ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for CARS

Gene summary

Gene information	Gene symbol	CARS
	Gene ID	833
	Gene name	cysteinyl-tRNA synthetase
	Synonyms	CARS1\|CYSRS\|MGC:11246
	Cytomap	11p15.4
	Type of gene	protein-coding
	Description	cysteine--tRNA ligase, cytoplasmiccysteine tRNA ligase 1, cytoplasmiccysteine translase
	Modification date	20180523
	UniProtAcc	P49589
	Context	PubMed: CARS [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene	GO ID	GO term	PubMed ID
CARS	GO:0006423	cysteinyl-tRNA aminoacylation	10908348\|17303165

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Exon skipping events across known transcript of Ensembl for CARS from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Gene isoform structures and expression levels for CARS

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

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Exon skipping events with PSIs in TCGA for CARS

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_68014	11	3022159:3022478:3023191:3023283:3023770:3023830	3023191:3023283	ENSG00000110619.12	ENST00000529772.1,ENST00000401769.3,ENST00000278224.9
exon_skip_68019	11	3022159:3022478:3023199:3023283:3023770:3023830	3023199:3023283	ENSG00000110619.12	ENST00000380525.4,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000397111.5
exon_skip_68020	11	3022159:3022478:3023199:3023283:3026595:3026663	3023199:3023283	ENSG00000110619.12	ENST00000470221.2
exon_skip_68025	11	3022159:3022478:3023199:3023404:3023770:3023830	3023199:3023404	ENSG00000110619.12	ENST00000466442.2
exon_skip_68027	11	3022159:3022478:3023199:3023830:3026595:3026663	3023199:3023830	ENSG00000110619.12	ENST00000484484.1
exon_skip_68034	11	3023199:3023283:3023770:3023830:3026595:3026651	3023770:3023830	ENSG00000110619.12	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9
exon_skip_68037	11	3023199:3023404:3023770:3023830:3026595:3026663	3023770:3023830	ENSG00000110619.12	ENST00000466442.2
exon_skip_68039	11	3023770:3023830:3026595:3026663:3028108:3028189	3026595:3026663	ENSG00000110619.12	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000466442.2,ENST00000531387.1,ENST00000397114.3,ENST00000484484.1,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9
exon_skip_68041	11	3026595:3026663:3028108:3028189:3033424:3033506	3028108:3028189	ENSG00000110619.12	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9
exon_skip_68044	11	3028108:3028189:3033424:3033506:3037010:3037079	3033424:3033506	ENSG00000110619.12	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9
exon_skip_68046	11	3033424:3033506:3037010:3037079:3038335:3038525	3037010:3037079	ENSG00000110619.12	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9
exon_skip_68047	11	3040419:3040497:3041449:3041562:3047905:3048027	3041449:3041562	ENSG00000110619.12	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000465240.1,ENST00000278224.9
exon_skip_68049	11	3047905:3048027:3050225:3050314:3050532:3050673	3050225:3050314	ENSG00000110619.12	ENST00000380525.4,ENST00000529772.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENSG00000110619.12	ENST00000527330.1
exon_skip_68054	11	3062125:3062214:3063394:3063486:3078572:3078610	3063394:3063486	ENSG00000110619.12	ENST00000527330.1,ENST00000397111.5,ENST00000278224.9
exon_skip_68055	11	3062125:3062214:3063394:3063560:3078572:3078610	3063394:3063560	ENSG00000110619.12	ENST00000524825.1
exon_skip_68056	11	3062125:3062261:3063394:3063486:3078572:3078610	3063394:3063486	ENSG00000110619.12	ENST00000439280.2,ENST00000526890.1
exon_skip_68059	11	3063394:3063486:3068982:3069231:3078572:3078610	3068982:3069231	ENSG00000110619.12	ENST00000531387.1,ENST00000397114.3,ENST00000465331.1
exon_skip_68060	11	3063394:3063486:3076106:3076269:3078572:3078610	3076106:3076269	ENSG00000110619.12	ENST00000529772.1,ENST00000401769.3

PSI values of skipped exons in TCGA.

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Exon skipping events with PSIs in GTEx for CARS

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_68014	11	3022159:3022478:3023191:3023283:3023770:3023830	3023191:3023283	ENSG00000110619.12	ENST00000278224.9,ENST00000529772.1,ENST00000401769.3
exon_skip_68019	11	3022159:3022478:3023199:3023283:3023770:3023830	3023199:3023283	ENSG00000110619.12	ENST00000380525.4,ENST00000531387.1,ENST00000397111.5,ENST00000526890.1,ENST00000397114.3
exon_skip_68020	11	3022159:3022478:3023199:3023283:3026595:3026663	3023199:3023283	ENSG00000110619.12	ENST00000470221.2
exon_skip_68025	11	3022159:3022478:3023199:3023404:3023770:3023830	3023199:3023404	ENSG00000110619.12	ENST00000466442.2
exon_skip_68027	11	3022159:3022478:3023199:3023830:3026595:3026663	3023199:3023830	ENSG00000110619.12	ENST00000484484.1
exon_skip_68034	11	3023199:3023283:3023770:3023830:3026595:3026651	3023770:3023830	ENSG00000110619.12	ENST00000380525.4,ENST00000531387.1,ENST00000397111.5,ENST00000278224.9,ENST00000526890.1,ENST00000529772.1,ENST00000397114.3,ENST00000401769.3
exon_skip_68037	11	3023199:3023404:3023770:3023830:3026595:3026663	3023770:3023830	ENSG00000110619.12	ENST00000466442.2
exon_skip_68039	11	3023770:3023830:3026595:3026663:3028108:3028189	3026595:3026663	ENSG00000110619.12	ENST00000380525.4,ENST00000531387.1,ENST00000397111.5,ENST00000484484.1,ENST00000278224.9,ENST00000466442.2,ENST00000526890.1,ENST00000529772.1,ENST00000397114.3,ENST00000401769.3
exon_skip_68041	11	3026595:3026663:3028108:3028189:3033424:3033506	3028108:3028189	ENSG00000110619.12	ENST00000380525.4,ENST00000531387.1,ENST00000397111.5,ENST00000278224.9,ENST00000526890.1,ENST00000529772.1,ENST00000397114.3,ENST00000401769.3
exon_skip_68044	11	3028108:3028189:3033424:3033506:3037010:3037079	3033424:3033506	ENSG00000110619.12	ENST00000380525.4,ENST00000531387.1,ENST00000397111.5,ENST00000278224.9,ENST00000526890.1,ENST00000529772.1,ENST00000397114.3,ENST00000401769.3
exon_skip_68046	11	3033424:3033506:3037010:3037079:3038335:3038525	3037010:3037079	ENSG00000110619.12	ENST00000380525.4,ENST00000531387.1,ENST00000397111.5,ENST00000278224.9,ENST00000526890.1,ENST00000529772.1,ENST00000397114.3,ENST00000401769.3
exon_skip_68047	11	3040419:3040497:3041449:3041562:3047905:3048027	3041449:3041562	ENSG00000110619.12	ENST00000380525.4,ENST00000531387.1,ENST00000397111.5,ENST00000278224.9,ENST00000526890.1,ENST00000529772.1,ENST00000397114.3,ENST00000401769.3,ENST00000465240.1
exon_skip_68049	11	3047905:3048027:3050225:3050314:3050532:3050673	3050225:3050314	ENSG00000110619.12	ENST00000380525.4,ENST00000531387.1,ENST00000397111.5,ENST00000278224.9,ENST00000529772.1,ENST00000397114.3,ENST00000401769.3
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENSG00000110619.12	ENST00000527330.1
exon_skip_68054	11	3062125:3062214:3063394:3063486:3078572:3078610	3063394:3063486	ENSG00000110619.12	ENST00000397111.5,ENST00000278224.9,ENST00000527330.1
exon_skip_68055	11	3062125:3062214:3063394:3063560:3078572:3078610	3063394:3063560	ENSG00000110619.12	ENST00000524825.1
exon_skip_68056	11	3062125:3062261:3063394:3063486:3078572:3078610	3063394:3063486	ENSG00000110619.12	ENST00000526890.1,ENST00000439280.2
exon_skip_68059	11	3063394:3063486:3068982:3069231:3078572:3078610	3068982:3069231	ENSG00000110619.12	ENST00000531387.1,ENST00000397114.3,ENST00000465331.1
exon_skip_68060	11	3063394:3063486:3076106:3076269:3078572:3078610	3076106:3076269	ENSG00000110619.12	ENST00000529772.1,ENST00000401769.3

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for CARS

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST

Start of skipped exon

End of skipped exon

ORF

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST

Start of skipped exon

End of skipped exon

ORF

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Infer the effects of exon skipping event on protein functional features for CARS

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST

Length of mRNA

Length of AA seq.

Genomic start

Genomic end

mRNA start

mRNA end

AA start

AA end

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.

Start of exon skipping (AA)

End of exon skipping (AA)

Protein feature start (AA)

Protein feature end (AA)

Category of protein feature

Description of feature

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SNVs in the skipped exons for CARS

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
LIHC	TCGA-4R-AA8I-01	exon_skip_68039	3026596	3026663	3026609	3026612	Frame_Shift_Del	TCTC	-	p.734_735del
LUAD	TCGA-69-7979-01	exon_skip_68054 exon_skip_68056	3063395	3063486	3063445	3063446	Frame_Shift_Ins	-	A	p.D106fs
LUAD	TCGA-69-7979-01	exon_skip_68055	3063395	3063560	3063445	3063446	Frame_Shift_Ins	-	A	p.D106fs

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons	Mutation description
	Sample: TCGA-69-7979-01
	Cancer type: LUAD
	ESID: exon_skip_68055
	Skipped exon start: 3063395
	Skipped exon end: 3063560
	Mutation start: 3063445
	Mutation end: 3063446
	Mutation type: Frame_Shift_Ins
	Reference seq: -
	Mutation seq: A
	AAchange: p.D106fs
	Sample: TCGA-69-7979-01
	Cancer type: LUAD
	ESID: exon_skip_68056
	Skipped exon start: 3063395
	Skipped exon end: 3063486
	Mutation start: 3063445
	Mutation end: 3063446
	Mutation type: Frame_Shift_Ins
	Reference seq: -
	Mutation seq: A
	AAchange: p.D106fs
exon_skip_503537_LUAD_TCGA-69-7979-01.png
exon_skip_68055_LUAD_TCGA-69-7979-01.png

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
MN60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	3023200	3023830	3023790	3023790	Missense_Mutation	C	T	p.R670Q
MN60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	3023771	3023830	3023790	3023790	Missense_Mutation	C	T	p.R670Q
C4I_CERVIX	3023200	3023830	3023816	3023816	Missense_Mutation	C	G	p.K661N
C4I_CERVIX	3023771	3023830	3023816	3023816	Missense_Mutation	C	G	p.K661N
KYSE450_OESOPHAGUS	3026596	3026663	3026603	3026603	Missense_Mutation	T	C	p.K654R
A427_LUNG	3028109	3028189	3028115	3028115	Missense_Mutation	G	C	p.H632D
PACADD188_PANCREAS	3033425	3033506	3033457	3033457	Missense_Mutation	T	G	p.E596A
CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	3033425	3033506	3033475	3033475	Missense_Mutation	A	G	p.V590A
SUPM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	3037011	3037079	3037039	3037039	Missense_Mutation	G	A	p.P570L
HCT15_LARGE_INTESTINE	3041450	3041562	3041482	3041482	Missense_Mutation	C	T	p.G329R
HRT18_LARGE_INTESTINE	3041450	3041562	3041482	3041482	Missense_Mutation	C	T	p.G329R
CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	3041450	3041562	3041494	3041494	Missense_Mutation	C	T	p.A325T
SW948_LARGE_INTESTINE	3041450	3041562	3041536	3041536	Missense_Mutation	G	T	p.L311M
HCC4006_LUNG	3050226	3050314	3050272	3050272	Missense_Mutation	G	A	p.P246S
NB1_AUTONOMIC_GANGLIA	3050226	3050314	3050294	3050294	Missense_Mutation	T	G	p.L238F
EN_ENDOMETRIUM	3063395	3063560	3063457	3063457	Missense_Mutation	A	T	p.S19T
EN_ENDOMETRIUM	3063395	3063486	3063457	3063457	Missense_Mutation	A	T	p.S19T
SW403_LARGE_INTESTINE	3063395	3063560	3063483	3063483	Missense_Mutation	T	C	p.K10R
SW403_LARGE_INTESTINE	3063395	3063486	3063483	3063483	Missense_Mutation	T	C	p.K10R

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CARS

sQTL information located at the skipped exons.

Exon skip ID	Chromosome	Three exons	Skippped exon	ENST	Cancer type	SNP id	Location	DNA change (ref/var)	P-value
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENST00000527330.1	GBM	rs399565	chr11:3061780	C/T	1.05e-14
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENST00000527330.1	CESC	rs399565	chr11:3061780	C/T	1.29e-08
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENST00000527330.1	COAD	rs399565	chr11:3061780	C/T	2.29e-12
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENST00000527330.1	BLCA	rs399565	chr11:3061780	C/T	1.69e-15
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENST00000527330.1	ESCA	rs399565	chr11:3061780	C/T	1.62e-13
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENST00000527330.1	HNSC	rs399565	chr11:3061780	C/T	1.71e-21
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENST00000527330.1	BRCA	rs399565	chr11:3061780	C/T	9.96e-40
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENST00000527330.1	LAML	rs399565	chr11:3061780	C/T	6.77e-06
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENST00000527330.1	LGG	rs399565	chr11:3061780	C/T	2.09e-50
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENST00000527330.1	LGG	rs399565	chr11:3061780	C/T	3.87e-03
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENST00000527330.1	KIRC	rs399565	chr11:3061780	C/T	2.45e-23
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENST00000527330.1	LUAD	rs399565	chr11:3061780	C/T	1.63e-18
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENST00000527330.1	LUSC	rs399565	chr11:3061780	C/T	2.10e-30
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENST00000527330.1	PAAD	rs399565	chr11:3061780	C/T	5.68e-10
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENST00000527330.1	PRAD	rs399565	chr11:3061780	C/T	1.94e-10
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENST00000527330.1	SARC	rs399565	chr11:3061780	C/T	3.98e-13
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENST00000527330.1	TGCT	rs399565	chr11:3061780	C/T	2.76e-10
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENST00000527330.1	SKCM	rs399565	chr11:3061780	C/T	5.07e-06
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENST00000527330.1	STAD	rs399565	chr11:3061780	C/T	2.30e-12
exon_skip_68051	11	3061064:3061161:3061677:3061811:3062125:3062210	3061677:3061811	ENST00000527330.1	THCA	rs399565	chr11:3061780	C/T	1.22e-19
exon_skip_68060	11	3063394:3063486:3076106:3076269:3078572:3078610	3076106:3076269	ENST00000529772.1,ENST00000401769.3	HNSC	rs7945933	chr11:3076257	C/T	1.40e-04
exon_skip_68060	11	3063394:3063486:3076106:3076269:3078572:3078610	3076106:3076269	ENST00000529772.1,ENST00000401769.3	BRCA	rs7945933	chr11:3076257	C/T	7.11e-06
exon_skip_68060	11	3063394:3063486:3076106:3076269:3078572:3078610	3076106:3076269	ENST00000529772.1,ENST00000401769.3	BRCA	rs7945933	chr11:3076257	C/T	3.71e-03
exon_skip_68060	11	3063394:3063486:3076106:3076269:3078572:3078610	3076106:3076269	ENST00000529772.1,ENST00000401769.3	LGG	rs7945933	chr11:3076257	C/T	3.74e-05
exon_skip_68060	11	3063394:3063486:3076106:3076269:3078572:3078610	3076106:3076269	ENST00000529772.1,ENST00000401769.3	LUAD	rs7945933	chr11:3076257	C/T	2.15e-03
exon_skip_68060	11	3063394:3063486:3076106:3076269:3078572:3078610	3076106:3076269	ENST00000529772.1,ENST00000401769.3	STAD	rs7945933	chr11:3076257	C/T	4.95e-05
exon_skip_68060	11	3063394:3063486:3076106:3076269:3078572:3078610	3076106:3076269	ENST00000529772.1,ENST00000401769.3	THCA	rs7945933	chr11:3076257	C/T	2.64e-07
exon_skip_68041	11	3026595:3026663:3028108:3028189:3033424:3033506	3028108:3028189	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9	GBM	rs729662	chr11:3028140	G/A	6.68e-10
exon_skip_68041	11	3026595:3026663:3028108:3028189:3033424:3033506	3028108:3028189	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9	CESC	rs729662	chr11:3028140	G/A	4.60e-05
exon_skip_68041	11	3026595:3026663:3028108:3028189:3033424:3033506	3028108:3028189	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9	COAD	rs729662	chr11:3028140	G/A	6.53e-10
exon_skip_68041	11	3026595:3026663:3028108:3028189:3033424:3033506	3028108:3028189	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9	BLCA	rs729662	chr11:3028140	G/A	3.01e-12
exon_skip_68041	11	3026595:3026663:3028108:3028189:3033424:3033506	3028108:3028189	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9	ESCA	rs729662	chr11:3028140	G/A	1.87e-07
exon_skip_68041	11	3026595:3026663:3028108:3028189:3033424:3033506	3028108:3028189	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9	HNSC	rs729662	chr11:3028140	G/A	1.85e-16
exon_skip_68041	11	3026595:3026663:3028108:3028189:3033424:3033506	3028108:3028189	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9	LAML	rs729662	chr11:3028140	G/A	2.08e-05
exon_skip_68041	11	3026595:3026663:3028108:3028189:3033424:3033506	3028108:3028189	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9	LGG	rs729662	chr11:3028140	G/A	1.81e-34
exon_skip_68041	11	3026595:3026663:3028108:3028189:3033424:3033506	3028108:3028189	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9	KIRC	rs729662	chr11:3028140	G/A	1.20e-15
exon_skip_68041	11	3026595:3026663:3028108:3028189:3033424:3033506	3028108:3028189	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9	LUAD	rs729662	chr11:3028140	G/A	1.03e-09
exon_skip_68041	11	3026595:3026663:3028108:3028189:3033424:3033506	3028108:3028189	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9	LUSC	rs729662	chr11:3028140	G/A	2.65e-17
exon_skip_68041	11	3026595:3026663:3028108:3028189:3033424:3033506	3028108:3028189	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9	PAAD	rs729662	chr11:3028140	G/A	4.84e-07
exon_skip_68041	11	3026595:3026663:3028108:3028189:3033424:3033506	3028108:3028189	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9	PRAD	rs729662	chr11:3028140	G/A	8.05e-11
exon_skip_68041	11	3026595:3026663:3028108:3028189:3033424:3033506	3028108:3028189	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9	SARC	rs729662	chr11:3028140	G/A	3.19e-08
exon_skip_68041	11	3026595:3026663:3028108:3028189:3033424:3033506	3028108:3028189	ENST00000380525.4,ENST00000529772.1,ENST00000526890.1,ENST00000531387.1,ENST00000397114.3,ENST00000401769.3,ENST00000397111.5,ENST00000278224.9	THCA	rs729662	chr11:3028140	G/A	3.51e-10

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CARS

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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CARS

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RelatedDrugs for CARS

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for CARS

Diseases associated with this gene.
(DisGeNet 4.0)

Gene	Disease ID	Disease name	# pubmeds	Source
CARS	C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for CARS

Exon skipping events across known transcript of Ensembl for CARS from UCSC genome browser

Gene isoform structures and expression levels for CARS

Exon skipping events with PSIs in TCGA for CARS

Exon skipping events with PSIs in GTEx for CARS

Open reading frame (ORF) annotation in the exon skipping event for CARS

Infer the effects of exon skipping event on protein functional features for CARS

SNVs in the skipped exons for CARS

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CARS

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CARS

Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CARS

RelatedDrugs for CARS

RelatedDiseases for CARS