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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for CCNL2 |
 Gene summary |
| Gene information | Gene symbol | CCNL2 | Gene ID | 81669 |
| Gene name | cyclin L2 | |
| Synonyms | ANIA-6B|CCNM|CCNS|HCLA-ISO|HLA-ISO|PCEE|SB138 | |
| Cytomap | 1p36.33 | |
| Type of gene | protein-coding | |
| Description | cyclin-L2cyclin Mcyclin Spaneth cell-enhanced expression protein | |
| Modification date | 20180523 | |
| UniProtAcc | Q96S94 | |
| Context | PubMed: CCNL2 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for CCNL2 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for CCNL2 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for CCNL2 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_20393 | 1 | 1323402:1323445:1323871:1323890:1324005:1324123 | 1323871:1323890 | ENSG00000221978.7 | ENST00000505849.1,ENST00000480479.1 |
| exon_skip_20400 | 1 | 1323402:1323445:1324005:1324123:1324329:1324427 | 1324005:1324123 | ENSG00000221978.7 | ENST00000496007.1 |
| exon_skip_20401 | 1 | 1323402:1323445:1324005:1324123:1325609:1325751 | 1324005:1324123 | ENSG00000221978.7 | ENST00000492998.1 |
| exon_skip_20407 | 1 | 1323402:1323445:1324329:1324427:1325609:1325751 | 1324329:1324427 | ENSG00000221978.7 | ENST00000482365.1 |
| exon_skip_20409 | 1 | 1323871:1323890:1324005:1324123:1325609:1325751 | 1324005:1324123 | ENSG00000221978.7 | ENST00000505849.1,ENST00000480479.1 |
| exon_skip_20412 | 1 | 1324005:1324123:1324329:1324427:1325609:1325751 | 1324329:1324427 | ENSG00000221978.7 | ENST00000496007.1 |
| exon_skip_20420 | 1 | 1326145:1326245:1326676:1326955:1328058:1328096 | 1326676:1326955 | ENSG00000221978.7 | ENST00000469113.1 |
| exon_skip_20426 | 1 | 1326145:1326245:1328058:1328183:1328775:1328819 | 1328058:1328183 | ENSG00000221978.7 | ENST00000482621.1,ENST00000408952.5 |
| exon_skip_20427 | 1 | 1326145:1326245:1328169:1328183:1328775:1328819 | 1328169:1328183 | ENSG00000221978.7 | ENST00000488340.1 |
| exon_skip_20428 | 1 | 1328823:1328840:1330773:1330894:1333612:1333667 | 1330773:1330894 | ENSG00000221978.7 | ENST00000471930.1,ENST00000488340.1,ENST00000473872.1,ENST00000481223.2,ENST00000496007.1,ENST00000400809.3,ENST00000408918.4,ENST00000425598.2 |
| exon_skip_20429 | 1 | 1328823:1328840:1330773:1330917:1333612:1333667 | 1330773:1330917 | ENSG00000221978.7 | ENST00000482621.1,ENST00000408952.5 |
| exon_skip_20430 | 1 | 1330816:1330894:1333612:1333722:1333976:1334051 | 1333612:1333722 | ENSG00000221978.7 | ENST00000497013.1,ENST00000488340.1,ENST00000481223.2,ENST00000496007.1,ENST00000400809.3,ENST00000408918.4,ENST00000425598.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for CCNL2 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_20393 | 1 | 1323402:1323445:1323871:1323890:1324005:1324123 | 1323871:1323890 | ENSG00000221978.7 | ENST00000480479.1,ENST00000505849.1 |
| exon_skip_20400 | 1 | 1323402:1323445:1324005:1324123:1324329:1324427 | 1324005:1324123 | ENSG00000221978.7 | ENST00000496007.1 |
| exon_skip_20401 | 1 | 1323402:1323445:1324005:1324123:1325609:1325751 | 1324005:1324123 | ENSG00000221978.7 | ENST00000492998.1 |
| exon_skip_20407 | 1 | 1323402:1323445:1324329:1324427:1325609:1325751 | 1324329:1324427 | ENSG00000221978.7 | ENST00000482365.1 |
| exon_skip_20409 | 1 | 1323871:1323890:1324005:1324123:1325609:1325751 | 1324005:1324123 | ENSG00000221978.7 | ENST00000480479.1,ENST00000505849.1 |
| exon_skip_20412 | 1 | 1324005:1324123:1324329:1324427:1325609:1325751 | 1324329:1324427 | ENSG00000221978.7 | ENST00000496007.1 |
| exon_skip_20420 | 1 | 1326145:1326245:1326676:1326955:1328058:1328096 | 1326676:1326955 | ENSG00000221978.7 | ENST00000469113.1 |
| exon_skip_20426 | 1 | 1326145:1326245:1328058:1328183:1328775:1328819 | 1328058:1328183 | ENSG00000221978.7 | ENST00000482621.1,ENST00000408952.5 |
| exon_skip_20427 | 1 | 1326145:1326245:1328169:1328183:1328775:1328819 | 1328169:1328183 | ENSG00000221978.7 | ENST00000488340.1 |
| exon_skip_20428 | 1 | 1328823:1328840:1330773:1330894:1333612:1333667 | 1330773:1330894 | ENSG00000221978.7 | ENST00000400809.3,ENST00000496007.1,ENST00000481223.2,ENST00000488340.1,ENST00000471930.1,ENST00000408918.4,ENST00000473872.1,ENST00000425598.2 |
| exon_skip_20429 | 1 | 1328823:1328840:1330773:1330917:1333612:1333667 | 1330773:1330917 | ENSG00000221978.7 | ENST00000482621.1,ENST00000408952.5 |
| exon_skip_20430 | 1 | 1330816:1330894:1333612:1333722:1333976:1334051 | 1333612:1333722 | ENSG00000221978.7 | ENST00000400809.3,ENST00000496007.1,ENST00000481223.2,ENST00000488340.1,ENST00000408918.4,ENST00000425598.2,ENST00000497013.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for CCNL2 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000400809 | 1330773 | 1330894 | Frame-shift |
| ENST00000400809 | 1333612 | 1333722 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000400809 | 1330773 | 1330894 | Frame-shift |
| ENST00000400809 | 1333612 | 1333722 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for CCNL2 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for CCNL2 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_20430 | 1333613 | 1333722 | 1333673 | 1333673 | Frame_Shift_Del | G | - | p.P138fs |
| UCEC | TCGA-B5-A11E-01 | exon_skip_20430 | 1333613 | 1333722 | 1333632 | 1333632 | Nonsense_Mutation | G | A | p.R152* |
| BLCA | TCGA-ZF-AA4X-01 | exon_skip_20430 | 1333613 | 1333722 | 1333715 | 1333715 | Nonsense_Mutation | G | T | p.S124* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| KYSE220_OESOPHAGUS | 1330774 | 1330894 | 1330852 | 1330852 | Missense_Mutation | T | G | p.L172F |
| KYSE220_OESOPHAGUS | 1330774 | 1330917 | 1330852 | 1330852 | Missense_Mutation | T | G | p.L172F |
| SNU119_OVARY | 1330774 | 1330894 | 1330854 | 1330854 | Missense_Mutation | A | C | p.L172V |
| SNU119_OVARY | 1330774 | 1330917 | 1330854 | 1330854 | Missense_Mutation | A | C | p.L172V |
| OSC19_UPPER_AERODIGESTIVE_TRACT | 1333613 | 1333722 | 1333620 | 1333620 | Missense_Mutation | C | T | p.D156N |
| MELHO_SKIN | 1333613 | 1333722 | 1333656 | 1333656 | Missense_Mutation | C | T | p.V144I |
| SNUC1_LARGE_INTESTINE | 1333613 | 1333722 | 1333670 | 1333670 | Missense_Mutation | C | T | p.R139K |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CCNL2 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CCNL2 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CCNL2 |
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RelatedDrugs for CCNL2 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CCNL2 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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