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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for FOSL1 |
 Gene summary |
| Gene information | Gene symbol | FOSL1 | Gene ID | 8061 |
| Gene name | FOS like 1, AP-1 transcription factor subunit | |
| Synonyms | FRA|FRA1|fra-1 | |
| Cytomap | 11q13.1 | |
| Type of gene | protein-coding | |
| Description | fos-related antigen 1FOS like 1, AP-1 trancription factor subunitFOS-like antigen-1 | |
| Modification date | 20180523 | |
| UniProtAcc | P15407 | |
| Context | PubMed: FOSL1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| FOSL1 | GO:0061614 | pri-miRNA transcription by RNA polymerase II | 21673316 |
| FOSL1 | GO:2000144 | positive regulation of DNA-templated transcription, initiation | 23027619 |
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Exon skipping events across known transcript of Ensembl for FOSL1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for FOSL1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for FOSL1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_74477 | 11 | 65660474:65660767:65661484:65661587:65664279:65664474 | 65661484:65661587 | ENSG00000175592.4 | ENST00000532401.1 |
| exon_skip_74481 | 11 | 65660474:65660767:65661484:65661592:65664279:65664474 | 65661484:65661592 | ENSG00000175592.4 | ENST00000312562.2 |
| exon_skip_74488 | 11 | 65660474:65660767:65664279:65664477:65667711:65667890 | 65664279:65664477 | ENSG00000175592.4 | ENST00000531493.1 |
| exon_skip_74494 | 11 | 65661484:65661587:65664279:65664477:65667711:65667890 | 65664279:65664477 | ENSG00000175592.4 | ENST00000532401.1 |
| exon_skip_74500 | 11 | 65661484:65661592:65664279:65664477:65667711:65667890 | 65664279:65664477 | ENSG00000175592.4 | ENST00000312562.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for FOSL1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_74477 | 11 | 65660474:65660767:65661484:65661587:65664279:65664474 | 65661484:65661587 | ENSG00000175592.4 | ENST00000532401.1 |
| exon_skip_74481 | 11 | 65660474:65660767:65661484:65661592:65664279:65664474 | 65661484:65661592 | ENSG00000175592.4 | ENST00000312562.2 |
| exon_skip_74488 | 11 | 65660474:65660767:65664279:65664477:65667711:65667890 | 65664279:65664477 | ENSG00000175592.4 | ENST00000531493.1 |
| exon_skip_74494 | 11 | 65661484:65661587:65664279:65664477:65667711:65667890 | 65664279:65664477 | ENSG00000175592.4 | ENST00000532401.1 |
| exon_skip_74500 | 11 | 65661484:65661592:65664279:65664477:65667711:65667890 | 65664279:65664477 | ENSG00000175592.4 | ENST00000312562.2 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for FOSL1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000312562 | 65661484 | 65661592 | In-frame |
| ENST00000312562 | 65664279 | 65664477 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000312562 | 65661484 | 65661592 | In-frame |
| ENST00000312562 | 65664279 | 65664477 | In-frame |
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Infer the effects of exon skipping event on protein functional features for FOSL1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000312562 | 1686 | 271 | 65664279 | 65664477 | 287 | 484 | 33 | 99 |
| ENST00000312562 | 1686 | 271 | 65661484 | 65661592 | 485 | 592 | 99 | 135 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000312562 | 1686 | 271 | 65664279 | 65664477 | 287 | 484 | 33 | 99 |
| ENST00000312562 | 1686 | 271 | 65661484 | 65661592 | 485 | 592 | 99 | 135 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P15407 | 33 | 99 | 34 | 135 | Alternative sequence | ID=VSP_055566;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P15407 | 33 | 99 | 1 | 271 | Chain | ID=PRO_0000076479;Note=Fos-related antigen 1 |
| P15407 | 99 | 135 | 34 | 135 | Alternative sequence | ID=VSP_055566;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P15407 | 99 | 135 | 1 | 271 | Chain | ID=PRO_0000076479;Note=Fos-related antigen 1 |
| P15407 | 99 | 135 | 103 | 106 | Compositional bias | Note=Poly-Glu |
| P15407 | 99 | 135 | 105 | 168 | Domain | Note=bZIP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978 |
| P15407 | 99 | 135 | 107 | 127 | Region | Note=Basic motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978 |
| P15407 | 99 | 135 | 133 | 161 | Region | Note=Leucine-zipper;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P15407 | 33 | 99 | 34 | 135 | Alternative sequence | ID=VSP_055566;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P15407 | 33 | 99 | 1 | 271 | Chain | ID=PRO_0000076479;Note=Fos-related antigen 1 |
| P15407 | 99 | 135 | 34 | 135 | Alternative sequence | ID=VSP_055566;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P15407 | 99 | 135 | 1 | 271 | Chain | ID=PRO_0000076479;Note=Fos-related antigen 1 |
| P15407 | 99 | 135 | 103 | 106 | Compositional bias | Note=Poly-Glu |
| P15407 | 99 | 135 | 105 | 168 | Domain | Note=bZIP;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978 |
| P15407 | 99 | 135 | 107 | 127 | Region | Note=Basic motif;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978 |
| P15407 | 99 | 135 | 133 | 161 | Region | Note=Leucine-zipper;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00978 |
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SNVs in the skipped exons for FOSL1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LUAD | TCGA-95-7039-01 | exon_skip_74494 exon_skip_74488 exon_skip_74500 | 65664280 | 65664477 | 65664461 | 65664461 | Frame_Shift_Del | G | - | p.P39fs |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SNU1040_LARGE_INTESTINE | 65664280 | 65664477 | 65664349 | 65664350 | Frame_Shift_Ins | - | G | p.P76fs |
| C32_SKIN | 65661485 | 65661592 | 65661526 | 65661526 | Missense_Mutation | A | G | p.C122R |
| C32_SKIN | 65661485 | 65661587 | 65661526 | 65661526 | Missense_Mutation | A | G | p.C122R |
| HEC151_ENDOMETRIUM | 65661485 | 65661592 | 65661567 | 65661567 | Missense_Mutation | C | T | p.R108H |
| HEC151_ENDOMETRIUM | 65661485 | 65661587 | 65661567 | 65661567 | Missense_Mutation | C | T | p.R108H |
| SNU175_LARGE_INTESTINE | 65661485 | 65661592 | 65661570 | 65661570 | Missense_Mutation | C | T | p.R107H |
| SNU175_LARGE_INTESTINE | 65661485 | 65661587 | 65661570 | 65661570 | Missense_Mutation | C | T | p.R107H |
| CP66MEL_SKIN | 65661485 | 65661592 | 65661580 | 65661580 | Missense_Mutation | C | T | p.E104K |
| CP66MEL_SKIN | 65661485 | 65661587 | 65661580 | 65661580 | Missense_Mutation | C | T | p.E104K |
| MCF7_BREAST | 65664280 | 65664477 | 65664296 | 65664296 | Missense_Mutation | C | T | p.R94Q |
| KPL1_BREAST | 65664280 | 65664477 | 65664296 | 65664296 | Missense_Mutation | C | T | p.R94Q |
| SKGT2_STOMACH | 65664280 | 65664477 | 65664396 | 65664396 | Missense_Mutation | G | T | p.P61T |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for FOSL1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FOSL1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for FOSL1 |
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RelatedDrugs for FOSL1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for FOSL1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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