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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ING5 |
 Gene summary |
| Gene information | Gene symbol | ING5 | Gene ID | 84289 |
| Gene name | inhibitor of growth family member 5 | |
| Synonyms | p28ING5 | |
| Cytomap | 2q37.3 | |
| Type of gene | protein-coding | |
| Description | inhibitor of growth protein 5 | |
| Modification date | 20180519 | |
| UniProtAcc | Q8WYH8 | |
| Context | PubMed: ING5 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ING5 | GO:0006260 | DNA replication | 16387653 |
| ING5 | GO:0006473 | protein acetylation | 12750254 |
| ING5 | GO:0008285 | negative regulation of cell proliferation | 12750254 |
| ING5 | GO:0043966 | histone H3 acetylation | 16387653 |
| ING5 | GO:0045893 | positive regulation of transcription, DNA-templated | 16387653 |
| ING5 | GO:0045926 | negative regulation of growth | 12750254 |
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Exon skipping events across known transcript of Ensembl for ING5 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ING5 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ING5 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_336199 | 2 | 242648630:242648797:242650791:242650903:242651392:242651486 | 242650791:242650903 | ENSG00000168395.10 | ENST00000492488.1,ENST00000482774.1,ENST00000406941.1,ENST00000313552.6,ENST00000489509.1 |
| exon_skip_336201 | 2 | 242651392:242651486:242658897:242659027:242659390:242661130 | 242658897:242659027 | ENSG00000168395.10 | ENST00000482774.1 |
| exon_skip_336204 | 2 | 242651392:242651486:242662353:242662489:242662624:242662686 | 242662353:242662489 | ENSG00000168395.10 | ENST00000406941.1,ENST00000313552.6 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ING5 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_336199 | 2 | 242648630:242648797:242650791:242650903:242651392:242651486 | 242650791:242650903 | ENSG00000168395.10 | ENST00000492488.1,ENST00000313552.6,ENST00000482774.1,ENST00000406941.1,ENST00000489509.1 |
| exon_skip_336200 | 2 | 242648630:242648797:242650791:242650999:242651392:242651486 | 242650791:242650999 | ENSG00000168395.10 | ENST00000445620.1 |
| exon_skip_336201 | 2 | 242651392:242651486:242658897:242659027:242659390:242661130 | 242658897:242659027 | ENSG00000168395.10 | ENST00000482774.1 |
| exon_skip_336204 | 2 | 242651392:242651486:242662353:242662489:242662624:242662686 | 242662353:242662489 | ENSG00000168395.10 | ENST00000313552.6,ENST00000406941.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ING5 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000313552 | 242650791 | 242650903 | Frame-shift |
| ENST00000313552 | 242662353 | 242662489 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000313552 | 242650791 | 242650903 | Frame-shift |
| ENST00000313552 | 242662353 | 242662489 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for ING5 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for ING5 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HNSC | TCGA-F7-A624-01 | exon_skip_336199 | 242650792 | 242650903 | 242650899 | 242650899 | Frame_Shift_Del | A | - | p.L128fs |
| UCEC | TCGA-DI-A0WH-01 | exon_skip_336199 | 242650792 | 242650903 | 242650899 | 242650899 | Frame_Shift_Del | A | - | p.L128fs |
| HNSC | TCGA-CV-7424-01 | exon_skip_336199 | 242650792 | 242650903 | 242650891 | 242650891 | Nonsense_Mutation | C | T | p.R126* |
| PAAD | TCGA-IB-7651-01 | exon_skip_336199 | 242650792 | 242650903 | 242650891 | 242650891 | Nonsense_Mutation | C | T | p.R126* |
| PAAD | TCGA-IB-7651-01 | exon_skip_336199 | 242650792 | 242650903 | 242650891 | 242650891 | Nonsense_Mutation | C | T | p.R126X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ING5 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ING5 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ING5 |
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RelatedDrugs for ING5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ING5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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