365* |
| HEC59_ENDOMETRIUM | 36116982 | 36117174 | 36117073 | 36117073 | Nonsense_Mutation | C | T | p.Q718* |
| EN_ENDOMETRIUM | 36116982 | 36117174 | 36116983 | 36116983 | Splice_Site | T | C | p.C688R |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for RECK |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RECK |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for RECK |
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RelatedDrugs for RECK |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for RECK |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| RECK | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| RECK | C0009171 | Cocaine Abuse | 1 | PSYGENET |
| RECK | C0009375 | Colonic Neoplasms | 1 | CTD_human |
| RECK | C0017636 | Glioblastoma | 1 | CTD_human |
| RECK | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| RECK | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
| RECK | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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