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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SLC35F5 |
 Gene summary |
| Gene information | Gene symbol | SLC35F5 | Gene ID | 80255 |
| Gene name | solute carrier family 35 member F5 | |
| Synonyms | - | |
| Cytomap | 2q14.1 | |
| Type of gene | protein-coding | |
| Description | solute carrier family 35 member F5HCV NS5A-transactivated protein 3hepatitis C virus NS5A-transactivated protein 3 | |
| Modification date | 20180519 | |
| UniProtAcc | Q8WV83 | |
| Context | PubMed: SLC35F5 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for SLC35F5 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SLC35F5 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SLC35F5 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_342836 | 2 | 114471929:114472618:114472734:114472772:114475329:114475425 | 114472734:114472772 | ENSG00000115084.8 | ENST00000409106.1 |
| exon_skip_342838 | 2 | 114472734:114472772:114475329:114475425:114476730:114476821 | 114475329:114475425 | ENSG00000115084.8 | ENST00000420066.1 |
| exon_skip_342839 | 2 | 114472734:114472772:114475329:114475427:114476730:114476821 | 114475329:114475427 | ENSG00000115084.8 | ENST00000409106.1,ENST00000245680.2 |
| exon_skip_342845 | 2 | 114489160:114489225:114490941:114490980:114492162:114492250 | 114490941:114490980 | ENSG00000115084.8 | ENST00000447673.1 |
| exon_skip_342846 | 2 | 114493353:114493435:114500268:114500456:114501289:114501371 | 114500268:114500456 | ENSG00000115084.8 | ENST00000409106.1,ENST00000245680.2 |
| exon_skip_342849 | 2 | 114501289:114501371:114503853:114503916:114508001:114508145 | 114503853:114503916 | ENSG00000115084.8 | ENST00000409342.1,ENST00000409106.1,ENST00000245680.2,ENST00000498768.1 |
| exon_skip_342853 | 2 | 114503853:114503916:114508001:114508145:114512741:114512883 | 114508001:114508145 | ENSG00000115084.8 | ENST00000409342.1,ENST00000409106.1,ENST00000245680.2,ENST00000498768.1 |
| exon_skip_342856 | 2 | 114508001:114508145:114512741:114512883:114513030:114513121 | 114512741:114512883 | ENSG00000115084.8 | ENST00000409342.1,ENST00000409106.1,ENST00000245680.2,ENST00000498768.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SLC35F5 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_342836 | 2 | 114471929:114472618:114472734:114472772:114475329:114475425 | 114472734:114472772 | ENSG00000115084.8 | ENST00000409106.1 |
| exon_skip_342838 | 2 | 114472734:114472772:114475329:114475425:114476730:114476821 | 114475329:114475425 | ENSG00000115084.8 | ENST00000420066.1 |
| exon_skip_342839 | 2 | 114472734:114472772:114475329:114475427:114476730:114476821 | 114475329:114475427 | ENSG00000115084.8 | ENST00000245680.2,ENST00000409106.1 |
| exon_skip_342845 | 2 | 114489160:114489225:114490941:114490980:114492162:114492250 | 114490941:114490980 | ENSG00000115084.8 | ENST00000447673.1 |
| exon_skip_342846 | 2 | 114493353:114493435:114500268:114500456:114501289:114501371 | 114500268:114500456 | ENSG00000115084.8 | ENST00000245680.2,ENST00000409106.1 |
| exon_skip_342849 | 2 | 114501289:114501371:114503853:114503916:114508001:114508145 | 114503853:114503916 | ENSG00000115084.8 | ENST00000245680.2,ENST00000409106.1,ENST00000409342.1,ENST00000498768.1 |
| exon_skip_342853 | 2 | 114503853:114503916:114508001:114508145:114512741:114512883 | 114508001:114508145 | ENSG00000115084.8 | ENST00000245680.2,ENST00000409106.1,ENST00000409342.1,ENST00000498768.1 |
| exon_skip_342856 | 2 | 114508001:114508145:114512741:114512883:114513030:114513121 | 114512741:114512883 | ENSG00000115084.8 | ENST00000245680.2,ENST00000409106.1,ENST00000409342.1,ENST00000498768.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SLC35F5 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000245680 | 114475329 | 114475427 | 5CDS-5UTR |
| ENST00000245680 | 114500268 | 114500456 | Frame-shift |
| ENST00000245680 | 114512741 | 114512883 | Frame-shift |
| ENST00000245680 | 114503853 | 114503916 | In-frame |
| ENST00000245680 | 114508001 | 114508145 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000245680 | 114475329 | 114475427 | 5CDS-5UTR |
| ENST00000245680 | 114500268 | 114500456 | Frame-shift |
| ENST00000245680 | 114512741 | 114512883 | Frame-shift |
| ENST00000245680 | 114503853 | 114503916 | In-frame |
| ENST00000245680 | 114508001 | 114508145 | In-frame |
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Infer the effects of exon skipping event on protein functional features for SLC35F5 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000245680 | 4429 | 523 | 114508001 | 114508145 | 688 | 831 | 91 | 139 |
| ENST00000245680 | 4429 | 523 | 114503853 | 114503916 | 832 | 894 | 139 | 160 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000245680 | 4429 | 523 | 114508001 | 114508145 | 688 | 831 | 91 | 139 |
| ENST00000245680 | 4429 | 523 | 114503853 | 114503916 | 832 | 894 | 139 | 160 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8WV83 | 91 | 139 | 1 | 523 | Chain | ID=PRO_0000311956;Note=Solute carrier family 35 member F5 |
| Q8WV83 | 91 | 139 | 101 | 121 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WV83 | 139 | 160 | 1 | 523 | Chain | ID=PRO_0000311956;Note=Solute carrier family 35 member F5 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q8WV83 | 91 | 139 | 1 | 523 | Chain | ID=PRO_0000311956;Note=Solute carrier family 35 member F5 |
| Q8WV83 | 91 | 139 | 101 | 121 | Transmembrane | Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q8WV83 | 139 | 160 | 1 | 523 | Chain | ID=PRO_0000311956;Note=Solute carrier family 35 member F5 |
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SNVs in the skipped exons for SLC35F5 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| ESCA | TCGA-L5-A4OI-01 | exon_skip_342846 | 114500269 | 114500456 | 114500277 | 114500278 | Frame_Shift_Del | AA | - | p.248_248del |
| ESCA | TCGA-L5-A4OI-01 | exon_skip_342846 | 114500269 | 114500456 | 114500277 | 114500278 | Frame_Shift_Del | AA | - | p.F247fs |
| SKCM | TCGA-D3-A1Q4-06 | exon_skip_342846 | 114500269 | 114500456 | 114500277 | 114500277 | Frame_Shift_Del | A | - | p.C248fs |
| SKCM | TCGA-D3-A51R-06 | exon_skip_342846 | 114500269 | 114500456 | 114500277 | 114500277 | Frame_Shift_Del | A | - | p.C248fs |
| THCA | TCGA-L6-A4EU-01 | exon_skip_342846 | 114500269 | 114500456 | 114500277 | 114500277 | Frame_Shift_Del | A | - | p.C248fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_342846 | 114500269 | 114500456 | 114500361 | 114500361 | Frame_Shift_Del | A | - | p.Y220fs |
| KICH | TCGA-KL-8336-01 | exon_skip_342853 | 114508002 | 114508145 | 114508020 | 114508020 | Frame_Shift_Del | G | - | p.R133fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_342853 | 114508002 | 114508145 | 114508072 | 114508072 | Frame_Shift_Del | A | - | p.L116fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_342853 | 114508002 | 114508145 | 114508137 | 114508137 | Frame_Shift_Del | A | - | p.F94fs |
| ACC | TCGA-OR-A5K5-01 | exon_skip_342856 | 114512742 | 114512883 | 114512866 | 114512869 | Frame_Shift_Del | ACAC | - | p.CV49fs |
| LGG | TCGA-DU-A7T6-01 | exon_skip_342853 | 114508002 | 114508145 | 114508047 | 114508047 | Nonsense_Mutation | C | T | p.W124* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| ISHIKAWAHERAKLIO02ER_ENDOMETRIUM | 114500269 | 114500456 | 114500279 | 114500279 | Frame_Shift_Del | A | - | p.F247fs |
| CAL27_UPPER_AERODIGESTIVE_TRACT | 114500269 | 114500456 | 114500374 | 114500374 | Missense_Mutation | C | A | p.L215F |
| BHT101_THYROID | 114500269 | 114500456 | 114500435 | 114500435 | Missense_Mutation | C | T | p.R195K |
| NCIH854_LUNG | 114500269 | 114500456 | 114500448 | 114500448 | Missense_Mutation | T | G | p.K191Q |
| IGROV1_OVARY | 114508002 | 114508145 | 114508019 | 114508019 | Missense_Mutation | C | T | p.G134R |
| PLCPRF5_LIVER | 114508002 | 114508145 | 114508069 | 114508069 | Missense_Mutation | C | A | p.G117V |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SLC35F5 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SLC35F5 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SLC35F5 |
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RelatedDrugs for SLC35F5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SLC35F5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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