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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TXNDC15 |
 Gene summary |
| Gene information | Gene symbol | TXNDC15 | Gene ID | 79770 |
| Gene name | thioredoxin domain containing 15 | |
| Synonyms | BUG|C5orf14|UNQ335 | |
| Cytomap | 5q31.1 | |
| Type of gene | protein-coding | |
| Description | thioredoxin domain-containing protein 152310047H23Rikdisulfide isomerase | |
| Modification date | 20180519 | |
| UniProtAcc | Q96J42 | |
| Context | PubMed: TXNDC15 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for TXNDC15 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TXNDC15 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TXNDC15 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_437546 | 5 | 134210086:134210173:134223384:134223872:134229181:134229345 | 134223384:134223872 | ENSG00000113621.10 | ENST00000507024.1 |
| exon_skip_437550 | 5 | 134210065:134210220:134229181:134229345:134231983:134232114 | 134229181:134229345 | ENSG00000113621.10 | ENST00000511070.1 |
| exon_skip_437553 | 5 | 134223842:134223872:134229181:134229345:134231983:134232114 | 134229181:134229345 | ENSG00000113621.10 | ENST00000507024.1,ENST00000546290.1,ENST00000508779.1,ENST00000358387.4 |
| exon_skip_437559 | 5 | 134229315:134229345:134231983:134232114:134235178:134235253 | 134231983:134232114 | ENSG00000113621.10 | ENST00000507024.1,ENST00000511070.1,ENST00000546290.1,ENST00000508779.1,ENST00000358387.4,ENST00000505174.1 |
| exon_skip_437560 | 5 | 134229315:134229345:134231995:134232114:134235178:134235253 | 134231995:134232114 | ENSG00000113621.10 | ENST00000509954.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TXNDC15 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_437546 | 5 | 134210086:134210173:134223384:134223872:134229181:134229345 | 134223384:134223872 | ENSG00000113621.10 | ENST00000507024.1 |
| exon_skip_437550 | 5 | 134210065:134210220:134229181:134229345:134231983:134232114 | 134229181:134229345 | ENSG00000113621.10 | ENST00000511070.1 |
| exon_skip_437553 | 5 | 134223842:134223872:134229181:134229345:134231983:134232114 | 134229181:134229345 | ENSG00000113621.10 | ENST00000358387.4,ENST00000507024.1,ENST00000508779.1,ENST00000546290.1 |
| exon_skip_437559 | 5 | 134229315:134229345:134231983:134232114:134235178:134235253 | 134231983:134232114 | ENSG00000113621.10 | ENST00000358387.4,ENST00000511070.1,ENST00000507024.1,ENST00000508779.1,ENST00000546290.1,ENST00000505174.1 |
| exon_skip_437560 | 5 | 134229315:134229345:134231995:134232114:134235178:134235253 | 134231995:134232114 | ENSG00000113621.10 | ENST00000509954.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TXNDC15 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000358387 | 134229181 | 134229345 | Frame-shift |
| ENST00000358387 | 134231983 | 134232114 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000358387 | 134229181 | 134229345 | Frame-shift |
| ENST00000358387 | 134231983 | 134232114 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for TXNDC15 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for TXNDC15 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_437550 exon_skip_437553 | 134229182 | 134229345 | 134229314 | 134229314 | Frame_Shift_Del | T | - | p.F242fs |
| PRAD | TCGA-XK-AAIW-01 | exon_skip_437546 | 134223385 | 134223872 | 134223831 | 134223831 | Nonsense_Mutation | G | T | p.G184* |
| BLCA | TCGA-XF-A9SY-01 | exon_skip_437559 exon_skip_437560 | 134231984 | 134232114 | 134232072 | 134232072 | Nonsense_Mutation | C | T | p.R282* |
| BLCA | TCGA-XF-A9SY-01 | exon_skip_437559 exon_skip_437560 | 134231996 | 134232114 | 134232072 | 134232072 | Nonsense_Mutation | C | T | p.R282* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| DMS53_LUNG | 134223385 | 134223872 | 134223604 | 134223605 | In_Frame_Ins | - | GCCTAG | p.109_110insRP |
| CCRFCEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 134223385 | 134223872 | 134223403 | 134223403 | Missense_Mutation | G | A | p.R41H |
| KMS11_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 134223385 | 134223872 | 134223432 | 134223432 | Missense_Mutation | C | A | p.P51T |
| TT_THYROID | 134223385 | 134223872 | 134223445 | 134223445 | Missense_Mutation | G | T | p.G55V |
| SLR26_KIDNEY | 134223385 | 134223872 | 134223661 | 134223661 | Missense_Mutation | G | C | p.R127P |
| P30OHK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 134229182 | 134229345 | 134229243 | 134229243 | Missense_Mutation | C | T | p.P218L |
| HCC1395_BREAST | 134229182 | 134229345 | 134229332 | 134229332 | Missense_Mutation | T | C | p.S248P |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TXNDC15 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_437546 | 5 | 134210086:134210173:134223384:134223872:134229181:134229345 | 134223384:134223872 | ENST00000507024.1 | ACC | rs3733897 | chr5:134223593 | A/G | 1.63e-04 |
| exon_skip_437546 | 5 | 134210086:134210173:134223384:134223872:134229181:134229345 | 134223384:134223872 | ENST00000507024.1 | GBM | rs3733897 | chr5:134223593 | A/G | 1.06e-04 |
| exon_skip_437546 | 5 | 134210086:134210173:134223384:134223872:134229181:134229345 | 134223384:134223872 | ENST00000507024.1 | BLCA | rs3733897 | chr5:134223593 | A/G | 5.49e-04 |
| exon_skip_437546 | 5 | 134210086:134210173:134223384:134223872:134229181:134229345 | 134223384:134223872 | ENST00000507024.1 | BRCA | rs3733897 | chr5:134223593 | A/G | 2.42e-09 |
| exon_skip_437546 | 5 | 134210086:134210173:134223384:134223872:134229181:134229345 | 134223384:134223872 | ENST00000507024.1 | KIRP | rs3733897 | chr5:134223593 | A/G | 4.25e-06 |
| exon_skip_437546 | 5 | 134210086:134210173:134223384:134223872:134229181:134229345 | 134223384:134223872 | ENST00000507024.1 | LGG | rs3733897 | chr5:134223593 | A/G | 1.66e-26 |
| exon_skip_437546 | 5 | 134210086:134210173:134223384:134223872:134229181:134229345 | 134223384:134223872 | ENST00000507024.1 | KIRC | rs3733897 | chr5:134223593 | A/G | 6.29e-09 |
| exon_skip_437546 | 5 | 134210086:134210173:134223384:134223872:134229181:134229345 | 134223384:134223872 | ENST00000507024.1 | LIHC | rs3733897 | chr5:134223593 | A/G | 2.16e-04 |
| exon_skip_437546 | 5 | 134210086:134210173:134223384:134223872:134229181:134229345 | 134223384:134223872 | ENST00000507024.1 | PRAD | rs3733897 | chr5:134223593 | A/G | 1.57e-03 |
| exon_skip_437546 | 5 | 134210086:134210173:134223384:134223872:134229181:134229345 | 134223384:134223872 | ENST00000507024.1 | THCA | rs3733897 | chr5:134223593 | A/G | 5.02e-16 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TXNDC15 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TXNDC15 |
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RelatedDrugs for TXNDC15 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TXNDC15 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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