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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TCL1A |
 Gene summary |
| Gene information | Gene symbol | TCL1A | Gene ID | 8115 |
| Gene name | T cell leukemia/lymphoma 1A | |
| Synonyms | TCL1 | |
| Cytomap | 14q32.13 | |
| Type of gene | protein-coding | |
| Description | T-cell leukemia/lymphoma protein 1AT-cell lymphoma-1oncogene TCL-1oncogene TCL1protein p14 TCL1 | |
| Modification date | 20180522 | |
| UniProtAcc | P56279 | |
| Context | PubMed: TCL1A [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TCL1A | GO:0008284 | positive regulation of cell proliferation | 10983986 |
| TCL1A | GO:0010918 | positive regulation of mitochondrial membrane potential | 10983986 |
| TCL1A | GO:0032461 | positive regulation of protein oligomerization | 10983986 |
| TCL1A | GO:0043066 | negative regulation of apoptotic process | 10983986 |
| TCL1A | GO:0070207 | protein homotrimerization | 10983986 |
| TCL1A | GO:0071356 | cellular response to tumor necrosis factor | 10983986 |
| TCL1A | GO:0071902 | positive regulation of protein serine/threonine kinase activity | 10983986 |
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Exon skipping events across known transcript of Ensembl for TCL1A from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TCL1A |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TCL1A |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_115647 | 14 | 96177103:96177218:96178085:96178139:96178556:96178733 | 96178085:96178139 | ENSG00000100721.6 | ENST00000556156.1,ENST00000402399.1,ENST00000557043.1,ENST00000555886.1 |
| exon_skip_115648 | 14 | 96177103:96177218:96178090:96178139:96178556:96178733 | 96178090:96178139 | ENSG00000100721.6 | ENST00000554012.1 |
| exon_skip_115650 | 14 | 96178556:96178733:96178887:96179111:96180283:96180426 | 96178887:96179111 | ENSG00000100721.6 | ENST00000555886.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TCL1A |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_115647 | 14 | 96177103:96177218:96178085:96178139:96178556:96178733 | 96178085:96178139 | ENSG00000100721.6 | ENST00000402399.1,ENST00000557043.1,ENST00000555886.1,ENST00000556156.1 |
| exon_skip_115648 | 14 | 96177103:96177218:96178090:96178139:96178556:96178733 | 96178090:96178139 | ENSG00000100721.6 | ENST00000554012.1 |
| exon_skip_115650 | 14 | 96178556:96178733:96178887:96179111:96180283:96180426 | 96178887:96179111 | ENSG00000100721.6 | ENST00000555886.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TCL1A |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000402399 | 96178085 | 96178139 | 5CDS-5UTR |
| ENST00000554012 | 96178090 | 96178139 | 5CDS-5UTR |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000402399 | 96178085 | 96178139 | 5CDS-5UTR |
| ENST00000554012 | 96178090 | 96178139 | 5CDS-5UTR |
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Infer the effects of exon skipping event on protein functional features for TCL1A |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for TCL1A |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC108_ENDOMETRIUM | 96178086 | 96178139 | 96178119 | 96178119 | Missense_Mutation | C | A | p.M106I |
| HEC108_ENDOMETRIUM | 96178091 | 96178139 | 96178119 | 96178119 | Missense_Mutation | C | A | p.M106I |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TCL1A |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TCL1A |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TCL1A |
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RelatedDrugs for TCL1A |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TCL1A |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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