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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TRRAP |
 Gene summary |
| Gene information | Gene symbol | TRRAP | Gene ID | 8295 |
| Gene name | transformation/transcription domain associated protein | |
| Synonyms | PAF350/400|PAF400|STAF40|TR-AP|Tra1 | |
| Cytomap | 7q22.1 | |
| Type of gene | protein-coding | |
| Description | transformation/transcription domain-associated protein350/400 kDa PCAF-associated factortra1 homolog | |
| Modification date | 20180523 | |
| UniProtAcc | Q9Y4A5 | |
| Context | PubMed: TRRAP [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TRRAP | GO:0016578 | histone deubiquitination | 18206972 |
| TRRAP | GO:0043967 | histone H4 acetylation | 14966270 |
| TRRAP | GO:0043968 | histone H2A acetylation | 14966270 |
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Exon skipping events across known transcript of Ensembl for TRRAP from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TRRAP |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TRRAP |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_468476 | 7 | 98478712:98478873:98479597:98479647:98487957:98488022 | 98479597:98479647 | ENSG00000196367.8 | ENST00000446306.3,ENST00000417523.1,ENST00000355540.3,ENST00000359863.4 |
| exon_skip_468477 | 7 | 98479597:98479647:98487957:98488068:98490046:98490151 | 98487957:98488068 | ENSG00000196367.8 | ENST00000446306.3,ENST00000355540.3,ENST00000359863.4 |
| exon_skip_468478 | 7 | 98501001:98501140:98503799:98503878:98506350:98506585 | 98503799:98503878 | ENSG00000196367.8 | ENST00000446306.3,ENST00000355540.3,ENST00000456197.1,ENST00000359863.4 |
| exon_skip_468479 | 7 | 98503799:98503878:98506350:98506585:98507678:98508042 | 98506350:98506585 | ENSG00000196367.8 | ENST00000446306.3,ENST00000355540.3,ENST00000456197.1,ENST00000359863.4 |
| exon_skip_468482 | 7 | 98524789:98524989:98527611:98527829:98528255:98528453 | 98527611:98527829 | ENSG00000196367.8 | ENST00000446306.3,ENST00000355540.3,ENST00000456197.1,ENST00000359863.4 |
| exon_skip_468484 | 7 | 98535272:98535443:98540571:98540640:98545843:98545963 | 98540571:98540640 | ENSG00000196367.8 | ENST00000446306.3,ENST00000355540.3 |
| exon_skip_468485 | 7 | 98540571:98540640:98543369:98543423:98543552:98543573 | 98543369:98543423 | ENSG00000196367.8 | ENST00000456197.1 |
| exon_skip_468486 | 7 | 98540571:98540640:98543369:98543423:98545843:98545963 | 98543369:98543423 | ENSG00000196367.8 | ENST00000359863.4 |
| exon_skip_468489 | 7 | 98543369:98543423:98543552:98543573:98545843:98545963 | 98543552:98543573 | ENSG00000196367.8 | ENST00000456197.1 |
| exon_skip_468490 | 7 | 98554021:98554156:98555603:98555714:98556966:98557113 | 98555603:98555714 | ENSG00000196367.8 | ENST00000446306.3,ENST00000355540.3,ENST00000456197.1,ENST00000359863.4 |
| exon_skip_468491 | 7 | 98556966:98557113:98558883:98559097:98559924:98560050 | 98558883:98559097 | ENSG00000196367.8 | ENST00000446306.3,ENST00000355540.3,ENST00000456197.1,ENST00000359863.4 |
| exon_skip_468495 | 7 | 98558883:98559097:98559924:98560050:98562251:98562398 | 98559924:98560050 | ENSG00000196367.8 | ENST00000446306.3,ENST00000355540.3,ENST00000456197.1,ENST00000359863.4 |
| exon_skip_468498 | 7 | 98559924:98560050:98562251:98562398:98563318:98563518 | 98562251:98562398 | ENSG00000196367.8 | ENST00000355540.3,ENST00000456197.1,ENST00000359863.4 |
| exon_skip_468499 | 7 | 98565107:98565321:98567734:98567914:98569421:98569568 | 98567734:98567914 | ENSG00000196367.8 | ENST00000446306.3,ENST00000355540.3,ENST00000456197.1,ENST00000359863.4 |
| exon_skip_468500 | 7 | 98576391:98576527:98579391:98579583:98580886:98581082 | 98579391:98579583 | ENSG00000196367.8 | ENST00000446306.3,ENST00000355540.3,ENST00000456197.1,ENST00000359863.4 |
| exon_skip_468502 | 7 | 98586387:98586589:98588077:98588242:98589759:98589850 | 98588077:98588242 | ENSG00000196367.8 | ENST00000446306.3,ENST00000355540.3,ENST00000456197.1,ENST00000359863.4 |
| exon_skip_468504 | 7 | 98589759:98589850:98591160:98591360:98592209:98592471 | 98591160:98591360 | ENSG00000196367.8 | ENST00000446306.3,ENST00000456197.1 |
| exon_skip_468505 | 7 | 98589759:98589850:98591214:98591360:98592209:98592471 | 98591214:98591360 | ENSG00000196367.8 | ENST00000355540.3,ENST00000359863.4 |
| exon_skip_468508 | 7 | 98602753:98602971:98605999:98606184:98608674:98608878 | 98605999:98606184 | ENSG00000196367.8 | ENST00000446306.3,ENST00000355540.3,ENST00000456197.1,ENST00000359863.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TRRAP |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_468476 | 7 | 98478712:98478873:98479597:98479647:98487957:98488022 | 98479597:98479647 | ENSG00000196367.8 | ENST00000417523.1,ENST00000359863.4,ENST00000355540.3,ENST00000446306.3 |
| exon_skip_468477 | 7 | 98479597:98479647:98487957:98488068:98490046:98490151 | 98487957:98488068 | ENSG00000196367.8 | ENST00000359863.4,ENST00000355540.3,ENST00000446306.3 |
| exon_skip_468478 | 7 | 98501001:98501140:98503799:98503878:98506350:98506585 | 98503799:98503878 | ENSG00000196367.8 | ENST00000359863.4,ENST00000355540.3,ENST00000446306.3,ENST00000456197.1 |
| exon_skip_468479 | 7 | 98503799:98503878:98506350:98506585:98507678:98508042 | 98506350:98506585 | ENSG00000196367.8 | ENST00000359863.4,ENST00000355540.3,ENST00000446306.3,ENST00000456197.1 |
| exon_skip_468482 | 7 | 98524789:98524989:98527611:98527829:98528255:98528453 | 98527611:98527829 | ENSG00000196367.8 | ENST00000359863.4,ENST00000355540.3,ENST00000446306.3,ENST00000456197.1 |
| exon_skip_468484 | 7 | 98535272:98535443:98540571:98540640:98545843:98545963 | 98540571:98540640 | ENSG00000196367.8 | ENST00000355540.3,ENST00000446306.3 |
| exon_skip_468485 | 7 | 98540571:98540640:98543369:98543423:98543552:98543573 | 98543369:98543423 | ENSG00000196367.8 | ENST00000456197.1 |
| exon_skip_468486 | 7 | 98540571:98540640:98543369:98543423:98545843:98545963 | 98543369:98543423 | ENSG00000196367.8 | ENST00000359863.4 |
| exon_skip_468489 | 7 | 98543369:98543423:98543552:98543573:98545843:98545963 | 98543552:98543573 | ENSG00000196367.8 | ENST00000456197.1 |
| exon_skip_468490 | 7 | 98554021:98554156:98555603:98555714:98556966:98557113 | 98555603:98555714 | ENSG00000196367.8 | ENST00000359863.4,ENST00000355540.3,ENST00000446306.3,ENST00000456197.1 |
| exon_skip_468491 | 7 | 98556966:98557113:98558883:98559097:98559924:98560050 | 98558883:98559097 | ENSG00000196367.8 | ENST00000359863.4,ENST00000355540.3,ENST00000446306.3,ENST00000456197.1 |
| exon_skip_468495 | 7 | 98558883:98559097:98559924:98560050:98562251:98562398 | 98559924:98560050 | ENSG00000196367.8 | ENST00000359863.4,ENST00000355540.3,ENST00000446306.3,ENST00000456197.1 |
| exon_skip_468498 | 7 | 98559924:98560050:98562251:98562398:98563318:98563518 | 98562251:98562398 | ENSG00000196367.8 | ENST00000359863.4,ENST00000355540.3,ENST00000456197.1 |
| exon_skip_468499 | 7 | 98565107:98565321:98567734:98567914:98569421:98569568 | 98567734:98567914 | ENSG00000196367.8 | ENST00000359863.4,ENST00000355540.3,ENST00000446306.3,ENST00000456197.1 |
| exon_skip_468500 | 7 | 98576391:98576527:98579391:98579583:98580886:98581082 | 98579391:98579583 | ENSG00000196367.8 | ENST00000359863.4,ENST00000355540.3,ENST00000446306.3,ENST00000456197.1 |
| exon_skip_468502 | 7 | 98586387:98586589:98588077:98588242:98589759:98589850 | 98588077:98588242 | ENSG00000196367.8 | ENST00000359863.4,ENST00000355540.3,ENST00000446306.3,ENST00000456197.1 |
| exon_skip_468504 | 7 | 98589759:98589850:98591160:98591360:98592209:98592471 | 98591160:98591360 | ENSG00000196367.8 | ENST00000446306.3,ENST00000456197.1 |
| exon_skip_468505 | 7 | 98589759:98589850:98591214:98591360:98592209:98592471 | 98591214:98591360 | ENSG00000196367.8 | ENST00000359863.4,ENST00000355540.3 |
| exon_skip_468508 | 7 | 98602753:98602971:98605999:98606184:98608674:98608878 | 98605999:98606184 | ENSG00000196367.8 | ENST00000359863.4,ENST00000355540.3,ENST00000446306.3,ENST00000456197.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TRRAP |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000359863 | 98479597 | 98479647 | Frame-shift |
| ENST00000359863 | 98503799 | 98503878 | Frame-shift |
| ENST00000359863 | 98506350 | 98506585 | Frame-shift |
| ENST00000359863 | 98527611 | 98527829 | Frame-shift |
| ENST00000359863 | 98558883 | 98559097 | Frame-shift |
| ENST00000359863 | 98591214 | 98591360 | Frame-shift |
| ENST00000359863 | 98605999 | 98606184 | Frame-shift |
| ENST00000359863 | 98487957 | 98488068 | In-frame |
| ENST00000359863 | 98543369 | 98543423 | In-frame |
| ENST00000359863 | 98555603 | 98555714 | In-frame |
| ENST00000359863 | 98559924 | 98560050 | In-frame |
| ENST00000359863 | 98562251 | 98562398 | In-frame |
| ENST00000359863 | 98567734 | 98567914 | In-frame |
| ENST00000359863 | 98579391 | 98579583 | In-frame |
| ENST00000359863 | 98588077 | 98588242 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000359863 | 98479597 | 98479647 | Frame-shift |
| ENST00000359863 | 98503799 | 98503878 | Frame-shift |
| ENST00000359863 | 98506350 | 98506585 | Frame-shift |
| ENST00000359863 | 98527611 | 98527829 | Frame-shift |
| ENST00000359863 | 98558883 | 98559097 | Frame-shift |
| ENST00000359863 | 98591214 | 98591360 | Frame-shift |
| ENST00000359863 | 98605999 | 98606184 | Frame-shift |
| ENST00000359863 | 98487957 | 98488068 | In-frame |
| ENST00000359863 | 98543369 | 98543423 | In-frame |
| ENST00000359863 | 98555603 | 98555714 | In-frame |
| ENST00000359863 | 98559924 | 98560050 | In-frame |
| ENST00000359863 | 98562251 | 98562398 | In-frame |
| ENST00000359863 | 98567734 | 98567914 | In-frame |
| ENST00000359863 | 98579391 | 98579583 | In-frame |
| ENST00000359863 | 98588077 | 98588242 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TRRAP |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000359863 | 12694 | 3859 | 98487957 | 98488068 | 360 | 470 | 50 | 87 |
| ENST00000359863 | 12694 | 3859 | 98543369 | 98543423 | 4683 | 4736 | 1491 | 1509 |
| ENST00000359863 | 12694 | 3859 | 98555603 | 98555714 | 6420 | 6530 | 2070 | 2107 |
| ENST00000359863 | 12694 | 3859 | 98559924 | 98560050 | 6892 | 7017 | 2227 | 2269 |
| ENST00000359863 | 12694 | 3859 | 98562251 | 98562398 | 7018 | 7164 | 2269 | 2318 |
| ENST00000359863 | 12694 | 3859 | 98567734 | 98567914 | 7701 | 7880 | 2497 | 2557 |
| ENST00000359863 | 12694 | 3859 | 98579391 | 98579583 | 8823 | 9014 | 2871 | 2935 |
| ENST00000359863 | 12694 | 3859 | 98588077 | 98588242 | 9813 | 9977 | 3201 | 3256 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000359863 | 12694 | 3859 | 98487957 | 98488068 | 360 | 470 | 50 | 87 |
| ENST00000359863 | 12694 | 3859 | 98543369 | 98543423 | 4683 | 4736 | 1491 | 1509 |
| ENST00000359863 | 12694 | 3859 | 98555603 | 98555714 | 6420 | 6530 | 2070 | 2107 |
| ENST00000359863 | 12694 | 3859 | 98559924 | 98560050 | 6892 | 7017 | 2227 | 2269 |
| ENST00000359863 | 12694 | 3859 | 98562251 | 98562398 | 7018 | 7164 | 2269 | 2318 |
| ENST00000359863 | 12694 | 3859 | 98567734 | 98567914 | 7701 | 7880 | 2497 | 2557 |
| ENST00000359863 | 12694 | 3859 | 98579391 | 98579583 | 8823 | 9014 | 2871 | 2935 |
| ENST00000359863 | 12694 | 3859 | 98588077 | 98588242 | 9813 | 9977 | 3201 | 3256 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y4A5 | 50 | 87 | 2 | 3859 | Chain | ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein |
| Q9Y4A5 | 1491 | 1509 | 1492 | 1509 | Alternative sequence | ID=VSP_009102;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9708738;Dbxref=PMID:9708738 |
| Q9Y4A5 | 1491 | 1509 | 2 | 3859 | Chain | ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein |
| Q9Y4A5 | 2070 | 2107 | 2 | 3859 | Chain | ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein |
| Q9Y4A5 | 2070 | 2107 | 2077 | 2077 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 |
| Q9Y4A5 | 2070 | 2107 | 2010 | 2388 | Region | Note=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12138177;Dbxref=PMID:12138177 |
| Q9Y4A5 | 2227 | 2269 | 2 | 3859 | Chain | ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein |
| Q9Y4A5 | 2227 | 2269 | 2010 | 2388 | Region | Note=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12138177;Dbxref=PMID:12138177 |
| Q9Y4A5 | 2269 | 2318 | 2 | 3859 | Chain | ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein |
| Q9Y4A5 | 2269 | 2318 | 2302 | 2302 | Natural variant | ID=VAR_041666;Note=In a colorectal adenocarcinoma sample%3B somatic mutation. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs528967912,PMID:17344846 |
| Q9Y4A5 | 2269 | 2318 | 2010 | 2388 | Region | Note=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12138177;Dbxref=PMID:12138177 |
| Q9Y4A5 | 2497 | 2557 | 2 | 3859 | Chain | ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein |
| Q9Y4A5 | 2497 | 2557 | 2543 | 2543 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| Q9Y4A5 | 2871 | 2935 | 2 | 3859 | Chain | ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein |
| Q9Y4A5 | 2871 | 2935 | 2704 | 3275 | Domain | Note=FAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00534 |
| Q9Y4A5 | 2871 | 2935 | 2931 | 2931 | Natural variant | ID=VAR_041671;Note=In a colorectal adenocarcinoma sample%3B somatic mutation. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 |
| Q9Y4A5 | 3201 | 3256 | 2 | 3859 | Chain | ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein |
| Q9Y4A5 | 3201 | 3256 | 2704 | 3275 | Domain | Note=FAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00534 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y4A5 | 50 | 87 | 2 | 3859 | Chain | ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein |
| Q9Y4A5 | 1491 | 1509 | 1492 | 1509 | Alternative sequence | ID=VSP_009102;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9708738;Dbxref=PMID:9708738 |
| Q9Y4A5 | 1491 | 1509 | 2 | 3859 | Chain | ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein |
| Q9Y4A5 | 2070 | 2107 | 2 | 3859 | Chain | ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein |
| Q9Y4A5 | 2070 | 2107 | 2077 | 2077 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:18669648,ECO:0000244|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 |
| Q9Y4A5 | 2070 | 2107 | 2010 | 2388 | Region | Note=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12138177;Dbxref=PMID:12138177 |
| Q9Y4A5 | 2227 | 2269 | 2 | 3859 | Chain | ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein |
| Q9Y4A5 | 2227 | 2269 | 2010 | 2388 | Region | Note=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12138177;Dbxref=PMID:12138177 |
| Q9Y4A5 | 2269 | 2318 | 2 | 3859 | Chain | ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein |
| Q9Y4A5 | 2269 | 2318 | 2302 | 2302 | Natural variant | ID=VAR_041666;Note=In a colorectal adenocarcinoma sample%3B somatic mutation. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=dbSNP:rs528967912,PMID:17344846 |
| Q9Y4A5 | 2269 | 2318 | 2010 | 2388 | Region | Note=Interaction with TP53;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:12138177;Dbxref=PMID:12138177 |
| Q9Y4A5 | 2497 | 2557 | 2 | 3859 | Chain | ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein |
| Q9Y4A5 | 2497 | 2557 | 2543 | 2543 | Cross-link | Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:28112733;Dbxref=PMID:28112733 |
| Q9Y4A5 | 2871 | 2935 | 2 | 3859 | Chain | ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein |
| Q9Y4A5 | 2871 | 2935 | 2704 | 3275 | Domain | Note=FAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00534 |
| Q9Y4A5 | 2871 | 2935 | 2931 | 2931 | Natural variant | ID=VAR_041671;Note=In a colorectal adenocarcinoma sample%3B somatic mutation. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17344846;Dbxref=PMID:17344846 |
| Q9Y4A5 | 3201 | 3256 | 2 | 3859 | Chain | ID=PRO_0000088851;Note=Transformation/transcription domain-associated protein |
| Q9Y4A5 | 3201 | 3256 | 2704 | 3275 | Domain | Note=FAT;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00534 |
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SNVs in the skipped exons for TRRAP |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_468479 | 98506351 | 98506585 | 98506406 | 98506406 | Frame_Shift_Del | C | - | p.P391fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_468484 | 98540572 | 98540640 | 98540617 | 98540617 | Frame_Shift_Del | G | - | p.G1485fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_468500 | 98579392 | 98579583 | 98579412 | 98579412 | Frame_Shift_Del | G | - | p.K2878fs |
| LIHC | TCGA-G3-A3CJ-01 | 98606000 | 98606184 | 98606021 | 98606021 | Frame_Shift_Del | C | - | p.S3578fs | |
| STAD | TCGA-BR-6802-01 | exon_skip_468499 | 98567735 | 98567914 | 98567888 | 98567889 | Frame_Shift_Ins | - | G | p.R2549fs |
| BRCA | TCGA-A2-A1FX-01 | exon_skip_468482 | 98527612 | 98527829 | 98527687 | 98527687 | Nonsense_Mutation | C | T | p.R799* |
| LGG | TCGA-DU-6392-01 | exon_skip_468482 | 98527612 | 98527829 | 98527692 | 98527692 | Nonsense_Mutation | G | T | p.G1086* |
| UCEC | TCGA-B5-A11E-01 | exon_skip_468482 | 98527612 | 98527829 | 98527692 | 98527692 | Nonsense_Mutation | G | T | p.G1086* |
| LUAD | TCGA-69-7978-01 | exon_skip_468482 | 98527612 | 98527829 | 98527770 | 98527770 | Nonsense_Mutation | G | T | p.E1112* |
| SKCM | TCGA-ER-A3ET-06 | exon_skip_468491 | 98558884 | 98559097 | 98558887 | 98558887 | Nonsense_Mutation | C | T | p.Q2158* |
| CESC | TCGA-C5-A2LZ-01 | exon_skip_468500 | 98579392 | 98579583 | 98579413 | 98579413 | Nonsense_Mutation | G | T | p.E2879* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| YKG1_CENTRAL_NERVOUS_SYSTEM | 98567735 | 98567914 | 98567825 | 98567826 | Frame_Shift_Del | GC | - | p.A2528fs |
| RS411_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 98479598 | 98479647 | 98479625 | 98479625 | Missense_Mutation | A | G | p.Q43R |
| NCIBL2126_MATCHED_NORMAL_TISSUE | 98503800 | 98503878 | 98503829 | 98503829 | Missense_Mutation | G | C | p.D356H |
| SNU407_LARGE_INTESTINE | 98506351 | 98506585 | 98506367 | 98506367 | Missense_Mutation | A | G | p.T378A |
| SW13_ADRENAL_CORTEX | 98506351 | 98506585 | 98506373 | 98506373 | Missense_Mutation | G | A | p.A380T |
| HEC59_ENDOMETRIUM | 98506351 | 98506585 | 98506382 | 98506382 | Missense_Mutation | G | A | p.V383M |
| HEC1A_ENDOMETRIUM | 98506351 | 98506585 | 98506388 | 98506388 | Missense_Mutation | C | A | p.H385N |
| HS294T_SKIN | 98506351 | 98506585 | 98506494 | 98506494 | Missense_Mutation | G | A | p.C420Y |
| HCE4_OESOPHAGUS | 98506351 | 98506585 | 98506560 | 98506560 | Missense_Mutation | G | A | p.R442K |
| SNU1040_LARGE_INTESTINE | 98506351 | 98506585 | 98506574 | 98506574 | Missense_Mutation | C | T | p.R447W |
| JHUEM1_ENDOMETRIUM | 98506351 | 98506585 | 98506575 | 98506575 | Missense_Mutation | G | A | p.R447Q |
| NCIH1648_LUNG | 98506351 | 98506585 | 98506579 | 98506579 | Missense_Mutation | G | T | p.M448I |
| HEC6_ENDOMETRIUM | 98527612 | 98527829 | 98527649 | 98527649 | Missense_Mutation | G | T | p.Q1071H |
| SNU1_STOMACH | 98527612 | 98527829 | 98527662 | 98527662 | Missense_Mutation | A | G | p.M1076V |
| NCIH1793_LUNG | 98527612 | 98527829 | 98527717 | 98527717 | Missense_Mutation | A | C | p.D1094A |
| SF172_CENTRAL_NERVOUS_SYSTEM | 98527612 | 98527829 | 98527815 | 98527815 | Missense_Mutation | G | T | p.G1127C |
| A498_KIDNEY | 98540572 | 98540640 | 98540574 | 98540574 | Missense_Mutation | A | C | p.Q1469H |
| HEC59_ENDOMETRIUM | 98555604 | 98555714 | 98555701 | 98555701 | Missense_Mutation | G | A | p.R2103H |
| VMRCMELG_SKIN | 98558884 | 98559097 | 98558989 | 98558989 | Missense_Mutation | C | G | p.P2192A |
| TC205_BONE | 98558884 | 98559097 | 98559049 | 98559049 | Missense_Mutation | G | A | p.V2212I |
| NCIH1623_LUNG | 98558884 | 98559097 | 98559075 | 98559075 | Missense_Mutation | G | A | p.M2220I |
| BFTC905_URINARY_TRACT | 98558884 | 98559097 | 98559082 | 98559082 | Missense_Mutation | T | C | p.F2223L |
| SNUC4_LARGE_INTESTINE | 98558884 | 98559097 | 98559095 | 98559095 | Missense_Mutation | C | A | p.P2227Q |
| SW684_SOFT_TISSUE | 98559925 | 98560050 | 98560035 | 98560035 | Missense_Mutation | C | T | p.P2265S |
| 639V_URINARY_TRACT | 98562252 | 98562398 | 98562317 | 98562317 | Missense_Mutation | G | A | p.V2292I |
| MHHNB11_AUTONOMIC_GANGLIA | 98562252 | 98562398 | 98562317 | 98562317 | Missense_Mutation | G | A | p.V2292I |
| SNU1040_LARGE_INTESTINE | 98562252 | 98562398 | 98562326 | 98562326 | Missense_Mutation | C | T | p.R2295C |
| HEC6_ENDOMETRIUM | 98562252 | 98562398 | 98562347 | 98562347 | Missense_Mutation | C | T | p.R2302W |
| COLO824_BREAST | 98562252 | 98562398 | 98562347 | 98562347 | Missense_Mutation | C | T | p.R2302W |
| MZ2MEL_SKIN | 98562252 | 98562398 | 98562372 | 98562372 | Missense_Mutation | C | T | p.A2310V |
| SNGM_ENDOMETRIUM | 98567735 | 98567914 | 98567745 | 98567745 | Missense_Mutation | C | T | p.A2501V |
| EB3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 98567735 | 98567914 | 98567760 | 98567760 | Missense_Mutation | G | C | p.S2506T |
| UBLC1_URINARY_TRACT | 98567735 | 98567914 | 98567787 | 98567787 | Missense_Mutation | G | A | p.G2515E |
| CW2_LARGE_INTESTINE | 98567735 | 98567914 | 98567840 | 98567840 | Missense_Mutation | C | T | p.R2533C |
| CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 98567735 | 98567914 | 98567888 | 98567888 | Missense_Mutation | C | T | p.R2549W |
| SNU1040_LARGE_INTESTINE | 98579392 | 98579583 | 98579408 | 98579408 | Missense_Mutation | C | T | p.P2877L |
| VMCUB1_URINARY_TRACT | 98579392 | 98579583 | 98579503 | 98579503 | Missense_Mutation | G | C | p.E2909Q |
| HEC108_ENDOMETRIUM | 98579392 | 98579583 | 98579533 | 98579533 | Missense_Mutation | T | C | p.W2919R |
| CW2_LARGE_INTESTINE | 98588078 | 98588242 | 98588193 | 98588193 | Missense_Mutation | C | T | p.T3240I |
| MOLT16_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 98591161 | 98591360 | 98591251 | 98591251 | Missense_Mutation | G | A | p.R3299H |
| MOLT16_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 98591215 | 98591360 | 98591251 | 98591251 | Missense_Mutation | G | A | p.R3299H |
| ES2_OVARY | 98591161 | 98591360 | 98591358 | 98591358 | Missense_Mutation | G | A | p.E3335K |
| ES2_OVARY | 98591215 | 98591360 | 98591358 | 98591358 | Missense_Mutation | G | A | p.E3335K |
| NCIH1876_LUNG | 98606000 | 98606184 | 98606063 | 98606063 | Missense_Mutation | C | G | p.S3592C |
| KYSE150_OESOPHAGUS | 98591161 | 98591360 | 98591259 | 98591259 | Nonsense_Mutation | C | T | p.R3302* |
| KYSE150_OESOPHAGUS | 98591215 | 98591360 | 98591259 | 98591259 | Nonsense_Mutation | C | T | p.R3302* |
| SNU182_LIVER | 98558884 | 98559097 | 98559096 | 98559096 | Splice_Site | G | A | p.P2227P |
| HEC59_ENDOMETRIUM | 98579392 | 98579583 | 98579583 | 98579583 | Splice_Site | G | A | p.Q2935Q |
| NCIH650_LUNG | 98588078 | 98588242 | 98588077 | 98588078 | Splice_Site | GG | TT | p.3201_3202KV>NL |
| NCIH650_LUNG | 98588078 | 98588242 | 98588078 | 98588078 | Splice_Site | G | T | p.V3202L |
| SNU1040_LARGE_INTESTINE | 98606000 | 98606184 | 98606001 | 98606001 | Splice_Site | G | A | p.V3571V |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRRAP |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRRAP |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRRAP |
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RelatedDrugs for TRRAP |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRRAP |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TRRAP | C0036341 | Schizophrenia | 2 | CTD_human |
| TRRAP | C0025202 | melanoma | 1 | CTD_human |
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