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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for DEK |
 Gene summary |
| Gene information | Gene symbol | DEK | Gene ID | 7913 |
| Gene name | DEK proto-oncogene | |
| Synonyms | D6S231E | |
| Cytomap | 6p22.3 | |
| Type of gene | protein-coding | |
| Description | protein DEKDEK oncogene (DNA binding) | |
| Modification date | 20180527 | |
| UniProtAcc | P35659 | |
| Context | PubMed: DEK [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for DEK from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for DEK |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for DEK |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_456531 | 6 | 18225841:18225961:18226404:18226473:18236682:18236827 | 18226404:18226473 | ENSG00000124795.10 | ENST00000505224.1,ENST00000397239.3,ENST00000244776.7 |
| exon_skip_456539 | 6 | 18226404:18226473:18236682:18236831:18237611:18237747 | 18236682:18236831 | ENSG00000124795.10 | ENST00000507591.1,ENST00000505224.1,ENST00000397239.3,ENST00000244776.7 |
| exon_skip_456542 | 6 | 18237611:18237747:18244738:18244834:18249881:18249910 | 18244738:18244834 | ENSG00000124795.10 | ENST00000515770.1 |
| exon_skip_456543 | 6 | 18237611:18237747:18249881:18250070:18255961:18256081 | 18249881:18250070 | ENSG00000124795.10 | ENST00000505224.1,ENST00000397239.3,ENST00000512145.1,ENST00000244776.7 |
| exon_skip_456545 | 6 | 18249881:18250070:18255961:18256082:18256591:18256605 | 18255961:18256082 | ENSG00000124795.10 | ENST00000515770.1,ENST00000505224.1,ENST00000397239.3,ENST00000512145.1,ENST00000244776.7 |
| exon_skip_456552 | 6 | 18255966:18256082:18256591:18256686:18258183:18258262 | 18256591:18256686 | ENSG00000124795.10 | ENST00000505224.1,ENST00000397239.3,ENST00000503715.1,ENST00000244776.7 |
| exon_skip_456554 | 6 | 18256603:18256686:18258183:18258293:18258534:18258636 | 18258183:18258293 | ENSG00000124795.10 | ENST00000397239.3,ENST00000503715.1,ENST00000515742.1 |
| exon_skip_456557 | 6 | 18258183:18258293:18258534:18258636:18264073:18264227 | 18258534:18258636 | ENSG00000124795.10 | ENST00000397239.3,ENST00000515742.1 |
| exon_skip_456564 | 6 | 18258587:18258636:18264073:18264227:18264615:18264766 | 18264073:18264227 | ENSG00000124795.10 | ENST00000505224.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for DEK |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_456531 | 6 | 18225841:18225961:18226404:18226473:18236682:18236827 | 18226404:18226473 | ENSG00000124795.10 | ENST00000397239.3,ENST00000505224.1,ENST00000244776.7 |
| exon_skip_456539 | 6 | 18226404:18226473:18236682:18236831:18237611:18237747 | 18236682:18236831 | ENSG00000124795.10 | ENST00000397239.3,ENST00000505224.1,ENST00000244776.7,ENST00000507591.1 |
| exon_skip_456542 | 6 | 18237611:18237747:18244738:18244834:18249881:18249910 | 18244738:18244834 | ENSG00000124795.10 | ENST00000515770.1 |
| exon_skip_456543 | 6 | 18237611:18237747:18249881:18250070:18255961:18256081 | 18249881:18250070 | ENSG00000124795.10 | ENST00000397239.3,ENST00000505224.1,ENST00000244776.7,ENST00000512145.1 |
| exon_skip_456545 | 6 | 18249881:18250070:18255961:18256082:18256591:18256605 | 18255961:18256082 | ENSG00000124795.10 | ENST00000397239.3,ENST00000505224.1,ENST00000244776.7,ENST00000515770.1,ENST00000512145.1 |
| exon_skip_456552 | 6 | 18255966:18256082:18256591:18256686:18258183:18258262 | 18256591:18256686 | ENSG00000124795.10 | ENST00000397239.3,ENST00000505224.1,ENST00000244776.7,ENST00000503715.1 |
| exon_skip_456554 | 6 | 18256603:18256686:18258183:18258293:18258534:18258636 | 18258183:18258293 | ENSG00000124795.10 | ENST00000397239.3,ENST00000503715.1,ENST00000515742.1 |
| exon_skip_456557 | 6 | 18258183:18258293:18258534:18258636:18264073:18264227 | 18258534:18258636 | ENSG00000124795.10 | ENST00000397239.3,ENST00000515742.1 |
| exon_skip_456564 | 6 | 18258587:18258636:18264073:18264227:18264615:18264766 | 18264073:18264227 | ENSG00000124795.10 | ENST00000505224.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for DEK |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000397239 | 18236682 | 18236831 | Frame-shift |
| ENST00000397239 | 18255961 | 18256082 | Frame-shift |
| ENST00000397239 | 18256591 | 18256686 | Frame-shift |
| ENST00000397239 | 18258183 | 18258293 | Frame-shift |
| ENST00000397239 | 18226404 | 18226473 | In-frame |
| ENST00000397239 | 18249881 | 18250070 | In-frame |
| ENST00000397239 | 18258534 | 18258636 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000397239 | 18236682 | 18236831 | Frame-shift |
| ENST00000397239 | 18255961 | 18256082 | Frame-shift |
| ENST00000397239 | 18256591 | 18256686 | Frame-shift |
| ENST00000397239 | 18258183 | 18258293 | Frame-shift |
| ENST00000397239 | 18226404 | 18226473 | In-frame |
| ENST00000397239 | 18249881 | 18250070 | In-frame |
| ENST00000397239 | 18258534 | 18258636 | In-frame |
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Infer the effects of exon skipping event on protein functional features for DEK |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000397239 | 3444 | 375 | 18258534 | 18258636 | 594 | 695 | 48 | 82 |
| ENST00000397239 | 3444 | 375 | 18249881 | 18250070 | 1022 | 1210 | 191 | 254 |
| ENST00000397239 | 3444 | 375 | 18226404 | 18226473 | 1496 | 1564 | 349 | 372 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000397239 | 3444 | 375 | 18258534 | 18258636 | 594 | 695 | 48 | 82 |
| ENST00000397239 | 3444 | 375 | 18249881 | 18250070 | 1022 | 1210 | 191 | 254 |
| ENST00000397239 | 3444 | 375 | 18226404 | 18226473 | 1496 | 1564 | 349 | 372 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P35659 | 48 | 82 | 49 | 82 | Alternative sequence | ID=VSP_042951;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P35659 | 48 | 82 | 2 | 375 | Chain | ID=PRO_0000079858;Note=Protein DEK |
| P35659 | 48 | 82 | 30 | 49 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
| P35659 | 48 | 82 | 51 | 51 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID |
| P35659 | 48 | 82 | 72 | 72 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| P35659 | 191 | 254 | 2 | 375 | Chain | ID=PRO_0000079858;Note=Protein DEK |
| P35659 | 191 | 254 | 228 | 236 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| P35659 | 191 | 254 | 241 | 254 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| P35659 | 191 | 254 | 199 | 199 | Modified residue | Note=Phosphothreonine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15199154;Dbxref=PMID:15199154 |
| P35659 | 191 | 254 | 201 | 201 | Modified residue | Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15199154;Dbxref=PMID:15199154 |
| P35659 | 191 | 254 | 204 | 204 | Modified residue | Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15199154;Dbxref=PMID:15199154 |
| P35659 | 191 | 254 | 210 | 210 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231 |
| P35659 | 191 | 254 | 227 | 227 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17081983;Dbxref=PMID:17081983 |
| P35659 | 191 | 254 | 230 | 230 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:20068231,PMID:24275569 |
| P35659 | 191 | 254 | 231 | 231 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:20068231,PMID:24275569 |
| P35659 | 191 | 254 | 232 | 232 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:20068231,PMID:24275569 |
| P35659 | 191 | 254 | 243 | 243 | Modified residue | Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15199154;Dbxref=PMID:15199154 |
| P35659 | 191 | 254 | 244 | 244 | Modified residue | Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15199154;Dbxref=PMID:15199154 |
| P35659 | 191 | 254 | 251 | 251 | Modified residue | Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15199154;Dbxref=PMID:15199154 |
| P35659 | 191 | 254 | 205 | 221 | Motif | Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P35659 | 349 | 372 | 355 | 357 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q1V |
| P35659 | 349 | 372 | 2 | 375 | Chain | ID=PRO_0000079858;Note=Protein DEK |
| P35659 | 349 | 372 | 337 | 351 | DNA binding | . |
| P35659 | 349 | 372 | 367 | 371 | DNA binding | . |
| P35659 | 349 | 372 | 343 | 353 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q1V |
| P35659 | 349 | 372 | 361 | 375 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q1V |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P35659 | 48 | 82 | 49 | 82 | Alternative sequence | ID=VSP_042951;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| P35659 | 48 | 82 | 2 | 375 | Chain | ID=PRO_0000079858;Note=Protein DEK |
| P35659 | 48 | 82 | 30 | 49 | Compositional bias | Note=Asp/Glu-rich (highly acidic) |
| P35659 | 48 | 82 | 51 | 51 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:21406692,ECO:0000244|PubMed:23186163;Dbxref=PMID:17081983,PMID:20068231,PMID:21406692,PMID |
| P35659 | 48 | 82 | 72 | 72 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:23186163;Dbxref=PMID:23186163 |
| P35659 | 191 | 254 | 2 | 375 | Chain | ID=PRO_0000079858;Note=Protein DEK |
| P35659 | 191 | 254 | 228 | 236 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| P35659 | 191 | 254 | 241 | 254 | Compositional bias | Note=Asp/Glu-rich (acidic) |
| P35659 | 191 | 254 | 199 | 199 | Modified residue | Note=Phosphothreonine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15199154;Dbxref=PMID:15199154 |
| P35659 | 191 | 254 | 201 | 201 | Modified residue | Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15199154;Dbxref=PMID:15199154 |
| P35659 | 191 | 254 | 204 | 204 | Modified residue | Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15199154;Dbxref=PMID:15199154 |
| P35659 | 191 | 254 | 210 | 210 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:20068231;Dbxref=PMID:20068231 |
| P35659 | 191 | 254 | 227 | 227 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:17081983;Dbxref=PMID:17081983 |
| P35659 | 191 | 254 | 230 | 230 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:20068231,PMID:24275569 |
| P35659 | 191 | 254 | 231 | 231 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:20068231,PMID:24275569 |
| P35659 | 191 | 254 | 232 | 232 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:17081983,ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:24275569;Dbxref=PMID:17081983,PMID:20068231,PMID:24275569 |
| P35659 | 191 | 254 | 243 | 243 | Modified residue | Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15199154;Dbxref=PMID:15199154 |
| P35659 | 191 | 254 | 244 | 244 | Modified residue | Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15199154;Dbxref=PMID:15199154 |
| P35659 | 191 | 254 | 251 | 251 | Modified residue | Note=Phosphoserine%3B by CK2;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15199154;Dbxref=PMID:15199154 |
| P35659 | 191 | 254 | 205 | 221 | Motif | Note=Nuclear localization signal;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P35659 | 349 | 372 | 355 | 357 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q1V |
| P35659 | 349 | 372 | 2 | 375 | Chain | ID=PRO_0000079858;Note=Protein DEK |
| P35659 | 349 | 372 | 337 | 351 | DNA binding | . |
| P35659 | 349 | 372 | 367 | 371 | DNA binding | . |
| P35659 | 349 | 372 | 343 | 353 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q1V |
| P35659 | 349 | 372 | 361 | 375 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:1Q1V |
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SNVs in the skipped exons for DEK |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_456531 | 18226405 | 18226473 | 18226419 | 18226419 | Frame_Shift_Del | T | - | p.T369fs |
| PAAD | TCGA-IB-7654-01 | exon_skip_456539 | 18236683 | 18236831 | 18236737 | 18236740 | Frame_Shift_Del | TTTC | - | p.KK330fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_456543 | 18249882 | 18250070 | 18249928 | 18249928 | Frame_Shift_Del | T | - | p.N239fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_456543 | 18249882 | 18250070 | 18249928 | 18249928 | Frame_Shift_Del | T | - | p.N239fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_456543 | 18249882 | 18250070 | 18249928 | 18249928 | Frame_Shift_Del | T | - | p.N239fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_456543 | 18249882 | 18250070 | 18249934 | 18249934 | Frame_Shift_Del | T | - | p.K238fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_456543 | 18249882 | 18250070 | 18249934 | 18249934 | Frame_Shift_Del | T | - | p.K238fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_456543 | 18249882 | 18250070 | 18249934 | 18249934 | Frame_Shift_Del | T | - | p.K238fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_456543 | 18249882 | 18250070 | 18250027 | 18250027 | Frame_Shift_Del | T | - | p.K206fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_456543 | 18249882 | 18250070 | 18250049 | 18250049 | Frame_Shift_Del | T | - | p.T199fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_456543 | 18249882 | 18250070 | 18250049 | 18250049 | Frame_Shift_Del | T | - | p.T199fs |
| COAD | TCGA-AY-6197-01 | exon_skip_456552 | 18256592 | 18256686 | 18256633 | 18256633 | Frame_Shift_Del | T | - | p.G138fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_456552 | 18256592 | 18256686 | 18256633 | 18256633 | Frame_Shift_Del | T | - | p.K137fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_456557 | 18258535 | 18258636 | 18258587 | 18258587 | Frame_Shift_Del | C | - | p.R65fs |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_456557 | 18258535 | 18258636 | 18258596 | 18258596 | Frame_Shift_Del | T | - | p.K62fs |
| HNSC | TCGA-F7-A624-01 | exon_skip_456564 | 18264074 | 18264227 | 18264188 | 18264188 | Frame_Shift_Del | C | - | p.E11fs |
| STAD | TCGA-CG-5723-01 | exon_skip_456557 | 18258535 | 18258636 | 18258595 | 18258596 | Frame_Shift_Ins | - | T | p.V63fs |
| STAD | TCGA-CG-5723-01 | exon_skip_456557 | 18258535 | 18258636 | 18258596 | 18258597 | Frame_Shift_Ins | - | T | p.K62fs |
| UCEC | TCGA-AX-A05Z-01 | exon_skip_456552 | 18256592 | 18256686 | 18256632 | 18256632 | Nonsense_Mutation | C | A | p.G138* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HCT116_LARGE_INTESTINE | 18258184 | 18258293 | 18258250 | 18258250 | Frame_Shift_Del | A | - | p.F97fs |
| SNU407_LARGE_INTESTINE | 18258184 | 18258293 | 18258250 | 18258250 | Frame_Shift_Del | A | - | p.F97fs |
| CW2_LARGE_INTESTINE | 18249882 | 18250070 | 18250048 | 18250049 | Frame_Shift_Ins | - | T | p.T199fs |
| NCIH250_LUNG | 18226405 | 18226473 | 18226436 | 18226436 | Missense_Mutation | C | T | p.R362K |
| JHUEM1_ENDOMETRIUM | 18226405 | 18226473 | 18226461 | 18226461 | Missense_Mutation | A | G | p.Y354H |
| HEC251_ENDOMETRIUM | 18236683 | 18236831 | 18236740 | 18236740 | Missense_Mutation | C | A | p.K330N |
| NCIH661_LUNG | 18236683 | 18236831 | 18236780 | 18236780 | Missense_Mutation | T | C | p.K317R |
| HCT15_LARGE_INTESTINE | 18255962 | 18256082 | 18256029 | 18256029 | Missense_Mutation | G | A | p.S169L |
| SC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 18256592 | 18256686 | 18256636 | 18256636 | Missense_Mutation | T | A | p.E136D |
| SCI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 18256592 | 18256686 | 18256636 | 18256636 | Missense_Mutation | T | A | p.E136D |
| HCC2450_LUNG | 18258184 | 18258293 | 18258221 | 18258221 | Missense_Mutation | C | G | p.R107T |
| COLO794_SKIN | 18264074 | 18264227 | 18264099 | 18264099 | Missense_Mutation | G | C | p.D40E |
| COLO800_SKIN | 18264074 | 18264227 | 18264099 | 18264099 | Missense_Mutation | G | C | p.D40E |
| COLO818_SKIN | 18264074 | 18264227 | 18264099 | 18264099 | Missense_Mutation | G | C | p.D40E |
| OVCA420_OVARY | 18264074 | 18264227 | 18264103 | 18264103 | Missense_Mutation | T | C | p.D39G |
| WM1799_SKIN | 18264074 | 18264227 | 18264121 | 18264121 | Missense_Mutation | T | C | p.E33G |
| KYSE270_OESOPHAGUS | 18264074 | 18264227 | 18264163 | 18264163 | Missense_Mutation | G | A | p.S19F |
| HPAFII_PANCREAS | 18264074 | 18264227 | 18264200 | 18264200 | Missense_Mutation | C | T | p.A7T |
| PCI6A_UPPER_AERODIGESTIVE_TRACT | 18249882 | 18250070 | 18249964 | 18249964 | Nonsense_Mutation | G | C | p.S227* |
| HCT15_LARGE_INTESTINE | 18256592 | 18256686 | 18256632 | 18256632 | Nonsense_Mutation | C | A | p.G138* |
| SNU324_PANCREAS | 18236683 | 18236831 | 18236684 | 18236684 | Splice_Site | T | - | p.K349fs |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 18255962 | 18256082 | 18256078 | 18256084 | Splice_Site | TAAATCT | - | p.KDL151fs |
| HS611T_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 18256592 | 18256686 | 18256686 | 18256686 | Splice_Site | C | T | p.V120M |
| HCC2450_LUNG | 18258184 | 18258293 | 18258293 | 18258293 | Splice_Site | C | G | p.G83A |
| COLO783_SKIN | 18264074 | 18264227 | 18264216 | 18264216 | Start_Codon_SNP | C | T | p.M1I |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for DEK |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DEK |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for DEK |
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RelatedDrugs for DEK |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for DEK |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| DEK | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
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