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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for IPO4 |
 Gene summary |
| Gene information | Gene symbol | IPO4 | Gene ID | 79711 |
| Gene name | importin 4 | |
| Synonyms | Imp4 | |
| Cytomap | 14q12 | |
| Type of gene | protein-coding | |
| Description | importin-4imp4bimportin-4bran-binding protein 4ranBP4 | |
| Modification date | 20180523 | |
| UniProtAcc | Q8TEX9 | |
| Context | PubMed: IPO4 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| IPO4 | GO:0006335 | DNA replication-dependent nucleosome assembly | 14718166 |
| IPO4 | GO:0006336 | DNA replication-independent nucleosome assembly | 14718166 |
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Exon skipping events across known transcript of Ensembl for IPO4 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for IPO4 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for IPO4 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_111966 | 14 | 24649894:24649964:24650718:24650823:24650916:24651049 | 24650718:24650823 | ENSG00000196497.11 | ENST00000561462.1,ENST00000559588.1,ENST00000561199.1,ENST00000560798.1,ENST00000558046.1,ENST00000561090.1,ENST00000560155.1,ENST00000354464.6,ENST00000558780.1 |
| exon_skip_111967 | 14 | 24653855:24653969:24654072:24654186:24654388:24654518 | 24654072:24654186 | ENSG00000196497.11 | ENST00000559588.1,ENST00000560798.1,ENST00000558046.1,ENST00000561090.1,ENST00000560155.1,ENST00000354464.6,ENST00000558780.1 |
| exon_skip_111968 | 14 | 24656605:24656785:24656872:24657002:24657421:24657463 | 24656872:24657002 | ENSG00000196497.11 | ENST00000559588.1,ENST00000561199.1,ENST00000558193.1,ENST00000560798.1,ENST00000558046.1,ENST00000561090.1,ENST00000560155.1,ENST00000354464.6 |
| exon_skip_111969 | 14 | 24656605:24656785:24656872:24657019:24657421:24657463 | 24656872:24657019 | ENSG00000196497.11 | ENST00000558780.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for IPO4 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_111966 | 14 | 24649894:24649964:24650718:24650823:24650916:24651049 | 24650718:24650823 | ENSG00000196497.11 | ENST00000561090.1,ENST00000354464.6,ENST00000561462.1,ENST00000560798.1,ENST00000558780.1,ENST00000558046.1,ENST00000559588.1,ENST00000560155.1,ENST00000561199.1 |
| exon_skip_111967 | 14 | 24653855:24653969:24654072:24654186:24654388:24654518 | 24654072:24654186 | ENSG00000196497.11 | ENST00000561090.1,ENST00000354464.6,ENST00000560798.1,ENST00000558780.1,ENST00000558046.1,ENST00000559588.1,ENST00000560155.1 |
| exon_skip_111968 | 14 | 24656605:24656785:24656872:24657002:24657421:24657463 | 24656872:24657002 | ENSG00000196497.11 | ENST00000561090.1,ENST00000354464.6,ENST00000560798.1,ENST00000558046.1,ENST00000559588.1,ENST00000560155.1,ENST00000561199.1,ENST00000558193.1 |
| exon_skip_111969 | 14 | 24656605:24656785:24656872:24657019:24657421:24657463 | 24656872:24657019 | ENSG00000196497.11 | ENST00000558780.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for IPO4 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
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Infer the effects of exon skipping event on protein functional features for IPO4 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for IPO4 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LUAD | TCGA-95-7947-01 | exon_skip_111968 | 24656873 | 24657002 | 24656911 | 24656911 | Nonsense_Mutation | G | A | p.Q124* |
| LUAD | TCGA-95-7947-01 | exon_skip_111969 | 24656873 | 24657019 | 24656911 | 24656911 | Nonsense_Mutation | G | A | p.Q124* |
| BLCA | TCGA-DK-A1AC-01 | exon_skip_111968 | 24656873 | 24657002 | 24656970 | 24656970 | Nonsense_Mutation | G | T | p.S104* |
| BLCA | TCGA-DK-A1AC-01 | exon_skip_111969 | 24656873 | 24657019 | 24656970 | 24656970 | Nonsense_Mutation | G | T | p.S104* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 24654073 | 24654186 | 24654135 | 24654136 | Frame_Shift_Ins | - | TG | p.L487fs |
| MHHPREB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 24650719 | 24650823 | 24650748 | 24650748 | Missense_Mutation | T | C | p.S1006G |
| HCC1569_BREAST | 24650719 | 24650823 | 24650757 | 24650757 | Missense_Mutation | G | A | p.R1003C |
| ECC12_STOMACH | 24650719 | 24650823 | 24650762 | 24650762 | Missense_Mutation | A | G | p.I1001T |
| SNU175_LARGE_INTESTINE | 24654073 | 24654186 | 24654088 | 24654088 | Missense_Mutation | C | T | p.A503T |
| NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 24654073 | 24654186 | 24654117 | 24654117 | Missense_Mutation | C | A | p.S493I |
| MCC26_SKIN | 24654073 | 24654186 | 24654118 | 24654118 | Missense_Mutation | T | A | p.S493C |
| AN3CA_ENDOMETRIUM | 24654073 | 24654186 | 24654119 | 24654119 | Missense_Mutation | G | T | p.S492R |
| SNU1040_LARGE_INTESTINE | 24656873 | 24657019 | 24656902 | 24656902 | Missense_Mutation | T | C | p.T127A |
| SNU1040_LARGE_INTESTINE | 24656873 | 24657002 | 24656902 | 24656902 | Missense_Mutation | T | C | p.T127A |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 24656873 | 24657019 | 24656937 | 24656937 | Missense_Mutation | G | A | p.A115V |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 24656873 | 24657002 | 24656937 | 24656937 | Missense_Mutation | G | A | p.A115V |
| TE9_OESOPHAGUS | 24656873 | 24657019 | 24656970 | 24656970 | Missense_Mutation | G | A | p.S104L |
| TE9_OESOPHAGUS | 24656873 | 24657002 | 24656970 | 24656970 | Missense_Mutation | G | A | p.S104L |
| HDMYZ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 24656873 | 24657019 | 24656997 | 24656997 | Missense_Mutation | C | T | p.C95Y |
| HDMYZ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 24656873 | 24657002 | 24656997 | 24656997 | Missense_Mutation | C | T | p.C95Y |
| P30OHK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 24654073 | 24654186 | 24654082 | 24654082 | Nonsense_Mutation | C | A | p.G505* |
| IGROV1_OVARY | 24656873 | 24657019 | 24656873 | 24656874 | Splice_Site | CT | - | p.E136fs |
| IGROV1_OVARY | 24656873 | 24657002 | 24656873 | 24656874 | Splice_Site | CT | - | p.E136fs |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for IPO4 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for IPO4 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for IPO4 |
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RelatedDrugs for IPO4 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IPO4 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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