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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for FCRL4 |
 Gene summary |
| Gene information | Gene symbol | FCRL4 | Gene ID | 83417 |
| Gene name | Fc receptor like 4 | |
| Synonyms | CD307d|FCRH4|IGFP2|IRTA1 | |
| Cytomap | 1q23.1 | |
| Type of gene | protein-coding | |
| Description | Fc receptor-like protein 4IFGP family protein 2fc receptor homolog 4fcR-like protein 4hIFGP2immune receptor translocation-associated protein 1immunoglobulin superfamily Fc receptor, gp42immunoglobulin superfamily receptor translocation associated 1 | |
| Modification date | 20180519 | |
| UniProtAcc | Q96PJ5 | |
| Context | PubMed: FCRL4 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for FCRL4 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for FCRL4 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for FCRL4 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_33571 | 1 | 157557065:157557350:157557654:157557909:157558993:157559041 | 157557654:157557909 | ENSG00000163518.6 | ENST00000448509.2,ENST00000271532.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for FCRL4 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_33571 | 1 | 157557065:157557350:157557654:157557909:157558993:157559041 | 157557654:157557909 | ENSG00000163518.6 | ENST00000271532.1,ENST00000448509.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for FCRL4 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000271532 | 157557654 | 157557909 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000271532 | 157557654 | 157557909 | In-frame |
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Infer the effects of exon skipping event on protein functional features for FCRL4 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000271532 | 3476 | 515 | 157557654 | 157557909 | 444 | 698 | 102 | 187 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000271532 | 3476 | 515 | 157557654 | 157557909 | 444 | 698 | 102 | 187 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96PJ5 | 102 | 187 | 20 | 515 | Chain | ID=PRO_0000331642;Note=Fc receptor-like protein 4 |
| Q96PJ5 | 102 | 187 | 123 | 167 | Disulfide bond | Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 |
| Q96PJ5 | 102 | 187 | 102 | 183 | Domain | Note=Ig-like C2-type 2 |
| Q96PJ5 | 102 | 187 | 179 | 179 | Sequence conflict | Note=S->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q96PJ5 | 102 | 187 | 20 | 387 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q96PJ5 | 102 | 187 | 20 | 515 | Chain | ID=PRO_0000331642;Note=Fc receptor-like protein 4 |
| Q96PJ5 | 102 | 187 | 123 | 167 | Disulfide bond | Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 |
| Q96PJ5 | 102 | 187 | 102 | 183 | Domain | Note=Ig-like C2-type 2 |
| Q96PJ5 | 102 | 187 | 179 | 179 | Sequence conflict | Note=S->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q96PJ5 | 102 | 187 | 20 | 387 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for FCRL4 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_33571 | 157557655 | 157557909 | 157557670 | 157557670 | Frame_Shift_Del | T | - | p.I184fs |
| COAD | TCGA-AA-3561-01 | exon_skip_33571 | 157557655 | 157557909 | 157557884 | 157557884 | Nonsense_Mutation | A | C | p.Y111X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC251_ENDOMETRIUM | 157557655 | 157557909 | 157557667 | 157557667 | Missense_Mutation | T | G | p.I184L |
| HCC2998_LARGE_INTESTINE | 157557655 | 157557909 | 157557694 | 157557694 | Missense_Mutation | C | A | p.D175Y |
| MCC13_SKIN | 157557655 | 157557909 | 157557798 | 157557798 | Missense_Mutation | C | T | p.G140E |
| COLO792_SKIN | 157557655 | 157557909 | 157557889 | 157557889 | Missense_Mutation | G | A | p.P110S |
| LNCAPCLONEFGC_PROSTATE | 157557655 | 157557909 | 157557655 | 157557656 | Splice_Site | - | T | p.E188fs |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FCRL4 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FCRL4 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FCRL4 |
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RelatedDrugs for FCRL4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FCRL4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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