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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ANXA9 |
 Gene summary |
| Gene information | Gene symbol | ANXA9 | Gene ID | 8416 |
| Gene name | annexin A9 | |
| Synonyms | ANX31 | |
| Cytomap | 1q21.3 | |
| Type of gene | protein-coding | |
| Description | annexin A9annexin 31annexin XXXIannexin-9pemphaxin | |
| Modification date | 20180519 | |
| UniProtAcc | O76027 | |
| Context | PubMed: ANXA9 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| ANXA9 | GO:0098609 | cell-cell adhesion | 10899159 |
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Exon skipping events across known transcript of Ensembl for ANXA9 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ANXA9 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ANXA9 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_9902 | 1 | 150954962:150955059:150955565:150955656:150955813:150955910 | 150955565:150955656 | ENSG00000143412.5 | ENST00000368947.4 |
| exon_skip_9911 | 1 | 150958811:150958891:150959077:150959137:150960347:150960432 | 150959077:150959137 | ENSG00000143412.5 | ENST00000368947.4 |
| exon_skip_9914 | 1 | 150960356:150960432:150960566:150960662:150960758:150960817 | 150960566:150960662 | ENSG00000143412.5 | ENST00000368947.4 |
| exon_skip_9916 | 1 | 150960758:150960817:150967052:150967175:150967735:150968110 | 150967052:150967175 | ENSG00000143412.5 | ENST00000368947.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ANXA9 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_9902 | 1 | 150954962:150955059:150955565:150955656:150955813:150955910 | 150955565:150955656 | ENSG00000143412.5 | ENST00000368947.4 |
| exon_skip_9911 | 1 | 150958811:150958891:150959077:150959137:150960347:150960432 | 150959077:150959137 | ENSG00000143412.5 | ENST00000368947.4 |
| exon_skip_9914 | 1 | 150960356:150960432:150960566:150960662:150960758:150960817 | 150960566:150960662 | ENSG00000143412.5 | ENST00000368947.4 |
| exon_skip_9916 | 1 | 150960758:150960817:150967052:150967175:150967735:150968110 | 150967052:150967175 | ENSG00000143412.5 | ENST00000368947.4 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ANXA9 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000368947 | 150955565 | 150955656 | 5CDS-5UTR |
| ENST00000368947 | 150959077 | 150959137 | In-frame |
| ENST00000368947 | 150960566 | 150960662 | In-frame |
| ENST00000368947 | 150967052 | 150967175 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000368947 | 150955565 | 150955656 | 5CDS-5UTR |
| ENST00000368947 | 150959077 | 150959137 | In-frame |
| ENST00000368947 | 150960566 | 150960662 | In-frame |
| ENST00000368947 | 150967052 | 150967175 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ANXA9 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000368947 | 1843 | 345 | 150959077 | 150959137 | 1029 | 1088 | 184 | 204 |
| ENST00000368947 | 1843 | 345 | 150960566 | 150960662 | 1174 | 1269 | 232 | 264 |
| ENST00000368947 | 1843 | 345 | 150967052 | 150967175 | 1329 | 1451 | 284 | 325 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000368947 | 1843 | 345 | 150959077 | 150959137 | 1029 | 1088 | 184 | 204 |
| ENST00000368947 | 1843 | 345 | 150960566 | 150960662 | 1174 | 1269 | 232 | 264 |
| ENST00000368947 | 1843 | 345 | 150967052 | 150967175 | 1329 | 1451 | 284 | 325 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O76027 | 184 | 204 | 1 | 345 | Chain | ID=PRO_0000067505;Note=Annexin A9 |
| O76027 | 184 | 204 | 199 | 264 | Repeat | Note=Annexin 3 |
| O76027 | 232 | 264 | 1 | 345 | Chain | ID=PRO_0000067505;Note=Annexin A9 |
| O76027 | 232 | 264 | 232 | 232 | Natural variant | ID=VAR_048258;Note=R->Q;Dbxref=dbSNP:rs7542365 |
| O76027 | 232 | 264 | 199 | 264 | Repeat | Note=Annexin 3 |
| O76027 | 284 | 325 | 1 | 345 | Chain | ID=PRO_0000067505;Note=Annexin A9 |
| O76027 | 284 | 325 | 272 | 339 | Repeat | Note=Annexin 4 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O76027 | 184 | 204 | 1 | 345 | Chain | ID=PRO_0000067505;Note=Annexin A9 |
| O76027 | 184 | 204 | 199 | 264 | Repeat | Note=Annexin 3 |
| O76027 | 232 | 264 | 1 | 345 | Chain | ID=PRO_0000067505;Note=Annexin A9 |
| O76027 | 232 | 264 | 232 | 232 | Natural variant | ID=VAR_048258;Note=R->Q;Dbxref=dbSNP:rs7542365 |
| O76027 | 232 | 264 | 199 | 264 | Repeat | Note=Annexin 3 |
| O76027 | 284 | 325 | 1 | 345 | Chain | ID=PRO_0000067505;Note=Annexin A9 |
| O76027 | 284 | 325 | 272 | 339 | Repeat | Note=Annexin 4 |
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SNVs in the skipped exons for ANXA9 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BLCA | TCGA-UY-A9PB-01 | exon_skip_9916 | 150967053 | 150967175 | 150967125 | 150967126 | Frame_Shift_Del | AG | - | p.R309fs |
| BLCA | TCGA-G2-A2EO-01 | exon_skip_9914 | 150960567 | 150960662 | 150960575 | 150960575 | Nonsense_Mutation | C | T | p.Q236* |
| BLCA | TCGA-XF-AAMG-01 | exon_skip_9914 | 150960567 | 150960662 | 150960608 | 150960608 | Nonsense_Mutation | G | T | p.E247* |
| LGG | TCGA-CS-4938-01 | exon_skip_9902 | 150955566 | 150955656 | 150955565 | 150955565 | Splice_Site | G | A | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| M059J_CENTRAL_NERVOUS_SYSTEM | 150955566 | 150955656 | 150955587 | 150955588 | Frame_Shift_Del | TG | - | p.V3fs |
| SW1783_CENTRAL_NERVOUS_SYSTEM | 150955566 | 150955656 | 150955597 | 150955597 | Missense_Mutation | G | A | p.G6R |
| MFE319_ENDOMETRIUM | 150955566 | 150955656 | 150955615 | 150955615 | Missense_Mutation | C | A | p.L12I |
| CHLA218_BONE | 150959078 | 150959137 | 150959120 | 150959120 | Missense_Mutation | G | T | p.A199S |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 150960567 | 150960662 | 150960584 | 150960584 | Missense_Mutation | C | T | p.R239W |
| MZ1PC_PANCREAS | 150960567 | 150960662 | 150960584 | 150960584 | Missense_Mutation | C | T | p.R239W |
| HEC6_ENDOMETRIUM | 150960567 | 150960662 | 150960612 | 150960612 | Missense_Mutation | C | A | p.A248D |
| NOS1_BONE | 150967053 | 150967175 | 150967068 | 150967068 | Missense_Mutation | T | C | p.Y290H |
| P3HR1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 150967053 | 150967175 | 150967137 | 150967137 | Missense_Mutation | A | G | p.R313G |
| JIYOYEP2003_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 150967053 | 150967175 | 150967137 | 150967137 | Missense_Mutation | A | G | p.R313G |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ANXA9 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ANXA9 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ANXA9 |
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RelatedDrugs for ANXA9 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANXA9 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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