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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MYCT1 |
 Gene summary |
| Gene information | Gene symbol | MYCT1 | Gene ID | 80177 |
| Gene name | MYC target 1 | |
| Synonyms | MTLC | |
| Cytomap | 6q25.2 | |
| Type of gene | protein-coding | |
| Description | myc target protein 1myc target in myeloid cells 1myc target in myeloid cells protein 1 | |
| Modification date | 20180402 | |
| UniProtAcc | Q8N699 | |
| Context | PubMed: MYCT1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for MYCT1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MYCT1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MYCT1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_454940 | 6 | 153019095:153019233:153042876:153043388:153043897:153044419 | 153042876:153043388 | ENSG00000120279.6 | ENST00000532295.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MYCT1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_454940 | 6 | 153019095:153019233:153042876:153043388:153043897:153044419 | 153042876:153043388 | ENSG00000120279.6 | ENST00000532295.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MYCT1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for MYCT1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for MYCT1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-BC-A10T-01 | exon_skip_454940 | 153042877 | 153043388 | 153043057 | 153043058 | Frame_Shift_Ins | - | C | p.Y126fs |
| HNSC | TCGA-CR-7383-01 | exon_skip_454940 | 153042877 | 153043388 | 153043080 | 153043080 | Nonsense_Mutation | C | T | p.R134* |
| SKCM | TCGA-EE-A29E-06 | exon_skip_454940 | 153042877 | 153043388 | 153043113 | 153043113 | Nonsense_Mutation | C | T | p.Q145* |
| BRCA | TCGA-A7-A0CE-01 | exon_skip_454940 | 153042877 | 153043388 | 153043116 | 153043116 | Nonsense_Mutation | C | T | p.R146* |
| PRAD | TCGA-ZG-A9LY-01 | exon_skip_454940 | 153042877 | 153043388 | 153043116 | 153043116 | Nonsense_Mutation | C | T | p.R146* |
| SKCM | TCGA-FW-A3R5-06 | exon_skip_454940 | 153042877 | 153043388 | 153043320 | 153043320 | Nonsense_Mutation | C | T | p.R214* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC151_ENDOMETRIUM | 153042877 | 153043388 | 153043341 | 153043341 | Frame_Shift_Del | C | - | p.P223fs |
| SW1417_LARGE_INTESTINE | 153042877 | 153043388 | 153042910 | 153042910 | Missense_Mutation | C | T | p.A77V |
| HS834T_FIBROBLAST | 153042877 | 153043388 | 153042981 | 153042981 | Missense_Mutation | G | T | p.A101S |
| CW2_LARGE_INTESTINE | 153042877 | 153043388 | 153043006 | 153043006 | Missense_Mutation | G | A | p.S109N |
| OVK18_OVARY | 153042877 | 153043388 | 153043039 | 153043039 | Missense_Mutation | T | C | p.L120P |
| PACADD137_PANCREAS | 153042877 | 153043388 | 153043060 | 153043060 | Missense_Mutation | G | A | p.R127H |
| JHH6_LIVER | 153042877 | 153043388 | 153043078 | 153043078 | Missense_Mutation | G | A | p.R133H |
| IALM_LUNG | 153042877 | 153043388 | 153043078 | 153043078 | Missense_Mutation | G | T | p.R133L |
| KPNYS_AUTONOMIC_GANGLIA | 153042877 | 153043388 | 153043078 | 153043078 | Missense_Mutation | G | A | p.R133H |
| NCIH630_LARGE_INTESTINE | 153042877 | 153043388 | 153043083 | 153043083 | Missense_Mutation | A | C | p.S135R |
| NCIH1666_LUNG | 153042877 | 153043388 | 153043102 | 153043102 | Missense_Mutation | G | C | p.S141T |
| TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 153042877 | 153043388 | 153043114 | 153043114 | Missense_Mutation | A | T | p.Q145L |
| KARPAS384_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 153042877 | 153043388 | 153043134 | 153043134 | Missense_Mutation | C | A | p.Q152K |
| WM88_SKIN | 153042877 | 153043388 | 153043136 | 153043136 | Missense_Mutation | A | C | p.Q152H |
| CGTHW1_THYROID | 153042877 | 153043388 | 153043223 | 153043223 | Missense_Mutation | G | T | p.E181D |
| MCC13_SKIN | 153042877 | 153043388 | 153043321 | 153043321 | Missense_Mutation | G | A | p.R214Q |
| NCIH524_LUNG | 153042877 | 153043388 | 153043354 | 153043354 | Missense_Mutation | A | T | p.Y225F |
| HEC251_ENDOMETRIUM | 153042877 | 153043388 | 153042930 | 153042930 | Nonsense_Mutation | G | T | p.G84* |
| RERFLCFM_LUNG | 153042877 | 153043388 | 153042940 | 153042940 | Nonsense_Mutation | G | A | p.W87* |
| HT115_LARGE_INTESTINE | 153042877 | 153043388 | 153043080 | 153043080 | Nonsense_Mutation | C | T | p.R134* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MYCT1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MYCT1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MYCT1 |
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RelatedDrugs for MYCT1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MYCT1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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