ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for WDR26

Gene summary

Gene information	Gene symbol	WDR26
	Gene ID	80232
	Gene name	WD repeat domain 26
	Synonyms	CDW2\|GID7\|MIP2\|SKDEAS
	Cytomap	1q42.11-q42.12
	Type of gene	protein-coding
	Description	WD repeat-containing protein 26CUL4- and DDB1-associated WDR protein 2GID complex subunit 7 homologmyocardial ischemic preconditioning upregulated protein 2
	Modification date	20180522
	UniProtAcc	Q9H7D7
	Context	PubMed: WDR26 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

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Exon skipping events across known transcript of Ensembl for WDR26 from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Gene isoform structures and expression levels for WDR26

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

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Exon skipping events with PSIs in TCGA for WDR26

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_37395	1	224573367:224574204:224577534:224577562:224581529:224581715	224577534:224577562	ENSG00000162923.10	ENST00000480676.2
exon_skip_37403	1	224577534:224577562:224581529:224581715:224585798:224585928	224581529:224581715	ENSG00000162923.10	ENST00000295024.6,ENST00000486652.1,ENST00000414423.2,ENST00000366852.2,ENST00000480676.2
exon_skip_37408	1	224581529:224581715:224585798:224585928:224586216:224586295	224585798:224585928	ENSG00000162923.10	ENST00000295024.6,ENST00000486652.1,ENST00000414423.2,ENST00000366852.2,ENST00000480676.2
exon_skip_37409	1	224585798:224585928:224586216:224586295:224586590:224586736	224586216:224586295	ENSG00000162923.10	ENST00000295024.6,ENST00000486652.1,ENST00000414423.2,ENST00000366852.2,ENST00000479727.1,ENST00000480676.2
exon_skip_37410	1	224586216:224586295:224586590:224586736:224588651:224588721	224586590:224586736	ENSG00000162923.10	ENST00000295024.6,ENST00000486652.1,ENST00000414423.2,ENST00000366852.2,ENST00000479727.1,ENST00000480676.2
exon_skip_37415	1	224586590:224586736:224588651:224588771:224592131:224592272	224588651:224588771	ENSG00000162923.10	ENST00000295024.6,ENST00000414423.2,ENST00000480676.2
exon_skip_37422	1	224588651:224588771:224589705:224589811:224592131:224592272	224589705:224589811	ENSG00000162923.10	ENST00000486652.1,ENST00000366852.2
exon_skip_37425	1	224588651:224588771:224592131:224592272:224599128:224599186	224592131:224592272	ENSG00000162923.10	ENST00000295024.6,ENST00000414423.2,ENST00000480676.2
exon_skip_37431	1	224592131:224592272:224599128:224599267:224605961:224606074	224599128:224599267	ENSG00000162923.10	ENST00000295024.6,ENST00000414423.2
exon_skip_37436	1	224599128:224599267:224600954:224601037:224605961:224605977	224600954:224601037	ENSG00000162923.10	ENST00000486652.1,ENST00000366852.2
exon_skip_37441	1	224599128:224599267:224605961:224606118:224607219:224607317	224605961:224606118	ENSG00000162923.10	ENST00000295024.6,ENST00000414423.2
exon_skip_37448	1	224607263:224607317:224612219:224612356:224619178:224619283	224612219:224612356	ENSG00000162923.10	ENST00000295024.6,ENST00000414423.2,ENST00000445239.1
exon_skip_37449	1	224607263:224607317:224612219:224612356:224619226:224619283	224612219:224612356	ENSG00000162923.10	ENST00000443112.2
exon_skip_37450	1	224607263:224607317:224612219:224612421:224619178:224619283	224612219:224612421	ENSG00000162923.10	ENST00000489825.1,ENST00000477425.1
exon_skip_37451	1	224607263:224607317:224612219:224612421:224619226:224619283	224612219:224612421	ENSG00000162923.10	ENST00000486652.1,ENST00000366852.2
exon_skip_37454	1	224619226:224619283:224619383:224619483:224621385:224621540	224619383:224619483	ENSG00000162923.10	ENST00000295024.6,ENST00000486652.1,ENST00000443112.2,ENST00000366852.2,ENST00000479778.1,ENST00000489825.1

PSI values of skipped exons in TCGA.

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Exon skipping events with PSIs in GTEx for WDR26

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_37395	1	224573367:224574204:224577534:224577562:224581529:224581715	224577534:224577562	ENSG00000162923.10	ENST00000480676.2
exon_skip_37403	1	224577534:224577562:224581529:224581715:224585798:224585928	224581529:224581715	ENSG00000162923.10	ENST00000414423.2,ENST00000295024.6,ENST00000480676.2,ENST00000486652.1,ENST00000366852.2
exon_skip_37408	1	224581529:224581715:224585798:224585928:224586216:224586295	224585798:224585928	ENSG00000162923.10	ENST00000414423.2,ENST00000295024.6,ENST00000480676.2,ENST00000486652.1,ENST00000366852.2
exon_skip_37409	1	224585798:224585928:224586216:224586295:224586590:224586736	224586216:224586295	ENSG00000162923.10	ENST00000414423.2,ENST00000295024.6,ENST00000480676.2,ENST00000486652.1,ENST00000366852.2,ENST00000479727.1
exon_skip_37410	1	224586216:224586295:224586590:224586736:224588651:224588721	224586590:224586736	ENSG00000162923.10	ENST00000414423.2,ENST00000295024.6,ENST00000480676.2,ENST00000486652.1,ENST00000366852.2,ENST00000479727.1
exon_skip_37415	1	224586590:224586736:224588651:224588771:224592131:224592272	224588651:224588771	ENSG00000162923.10	ENST00000414423.2,ENST00000295024.6,ENST00000480676.2
exon_skip_37422	1	224588651:224588771:224589705:224589811:224592131:224592272	224589705:224589811	ENSG00000162923.10	ENST00000486652.1,ENST00000366852.2
exon_skip_37425	1	224588651:224588771:224592131:224592272:224599128:224599186	224592131:224592272	ENSG00000162923.10	ENST00000414423.2,ENST00000295024.6,ENST00000480676.2
exon_skip_37431	1	224592131:224592272:224599128:224599267:224605961:224606074	224599128:224599267	ENSG00000162923.10	ENST00000414423.2,ENST00000295024.6
exon_skip_37436	1	224599128:224599267:224600954:224601037:224605961:224605977	224600954:224601037	ENSG00000162923.10	ENST00000486652.1,ENST00000366852.2
exon_skip_37441	1	224599128:224599267:224605961:224606118:224607219:224607317	224605961:224606118	ENSG00000162923.10	ENST00000414423.2,ENST00000295024.6
exon_skip_37448	1	224607263:224607317:224612219:224612356:224619178:224619283	224612219:224612356	ENSG00000162923.10	ENST00000414423.2,ENST00000295024.6,ENST00000445239.1
exon_skip_37449	1	224607263:224607317:224612219:224612356:224619226:224619283	224612219:224612356	ENSG00000162923.10	ENST00000443112.2
exon_skip_37450	1	224607263:224607317:224612219:224612421:224619178:224619283	224612219:224612421	ENSG00000162923.10	ENST00000489825.1,ENST00000477425.1
exon_skip_37451	1	224607263:224607317:224612219:224612421:224619226:224619283	224612219:224612421	ENSG00000162923.10	ENST00000486652.1,ENST00000366852.2
exon_skip_37454	1	224619226:224619283:224619383:224619483:224621385:224621540	224619383:224619483	ENSG00000162923.10	ENST00000295024.6,ENST00000486652.1,ENST00000366852.2,ENST00000443112.2,ENST00000489825.1,ENST00000479778.1

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for WDR26

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000414423	224585798	224585928	Frame-shift
ENST00000414423	224586216	224586295	Frame-shift
ENST00000414423	224586590	224586736	Frame-shift
ENST00000414423	224599128	224599267	Frame-shift
ENST00000414423	224605961	224606118	Frame-shift
ENST00000414423	224612219	224612356	Frame-shift
ENST00000414423	224581529	224581715	In-frame
ENST00000414423	224588651	224588771	In-frame
ENST00000414423	224592131	224592272	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000414423	224585798	224585928	Frame-shift
ENST00000414423	224586216	224586295	Frame-shift
ENST00000414423	224586590	224586736	Frame-shift
ENST00000414423	224599128	224599267	Frame-shift
ENST00000414423	224605961	224606118	Frame-shift
ENST00000414423	224612219	224612356	Frame-shift
ENST00000414423	224581529	224581715	In-frame
ENST00000414423	224588651	224588771	In-frame
ENST00000414423	224592131	224592272	In-frame

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Infer the effects of exon skipping event on protein functional features for WDR26

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000414423	6889	661	224592131	224592272	1353	1493	386	433
ENST00000414423	6889	661	224588651	224588771	1494	1613	433	473
ENST00000414423	6889	661	224581529	224581715	1969	2154	591	653

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000414423	6889	661	224592131	224592272	1353	1493	386	433
ENST00000414423	6889	661	224588651	224588771	1494	1613	433	473
ENST00000414423	6889	661	224581529	224581715	1969	2154	591	653

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9H7D7	386	433	217	661	Alternative sequence	ID=VSP_023898;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9H7D7	386	433	224	661	Alternative sequence	ID=VSP_023899;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q9H7D7	386	433	1	661	Chain	ID=PRO_0000051373;Note=WD repeat-containing protein 26
Q9H7D7	386	433	46	661	Natural variant	ID=VAR_079297;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	386	433	279	661	Natural variant	ID=VAR_079301;Note=In SKDEAS%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	386	433	426	661	Natural variant	ID=VAR_079303;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	386	433	428	661	Natural variant	ID=VAR_079304;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	386	433	353	392	Repeat	Note=WD 1
Q9H7D7	386	433	399	438	Repeat	Note=WD 2
Q9H7D7	433	473	217	661	Alternative sequence	ID=VSP_023898;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9H7D7	433	473	224	661	Alternative sequence	ID=VSP_023899;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q9H7D7	433	473	1	661	Chain	ID=PRO_0000051373;Note=WD repeat-containing protein 26
Q9H7D7	433	473	46	661	Natural variant	ID=VAR_079297;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	433	473	279	661	Natural variant	ID=VAR_079301;Note=In SKDEAS%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	433	473	426	661	Natural variant	ID=VAR_079303;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	433	473	428	661	Natural variant	ID=VAR_079304;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	433	473	399	438	Repeat	Note=WD 2
Q9H7D7	433	473	444	484	Repeat	Note=WD 3
Q9H7D7	591	653	217	661	Alternative sequence	ID=VSP_023898;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9H7D7	591	653	224	661	Alternative sequence	ID=VSP_023899;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q9H7D7	591	653	1	661	Chain	ID=PRO_0000051373;Note=WD repeat-containing protein 26
Q9H7D7	591	653	46	661	Natural variant	ID=VAR_079297;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	591	653	279	661	Natural variant	ID=VAR_079301;Note=In SKDEAS%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	591	653	426	661	Natural variant	ID=VAR_079303;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	591	653	428	661	Natural variant	ID=VAR_079304;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	591	653	524	661	Natural variant	ID=VAR_079305;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	591	653	566	608	Repeat	Note=WD 5
Q9H7D7	591	653	611	651	Repeat	Note=WD 6

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
Q9H7D7	386	433	217	661	Alternative sequence	ID=VSP_023898;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9H7D7	386	433	224	661	Alternative sequence	ID=VSP_023899;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q9H7D7	386	433	1	661	Chain	ID=PRO_0000051373;Note=WD repeat-containing protein 26
Q9H7D7	386	433	46	661	Natural variant	ID=VAR_079297;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	386	433	279	661	Natural variant	ID=VAR_079301;Note=In SKDEAS%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	386	433	426	661	Natural variant	ID=VAR_079303;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	386	433	428	661	Natural variant	ID=VAR_079304;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	386	433	353	392	Repeat	Note=WD 1
Q9H7D7	386	433	399	438	Repeat	Note=WD 2
Q9H7D7	433	473	217	661	Alternative sequence	ID=VSP_023898;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9H7D7	433	473	224	661	Alternative sequence	ID=VSP_023899;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q9H7D7	433	473	1	661	Chain	ID=PRO_0000051373;Note=WD repeat-containing protein 26
Q9H7D7	433	473	46	661	Natural variant	ID=VAR_079297;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	433	473	279	661	Natural variant	ID=VAR_079301;Note=In SKDEAS%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	433	473	426	661	Natural variant	ID=VAR_079303;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	433	473	428	661	Natural variant	ID=VAR_079304;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	433	473	399	438	Repeat	Note=WD 2
Q9H7D7	433	473	444	484	Repeat	Note=WD 3
Q9H7D7	591	653	217	661	Alternative sequence	ID=VSP_023898;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:15489334;Dbxref=PMID:15489334
Q9H7D7	591	653	224	661	Alternative sequence	ID=VSP_023899;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|Ref.6
Q9H7D7	591	653	1	661	Chain	ID=PRO_0000051373;Note=WD repeat-containing protein 26
Q9H7D7	591	653	46	661	Natural variant	ID=VAR_079297;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	591	653	279	661	Natural variant	ID=VAR_079301;Note=In SKDEAS%3B unknown pathological significance. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	591	653	426	661	Natural variant	ID=VAR_079303;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	591	653	428	661	Natural variant	ID=VAR_079304;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	591	653	524	661	Natural variant	ID=VAR_079305;Note=In SKDEAS. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:28686853;Dbxref=PMID:28686853
Q9H7D7	591	653	566	608	Repeat	Note=WD 5
Q9H7D7	591	653	611	651	Repeat	Note=WD 6

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SNVs in the skipped exons for WDR26

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
LIHC	TCGA-DD-A3A0-01	exon_skip_37409	224586217	224586295	224586258	224586258	Frame_Shift_Del	A	-	p.S535fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_37415	224588652	224588771	224588688	224588688	Frame_Shift_Del	A	-	p.F461fs
LIHC	TCGA-DD-A1EG-01	exon_skip_37425	224592132	224592272	224592245	224592245	Frame_Shift_Del	T	-	p.T396fs
LIHC	TCGA-DD-A39Y-01	exon_skip_37431	224599129	224599267	224599155	224599155	Frame_Shift_Del	T	-	p.T378fs
LIHC	TCGA-DD-A3A0-01	exon_skip_37441	224605962	224606118	224605969	224605969	Frame_Shift_Del	A	-	p.C338fs
LIHC	TCGA-G3-A3CJ-01	exon_skip_37441	224605962	224606118	224606032	224606032	Frame_Shift_Del	G	-	p.L317fs
LIHC	TCGA-BC-A3KG-01	exon_skip_37441	224605962	224606118	224606059	224606059	Frame_Shift_Del	C	-	p.A308fs
COAD	TCGA-A6-6780-01	exon_skip_37415	224588652	224588771	224588749	224588750	Frame_Shift_Ins	-	T	p.M441fs
LUSC	TCGA-34-5236-01	exon_skip_37395	224577535	224577562	224577560	224577560	Nonsense_Mutation	C	A	p.E655*
COAD	TCGA-G4-6303-01	exon_skip_37408	224585799	224585928	224585868	224585868	Nonsense_Mutation	G	A	p.Q569X
CHOL	TCGA-W5-AA2U-01	exon_skip_37431	224599129	224599267	224599141	224599141	Nonsense_Mutation	C	T	p.W382X
LGG	TCGA-HW-7495-01	exon_skip_37454	224619384	224619483	224619390	224619390	Nonsense_Mutation	C	T	p.W172*

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons

Mutation description

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
22RV1_PROSTATE	224586591	224586736	224586681	224586682	Frame_Shift_Ins	-	A	p.W492fs
HEC6_ENDOMETRIUM	224577535	224577562	224577556	224577556	Missense_Mutation	C	T	p.C656Y
NCIH522_LUNG	224581530	224581715	224581601	224581601	Missense_Mutation	G	A	p.A630V
22RV1_PROSTATE	224581530	224581715	224581670	224581670	Missense_Mutation	G	A	p.A607V
MCC26_SKIN	224581530	224581715	224581674	224581674	Missense_Mutation	T	A	p.I606F
COV504_OVARY	224581530	224581715	224581674	224581674	Missense_Mutation	T	C	p.I606V
SNU81_LARGE_INTESTINE	224585799	224585928	224585850	224585850	Missense_Mutation	G	A	p.H575Y
NCIH630_LARGE_INTESTINE	224586217	224586295	224586227	224586227	Missense_Mutation	A	G	p.V545A
GAK_SKIN	224592132	224592272	224592145	224592145	Missense_Mutation	A	G	p.L429P
BICR18_UPPER_AERODIGESTIVE_TRACT	224592132	224592272	224592190	224592190	Missense_Mutation	T	C	p.N414S
HCC2998_LARGE_INTESTINE	224592132	224592272	224592217	224592217	Missense_Mutation	G	T	p.S405Y
SNU81_LARGE_INTESTINE	224599129	224599267	224599198	224599198	Missense_Mutation	G	T	p.F363L
SNU81_LARGE_INTESTINE	224599129	224599267	224599202	224599202	Missense_Mutation	T	G	p.K362T
HOP62_LUNG	224605962	224606118	224605999	224605999	Missense_Mutation	C	G	p.D328H
NTERA2CLD1_TESTIS	224605962	224606118	224606011	224606011	Missense_Mutation	C	T	p.D324N
SNU324_PANCREAS	224612220	224612356	224612325	224612325	Missense_Mutation	T	C	p.Y220C
SNU324_PANCREAS	224612220	224612421	224612325	224612325	Missense_Mutation	T	C	p.Y220C
SNU626_CENTRAL_NERVOUS_SYSTEM	224581530	224581715	224581696	224581696	Nonsense_Mutation	C	T	p.W598*
BICR18_UPPER_AERODIGESTIVE_TRACT	224592132	224592272	224592132	224592132	Splice_Site	T	C	p.Q433Q
MFE296_ENDOMETRIUM	224599129	224599267	224599130	224599130	Splice_Site	G	A	p.P386L

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for WDR26

sQTL information located at the skipped exons.

Exon skip ID

Chromosome

Three exons

Skippped exon

ENST

Cancer type

SNP id

Location

DNA change (ref/var)

P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for WDR26

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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for WDR26

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RelatedDrugs for WDR26

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for WDR26

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

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Gene summary for WDR26

Exon skipping events across known transcript of Ensembl for WDR26 from UCSC genome browser

Gene isoform structures and expression levels for WDR26

Exon skipping events with PSIs in TCGA for WDR26

Exon skipping events with PSIs in GTEx for WDR26

Open reading frame (ORF) annotation in the exon skipping event for WDR26

Infer the effects of exon skipping event on protein functional features for WDR26

SNVs in the skipped exons for WDR26

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for WDR26

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for WDR26

Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for WDR26

RelatedDrugs for WDR26

RelatedDiseases for WDR26