ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for TSPAN14

Gene summary

Gene information	Gene symbol	TSPAN14
	Gene ID	81619
	Gene name	tetraspanin 14
	Synonyms	DC-TM4F2\|TM4SF14
	Cytomap	10q23.1
	Type of gene	protein-coding
	Description	tetraspanin-14tetraspanin similar to TM4SF9transmembrane 4 superfamily member 14tspan-14
	Modification date	20180523
	UniProtAcc	Q8NG11
	Context	PubMed: TSPAN14 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Exon skipping events across known transcript of Ensembl for TSPAN14 from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Gene isoform structures and expression levels for TSPAN14

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

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Exon skipping events with PSIs in TCGA for TSPAN14

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_43335	10	82214110:82214127:82222843:82222883:82228302:82228443	82222843:82222883	ENSG00000108219.10	ENST00000372158.1
exon_skip_43348	10	82214110:82214127:82248972:82249070:82264483:82264533	82248972:82249070	ENSG00000108219.10	ENST00000469149.1,ENST00000372157.2,ENST00000341863.6
exon_skip_43349	10	82214110:82214127:82248972:82249070:82266983:82267052	82248972:82249070	ENSG00000108219.10	ENST00000372164.3
exon_skip_43372	10	82222843:82222883:82226196:82226294:82228302:82228443	82226196:82226294	ENSG00000108219.10	ENST00000372156.1
exon_skip_43375	10	82222843:82222883:82228302:82228443:82248972:82249070	82228302:82228443	ENSG00000108219.10	ENST00000372158.1
exon_skip_43382	10	82228337:82228443:82248972:82249070:82264483:82264534	82248972:82249070	ENSG00000108219.10	ENST00000372158.1,ENST00000372156.1
exon_skip_43395	10	82248972:82249070:82264483:82264534:82266954:82267130	82264483:82264534	ENSG00000108219.10	ENST00000372157.2
exon_skip_43396	10	82248972:82249070:82264483:82264534:82266983:82267052	82264483:82264534	ENSG00000108219.10	ENST00000469149.1,ENST00000372158.1,ENST00000429989.3,ENST00000341863.6,ENST00000372156.1
exon_skip_43403	10	82248972:82249070:82266983:82267130:82269056:82269227	82266983:82267130	ENSG00000108219.10	ENST00000372164.3
exon_skip_43406	10	82264483:82264534:82266954:82267130:82269056:82269227	82266954:82267130	ENSG00000108219.10	ENST00000372157.2
exon_skip_43410	10	82264483:82264534:82266983:82267130:82269056:82269227	82266983:82267130	ENSG00000108219.10	ENST00000469149.1,ENST00000372158.1,ENST00000429989.3,ENST00000372156.1
exon_skip_43411	10	82264483:82264534:82266983:82267130:82271899:82272025	82266983:82267130	ENSG00000108219.10	ENST00000341863.6
exon_skip_43414	10	82266983:82267130:82269056:82269227:82271899:82272025	82269056:82269227	ENSG00000108219.10	ENST00000372157.2,ENST00000372158.1,ENST00000429989.3,ENST00000372164.3,ENST00000372156.1
exon_skip_43415	10	82271899:82272025:82273774:82273819:82275959:82276079	82273774:82273819	ENSG00000108219.10	ENST00000372157.2,ENST00000481124.1,ENST00000372158.1,ENST00000429989.3,ENST00000372164.3,ENST00000341863.6,ENST00000372156.1
exon_skip_43416	10	82273774:82273819:82275959:82276079:82277660:82277678	82275959:82276079	ENSG00000108219.10	ENST00000372157.2,ENST00000481124.1,ENST00000372158.1,ENST00000429989.3,ENST00000372164.3,ENST00000341863.6,ENST00000372156.1

PSI values of skipped exons in TCGA.

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Exon skipping events with PSIs in GTEx for TSPAN14

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_43335	10	82214110:82214127:82222843:82222883:82228302:82228443	82222843:82222883	ENSG00000108219.10	ENST00000372158.1
exon_skip_43348	10	82214110:82214127:82248972:82249070:82264483:82264533	82248972:82249070	ENSG00000108219.10	ENST00000372157.2,ENST00000469149.1,ENST00000341863.6
exon_skip_43349	10	82214110:82214127:82248972:82249070:82266983:82267052	82248972:82249070	ENSG00000108219.10	ENST00000372164.3
exon_skip_43372	10	82222843:82222883:82226196:82226294:82228302:82228443	82226196:82226294	ENSG00000108219.10	ENST00000372156.1
exon_skip_43375	10	82222843:82222883:82228302:82228443:82248972:82249070	82228302:82228443	ENSG00000108219.10	ENST00000372158.1
exon_skip_43382	10	82228337:82228443:82248972:82249070:82264483:82264534	82248972:82249070	ENSG00000108219.10	ENST00000372158.1,ENST00000372156.1
exon_skip_43395	10	82248972:82249070:82264483:82264534:82266954:82267130	82264483:82264534	ENSG00000108219.10	ENST00000372157.2
exon_skip_43396	10	82248972:82249070:82264483:82264534:82266983:82267052	82264483:82264534	ENSG00000108219.10	ENST00000429989.3,ENST00000469149.1,ENST00000372158.1,ENST00000341863.6,ENST00000372156.1
exon_skip_43403	10	82248972:82249070:82266983:82267130:82269056:82269227	82266983:82267130	ENSG00000108219.10	ENST00000372164.3
exon_skip_43406	10	82264483:82264534:82266954:82267130:82269056:82269227	82266954:82267130	ENSG00000108219.10	ENST00000372157.2
exon_skip_43410	10	82264483:82264534:82266983:82267130:82269056:82269227	82266983:82267130	ENSG00000108219.10	ENST00000429989.3,ENST00000469149.1,ENST00000372158.1,ENST00000372156.1
exon_skip_43411	10	82264483:82264534:82266983:82267130:82271899:82272025	82266983:82267130	ENSG00000108219.10	ENST00000341863.6
exon_skip_43414	10	82266983:82267130:82269056:82269227:82271899:82272025	82269056:82269227	ENSG00000108219.10	ENST00000429989.3,ENST00000372157.2,ENST00000372164.3,ENST00000372158.1,ENST00000372156.1
exon_skip_43415	10	82271899:82272025:82273774:82273819:82275959:82276079	82273774:82273819	ENSG00000108219.10	ENST00000429989.3,ENST00000481124.1,ENST00000372157.2,ENST00000372164.3,ENST00000372158.1,ENST00000341863.6,ENST00000372156.1
exon_skip_43416	10	82273774:82273819:82275959:82276079:82277660:82277678	82275959:82276079	ENSG00000108219.10	ENST00000429989.3,ENST00000481124.1,ENST00000372157.2,ENST00000372164.3,ENST00000372158.1,ENST00000341863.6,ENST00000372156.1

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for TSPAN14

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000372156	82248972	82249070	5CDS-5UTR
ENST00000372158	82248972	82249070	5CDS-5UTR
ENST00000372158	82222843	82222883	5UTR-5UTR
ENST00000372156	82226196	82226294	5UTR-5UTR
ENST00000372158	82228302	82228443	5UTR-5UTR
ENST00000372156	82264483	82264534	In-frame
ENST00000372158	82264483	82264534	In-frame
ENST00000429989	82264483	82264534	In-frame
ENST00000372156	82266983	82267130	In-frame
ENST00000372158	82266983	82267130	In-frame
ENST00000429989	82266983	82267130	In-frame
ENST00000372156	82269056	82269227	In-frame
ENST00000372158	82269056	82269227	In-frame
ENST00000429989	82269056	82269227	In-frame
ENST00000372156	82273774	82273819	In-frame
ENST00000372158	82273774	82273819	In-frame
ENST00000429989	82273774	82273819	In-frame
ENST00000372156	82275959	82276079	In-frame
ENST00000372158	82275959	82276079	In-frame
ENST00000429989	82275959	82276079	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000372156	82248972	82249070	5CDS-5UTR
ENST00000372158	82248972	82249070	5CDS-5UTR
ENST00000372158	82222843	82222883	5UTR-5UTR
ENST00000372156	82226196	82226294	5UTR-5UTR
ENST00000372158	82228302	82228443	5UTR-5UTR
ENST00000372156	82264483	82264534	In-frame
ENST00000372158	82264483	82264534	In-frame
ENST00000429989	82264483	82264534	In-frame
ENST00000372156	82266983	82267130	In-frame
ENST00000372158	82266983	82267130	In-frame
ENST00000429989	82266983	82267130	In-frame
ENST00000372156	82269056	82269227	In-frame
ENST00000372158	82269056	82269227	In-frame
ENST00000429989	82269056	82269227	In-frame
ENST00000372156	82273774	82273819	In-frame
ENST00000372158	82273774	82273819	In-frame
ENST00000429989	82273774	82273819	In-frame
ENST00000372156	82275959	82276079	In-frame
ENST00000372158	82275959	82276079	In-frame
ENST00000429989	82275959	82276079	In-frame

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Infer the effects of exon skipping event on protein functional features for TSPAN14

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000372156	1397	270	82264483	82264534	584	634	27	44
ENST00000372158	1112	270	82264483	82264534	299	349	27	44
ENST00000429989	16200	270	82264483	82264534	305	355	27	44
ENST00000372156	1397	270	82266983	82267130	635	781	44	93
ENST00000372158	1112	270	82266983	82267130	350	496	44	93
ENST00000429989	16200	270	82266983	82267130	356	502	44	93
ENST00000372156	1397	270	82269056	82269227	782	952	93	150
ENST00000372158	1112	270	82269056	82269227	497	667	93	150
ENST00000429989	16200	270	82269056	82269227	503	673	93	150
ENST00000372156	1397	270	82273774	82273819	1079	1123	192	207
ENST00000372158	1112	270	82273774	82273819	794	838	192	207
ENST00000429989	16200	270	82273774	82273819	800	844	192	207
ENST00000372156	1397	270	82275959	82276079	1124	1243	207	247
ENST00000372158	1112	270	82275959	82276079	839	958	207	247
ENST00000429989	16200	270	82275959	82276079	845	964	207	247

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000372156	1397	270	82264483	82264534	584	634	27	44
ENST00000372158	1112	270	82264483	82264534	299	349	27	44
ENST00000429989	16200	270	82264483	82264534	305	355	27	44
ENST00000372156	1397	270	82266983	82267130	635	781	44	93
ENST00000372158	1112	270	82266983	82267130	350	496	44	93
ENST00000429989	16200	270	82266983	82267130	356	502	44	93
ENST00000372156	1397	270	82269056	82269227	782	952	93	150
ENST00000372158	1112	270	82269056	82269227	497	667	93	150
ENST00000429989	16200	270	82269056	82269227	503	673	93	150
ENST00000372156	1397	270	82273774	82273819	1079	1123	192	207
ENST00000372158	1112	270	82273774	82273819	794	838	192	207
ENST00000429989	16200	270	82273774	82273819	800	844	192	207
ENST00000372156	1397	270	82275959	82276079	1124	1243	207	247
ENST00000372158	1112	270	82275959	82276079	839	958	207	247
ENST00000429989	16200	270	82275959	82276079	845	964	207	247

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q8NG11	27	44	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8NG11	27	44	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8NG11	27	44	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8NG11	27	44	28	44	Alternative sequence	ID=VSP_011878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NG11	27	44	28	44	Alternative sequence	ID=VSP_011878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NG11	27	44	28	44	Alternative sequence	ID=VSP_011878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NG11	27	44	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	27	44	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	27	44	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	27	44	39	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	27	44	39	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	27	44	39	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	27	44	18	38	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	27	44	18	38	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	27	44	18	38	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	44	93	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8NG11	44	93	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8NG11	44	93	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8NG11	44	93	28	44	Alternative sequence	ID=VSP_011878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NG11	44	93	28	44	Alternative sequence	ID=VSP_011878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NG11	44	93	28	44	Alternative sequence	ID=VSP_011878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NG11	44	93	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	44	93	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	44	93	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	44	93	39	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	44	93	39	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	44	93	39	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	44	93	83	92	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	44	93	83	92	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	44	93	83	92	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	44	93	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	44	93	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	44	93	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	44	93	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	44	93	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	44	93	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	93	150	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8NG11	93	150	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8NG11	93	150	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8NG11	93	150	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	93	150	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	93	150	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	93	150	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26668317;Dbxref=PMID:26668317
Q8NG11	93	150	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26668317;Dbxref=PMID:26668317
Q8NG11	93	150	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26668317;Dbxref=PMID:26668317
Q8NG11	93	150	143	143	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	93	150	143	143	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	93	150	143	143	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	93	150	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	93	150	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	93	150	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	93	150	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	93	150	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	93	150	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	192	207	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	192	207	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	192	207	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	192	207	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26668317;Dbxref=PMID:26668317
Q8NG11	192	207	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26668317;Dbxref=PMID:26668317
Q8NG11	192	207	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26668317;Dbxref=PMID:26668317
Q8NG11	192	207	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	192	207	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	192	207	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	207	247	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	207	247	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	207	247	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	207	247	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26668317;Dbxref=PMID:26668317
Q8NG11	207	247	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26668317;Dbxref=PMID:26668317
Q8NG11	207	247	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26668317;Dbxref=PMID:26668317
Q8NG11	207	247	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	207	247	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	207	247	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	207	247	233	253	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	207	247	233	253	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	207	247	233	253	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q8NG11	27	44	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8NG11	27	44	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8NG11	27	44	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8NG11	27	44	28	44	Alternative sequence	ID=VSP_011878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NG11	27	44	28	44	Alternative sequence	ID=VSP_011878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NG11	27	44	28	44	Alternative sequence	ID=VSP_011878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NG11	27	44	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	27	44	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	27	44	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	27	44	39	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	27	44	39	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	27	44	39	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	27	44	18	38	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	27	44	18	38	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	27	44	18	38	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	44	93	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8NG11	44	93	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8NG11	44	93	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8NG11	44	93	28	44	Alternative sequence	ID=VSP_011878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NG11	44	93	28	44	Alternative sequence	ID=VSP_011878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NG11	44	93	28	44	Alternative sequence	ID=VSP_011878;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q8NG11	44	93	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	44	93	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	44	93	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	44	93	39	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	44	93	39	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	44	93	39	61	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	44	93	83	92	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	44	93	83	92	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	44	93	83	92	Topological domain	Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	44	93	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	44	93	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	44	93	62	82	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	44	93	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	44	93	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	44	93	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	93	150	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8NG11	93	150	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8NG11	93	150	28	150	Alternative sequence	ID=VSP_043194;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q8NG11	93	150	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	93	150	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	93	150	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	93	150	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26668317;Dbxref=PMID:26668317
Q8NG11	93	150	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26668317;Dbxref=PMID:26668317
Q8NG11	93	150	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26668317;Dbxref=PMID:26668317
Q8NG11	93	150	143	143	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	93	150	143	143	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	93	150	143	143	Sequence conflict	Note=L->V;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	93	150	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	93	150	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	93	150	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	93	150	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	93	150	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	93	150	93	113	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	192	207	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	192	207	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	192	207	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	192	207	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26668317;Dbxref=PMID:26668317
Q8NG11	192	207	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26668317;Dbxref=PMID:26668317
Q8NG11	192	207	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26668317;Dbxref=PMID:26668317
Q8NG11	192	207	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	192	207	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	192	207	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	207	247	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	207	247	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	207	247	1	270	Chain	ID=PRO_0000219261;Note=Tetraspanin-14
Q8NG11	207	247	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26668317;Dbxref=PMID:26668317
Q8NG11	207	247	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26668317;Dbxref=PMID:26668317
Q8NG11	207	247	114	232	Region	Note=Necessary and sufficient for interaction with ADAM10;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:26668317;Dbxref=PMID:26668317
Q8NG11	207	247	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	207	247	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	207	247	114	232	Topological domain	Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q8NG11	207	247	233	253	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	207	247	233	253	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255
Q8NG11	207	247	233	253	Transmembrane	Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255

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SNVs in the skipped exons for TSPAN14

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
HNSC	TCGA-CV-7097-01	exon_skip_43348 exon_skip_43349 exon_skip_43382	82248973	82249070	82249069	82249069	Frame_Shift_Del	G	-	p.W27fs
LIHC	TCGA-DD-A1EG-01	exon_skip_43410 exon_skip_43411 exon_skip_43406 exon_skip_43403	82266955	82267130	82267031	82267031	Frame_Shift_Del	C	-	p.D60fs
LIHC	TCGA-DD-A1EG-01	exon_skip_43410 exon_skip_43411 exon_skip_43406 exon_skip_43403	82266984	82267130	82267031	82267031	Frame_Shift_Del	C	-	p.D60fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_43410 exon_skip_43411 exon_skip_43406 exon_skip_43403	82266955	82267130	82267076	82267076	Frame_Shift_Del	G	-	p.L75fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_43410 exon_skip_43411 exon_skip_43406 exon_skip_43403	82266984	82267130	82267076	82267076	Frame_Shift_Del	G	-	p.L75fs
LIHC	TCGA-DD-A1EG-01	exon_skip_43414	82269057	82269227	82269081	82269081	Frame_Shift_Del	T	-	p.F103fs
LIHC	TCGA-DD-A1EG-01	exon_skip_43414	82269057	82269227	82269199	82269199	Frame_Shift_Del	A	-	p.Q141fs

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons

Mutation description

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
MN60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	82264484	82264534	82264511	82264511	Missense_Mutation	G	A	p.G37R
RERFLCAD1_LUNG	82264484	82264534	82264519	82264519	Missense_Mutation	G	T	p.W39C
NCIH2172_LUNG	82266984	82267130	82267017	82267017	Missense_Mutation	A	T	p.M56L
NCIH2172_LUNG	82266955	82267130	82267017	82267017	Missense_Mutation	A	T	p.M56L
BE2M17_AUTONOMIC_GANGLIA	82266984	82267130	82267068	82267068	Missense_Mutation	T	C	p.F73L
BE2M17_AUTONOMIC_GANGLIA	82266955	82267130	82267068	82267068	Missense_Mutation	T	C	p.F73L
SKNBE2_AUTONOMIC_GANGLIA	82266984	82267130	82267068	82267068	Missense_Mutation	T	C	p.F73L
SKNBE2_AUTONOMIC_GANGLIA	82266955	82267130	82267068	82267068	Missense_Mutation	T	C	p.F73L
DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	82266984	82267130	82267080	82267080	Missense_Mutation	T	C	p.F77L
DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	82266955	82267130	82267080	82267080	Missense_Mutation	T	C	p.F77L
NCIH661_LUNG	82266984	82267130	82267092	82267092	Missense_Mutation	G	C	p.V81L
NCIH661_LUNG	82266955	82267130	82267092	82267092	Missense_Mutation	G	C	p.V81L
JHUEM1_ENDOMETRIUM	82269057	82269227	82269078	82269078	Missense_Mutation	A	G	p.I101V
DG75_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	82269057	82269227	82269105	82269105	Missense_Mutation	G	A	p.V110M
HEC265_ENDOMETRIUM	82269057	82269227	82269111	82269111	Missense_Mutation	G	A	p.A112T
LS411N_LARGE_INTESTINE	82275960	82276079	82276020	82276020	Missense_Mutation	T	C	p.W228R
HCT15_LARGE_INTESTINE	82275960	82276079	82276022	82276022	Nonsense_Mutation	G	A	p.W228*
BICR18_UPPER_AERODIGESTIVE_TRACT	82264484	82264534	82264484	82264484	Splice_Site	T	C	p.L28L

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TSPAN14

sQTL information located at the skipped exons.

Exon skip ID

Chromosome

Three exons

Skippped exon

ENST

Cancer type

SNP id

Location

DNA change (ref/var)

P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TSPAN14

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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TSPAN14

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RelatedDrugs for TSPAN14

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for TSPAN14

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for TSPAN14

Exon skipping events across known transcript of Ensembl for TSPAN14 from UCSC genome browser

Gene isoform structures and expression levels for TSPAN14

Exon skipping events with PSIs in TCGA for TSPAN14

Exon skipping events with PSIs in GTEx for TSPAN14

Open reading frame (ORF) annotation in the exon skipping event for TSPAN14

Infer the effects of exon skipping event on protein functional features for TSPAN14

SNVs in the skipped exons for TSPAN14

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TSPAN14

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TSPAN14

Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TSPAN14

RelatedDrugs for TSPAN14

RelatedDiseases for TSPAN14