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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ZFAND5 |
 Gene summary |
| Gene information | Gene symbol | ZFAND5 | Gene ID | 7763 |
| Gene name | zinc finger AN1-type containing 5 | |
| Synonyms | ZA20D2|ZFAND5A|ZNF216 | |
| Cytomap | 9q21.13 | |
| Type of gene | protein-coding | |
| Description | AN1-type zinc finger protein 5zinc finger A20 domain-containing protein 2zinc finger protein 216zinc finger, A20 domain containing 2zinc finger, AN1-type domain 5 | |
| Modification date | 20180519 | |
| UniProtAcc | O76080 | |
| Context | PubMed: ZFAND5 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ZFAND5 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ZFAND5 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ZFAND5 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_504184 | 9 | 74970870:74971017:74971846:74971972:74974333:74974437 | 74971846:74971972 | ENSG00000107372.8 | ENST00000376960.4,ENST00000237937.3,ENST00000488164.1,ENST00000376962.5,ENST00000471197.1,ENST00000343431.2 |
| exon_skip_504189 | 9 | 74971861:74971972:74974333:74974437:74975025:74975131 | 74974333:74974437 | ENSG00000107372.8 | ENST00000376960.4,ENST00000237937.3,ENST00000376956.3,ENST00000488164.1,ENST00000376962.5,ENST00000471197.1,ENST00000343431.2 |
| exon_skip_504202 | 9 | 74974333:74974437:74975025:74975137:74975543:74975700 | 74975025:74975137 | ENSG00000107372.8 | ENST00000376960.4,ENST00000237937.3,ENST00000376956.3,ENST00000488164.1,ENST00000376962.5,ENST00000343431.2 |
| exon_skip_504234 | 9 | 74975543:74975703:74978385:74978522:74979377:74979542 | 74978385:74978522 | ENSG00000107372.8 | ENST00000343431.2 |
| exon_skip_504235 | 9 | 74975543:74975703:74978385:74978522:74979611:74979892 | 74978385:74978522 | ENSG00000107372.8 | ENST00000376962.5 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ZFAND5 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_504184 | 9 | 74970870:74971017:74971846:74971972:74974333:74974437 | 74971846:74971972 | ENSG00000107372.8 | ENST00000237937.3,ENST00000488164.1,ENST00000376962.5,ENST00000376960.4,ENST00000343431.2,ENST00000471197.1 |
| exon_skip_504189 | 9 | 74971861:74971972:74974333:74974437:74975025:74975131 | 74974333:74974437 | ENSG00000107372.8 | ENST00000237937.3,ENST00000488164.1,ENST00000376962.5,ENST00000376960.4,ENST00000343431.2,ENST00000471197.1,ENST00000376956.3 |
| exon_skip_504202 | 9 | 74974333:74974437:74975025:74975137:74975543:74975700 | 74975025:74975137 | ENSG00000107372.8 | ENST00000237937.3,ENST00000488164.1,ENST00000376962.5,ENST00000376960.4,ENST00000343431.2,ENST00000376956.3 |
| exon_skip_504234 | 9 | 74975543:74975703:74978385:74978522:74979377:74979542 | 74978385:74978522 | ENSG00000107372.8 | ENST00000343431.2 |
| exon_skip_504235 | 9 | 74975543:74975703:74978385:74978522:74979611:74979892 | 74978385:74978522 | ENSG00000107372.8 | ENST00000376962.5 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ZFAND5 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000343431 | 74978385 | 74978522 | 3UTR-3UTR |
| ENST00000376962 | 74978385 | 74978522 | 3UTR-3UTR |
| ENST00000237937 | 74974333 | 74974437 | Frame-shift |
| ENST00000343431 | 74974333 | 74974437 | Frame-shift |
| ENST00000376960 | 74974333 | 74974437 | Frame-shift |
| ENST00000376962 | 74974333 | 74974437 | Frame-shift |
| ENST00000237937 | 74975025 | 74975137 | Frame-shift |
| ENST00000343431 | 74975025 | 74975137 | Frame-shift |
| ENST00000376960 | 74975025 | 74975137 | Frame-shift |
| ENST00000376962 | 74975025 | 74975137 | Frame-shift |
| ENST00000237937 | 74971846 | 74971972 | In-frame |
| ENST00000343431 | 74971846 | 74971972 | In-frame |
| ENST00000376960 | 74971846 | 74971972 | In-frame |
| ENST00000376962 | 74971846 | 74971972 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000343431 | 74978385 | 74978522 | 3UTR-3UTR |
| ENST00000376962 | 74978385 | 74978522 | 3UTR-3UTR |
| ENST00000237937 | 74974333 | 74974437 | Frame-shift |
| ENST00000343431 | 74974333 | 74974437 | Frame-shift |
| ENST00000376960 | 74974333 | 74974437 | Frame-shift |
| ENST00000376962 | 74974333 | 74974437 | Frame-shift |
| ENST00000237937 | 74975025 | 74975137 | Frame-shift |
| ENST00000343431 | 74975025 | 74975137 | Frame-shift |
| ENST00000376960 | 74975025 | 74975137 | Frame-shift |
| ENST00000376962 | 74975025 | 74975137 | Frame-shift |
| ENST00000237937 | 74971846 | 74971972 | In-frame |
| ENST00000343431 | 74971846 | 74971972 | In-frame |
| ENST00000376960 | 74971846 | 74971972 | In-frame |
| ENST00000376962 | 74971846 | 74971972 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZFAND5 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000237937 | 5745 | 213 | 74971846 | 74971972 | 926 | 1051 | 122 | 164 |
| ENST00000343431 | 1090 | 213 | 74971846 | 74971972 | 679 | 804 | 122 | 164 |
| ENST00000376960 | 2703 | 213 | 74971846 | 74971972 | 917 | 1042 | 122 | 164 |
| ENST00000376962 | 2802 | 213 | 74971846 | 74971972 | 1016 | 1141 | 122 | 164 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000237937 | 5745 | 213 | 74971846 | 74971972 | 926 | 1051 | 122 | 164 |
| ENST00000343431 | 1090 | 213 | 74971846 | 74971972 | 679 | 804 | 122 | 164 |
| ENST00000376960 | 2703 | 213 | 74971846 | 74971972 | 917 | 1042 | 122 | 164 |
| ENST00000376962 | 2802 | 213 | 74971846 | 74971972 | 1016 | 1141 | 122 | 164 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O76080 | 122 | 164 | 1 | 213 | Chain | ID=PRO_0000066557;Note=AN1-type zinc finger protein 5 |
| O76080 | 122 | 164 | 1 | 213 | Chain | ID=PRO_0000066557;Note=AN1-type zinc finger protein 5 |
| O76080 | 122 | 164 | 1 | 213 | Chain | ID=PRO_0000066557;Note=AN1-type zinc finger protein 5 |
| O76080 | 122 | 164 | 1 | 213 | Chain | ID=PRO_0000066557;Note=AN1-type zinc finger protein 5 |
| O76080 | 122 | 164 | 151 | 194 | Zinc finger | Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449 |
| O76080 | 122 | 164 | 151 | 194 | Zinc finger | Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449 |
| O76080 | 122 | 164 | 151 | 194 | Zinc finger | Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449 |
| O76080 | 122 | 164 | 151 | 194 | Zinc finger | Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| O76080 | 122 | 164 | 1 | 213 | Chain | ID=PRO_0000066557;Note=AN1-type zinc finger protein 5 |
| O76080 | 122 | 164 | 1 | 213 | Chain | ID=PRO_0000066557;Note=AN1-type zinc finger protein 5 |
| O76080 | 122 | 164 | 1 | 213 | Chain | ID=PRO_0000066557;Note=AN1-type zinc finger protein 5 |
| O76080 | 122 | 164 | 1 | 213 | Chain | ID=PRO_0000066557;Note=AN1-type zinc finger protein 5 |
| O76080 | 122 | 164 | 151 | 194 | Zinc finger | Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449 |
| O76080 | 122 | 164 | 151 | 194 | Zinc finger | Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449 |
| O76080 | 122 | 164 | 151 | 194 | Zinc finger | Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449 |
| O76080 | 122 | 164 | 151 | 194 | Zinc finger | Note=AN1-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00449 |
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SNVs in the skipped exons for ZFAND5 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_504189 | 74974334 | 74974437 | 74974352 | 74974352 | Frame_Shift_Del | T | - | p.T117fs |
| BLCA | TCGA-DK-AA6W-01 | exon_skip_504184 | 74971847 | 74971972 | 74971943 | 74971943 | Nonsense_Mutation | G | A | p.Q133* |
| KIRC | TCGA-B0-5706-01 | exon_skip_504184 | 74971847 | 74971972 | 74971943 | 74971943 | Nonsense_Mutation | G | A | p.Q133X |
| THCA | TCGA-DE-A0Y2-01 | exon_skip_504184 | 74971847 | 74971972 | 74971943 | 74971943 | Nonsense_Mutation | G | A | p.Q133* |
| THCA | TCGA-DE-A0Y2-01 | exon_skip_504184 | 74971847 | 74971972 | 74971943 | 74971943 | Nonsense_Mutation | G | A | p.Q133X |
| UCEC | TCGA-BS-A0UF-01 | exon_skip_504189 | 74974334 | 74974437 | 74974438 | 74974438 | Splice_Site | C | A | e3-1 |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| ESO51_OESOPHAGUS | 74974334 | 74974437 | 74974405 | 74974409 | Frame_Shift_Del | TGAGT | - | p.TQ98fs |
| CME1_SOFT_TISSUE | 74974334 | 74974437 | 74974360 | 74974360 | Missense_Mutation | G | A | p.T114I |
| LS411N_LARGE_INTESTINE | 74975026 | 74975137 | 74975102 | 74975102 | Missense_Mutation | A | T | p.S63T |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZFAND5 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZFAND5 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZFAND5 |
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RelatedDrugs for ZFAND5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZFAND5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| ZFAND5 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
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