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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for WDR25 |
 Gene summary |
| Gene information | Gene symbol | WDR25 | Gene ID | 79446 |
| Gene name | WD repeat domain 25 | |
| Synonyms | C14orf67 | |
| Cytomap | 14q32.2 | |
| Type of gene | protein-coding | |
| Description | WD repeat-containing protein 25 | |
| Modification date | 20180519 | |
| UniProtAcc | Q64LD2 | |
| Context | PubMed: WDR25 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for WDR25 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for WDR25 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for WDR25 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_109961 | 14 | 100842775:100842832:100847246:100848083:100934357:100934505 | 100847246:100848083 | ENSG00000176473.9 | ENST00000402312.3 |
| exon_skip_109968 | 14 | 100842769:100842841:100847246:100848083:100934357:100934505 | 100847246:100848083 | ENSG00000176473.9 | ENST00000554998.1 |
| exon_skip_109971 | 14 | 100842877:100843041:100847246:100848083:100934357:100934505 | 100847246:100848083 | ENSG00000176473.9 | ENST00000335290.6 |
| exon_skip_109976 | 14 | 100847991:100848083:100934357:100934505:100950330:100950461 | 100934357:100934505 | ENSG00000176473.9 | ENST00000554998.1,ENST00000402312.3,ENST00000335290.6 |
| exon_skip_109981 | 14 | 100934357:100934505:100950330:100950461:100992206:100992232 | 100950330:100950461 | ENSG00000176473.9 | ENST00000555775.1,ENST00000542471.2,ENST00000554998.1,ENST00000402312.3,ENST00000335290.6,ENST00000554492.1 |
| exon_skip_109982 | 14 | 100992282:100992377:100995404:100995545:100996156:100996192 | 100995404:100995545 | ENSG00000176473.9 | ENST00000555775.1,ENST00000542471.2,ENST00000554998.1,ENST00000557710.1,ENST00000402312.3,ENST00000335290.6,ENST00000557502.1,ENST00000555865.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for WDR25 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_109961 | 14 | 100842775:100842832:100847246:100848083:100934357:100934505 | 100847246:100848083 | ENSG00000176473.9 | ENST00000402312.3 |
| exon_skip_109968 | 14 | 100842769:100842841:100847246:100848083:100934357:100934505 | 100847246:100848083 | ENSG00000176473.9 | ENST00000554998.1 |
| exon_skip_109971 | 14 | 100842877:100843041:100847246:100848083:100934357:100934505 | 100847246:100848083 | ENSG00000176473.9 | ENST00000335290.6 |
| exon_skip_109976 | 14 | 100847991:100848083:100934357:100934505:100950330:100950461 | 100934357:100934505 | ENSG00000176473.9 | ENST00000554998.1,ENST00000402312.3,ENST00000335290.6 |
| exon_skip_109979 | 14 | 100847246:100848083:100950330:100950461:100992206:100992232 | 100950330:100950461 | ENSG00000176473.9 | ENST00000557710.1 |
| exon_skip_109981 | 14 | 100934357:100934505:100950330:100950461:100992206:100992232 | 100950330:100950461 | ENSG00000176473.9 | ENST00000555775.1,ENST00000554998.1,ENST00000402312.3,ENST00000335290.6,ENST00000554492.1,ENST00000542471.2 |
| exon_skip_109982 | 14 | 100992282:100992377:100995404:100995545:100996156:100996192 | 100995404:100995545 | ENSG00000176473.9 | ENST00000555775.1,ENST00000554998.1,ENST00000402312.3,ENST00000335290.6,ENST00000557710.1,ENST00000542471.2,ENST00000555865.1,ENST00000557502.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for WDR25 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000335290 | 100847246 | 100848083 | 5CDS-5UTR |
| ENST00000402312 | 100847246 | 100848083 | 5CDS-5UTR |
| ENST00000554998 | 100847246 | 100848083 | 5CDS-5UTR |
| ENST00000335290 | 100934357 | 100934505 | Frame-shift |
| ENST00000402312 | 100934357 | 100934505 | Frame-shift |
| ENST00000554998 | 100934357 | 100934505 | Frame-shift |
| ENST00000335290 | 100950330 | 100950461 | Frame-shift |
| ENST00000402312 | 100950330 | 100950461 | Frame-shift |
| ENST00000554998 | 100950330 | 100950461 | Frame-shift |
| ENST00000335290 | 100995404 | 100995545 | In-frame |
| ENST00000402312 | 100995404 | 100995545 | In-frame |
| ENST00000554998 | 100995404 | 100995545 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000335290 | 100847246 | 100848083 | 5CDS-5UTR |
| ENST00000402312 | 100847246 | 100848083 | 5CDS-5UTR |
| ENST00000554998 | 100847246 | 100848083 | 5CDS-5UTR |
| ENST00000335290 | 100934357 | 100934505 | Frame-shift |
| ENST00000402312 | 100934357 | 100934505 | Frame-shift |
| ENST00000554998 | 100934357 | 100934505 | Frame-shift |
| ENST00000335290 | 100950330 | 100950461 | Frame-shift |
| ENST00000402312 | 100950330 | 100950461 | Frame-shift |
| ENST00000554998 | 100950330 | 100950461 | Frame-shift |
| ENST00000335290 | 100995404 | 100995545 | In-frame |
| ENST00000402312 | 100995404 | 100995545 | In-frame |
| ENST00000554998 | 100995404 | 100995545 | In-frame |
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Infer the effects of exon skipping event on protein functional features for WDR25 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000335290 | 2140 | 544 | 100995404 | 100995545 | 1499 | 1639 | 424 | 471 |
| ENST00000402312 | 1986 | 544 | 100995404 | 100995545 | 1345 | 1485 | 424 | 471 |
| ENST00000554998 | 1969 | 544 | 100995404 | 100995545 | 1360 | 1500 | 424 | 471 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000335290 | 2140 | 544 | 100995404 | 100995545 | 1499 | 1639 | 424 | 471 |
| ENST00000402312 | 1986 | 544 | 100995404 | 100995545 | 1345 | 1485 | 424 | 471 |
| ENST00000554998 | 1969 | 544 | 100995404 | 100995545 | 1360 | 1500 | 424 | 471 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q64LD2 | 424 | 471 | 1 | 544 | Chain | ID=PRO_0000256227;Note=WD repeat-containing protein 25 |
| Q64LD2 | 424 | 471 | 1 | 544 | Chain | ID=PRO_0000256227;Note=WD repeat-containing protein 25 |
| Q64LD2 | 424 | 471 | 1 | 544 | Chain | ID=PRO_0000256227;Note=WD repeat-containing protein 25 |
| Q64LD2 | 424 | 471 | 424 | 463 | Repeat | Note=WD 5 |
| Q64LD2 | 424 | 471 | 424 | 463 | Repeat | Note=WD 5 |
| Q64LD2 | 424 | 471 | 424 | 463 | Repeat | Note=WD 5 |
| Q64LD2 | 424 | 471 | 469 | 510 | Repeat | Note=WD 6 |
| Q64LD2 | 424 | 471 | 469 | 510 | Repeat | Note=WD 6 |
| Q64LD2 | 424 | 471 | 469 | 510 | Repeat | Note=WD 6 |
| Q64LD2 | 424 | 471 | 462 | 462 | Sequence conflict | Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q64LD2 | 424 | 471 | 462 | 462 | Sequence conflict | Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q64LD2 | 424 | 471 | 462 | 462 | Sequence conflict | Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q64LD2 | 424 | 471 | 1 | 544 | Chain | ID=PRO_0000256227;Note=WD repeat-containing protein 25 |
| Q64LD2 | 424 | 471 | 1 | 544 | Chain | ID=PRO_0000256227;Note=WD repeat-containing protein 25 |
| Q64LD2 | 424 | 471 | 1 | 544 | Chain | ID=PRO_0000256227;Note=WD repeat-containing protein 25 |
| Q64LD2 | 424 | 471 | 424 | 463 | Repeat | Note=WD 5 |
| Q64LD2 | 424 | 471 | 424 | 463 | Repeat | Note=WD 5 |
| Q64LD2 | 424 | 471 | 424 | 463 | Repeat | Note=WD 5 |
| Q64LD2 | 424 | 471 | 469 | 510 | Repeat | Note=WD 6 |
| Q64LD2 | 424 | 471 | 469 | 510 | Repeat | Note=WD 6 |
| Q64LD2 | 424 | 471 | 469 | 510 | Repeat | Note=WD 6 |
| Q64LD2 | 424 | 471 | 462 | 462 | Sequence conflict | Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q64LD2 | 424 | 471 | 462 | 462 | Sequence conflict | Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q64LD2 | 424 | 471 | 462 | 462 | Sequence conflict | Note=S->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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SNVs in the skipped exons for WDR25 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_109961 exon_skip_109968 exon_skip_109971 | 100847247 | 100848083 | 100847348 | 100847348 | Frame_Shift_Del | T | - | p.S29fs |
| KIRC | TCGA-CZ-4856-01 | exon_skip_109961 exon_skip_109968 exon_skip_109971 | 100847247 | 100848083 | 100847481 | 100847481 | Frame_Shift_Del | G | - | p.G75fs |
| KIRC | TCGA-CZ-4856-01 | exon_skip_109961 exon_skip_109968 exon_skip_109971 | 100847247 | 100848083 | 100847481 | 100847481 | Frame_Shift_Del | G | - | p.P73fs |
| CHOL | TCGA-ZH-A8Y5-01 | exon_skip_109961 exon_skip_109968 exon_skip_109971 | 100847247 | 100848083 | 100847912 | 100847916 | Frame_Shift_Del | GTCTG | - | p.VSE217fs |
| CHOL | TCGA-ZH-A8Y5-01 | exon_skip_109961 exon_skip_109968 exon_skip_109971 | 100847247 | 100848083 | 100847918 | 100847924 | Frame_Shift_Del | GTTTATT | - | p.EFI219fs |
| KIRC | TCGA-B0-5119-01 | exon_skip_109961 exon_skip_109968 exon_skip_109971 | 100847247 | 100848083 | 100847489 | 100847489 | Nonsense_Mutation | T | A | p.Y76* |
| KIRC | TCGA-B0-5119-01 | exon_skip_109961 exon_skip_109968 exon_skip_109971 | 100847247 | 100848083 | 100847489 | 100847489 | Nonsense_Mutation | T | A | p.Y76X |
| LUAD | TCGA-64-1676-01 | exon_skip_109976 | 100934358 | 100934505 | 100934506 | 100934507 | Splice_Site | - | T | p.G324_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC59_ENDOMETRIUM | 100847247 | 100848083 | 100847865 | 100847865 | Frame_Shift_Del | C | - | p.P203fs |
| C33A_CERVIX | 100847247 | 100848083 | 100847998 | 100847998 | Frame_Shift_Del | G | - | p.R246fs |
| KM12_LARGE_INTESTINE | 100847247 | 100848083 | 100847565 | 100847565 | Missense_Mutation | G | A | p.E102K |
| A431_SKIN | 100847247 | 100848083 | 100847588 | 100847588 | Missense_Mutation | C | G | p.I109M |
| SKUT1_SOFT_TISSUE | 100847247 | 100848083 | 100847706 | 100847706 | Missense_Mutation | C | T | p.H149Y |
| SKMEL5_SKIN | 100847247 | 100848083 | 100847827 | 100847827 | Missense_Mutation | C | G | p.T189R |
| NCIH1573_LUNG | 100847247 | 100848083 | 100847908 | 100847908 | Missense_Mutation | G | T | p.G216V |
| LOVO_LARGE_INTESTINE | 100847247 | 100848083 | 100848003 | 100848003 | Missense_Mutation | C | T | p.P248S |
| TE6_OESOPHAGUS | 100847247 | 100848083 | 100848013 | 100848013 | Missense_Mutation | C | T | p.T251I |
| 2313287_STOMACH | 100934358 | 100934505 | 100934418 | 100934418 | Missense_Mutation | G | A | p.V295M |
| NCIH748_LUNG | 100934358 | 100934505 | 100934431 | 100934431 | Missense_Mutation | G | A | p.R299Q |
| COGAR359_SOFT_TISSUE | 100934358 | 100934505 | 100934448 | 100934448 | Missense_Mutation | C | T | p.R305W |
| LIM1215_LARGE_INTESTINE | 100934358 | 100934505 | 100934451 | 100934451 | Missense_Mutation | C | T | p.R306C |
| MINO_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 100934358 | 100934505 | 100934452 | 100934452 | Missense_Mutation | G | A | p.R306H |
| KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 100950331 | 100950461 | 100950346 | 100950346 | Missense_Mutation | G | A | p.S329N |
| HEC251_ENDOMETRIUM | 100950331 | 100950461 | 100950352 | 100950352 | Missense_Mutation | G | A | p.R331Q |
| SNU878_LIVER | 100950331 | 100950461 | 100950366 | 100950366 | Missense_Mutation | A | G | p.I336V |
| LNCAPCLONEFGC_PROSTATE | 100950331 | 100950461 | 100950415 | 100950415 | Missense_Mutation | G | A | p.G352E |
| CL34_LARGE_INTESTINE | 100995405 | 100995545 | 100995525 | 100995525 | Missense_Mutation | C | T | p.R465W |
| SNU175_LARGE_INTESTINE | 100995405 | 100995545 | 100995529 | 100995529 | Missense_Mutation | G | A | p.R466H |
| NCIH1793_LUNG | 100847247 | 100848083 | 100847615 | 100847615 | Nonsense_Mutation | G | A | p.W118* |
| NCIH446_LUNG | 100950331 | 100950461 | 100950363 | 100950363 | Nonsense_Mutation | A | T | p.R335* |
| HEC108_ENDOMETRIUM | 100934358 | 100934505 | 100934504 | 100934504 | Splice_Site | A | G | p.T323T |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for WDR25 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_109961 | 14 | 100842775:100842832:100847246:100848083:100934357:100934505 | 100847246:100848083 | ENST00000402312.3 | GBM | rs3742387 | chr14:100847930 | C/T | 2.67e-04 |
| exon_skip_109961 | 14 | 100842775:100842832:100847246:100848083:100934357:100934505 | 100847246:100848083 | ENST00000402312.3 | GBM | rs2273800 | chr14:100847707 | C/T | 3.37e-04 |
| exon_skip_109968 | 14 | 100842769:100842841:100847246:100848083:100934357:100934505 | 100847246:100848083 | ENST00000554998.1 | GBM | rs3742387 | chr14:100847930 | C/T | 2.67e-04 |
| exon_skip_109968 | 14 | 100842769:100842841:100847246:100848083:100934357:100934505 | 100847246:100848083 | ENST00000554998.1 | GBM | rs2273800 | chr14:100847707 | C/T | 3.37e-04 |
| exon_skip_109971 | 14 | 100842877:100843041:100847246:100848083:100934357:100934505 | 100847246:100848083 | ENST00000335290.6 | GBM | rs3742387 | chr14:100847930 | C/T | 2.67e-04 |
| exon_skip_109971 | 14 | 100842877:100843041:100847246:100848083:100934357:100934505 | 100847246:100848083 | ENST00000335290.6 | GBM | rs2273800 | chr14:100847707 | C/T | 3.37e-04 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for WDR25 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for WDR25 |
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RelatedDrugs for WDR25 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WDR25 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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