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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for CDCA7 |
 Gene summary |
| Gene information | Gene symbol | CDCA7 | Gene ID | 83879 |
| Gene name | cell division cycle associated 7 | |
| Synonyms | ICF3|JPO1 | |
| Cytomap | 2q31.1 | |
| Type of gene | protein-coding | |
| Description | cell division cycle-associated protein 7c-Myc target JPO1 | |
| Modification date | 20180523 | |
| UniProtAcc | Q9BWT1 | |
| Context | PubMed: CDCA7 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CDCA7 | GO:0042127 | regulation of cell proliferation | 11598121 |
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Exon skipping events across known transcript of Ensembl for CDCA7 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for CDCA7 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for CDCA7 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_331265 | 2 | 174219620:174219712:174223439:174223565:174227953:174228190 | 174223439:174223565 | ENSG00000144354.9 | ENST00000467411.1,ENST00000392567.2,ENST00000496441.1 |
| exon_skip_331268 | 2 | 174223442:174223565:174223982:174224219:174227953:174228190 | 174223982:174224219 | ENSG00000144354.9 | ENST00000306721.3 |
| exon_skip_331270 | 2 | 174223442:174223565:174224070:174224219:174227953:174228190 | 174224070:174224219 | ENSG00000144354.9 | ENST00000435616.1 |
| exon_skip_331272 | 2 | 174223442:174223565:174224114:174224219:174227953:174228190 | 174224114:174224219 | ENSG00000144354.9 | ENST00000410101.3 |
| exon_skip_331274 | 2 | 174228545:174228623:174228727:174228889:174229522:174229601 | 174228727:174228889 | ENSG00000144354.9 | ENST00000435616.1 |
| exon_skip_331275 | 2 | 174230179:174230320:174231010:174231160:174231877:174232014 | 174231010:174231160 | ENSG00000144354.9 | ENST00000410019.3,ENST00000347703.3,ENST00000410101.3,ENST00000496441.1,ENST00000306721.3 |
| exon_skip_331276 | 2 | 174231010:174231160:174231877:174232014:174232361:174232448 | 174231877:174232014 | ENSG00000144354.9 | ENST00000410019.3,ENST00000347703.3,ENST00000410101.3,ENST00000496441.1,ENST00000306721.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for CDCA7 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_331265 | 2 | 174219620:174219712:174223439:174223565:174227953:174228190 | 174223439:174223565 | ENSG00000144354.9 | ENST00000392567.2,ENST00000496441.1,ENST00000467411.1 |
| exon_skip_331268 | 2 | 174223442:174223565:174223982:174224219:174227953:174228190 | 174223982:174224219 | ENSG00000144354.9 | ENST00000306721.3 |
| exon_skip_331270 | 2 | 174223442:174223565:174224070:174224219:174227953:174228190 | 174224070:174224219 | ENSG00000144354.9 | ENST00000435616.1 |
| exon_skip_331272 | 2 | 174223442:174223565:174224114:174224219:174227953:174228190 | 174224114:174224219 | ENSG00000144354.9 | ENST00000410101.3 |
| exon_skip_331274 | 2 | 174228545:174228623:174228727:174228889:174229522:174229601 | 174228727:174228889 | ENSG00000144354.9 | ENST00000435616.1 |
| exon_skip_331275 | 2 | 174230179:174230320:174231010:174231160:174231877:174232014 | 174231010:174231160 | ENSG00000144354.9 | ENST00000347703.3,ENST00000306721.3,ENST00000410101.3,ENST00000410019.3,ENST00000496441.1 |
| exon_skip_331276 | 2 | 174231010:174231160:174231877:174232014:174232361:174232448 | 174231877:174232014 | ENSG00000144354.9 | ENST00000347703.3,ENST00000306721.3,ENST00000410101.3,ENST00000410019.3,ENST00000496441.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for CDCA7 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000347703 | 174231877 | 174232014 | Frame-shift |
| ENST00000347703 | 174231010 | 174231160 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000347703 | 174231877 | 174232014 | Frame-shift |
| ENST00000347703 | 174231010 | 174231160 | In-frame |
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Infer the effects of exon skipping event on protein functional features for CDCA7 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000347703 | 2517 | 371 | 174231010 | 174231160 | 943 | 1092 | 266 | 316 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000347703 | 2517 | 371 | 174231010 | 174231160 | 943 | 1092 | 266 | 316 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for CDCA7 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_331268 | 174223983 | 174224219 | 174224181 | 174224181 | Frame_Shift_Del | T | - | p.F116fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_331270 | 174224071 | 174224219 | 174224181 | 174224181 | Frame_Shift_Del | T | - | p.F116fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_331272 | 174224115 | 174224219 | 174224181 | 174224181 | Frame_Shift_Del | T | - | p.F116fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_331275 | 174231011 | 174231160 | 174231106 | 174231106 | Frame_Shift_Del | C | - | p.G377fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_331276 | 174231878 | 174232014 | 174231953 | 174231953 | Frame_Shift_Del | G | - | p.G421fs |
| BLCA | TCGA-GD-A2C5-01 | exon_skip_331275 | 174231011 | 174231160 | 174231089 | 174231089 | Nonsense_Mutation | C | T | p.R293* |
| BLCA | TCGA-GD-A2C5-01 | exon_skip_331275 | 174231011 | 174231160 | 174231089 | 174231089 | Nonsense_Mutation | C | T | p.R372* |
| LUAD | TCGA-44-7662-01 | exon_skip_331265 | 174223440 | 174223565 | 174223566 | 174223566 | Splice_Site | G | T | p.T49_splice |
| UCEC | TCGA-AP-A056-01 | exon_skip_331276 | 174231878 | 174232014 | 174231876 | 174231876 | Splice_Site | A | C | e9-2 |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-AP-A056-01 |
| Cancer type: UCEC | |
| ESID: exon_skip_331276 | |
| Skipped exon start: 174231878 | |
| Skipped exon end: 174232014 | |
| Mutation start: 174231876 | |
| Mutation end: 174231876 | |
| Mutation type: Splice_Site | |
| Reference seq: A | |
| Mutation seq: C | |
| AAchange: e9-2 | |
exon_skip_148936_UCEC_TCGA-AP-A056-01.png | |
exon_skip_331276_UCEC_TCGA-AP-A056-01.png | |
exon_skip_347552_UCEC_TCGA-AP-A056-01.png | |
exon_skip_37318_UCEC_TCGA-AP-A056-01.png | |
exon_skip_389380_UCEC_TCGA-AP-A056-01.png | |
exon_skip_445277_UCEC_TCGA-AP-A056-01.png | |
exon_skip_470936_UCEC_TCGA-AP-A056-01.png | |
exon_skip_54221_UCEC_TCGA-AP-A056-01.png | |
exon_skip_81411_UCEC_TCGA-AP-A056-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SN12C_KIDNEY | 174223440 | 174223565 | 174223458 | 174223460 | In_Frame_Del | AAG | - | p.K15del |
| CW2_LARGE_INTESTINE | 174223440 | 174223565 | 174223483 | 174223483 | Missense_Mutation | A | G | p.Y22C |
| SISO_CERVIX | 174231011 | 174231160 | 174231023 | 174231023 | Missense_Mutation | C | T | p.H271Y |
| GRST_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 174231011 | 174231160 | 174231023 | 174231023 | Missense_Mutation | C | T | p.H271Y |
| NCIBL1395_MATCHED_NORMAL_TISSUE | 174231011 | 174231160 | 174231117 | 174231117 | Missense_Mutation | G | A | p.R302Q |
| NCIH1395_LUNG | 174231011 | 174231160 | 174231117 | 174231117 | Missense_Mutation | G | A | p.R302Q |
| NCIH747_LARGE_INTESTINE | 174231011 | 174231160 | 174231122 | 174231122 | Missense_Mutation | C | T | p.R304C |
| CORL321_PLEURA | 174231011 | 174231160 | 174231142 | 174231142 | Missense_Mutation | G | T | p.R310S |
| SNU1040_LARGE_INTESTINE | 174231878 | 174232014 | 174231927 | 174231927 | Missense_Mutation | G | A | p.R333Q |
| MZ2MEL_SKIN | 174231878 | 174232014 | 174231933 | 174231933 | Missense_Mutation | G | A | p.R335Q |
| HCC1569_BREAST | 174231878 | 174232014 | 174231957 | 174231957 | Missense_Mutation | T | C | p.V343A |
| HCC366_LUNG | 174231878 | 174232014 | 174231980 | 174231980 | Missense_Mutation | C | T | p.H351Y |
| DG75_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 174231011 | 174231160 | 174231012 | 174231012 | Splice_Site | G | A | p.G267D |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CDCA7 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_331274 | 2 | 174228545:174228623:174228727:174228889:174229522:174229601 | 174228727:174228889 | ENST00000435616.1 | COAD | rs1529887 | chr2:174228744 | T/C | 6.58e-05 |
| exon_skip_331274 | 2 | 174228545:174228623:174228727:174228889:174229522:174229601 | 174228727:174228889 | ENST00000435616.1 | COAD | rs1529887 | chr2:174228744 | T/C | 1.94e-03 |
| exon_skip_331274 | 2 | 174228545:174228623:174228727:174228889:174229522:174229601 | 174228727:174228889 | ENST00000435616.1 | HNSC | rs1529887 | chr2:174228744 | T/C | 1.75e-08 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CDCA7 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CDCA7 |
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RelatedDrugs for CDCA7 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDCA7 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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