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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for WDR59 |
 Gene summary |
| Gene information | Gene symbol | WDR59 | Gene ID | 79726 |
| Gene name | WD repeat domain 59 | |
| Synonyms | CDW12|FP977|p90-120 | |
| Cytomap | 16q23.1 | |
| Type of gene | protein-coding | |
| Description | GATOR complex protein WDR59CDw12 antigenWD repeat-containing protein 59 | |
| Modification date | 20180519 | |
| UniProtAcc | Q6PJI9 | |
| Context | PubMed: WDR59 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for WDR59 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for WDR59 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for WDR59 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_146122 | 16 | 74920167:74920294:74921580:74921653:74926381:74926463 | 74921580:74921653 | ENSG00000103091.10 | ENST00000563797.1 |
| exon_skip_146126 | 16 | 74922141:74922217:74923600:74923713:74926381:74926463 | 74923600:74923713 | ENSG00000103091.10 | ENST00000569788.1,ENST00000567018.1,ENST00000262144.6 |
| exon_skip_146127 | 16 | 74927604:74927710:74933595:74933652:74937844:74937918 | 74933595:74933652 | ENSG00000103091.10 | ENST00000569229.1 |
| exon_skip_146128 | 16 | 74927604:74927710:74937844:74937998:74942805:74942875 | 74937844:74937998 | ENSG00000103091.10 | ENST00000570070.1,ENST00000262144.6 |
| exon_skip_146130 | 16 | 74937844:74937998:74942805:74942875:74943398:74943504 | 74942805:74942875 | ENSG00000103091.10 | ENST00000569229.1,ENST00000570070.1,ENST00000262144.6 |
| exon_skip_146135 | 16 | 74943422:74943555:74943719:74943815:74946095:74946133 | 74943719:74943815 | ENSG00000103091.10 | ENST00000569229.1,ENST00000562371.1,ENST00000262144.6 |
| exon_skip_146136 | 16 | 74950024:74950157:74951826:74951906:74955844:74955858 | 74951826:74951906 | ENSG00000103091.10 | ENST00000569549.1,ENST00000536050.1,ENST00000561717.1,ENST00000262144.6 |
| exon_skip_146139 | 16 | 74955844:74956001:74957823:74957901:74972047:74972164 | 74957823:74957901 | ENSG00000103091.10 | ENST00000536050.1,ENST00000262144.6 |
| exon_skip_146143 | 16 | 74957847:74957901:74972047:74972164:74976635:74976724 | 74972047:74972164 | ENSG00000103091.10 | ENST00000536050.1,ENST00000262144.6 |
| exon_skip_146144 | 16 | 74957847:74957901:74972047:74972164:74982416:74982454 | 74972047:74972164 | ENSG00000103091.10 | ENST00000568462.1 |
| exon_skip_146150 | 16 | 74972148:74972164:74976635:74976724:74982416:74982454 | 74976635:74976724 | ENSG00000103091.10 | ENST00000536050.1,ENST00000262144.6 |
| exon_skip_146155 | 16 | 74985355:74985441:74990372:74990508:74999670:74999708 | 74990372:74990508 | ENSG00000103091.10 | ENST00000562331.1,ENST00000536050.1,ENST00000568323.1,ENST00000262144.6,ENST00000563111.1,ENST00000568462.1 |
| exon_skip_146157 | 16 | 74990381:74990508:74993247:74993490:74999670:74999708 | 74993247:74993490 | ENSG00000103091.10 | ENST00000564859.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for WDR59 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_146122 | 16 | 74920167:74920294:74921580:74921653:74926381:74926463 | 74921580:74921653 | ENSG00000103091.10 | ENST00000563797.1 |
| exon_skip_146126 | 16 | 74922141:74922217:74923600:74923713:74926381:74926463 | 74923600:74923713 | ENSG00000103091.10 | ENST00000262144.6,ENST00000567018.1,ENST00000569788.1 |
| exon_skip_146127 | 16 | 74927604:74927710:74933595:74933652:74937844:74937918 | 74933595:74933652 | ENSG00000103091.10 | ENST00000569229.1 |
| exon_skip_146128 | 16 | 74927604:74927710:74937844:74937998:74942805:74942875 | 74937844:74937998 | ENSG00000103091.10 | ENST00000262144.6,ENST00000570070.1 |
| exon_skip_146130 | 16 | 74937844:74937998:74942805:74942875:74943398:74943504 | 74942805:74942875 | ENSG00000103091.10 | ENST00000262144.6,ENST00000569229.1,ENST00000570070.1 |
| exon_skip_146135 | 16 | 74943422:74943555:74943719:74943815:74946095:74946133 | 74943719:74943815 | ENSG00000103091.10 | ENST00000262144.6,ENST00000569229.1,ENST00000562371.1 |
| exon_skip_146136 | 16 | 74950024:74950157:74951826:74951906:74955844:74955858 | 74951826:74951906 | ENSG00000103091.10 | ENST00000262144.6,ENST00000569549.1,ENST00000536050.1,ENST00000561717.1 |
| exon_skip_146139 | 16 | 74955844:74956001:74957823:74957901:74972047:74972164 | 74957823:74957901 | ENSG00000103091.10 | ENST00000262144.6,ENST00000536050.1 |
| exon_skip_146143 | 16 | 74957847:74957901:74972047:74972164:74976635:74976724 | 74972047:74972164 | ENSG00000103091.10 | ENST00000262144.6,ENST00000536050.1 |
| exon_skip_146144 | 16 | 74957847:74957901:74972047:74972164:74982416:74982454 | 74972047:74972164 | ENSG00000103091.10 | ENST00000568462.1 |
| exon_skip_146150 | 16 | 74972148:74972164:74976635:74976724:74982416:74982454 | 74976635:74976724 | ENSG00000103091.10 | ENST00000262144.6,ENST00000536050.1 |
| exon_skip_146155 | 16 | 74985355:74985441:74990372:74990508:74999670:74999708 | 74990372:74990508 | ENSG00000103091.10 | ENST00000262144.6,ENST00000536050.1,ENST00000568462.1,ENST00000568323.1,ENST00000563111.1,ENST00000562331.1 |
| exon_skip_146157 | 16 | 74990381:74990508:74993247:74993490:74999670:74999708 | 74993247:74993490 | ENSG00000103091.10 | ENST00000564859.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for WDR59 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000262144 | 74923600 | 74923713 | Frame-shift |
| ENST00000262144 | 74937844 | 74937998 | Frame-shift |
| ENST00000262144 | 74942805 | 74942875 | Frame-shift |
| ENST00000262144 | 74951826 | 74951906 | Frame-shift |
| ENST00000262144 | 74976635 | 74976724 | Frame-shift |
| ENST00000262144 | 74990372 | 74990508 | Frame-shift |
| ENST00000262144 | 74943719 | 74943815 | In-frame |
| ENST00000262144 | 74957823 | 74957901 | In-frame |
| ENST00000262144 | 74972047 | 74972164 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000262144 | 74923600 | 74923713 | Frame-shift |
| ENST00000262144 | 74937844 | 74937998 | Frame-shift |
| ENST00000262144 | 74942805 | 74942875 | Frame-shift |
| ENST00000262144 | 74951826 | 74951906 | Frame-shift |
| ENST00000262144 | 74976635 | 74976724 | Frame-shift |
| ENST00000262144 | 74990372 | 74990508 | Frame-shift |
| ENST00000262144 | 74943719 | 74943815 | In-frame |
| ENST00000262144 | 74957823 | 74957901 | In-frame |
| ENST00000262144 | 74972047 | 74972164 | In-frame |
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Infer the effects of exon skipping event on protein functional features for WDR59 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000262144 | 3712 | 974 | 74972047 | 74972164 | 666 | 782 | 178 | 217 |
| ENST00000262144 | 3712 | 974 | 74957823 | 74957901 | 783 | 860 | 217 | 243 |
| ENST00000262144 | 3712 | 974 | 74943719 | 74943815 | 1521 | 1616 | 463 | 495 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000262144 | 3712 | 974 | 74972047 | 74972164 | 666 | 782 | 178 | 217 |
| ENST00000262144 | 3712 | 974 | 74957823 | 74957901 | 783 | 860 | 217 | 243 |
| ENST00000262144 | 3712 | 974 | 74943719 | 74943815 | 1521 | 1616 | 463 | 495 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6PJI9 | 178 | 217 | 1 | 556 | Alternative sequence | ID=VSP_023881;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q6PJI9 | 178 | 217 | 1 | 408 | Alternative sequence | ID=VSP_023882;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15498874;Dbxref=PMID:14702039,PMID:15498874 |
| Q6PJI9 | 178 | 217 | 1 | 974 | Chain | ID=PRO_0000280721;Note=GATOR complex protein WDR59 |
| Q6PJI9 | 178 | 217 | 201 | 201 | Natural variant | ID=VAR_053436;Note=P->T;Dbxref=dbSNP:rs11557260 |
| Q6PJI9 | 178 | 217 | 146 | 185 | Repeat | Note=WD 3 |
| Q6PJI9 | 178 | 217 | 189 | 229 | Repeat | Note=WD 4 |
| Q6PJI9 | 217 | 243 | 1 | 556 | Alternative sequence | ID=VSP_023881;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q6PJI9 | 217 | 243 | 1 | 408 | Alternative sequence | ID=VSP_023882;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15498874;Dbxref=PMID:14702039,PMID:15498874 |
| Q6PJI9 | 217 | 243 | 1 | 974 | Chain | ID=PRO_0000280721;Note=GATOR complex protein WDR59 |
| Q6PJI9 | 217 | 243 | 189 | 229 | Repeat | Note=WD 4 |
| Q6PJI9 | 217 | 243 | 232 | 276 | Repeat | Note=WD 5 |
| Q6PJI9 | 463 | 495 | 1 | 556 | Alternative sequence | ID=VSP_023881;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q6PJI9 | 463 | 495 | 1 | 974 | Chain | ID=PRO_0000280721;Note=GATOR complex protein WDR59 |
| Q6PJI9 | 463 | 495 | 393 | 494 | Domain | Note=RWD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00179 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q6PJI9 | 178 | 217 | 1 | 556 | Alternative sequence | ID=VSP_023881;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q6PJI9 | 178 | 217 | 1 | 408 | Alternative sequence | ID=VSP_023882;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15498874;Dbxref=PMID:14702039,PMID:15498874 |
| Q6PJI9 | 178 | 217 | 1 | 974 | Chain | ID=PRO_0000280721;Note=GATOR complex protein WDR59 |
| Q6PJI9 | 178 | 217 | 201 | 201 | Natural variant | ID=VAR_053436;Note=P->T;Dbxref=dbSNP:rs11557260 |
| Q6PJI9 | 178 | 217 | 146 | 185 | Repeat | Note=WD 3 |
| Q6PJI9 | 178 | 217 | 189 | 229 | Repeat | Note=WD 4 |
| Q6PJI9 | 217 | 243 | 1 | 556 | Alternative sequence | ID=VSP_023881;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q6PJI9 | 217 | 243 | 1 | 408 | Alternative sequence | ID=VSP_023882;Note=In isoform 3. Missing;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15498874;Dbxref=PMID:14702039,PMID:15498874 |
| Q6PJI9 | 217 | 243 | 1 | 974 | Chain | ID=PRO_0000280721;Note=GATOR complex protein WDR59 |
| Q6PJI9 | 217 | 243 | 189 | 229 | Repeat | Note=WD 4 |
| Q6PJI9 | 217 | 243 | 232 | 276 | Repeat | Note=WD 5 |
| Q6PJI9 | 463 | 495 | 1 | 556 | Alternative sequence | ID=VSP_023881;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q6PJI9 | 463 | 495 | 1 | 974 | Chain | ID=PRO_0000280721;Note=GATOR complex protein WDR59 |
| Q6PJI9 | 463 | 495 | 393 | 494 | Domain | Note=RWD;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00179 |
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SNVs in the skipped exons for WDR59 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
WDR59_COAD_exon_skip_146150_psi_boxplot.png |
WDR59_LUAD_exon_skip_146150_psi_boxplot.png |
WDR59_STAD_exon_skip_146150_psi_boxplot.png |
WDR59_STAD_exon_skip_146155_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_146128 | 74937845 | 74937998 | 74937899 | 74937899 | Frame_Shift_Del | G | - | p.P604fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_146135 | 74943720 | 74943815 | 74943723 | 74943723 | Frame_Shift_Del | A | - | p.F494fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_146135 | 74943720 | 74943815 | 74943812 | 74943812 | Frame_Shift_Del | G | - | p.L465fs |
| COAD | TCGA-G4-6628-01 | exon_skip_146150 | 74976636 | 74976724 | 74976691 | 74976691 | Frame_Shift_Del | T | - | p.N160fs |
| KICH | TCGA-KN-8430-01 | exon_skip_146150 | 74976636 | 74976724 | 74976691 | 74976691 | Frame_Shift_Del | T | - | p.N160fs |
| SARC | TCGA-WK-A8XX-01 | exon_skip_146150 | 74976636 | 74976724 | 74976691 | 74976691 | Frame_Shift_Del | T | - | p.N160fs |
| STAD | TCGA-CD-A4MI-01 | exon_skip_146150 | 74976636 | 74976724 | 74976691 | 74976691 | Frame_Shift_Del | T | - | p.N160fs |
| STAD | TCGA-CG-4305-01 | exon_skip_146150 | 74976636 | 74976724 | 74976691 | 74976691 | Frame_Shift_Del | T | - | p.N160fs |
| STAD | TCGA-HU-A4GX-01 | exon_skip_146150 | 74976636 | 74976724 | 74976691 | 74976691 | Frame_Shift_Del | T | - | p.N160fs |
| HNSC | TCGA-QK-A64Z-01 | exon_skip_146136 | 74951827 | 74951906 | 74951892 | 74951892 | Nonsense_Mutation | G | A | p.Q301* |
| LUAD | TCGA-44-8117-01 | exon_skip_146143 exon_skip_146144 | 74972048 | 74972164 | 74972089 | 74972089 | Nonsense_Mutation | C | A | p.E204* |
| STAD | TCGA-EQ-8122-01 | exon_skip_146155 | 74990373 | 74990508 | 74990459 | 74990459 | Nonsense_Mutation | G | A | p.R52* |
| STAD | TCGA-EQ-8122-01 | exon_skip_146155 | 74990373 | 74990508 | 74990459 | 74990459 | Nonsense_Mutation | G | A | p.R52X |
| STAD | TCGA-FP-A4BE-01 | exon_skip_146155 | 74990373 | 74990508 | 74990459 | 74990459 | Nonsense_Mutation | G | A | p.R52* |
| STAD | TCGA-FP-A4BE-01 | exon_skip_146155 | 74990373 | 74990508 | 74990459 | 74990459 | Nonsense_Mutation | G | A | p.R52X |
| LUAD | TCGA-05-4382-01 | exon_skip_146150 | 74976636 | 74976724 | 74976635 | 74976635 | Splice_Site | C | T | p.R178_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-EQ-8122-01 |
| Cancer type: STAD | |
| ESID: exon_skip_146155 | |
| Skipped exon start: 74990373 | |
| Skipped exon end: 74990508 | |
| Mutation start: 74990459 | |
| Mutation end: 74990459 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R52X | |
| Sample: TCGA-EQ-8122-01 |
| Cancer type: STAD | |
| ESID: exon_skip_146155 | |
| Skipped exon start: 74990373 | |
| Skipped exon end: 74990508 | |
| Mutation start: 74990459 | |
| Mutation end: 74990459 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R52* | |
exon_skip_146155_STAD_TCGA-EQ-8122-01.png | |
 | Sample: TCGA-05-4382-01 |
| Cancer type: LUAD | |
| ESID: exon_skip_146150 | |
| Skipped exon start: 74976636 | |
| Skipped exon end: 74976724 | |
| Mutation start: 74976635 | |
| Mutation end: 74976635 | |
| Mutation type: Splice_Site | |
| Reference seq: C | |
| Mutation seq: T | |
| AAchange: p.R178_splice | |
exon_skip_129994_LUAD_TCGA-05-4382-01.png | |
exon_skip_129996_LUAD_TCGA-05-4382-01.png | |
exon_skip_146150_LUAD_TCGA-05-4382-01.png | |
exon_skip_19523_LUAD_TCGA-05-4382-01.png | |
exon_skip_327136_LUAD_TCGA-05-4382-01.png | |
exon_skip_331845_LUAD_TCGA-05-4382-01.png | |
exon_skip_347552_LUAD_TCGA-05-4382-01.png | |
exon_skip_347557_LUAD_TCGA-05-4382-01.png | |
exon_skip_359496_LUAD_TCGA-05-4382-01.png | |
exon_skip_367842_LUAD_TCGA-05-4382-01.png | |
exon_skip_367844_LUAD_TCGA-05-4382-01.png | |
exon_skip_425876_LUAD_TCGA-05-4382-01.png | |
exon_skip_434000_LUAD_TCGA-05-4382-01.png | |
exon_skip_448593_LUAD_TCGA-05-4382-01.png | |
exon_skip_91823_LUAD_TCGA-05-4382-01.png | |
 | Sample: TCGA-CG-4305-01 |
| Cancer type: STAD | |
| ESID: exon_skip_146150 | |
| Skipped exon start: 74976636 | |
| Skipped exon end: 74976724 | |
| Mutation start: 74976691 | |
| Mutation end: 74976691 | |
| Mutation type: Frame_Shift_Del | |
| Reference seq: T | |
| Mutation seq: - | |
| AAchange: p.N160fs | |
exon_skip_111824_STAD_TCGA-CG-4305-01.png | |
exon_skip_111829_STAD_TCGA-CG-4305-01.png | |
exon_skip_146150_STAD_TCGA-CG-4305-01.png | |
exon_skip_290798_STAD_TCGA-CG-4305-01.png | |
exon_skip_301298_STAD_TCGA-CG-4305-01.png | |
exon_skip_306904_STAD_TCGA-CG-4305-01.png | |
exon_skip_331098_STAD_TCGA-CG-4305-01.png | |
exon_skip_340412_STAD_TCGA-CG-4305-01.png | |
exon_skip_340419_STAD_TCGA-CG-4305-01.png | |
exon_skip_361126_STAD_TCGA-CG-4305-01.png | |
exon_skip_382354_STAD_TCGA-CG-4305-01.png | |
exon_skip_423582_STAD_TCGA-CG-4305-01.png | |
exon_skip_45131_STAD_TCGA-CG-4305-01.png | |
exon_skip_45132_STAD_TCGA-CG-4305-01.png | |
exon_skip_6108_STAD_TCGA-CG-4305-01.png | |
exon_skip_64984_STAD_TCGA-CG-4305-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| JHUEM3_ENDOMETRIUM | 74937845 | 74937998 | 74937976 | 74937976 | Frame_Shift_Del | A | - | p.Y579fs |
| CMLT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 74976636 | 74976724 | 74976691 | 74976691 | Frame_Shift_Del | T | - | p.N160fs |
| DV90_LUNG | 74976636 | 74976724 | 74976691 | 74976691 | Frame_Shift_Del | T | - | p.N160fs |
| CW2_LARGE_INTESTINE | 74976636 | 74976724 | 74976690 | 74976691 | Frame_Shift_Ins | - | T | p.N160fs |
| STS0421_SOFT_TISSUE | 74921581 | 74921653 | 74921605 | 74921605 | Missense_Mutation | G | C | p.L799V |
| NCIH1793_LUNG | 74923601 | 74923713 | 74923622 | 74923622 | Missense_Mutation | C | A | p.G725V |
| LS180_LARGE_INTESTINE | 74923601 | 74923713 | 74923670 | 74923670 | Missense_Mutation | G | A | p.P709L |
| HPBALL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 74937845 | 74937998 | 74937847 | 74937847 | Missense_Mutation | G | A | p.R622W |
| MCC13_SKIN | 74937845 | 74937998 | 74937931 | 74937931 | Missense_Mutation | G | A | p.P594S |
| NCIH2342_LUNG | 74937845 | 74937998 | 74937942 | 74937942 | Missense_Mutation | C | A | p.R590L |
| HT115_LARGE_INTESTINE | 74943720 | 74943815 | 74943787 | 74943787 | Missense_Mutation | A | G | p.V473A |
| KMH2_THYROID | 74943720 | 74943815 | 74943808 | 74943808 | Missense_Mutation | T | C | p.K466R |
| NCIH28_PLEURA | 74943720 | 74943815 | 74943809 | 74943809 | Missense_Mutation | T | C | p.K466E |
| MELJUSO_SKIN | 74957824 | 74957901 | 74957859 | 74957859 | Missense_Mutation | G | A | p.P232S |
| SNU175_LARGE_INTESTINE | 74957824 | 74957901 | 74957880 | 74957880 | Missense_Mutation | G | A | p.R225W |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 74957824 | 74957901 | 74957888 | 74957888 | Missense_Mutation | C | T | p.R222H |
| P30OHK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 74972048 | 74972164 | 74972085 | 74972085 | Missense_Mutation | T | C | p.H205R |
| TE10_OESOPHAGUS | 74976636 | 74976724 | 74976648 | 74976648 | Missense_Mutation | T | C | p.I174M |
| T84_LARGE_INTESTINE | 74990373 | 74990508 | 74990380 | 74990380 | Missense_Mutation | G | A | p.A78V |
| PL18_PANCREAS | 74990373 | 74990508 | 74990404 | 74990404 | Missense_Mutation | T | A | p.H70L |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 74990373 | 74990508 | 74990446 | 74990446 | Missense_Mutation | C | T | p.R56H |
| EFO27_OVARY | 74990373 | 74990508 | 74990465 | 74990465 | Missense_Mutation | C | A | p.G50C |
| SNU81_LARGE_INTESTINE | 74990373 | 74990508 | 74990374 | 74990374 | Splice_Site | G | A | p.S80L |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for WDR59 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_146157 | 16 | 74990381:74990508:74993247:74993490:74999670:74999708 | 74993247:74993490 | ENST00000564859.1 | LGG | rs61262797 | chr16:74993291 | C/A | 2.02e-05 |
| exon_skip_146157 | 16 | 74990381:74990508:74993247:74993490:74999670:74999708 | 74993247:74993490 | ENST00000564859.1 | LGG | rs77485994 | chr16:74993426 | C/T | 2.23e-05 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for WDR59 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for WDR59 |
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RelatedDrugs for WDR59 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WDR59 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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