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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SNX27 |
 Gene summary |
| Gene information | Gene symbol | SNX27 | Gene ID | 81609 |
| Gene name | sorting nexin family member 27 | |
| Synonyms | MRT1|MY014 | |
| Cytomap | 1q21.3 | |
| Type of gene | protein-coding | |
| Description | sorting nexin-27methamphetamine-responsive transcript 1 | |
| Modification date | 20180523 | |
| UniProtAcc | Q96L92 | |
| Context | PubMed: SNX27 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for SNX27 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SNX27 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SNX27 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_10263 | 1 | 151584557:151584988:151611363:151611595:151630710:151630903 | 151611363:151611595 | ENSG00000143376.8 | ENST00000368843.3,ENST00000458013.2 |
| exon_skip_10264 | 1 | 151633273:151633338:151634641:151634746:151638408:151638487 | 151634641:151634746 | ENSG00000143376.8 | ENST00000368843.3,ENST00000458013.2,ENST00000368838.1,ENST00000368841.2 |
| exon_skip_10265 | 1 | 151634719:151634746:151638408:151638487:151640947:151641111 | 151638408:151638487 | ENSG00000143376.8 | ENST00000482791.1,ENST00000368843.3,ENST00000458013.2,ENST00000368838.1,ENST00000368841.2 |
| exon_skip_10266 | 1 | 151665386:151665515:151665899:151665959:151666845:151671550 | 151665899:151665959 | ENSG00000143376.8 | ENST00000458013.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SNX27 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_10263 | 1 | 151584557:151584988:151611363:151611595:151630710:151630903 | 151611363:151611595 | ENSG00000143376.8 | ENST00000458013.2,ENST00000368843.3 |
| exon_skip_10264 | 1 | 151633273:151633338:151634641:151634746:151638408:151638487 | 151634641:151634746 | ENSG00000143376.8 | ENST00000368841.2,ENST00000458013.2,ENST00000368843.3,ENST00000368838.1 |
| exon_skip_10265 | 1 | 151634719:151634746:151638408:151638487:151640947:151641111 | 151638408:151638487 | ENSG00000143376.8 | ENST00000368841.2,ENST00000458013.2,ENST00000368843.3,ENST00000368838.1,ENST00000482791.1 |
| exon_skip_10266 | 1 | 151665386:151665515:151665899:151665959:151666845:151671550 | 151665899:151665959 | ENSG00000143376.8 | ENST00000458013.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SNX27 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000458013 | 151611363 | 151611595 | Frame-shift |
| ENST00000458013 | 151638408 | 151638487 | Frame-shift |
| ENST00000458013 | 151634641 | 151634746 | In-frame |
| ENST00000458013 | 151665899 | 151665959 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000458013 | 151611363 | 151611595 | Frame-shift |
| ENST00000458013 | 151638408 | 151638487 | Frame-shift |
| ENST00000458013 | 151634641 | 151634746 | In-frame |
| ENST00000458013 | 151665899 | 151665959 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SNX27 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000458013 | 6420 | 541 | 151634641 | 151634746 | 922 | 1026 | 267 | 302 |
| ENST00000458013 | 6420 | 541 | 151665899 | 151665959 | 1639 | 1698 | 506 | 526 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000458013 | 6420 | 541 | 151634641 | 151634746 | 922 | 1026 | 267 | 302 |
| ENST00000458013 | 6420 | 541 | 151665899 | 151665959 | 1639 | 1698 | 506 | 526 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for SNX27 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_10263 | 151611364 | 151611595 | 151611382 | 151611382 | Frame_Shift_Del | G | - | p.E110fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_10265 | 151638409 | 151638487 | 151638454 | 151638454 | Frame_Shift_Del | T | - | p.F318fs |
| UCS | TCGA-ND-A4WC-01 | exon_skip_10263 | 151611364 | 151611595 | 151611416 | 151611416 | Nonsense_Mutation | C | T | p.R122* |
| UCS | TCGA-ND-A4WC-01 | exon_skip_10263 | 151611364 | 151611595 | 151611416 | 151611416 | Nonsense_Mutation | C | T | p.R122X |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 151611364 | 151611595 | 151611368 | 151611369 | Missense_Mutation | CA | GG | p.H106G |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 151611364 | 151611595 | 151611368 | 151611369 | Missense_Mutation | CA | GG | p.H106G |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 151611364 | 151611595 | 151611369 | 151611369 | Missense_Mutation | A | G | p.H106R |
| NCIH847_LUNG | 151611364 | 151611595 | 151611408 | 151611408 | Missense_Mutation | A | G | p.D119G |
| SNU1040_LARGE_INTESTINE | 151611364 | 151611595 | 151611443 | 151611443 | Missense_Mutation | A | G | p.T131A |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 151611364 | 151611595 | 151611558 | 151611558 | Missense_Mutation | G | C | p.R169T |
| DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 151611364 | 151611595 | 151611558 | 151611558 | Missense_Mutation | G | C | p.R169T |
| HSC2_UPPER_AERODIGESTIVE_TRACT | 151634642 | 151634746 | 151634660 | 151634660 | Missense_Mutation | G | T | p.D274Y |
| SNU175_LARGE_INTESTINE | 151638409 | 151638487 | 151638415 | 151638415 | Missense_Mutation | G | A | p.A305T |
| MN60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 151638409 | 151638487 | 151638415 | 151638415 | Missense_Mutation | G | A | p.A305T |
| NCIH2009_LUNG | 151638409 | 151638487 | 151638475 | 151638475 | Missense_Mutation | A | T | p.S325C |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 151638409 | 151638487 | 151638476 | 151638476 | Missense_Mutation | G | A | p.S325N |
| CW2_LARGE_INTESTINE | 151665900 | 151665959 | 151665924 | 151665924 | Missense_Mutation | G | A | p.E515K |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SNX27 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SNX27 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SNX27 |
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RelatedDrugs for SNX27 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SNX27 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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