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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for YEATS4 |
 Gene summary |
| Gene information | Gene symbol | YEATS4 | Gene ID | 8089 |
| Gene name | YEATS domain containing 4 | |
| Synonyms | 4930573H17Rik|B230215M10Rik|GAS41|NUBI-1|YAF9 | |
| Cytomap | 12q15 | |
| Type of gene | protein-coding | |
| Description | YEATS domain-containing protein 4NuMA binding protein 1glioma-amplified sequence 41nuBI1 | |
| Modification date | 20180519 | |
| UniProtAcc | O95619 | |
| Context | PubMed: YEATS4 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| YEATS4 | GO:0043967 | histone H4 acetylation | 14966270 |
| YEATS4 | GO:0043968 | histone H2A acetylation | 14966270 |
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Exon skipping events across known transcript of Ensembl for YEATS4 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for YEATS4 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for YEATS4 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_85276 | 12 | 69753558:69753803:69755096:69755213:69756567:69756687 | 69755096:69755213 | ENSG00000127337.2 | ENST00000549685.1 |
| exon_skip_85279 | 12 | 69753558:69753803:69756567:69756687:69764485:69764578 | 69756567:69756687 | ENSG00000127337.2 | ENST00000548020.1 |
| exon_skip_85281 | 12 | 69756567:69756687:69757956:69758079:69759412:69759479 | 69757956:69758079 | ENSG00000127337.2 | ENST00000552955.1 |
| exon_skip_85282 | 12 | 69756567:69756687:69759412:69759479:69759569:69759664 | 69759412:69759479 | ENSG00000127337.2 | ENST00000247843.2,ENST00000549685.1 |
| exon_skip_85286 | 12 | 69759412:69759479:69759569:69759664:69764485:69764578 | 69759569:69759664 | ENSG00000127337.2 | ENST00000247843.2,ENST00000552955.1,ENST00000549685.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for YEATS4 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_85276 | 12 | 69753558:69753803:69755096:69755213:69756567:69756687 | 69755096:69755213 | ENSG00000127337.2 | ENST00000549685.1 |
| exon_skip_85279 | 12 | 69753558:69753803:69756567:69756687:69764485:69764578 | 69756567:69756687 | ENSG00000127337.2 | ENST00000548020.1 |
| exon_skip_85281 | 12 | 69756567:69756687:69757956:69758079:69759412:69759479 | 69757956:69758079 | ENSG00000127337.2 | ENST00000552955.1 |
| exon_skip_85282 | 12 | 69756567:69756687:69759412:69759479:69759569:69759664 | 69759412:69759479 | ENSG00000127337.2 | ENST00000247843.2,ENST00000549685.1 |
| exon_skip_85286 | 12 | 69759412:69759479:69759569:69759664:69764485:69764578 | 69759569:69759664 | ENSG00000127337.2 | ENST00000247843.2,ENST00000549685.1,ENST00000552955.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for YEATS4 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000247843 | 69759412 | 69759479 | Frame-shift |
| ENST00000247843 | 69759569 | 69759664 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000247843 | 69759412 | 69759479 | Frame-shift |
| ENST00000247843 | 69759569 | 69759664 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for YEATS4 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for YEATS4 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
YEATS4_LIHC_exon_skip_85286_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-UB-A7MB-01 | exon_skip_85286 | 69759570 | 69759664 | 69759665 | 69759665 | Splice_Site | G | T | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-UB-A7MB-01 |
| Cancer type: LIHC | |
| ESID: exon_skip_85286 | |
| Skipped exon start: 69759570 | |
| Skipped exon end: 69759664 | |
| Mutation start: 69759665 | |
| Mutation end: 69759665 | |
| Mutation type: Splice_Site | |
| Reference seq: G | |
| Mutation seq: T | |
| AAchange: . | |
exon_skip_124728_LIHC_TCGA-UB-A7MB-01.png | |
exon_skip_128735_LIHC_TCGA-UB-A7MB-01.png | |
exon_skip_136487_LIHC_TCGA-UB-A7MB-01.png | |
exon_skip_32461_LIHC_TCGA-UB-A7MB-01.png | |
exon_skip_495073_LIHC_TCGA-UB-A7MB-01.png | |
exon_skip_85286_LIHC_TCGA-UB-A7MB-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 69756568 | 69756687 | 69756646 | 69756646 | Missense_Mutation | A | G | p.T44A |
| NCIH513_PLEURA | 69759413 | 69759479 | 69759423 | 69759423 | Missense_Mutation | C | T | p.A61V |
| HCT15_LARGE_INTESTINE | 69759413 | 69759479 | 69759465 | 69759465 | Missense_Mutation | G | A | p.G75D |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for YEATS4 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for YEATS4 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for YEATS4 |
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RelatedDrugs for YEATS4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for YEATS4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| YEATS4 | C0023827 | liposarcoma | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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