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Center for Computational Systems Medicine
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Gene summary

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Gene structures and expression levels

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Exon skipping events with PSIs in TCGA

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Exon skipping events with PSIs in GTEx

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Open reading frame (ORF) annotation in the exon skipping event

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Exon skipping events in the canonical protein sequence

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SNVs in the skipped exons with depth of coverage

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Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

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Related drugs with this gene

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Related diseases with this gene

Gene summary for MAP3K19

check button Gene summary
Gene informationGene symbol

MAP3K19

Gene ID

80122

Gene namemitogen-activated protein kinase kinase kinase 19
SynonymsRCK|YSK4
Cytomap

2q21.3

Type of geneprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase 19SPS1/STE20-related protein kinase YSK4YSK4 Sps1/Ste20-related kinase homologregulated in COPD kinaseregulated in COPD, protein kinaseyeast Sps1/Ste20-related kinase 4
Modification date20180523
UniProtAcc

Q56UN5

ContextPubMed: MAP3K19 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

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Exon skipping events across known transcript of Ensembl for MAP3K19 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

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Gene isoform structures and expression levels for MAP3K19

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


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Exon skipping events with PSIs in TCGA for MAP3K19

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3437142135738390:135739088:135740749:135740901:135741245:135741395135740749:135740901ENSG00000176601.7ENST00000315513.3,ENST00000392915.1
exon_skip_3437152135738390:135739088:135741245:135741395:135743369:135744611135741245:135741395ENSG00000176601.7ENST00000437365.1,ENST00000358371.4,ENST00000375845.3
exon_skip_3437202135741277:135741395:135743369:135745823:135749106:135749150135743369:135745823ENSG00000176601.7ENST00000315513.3,ENST00000358371.4,ENST00000392915.1,ENST00000375845.3
exon_skip_3437212135743369:135745823:135749106:135749150:135756307:135756567135749106:135749150ENSG00000176601.7ENST00000315513.3,ENST00000392915.1,ENST00000375845.3
exon_skip_3437222135763090:135763101:135779284:135779400:135797932:135798072135779284:135779400ENSG00000176601.7ENST00000414343.1
exon_skip_3437242135779284:135779400:135787881:135788070:135797932:135798069135787881:135788070ENSG00000176601.7ENST00000468155.1

check button PSI values of skipped exons in TCGA.
psi tcga

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Exon skipping events with PSIs in GTEx for MAP3K19

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_3437142135738390:135739088:135740749:135740901:135741245:135741395135740749:135740901ENSG00000176601.7ENST00000392915.1,ENST00000315513.3
exon_skip_3437152135738390:135739088:135741245:135741395:135743369:135744611135741245:135741395ENSG00000176601.7ENST00000375845.3,ENST00000358371.4,ENST00000437365.1
exon_skip_3437202135741277:135741395:135743369:135745823:135749106:135749150135743369:135745823ENSG00000176601.7ENST00000375845.3,ENST00000358371.4,ENST00000392915.1,ENST00000315513.3
exon_skip_3437212135743369:135745823:135749106:135749150:135756307:135756567135749106:135749150ENSG00000176601.7ENST00000375845.3,ENST00000392915.1,ENST00000315513.3
exon_skip_3437242135779284:135779400:135787881:135788070:135797932:135798069135787881:135788070ENSG00000176601.7ENST00000468155.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

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Open reading frame (ORF) annotation in the exon skipping event for MAP3K19

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000392915135740749135740901Frame-shift
ENST00000375845135749106135749150Frame-shift
ENST00000392915135749106135749150Frame-shift
ENST00000375845135741245135741395In-frame
ENST00000375845135743369135745823In-frame
ENST00000392915135743369135745823In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000392915135740749135740901Frame-shift
ENST00000375845135749106135749150Frame-shift
ENST00000392915135749106135749150Frame-shift
ENST00000375845135741245135741395In-frame
ENST00000375845135743369135745823In-frame
ENST00000392915135743369135745823In-frame

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Infer the effects of exon skipping event on protein functional features for MAP3K19

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000003758454394132813574336913574582365031032061024
ENST000003929154367132813574336913574582379032432231041
ENST00000375845439413281357412451357413953104325310241074

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000003758454394132813574336913574582365031032061024
ENST000003929154367132813574336913574582379032432231041
ENST00000375845439413281357412451357413953104325310241074

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature


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SNVs in the skipped exons for MAP3K19

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-G3-A3CJ-01exon_skip_343714
135740750135740901135740810135740810Frame_Shift_DelT-p.K1122fs
STADTCGA-FP-A4BE-01exon_skip_343720
135743370135745823135743471135743471Frame_Shift_DelT-p.M991fs
SARCTCGA-IS-A3K6-01exon_skip_343720
135743370135745823135744087135744087Frame_Shift_DelG-p.M786fs
SARCTCGA-IS-A3K6-01exon_skip_343720
135743370135745823135744087135744087Frame_Shift_DelG-p.P785fs
LIHCTCGA-G3-A3CJ-01exon_skip_343720
135743370135745823135744281135744281Frame_Shift_DelT-p.T721fs
LIHCTCGA-G3-A3CJ-01exon_skip_343720
135743370135745823135744786135744786Frame_Shift_DelA-p.F552fs
LIHCTCGA-G3-A3CJ-01exon_skip_343720
135743370135745823135745522135745522Frame_Shift_DelT-p.N307fs
SKCMTCGA-EE-A3JA-06exon_skip_343714
135740750135740901135740840135740840Nonsense_MutationCTp.W1112*
SKCMTCGA-EE-A3AG-06exon_skip_343714
135740750135740901135740892135740892Nonsense_MutationGAp.Q1095*
STADTCGA-BR-8680-01exon_skip_343715
135741246135741395135741299135741299Nonsense_MutationCAp.E1057X
CESCTCGA-IR-A3LA-01exon_skip_343720
135743370135745823135744028135744028Nonsense_MutationGCp.S805*
UCSTCGA-N8-A4PN-01exon_skip_343720
135743370135745823135745259135745259Nonsense_MutationGAp.Q395*
UCSTCGA-N8-A4PN-01exon_skip_343720
135743370135745823135745259135745259Nonsense_MutationGAp.Q395X
LGGTCGA-CS-5395-01exon_skip_343720
135743370135745823135745373135745373Nonsense_MutationGAp.R357*
LGGTCGA-CS-5395-01exon_skip_343720
135743370135745823135745373135745373Nonsense_MutationGAp.R357X
THCATCGA-ET-A25J-01exon_skip_343720
135743370135745823135745373135745373Nonsense_MutationGAp.R357*
THCATCGA-ET-A25J-01exon_skip_343720
135743370135745823135745373135745373Nonsense_MutationGAp.R357X
UCSTCGA-N9-A4Q4-01exon_skip_343720
135743370135745823135745373135745373Nonsense_MutationGAp.R357*
UCSTCGA-N9-A4Q4-01exon_skip_343720
135743370135745823135745373135745373Nonsense_MutationGAp.R357X
KIRCTCGA-B8-A8YJ-01exon_skip_343720
135743370135745823135745518135745518Nonsense_MutationCTp.W308X
SKCMTCGA-FR-A8YC-06exon_skip_343720
135743370135745823135745518135745518Nonsense_MutationCTp.W308*
KIRPTCGA-2Z-A9JQ-01exon_skip_343722
135779285135779400135779307135779307Nonsense_MutationATp.L39X

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
IMR32_AUTONOMIC_GANGLIA135741246135741395135741265135741265Frame_Shift_DelC-p.G1068fs
OVK18_OVARY135743370135745823135743471135743471Frame_Shift_DelT-p.M991fs
253J_URINARY_TRACT135743370135745823135743731135743734Frame_Shift_DelGTAA-p.LT903fs
253JBV_URINARY_TRACT135743370135745823135743731135743734Frame_Shift_DelGTAA-p.LT903fs
SNU119_OVARY135743370135745823135743940135743953Frame_Shift_DelGAGGCTTGTGGTGA-p.LTTSL830fs
KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE135743370135745823135744280135744281Frame_Shift_Ins-Tp.T721fs
HUH1_LIVER135779285135779400135779321135779322Frame_Shift_Ins-Tp.N34fs
DU145_PROSTATE135741246135741395135741313135741313Missense_MutationCTp.S1052N
DM3_FIBROBLAST135741246135741395135741367135741367Missense_MutationTAp.D1034V
LS411N_LARGE_INTESTINE135743370135745823135743410135743410Missense_MutationGTp.P1011Q
SW684_SOFT_TISSUE135743370135745823135743428135743428Missense_MutationCTp.R1005K
MDAPCA2B_PROSTATE135743370135745823135743452135743452Missense_MutationGTp.P997H
SJSA1_BONE135743370135745823135743504135743504Missense_MutationGTp.L980I
HEC251_ENDOMETRIUM135743370135745823135743586135743586Missense_MutationACp.I952M
LI7_LIVER135743370135745823135743605135743605Missense_MutationAGp.L946S
MFE296_ENDOMETRIUM135743370135745823135743683135743683Missense_MutationTCp.Y920C
WM88_SKIN135743370135745823135743698135743698Missense_MutationGAp.A915V
HEC1A_ENDOMETRIUM135743370135745823135743698135743698Missense_MutationGAp.A915V
HEC251_ENDOMETRIUM135743370135745823135743788135743788Missense_MutationCTp.R885Q
MEWO_SKIN135743370135745823135743788135743788Missense_MutationCTp.R885Q
SNU81_LARGE_INTESTINE135743370135745823135743788135743788Missense_MutationCTp.R885Q
DSH1_URINARY_TRACT135743370135745823135743851135743851Missense_MutationGTp.S864Y
FTC238_THYROID135743370135745823135743863135743863Missense_MutationCAp.S860I
MRKNU1_BREAST135743370135745823135743887135743887Missense_MutationGAp.S852L
EFM192A_BREAST135743370135745823135743914135743914Missense_MutationACp.L843R
SW684_SOFT_TISSUE135743370135745823135744037135744037Missense_MutationGAp.P802L
MCAS_OVARY135743370135745823135744092135744092Missense_MutationGTp.H784N
PACADD137_PANCREAS135743370135745823135744167135744167Missense_MutationCAp.G759C
CA922_UPPER_AERODIGESTIVE_TRACT135743370135745823135744197135744197Missense_MutationCGp.V749L
NB13_AUTONOMIC_GANGLIA135743370135745823135744261135744261Missense_MutationCAp.K727N
LS411N_LARGE_INTESTINE135743370135745823135744265135744265Missense_MutationGAp.P726L
EW3_BONE135743370135745823135744273135744273Missense_MutationCTp.M723I
SNU899_UPPER_AERODIGESTIVE_TRACT135743370135745823135744277135744277Missense_MutationTCp.H722R
ISHIKAWAHERAKLIO02ER_ENDOMETRIUM135743370135745823135744304135744304Missense_MutationCAp.R713I
HEC251_ENDOMETRIUM135743370135745823135744343135744343Missense_MutationTCp.K700R
CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE135743370135745823135744357135744357Missense_MutationTGp.R695S
L33_PANCREAS135743370135745823135744434135744434Missense_MutationCTp.V670I
MDAMB231_BREAST135743370135745823135744526135744526Missense_MutationACp.L639R
YT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE135743370135745823135744535135744535Missense_MutationTCp.E636G
RERFLCKJ_LUNG135743370135745823135744554135744554Missense_MutationGAp.L630F
HCT15_LARGE_INTESTINE135743370135745823135744598135744598Missense_MutationGTp.P615H
MM370_SKIN135743370135745823135744670135744670Missense_MutationTAp.Q591L
SNU719_STOMACH135743370135745823135744836135744836Missense_MutationTAp.S536C
SW48_LARGE_INTESTINE135743370135745823135744838135744838Missense_MutationCAp.R535M
MHHPREB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE135743370135745823135744838135744838Missense_MutationCTp.R535K
HEC251_ENDOMETRIUM135743370135745823135744917135744917Missense_MutationTCp.K509E
JEKO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE135743370135745823135744968135744968Missense_MutationCAp.D492Y
RERFLCMS_LUNG135743370135745823135745024135745024Missense_MutationCTp.R473K
KYSE520_OESOPHAGUS135743370135745823135745066135745066Missense_MutationCTp.C459Y
ECC12_STOMACH135743370135745823135745066135745066Missense_MutationCTp.C459Y
AGS_STOMACH135743370135745823135745123135745123Missense_MutationAGp.L440P
SW684_SOFT_TISSUE135743370135745823135745166135745166Missense_MutationCTp.E426K
KE39_STOMACH135743370135745823135745237135745237Missense_MutationATp.I402K
SNU81_LARGE_INTESTINE135743370135745823135745274135745274Missense_MutationTCp.I390V
JHUEM7_ENDOMETRIUM135743370135745823135745361135745361Missense_MutationCTp.E361K
LAN6_AUTONOMIC_GANGLIA135743370135745823135745372135745372Missense_MutationCAp.R357L
HS616T_FIBROBLAST135743370135745823135745375135745375Missense_MutationGAp.T356M
CROAP3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE135743370135745823135745424135745424Missense_MutationTCp.N340D
G361_SKIN135743370135745823135745570135745570Missense_MutationGAp.S291F
RD_SOFT_TISSUE135743370135745823135745633135745633Missense_MutationTAp.K270M
JHUEM7_ENDOMETRIUM135743370135745823135745645135745645Missense_MutationCTp.G266E
GP5D_LARGE_INTESTINE135743370135745823135745654135745654Missense_MutationTCp.E263G
JHUEM7_ENDOMETRIUM135743370135745823135745655135745655Missense_MutationCTp.E263K
HEC251_ENDOMETRIUM135743370135745823135745789135745789Missense_MutationCTp.R218Q
SNU81_LARGE_INTESTINE135743370135745823135745789135745789Missense_MutationCTp.R218Q
HEC108_ENDOMETRIUM135743370135745823135745792135745792Missense_MutationGAp.T217M
CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE135743370135745823135745817135745817Missense_MutationGTp.L209M
MZ7MEL_SKIN135749107135749150135749120135749120Missense_MutationCTp.G202D
JHUEM7_ENDOMETRIUM135779285135779400135779352135779352Missense_MutationGTp.S24Y
HELA_CERVIX135779285135779400135779394135779394Missense_MutationTGp.H10P
SNU81_LARGE_INTESTINE135741246135741395135741338135741338Nonsense_MutationCAp.E1044*
SNU81_LARGE_INTESTINE135743370135745823135743579135743579Nonsense_MutationCAp.E955*
NCIH526_LUNG135743370135745823135743681135743681Nonsense_MutationGAp.Q921*
639V_URINARY_TRACT135743370135745823135744338135744338Nonsense_MutationGAp.R702*
EMCBAC2_LUNG135743370135745823135744728135744728Nonsense_MutationGAp.Q572*
NCIH2591_PLEURA135743370135745823135745373135745373Nonsense_MutationGAp.R357*
L1236_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE135743370135745823135745736135745736Nonsense_MutationTAp.R236*

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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAP3K19

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAP3K19


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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAP3K19


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RelatedDrugs for MAP3K19

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
Q56UN5DB12010FostamatinibMitogen-activated protein kinase kinase kinase 19small moleculeapproved|investigational

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RelatedDiseases for MAP3K19

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource