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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for CDADC1 |
 Gene summary |
| Gene information | Gene symbol | CDADC1 | Gene ID | 81602 |
| Gene name | cytidine and dCMP deaminase domain containing 1 | |
| Synonyms | NYD-SP15|bA103J18.1 | |
| Cytomap | 13q14.2 | |
| Type of gene | protein-coding | |
| Description | cytidine and dCMP deaminase domain-containing protein 1protein kinase NYD-SP15testis development protein NYD-SP15 | |
| Modification date | 20180523 | |
| UniProtAcc | Q9BWV3 | |
| Context | PubMed: CDADC1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| CDADC1 | GO:0009972 | cytidine deamination | 26945630 |
| CDADC1 | GO:0070383 | DNA cytosine deamination | 26945630 |
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Exon skipping events across known transcript of Ensembl for CDADC1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for CDADC1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for CDADC1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_100352 | 13 | 49829974:49830049:49833481:49833659:49840014:49840046 | 49833481:49833659 | ENSG00000102543.10 | ENST00000496061.1,ENST00000538056.1 |
| exon_skip_100353 | 13 | 49829974:49830049:49833481:49833659:49841625:49841661 | 49833481:49833659 | ENSG00000102543.10 | ENST00000251108.6 |
| exon_skip_100354 | 13 | 49829974:49830049:49833621:49833659:49840014:49840046 | 49833621:49833659 | ENSG00000102543.10 | ENST00000484126.1 |
| exon_skip_100355 | 13 | 49829974:49830049:49833621:49833659:49841625:49841661 | 49833621:49833659 | ENSG00000102543.10 | ENST00000466868.1 |
| exon_skip_100360 | 13 | 49833621:49833659:49840014:49840139:49841625:49841661 | 49840014:49840139 | ENSG00000102543.10 | ENST00000484126.1,ENST00000496061.1 |
| exon_skip_100366 | 13 | 49841625:49842195:49848426:49848476:49852485:49852655 | 49848426:49848476 | ENSG00000102543.10 | ENST00000251108.6,ENST00000444959.1 |
| exon_skip_100369 | 13 | 49854644:49854834:49860357:49860418:49865819:49866333 | 49860357:49860418 | ENSG00000102543.10 | ENST00000251108.6,ENST00000444959.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for CDADC1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_100352 | 13 | 49829974:49830049:49833481:49833659:49840014:49840046 | 49833481:49833659 | ENSG00000102543.10 | ENST00000538056.1,ENST00000496061.1 |
| exon_skip_100353 | 13 | 49829974:49830049:49833481:49833659:49841625:49841661 | 49833481:49833659 | ENSG00000102543.10 | ENST00000251108.6 |
| exon_skip_100354 | 13 | 49829974:49830049:49833621:49833659:49840014:49840046 | 49833621:49833659 | ENSG00000102543.10 | ENST00000484126.1 |
| exon_skip_100355 | 13 | 49829974:49830049:49833621:49833659:49841625:49841661 | 49833621:49833659 | ENSG00000102543.10 | ENST00000466868.1 |
| exon_skip_100360 | 13 | 49833621:49833659:49840014:49840139:49841625:49841661 | 49840014:49840139 | ENSG00000102543.10 | ENST00000496061.1,ENST00000484126.1 |
| exon_skip_100366 | 13 | 49841625:49842195:49848426:49848476:49852485:49852655 | 49848426:49848476 | ENSG00000102543.10 | ENST00000251108.6,ENST00000444959.1 |
| exon_skip_100369 | 13 | 49854644:49854834:49860357:49860418:49865819:49866333 | 49860357:49860418 | ENSG00000102543.10 | ENST00000251108.6,ENST00000444959.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for CDADC1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000251108 | 49833481 | 49833659 | Frame-shift |
| ENST00000251108 | 49848426 | 49848476 | Frame-shift |
| ENST00000251108 | 49860357 | 49860418 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000251108 | 49833481 | 49833659 | Frame-shift |
| ENST00000251108 | 49848426 | 49848476 | Frame-shift |
| ENST00000251108 | 49860357 | 49860418 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for CDADC1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for CDADC1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_100352 exon_skip_100353 | 49833482 | 49833659 | 49833584 | 49833584 | Frame_Shift_Del | G | - | p.G119fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_100352 exon_skip_100353 | 49833482 | 49833659 | 49833613 | 49833613 | Frame_Shift_Del | T | - | p.Y128fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_100352 exon_skip_100353 | 49833482 | 49833659 | 49833613 | 49833613 | Frame_Shift_Del | T | - | p.Y128fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_100366 | 49848427 | 49848476 | 49848435 | 49848435 | Frame_Shift_Del | A | - | p.K337fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_100366 | 49848427 | 49848476 | 49848447 | 49848447 | Frame_Shift_Del | G | - | p.G341fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_100366 | 49848427 | 49848476 | 49848460 | 49848460 | Frame_Shift_Del | G | - | p.W345fs |
| BLCA | TCGA-CU-A0YR-01 | exon_skip_100352 exon_skip_100353 | 49833482 | 49833659 | 49833659 | 49833660 | Splice_Site | - | GTAA | p.A144fs |
| BLCA | TCGA-CU-A0YR-01 | exon_skip_100352 exon_skip_100353 | 49833482 | 49833659 | 49833659 | 49833660 | Splice_Site | - | GTAA | p.A144_splice |
| BLCA | TCGA-CU-A0YR-01 | exon_skip_100354 exon_skip_100355 | 49833622 | 49833659 | 49833659 | 49833660 | Splice_Site | - | GTAA | p.A144fs |
| BLCA | TCGA-CU-A0YR-01 | exon_skip_100354 exon_skip_100355 | 49833622 | 49833659 | 49833659 | 49833660 | Splice_Site | - | GTAA | p.A144_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| OCILY3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 49833482 | 49833659 | 49833534 | 49833534 | Missense_Mutation | A | G | p.H102R |
| HEC251_ENDOMETRIUM | 49833482 | 49833659 | 49833551 | 49833551 | Missense_Mutation | T | G | p.L108V |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for CDADC1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CDADC1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for CDADC1 |
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RelatedDrugs for CDADC1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CDADC1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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