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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ZNF142 |
 Gene summary |
| Gene information | Gene symbol | ZNF142 | Gene ID | 7701 |
| Gene name | zinc finger protein 142 | |
| Synonyms | pHZ-49 | |
| Cytomap | 2q35 | |
| Type of gene | protein-coding | |
| Description | zinc finger protein 142HA4654zinc finger protein 142 (clone pHZ-49) | |
| Modification date | 20180523 | |
| UniProtAcc | P52746 | |
| Context | PubMed: ZNF142 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ZNF142 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ZNF142 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ZNF142 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_346787 | 2 | 219506750:219509787:219510893:219511071:219513357:219514182 | 219510893:219511071 | ENSG00000115568.11 | ENST00000433921.1,ENST00000450765.1,ENST00000411696.2,ENST00000449707.1 |
| exon_skip_346791 | 2 | 219515223:219515249:219516423:219516545:219520872:219521126 | 219516423:219516545 | ENSG00000115568.11 | ENST00000433921.1,ENST00000450765.1 |
| exon_skip_346795 | 2 | 219515223:219515249:219516423:219517023:219520872:219521126 | 219516423:219517023 | ENSG00000115568.11 | ENST00000440934.1 |
| exon_skip_346797 | 2 | 219515223:219515249:219520872:219521186:219523423:219523524 | 219520872:219521186 | ENSG00000115568.11 | ENST00000449707.1 |
| exon_skip_346807 | 2 | 219521109:219521186:219523423:219523524:219523702:219523758 | 219523423:219523524 | ENSG00000115568.11 | ENST00000433921.1 |
| exon_skip_346808 | 2 | 219521109:219521186:219523423:219523599:219523702:219523758 | 219523423:219523599 | ENSG00000115568.11 | ENST00000450765.1,ENST00000432460.1,ENST00000449707.1 |
| exon_skip_346812 | 2 | 219523423:219523524:219523702:219523853:219524091:219524199 | 219523702:219523853 | ENSG00000115568.11 | ENST00000433921.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ZNF142 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_346787 | 2 | 219506750:219509787:219510893:219511071:219513357:219514182 | 219510893:219511071 | ENSG00000115568.11 | ENST00000449707.1,ENST00000433921.1,ENST00000450765.1,ENST00000411696.2 |
| exon_skip_346791 | 2 | 219515223:219515249:219516423:219516545:219520872:219521126 | 219516423:219516545 | ENSG00000115568.11 | ENST00000433921.1,ENST00000450765.1 |
| exon_skip_346795 | 2 | 219515223:219515249:219516423:219517023:219520872:219521126 | 219516423:219517023 | ENSG00000115568.11 | ENST00000440934.1 |
| exon_skip_346797 | 2 | 219515223:219515249:219520872:219521186:219523423:219523524 | 219520872:219521186 | ENSG00000115568.11 | ENST00000449707.1 |
| exon_skip_346799 | 2 | 219515223:219515249:219520872:219521195:219523423:219523524 | 219520872:219521195 | ENSG00000115568.11 | ENST00000411696.2 |
| exon_skip_346807 | 2 | 219521109:219521186:219523423:219523524:219523702:219523758 | 219523423:219523524 | ENSG00000115568.11 | ENST00000433921.1 |
| exon_skip_346808 | 2 | 219521109:219521186:219523423:219523599:219523702:219523758 | 219523423:219523599 | ENSG00000115568.11 | ENST00000449707.1,ENST00000450765.1,ENST00000432460.1 |
| exon_skip_346812 | 2 | 219523423:219523524:219523702:219523853:219524091:219524199 | 219523702:219523853 | ENSG00000115568.11 | ENST00000433921.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF142 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000449707 | 219520872 | 219521186 | 3UTR-3CDS |
| ENST00000449707 | 219523423 | 219523599 | 3UTR-3UTR |
| ENST00000411696 | 219510893 | 219511071 | Frame-shift |
| ENST00000449707 | 219510893 | 219511071 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000411696 | 219520872 | 219521195 | 3UTR-3CDS |
| ENST00000449707 | 219520872 | 219521186 | 3UTR-3CDS |
| ENST00000449707 | 219523423 | 219523599 | 3UTR-3UTR |
| ENST00000411696 | 219510893 | 219511071 | Frame-shift |
| ENST00000449707 | 219510893 | 219511071 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for ZNF142 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for ZNF142 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_346797 | 219520873 | 219521186 | 219520875 | 219520875 | Frame_Shift_Del | G | - | p.P93fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_346797 | 219520873 | 219521186 | 219521067 | 219521067 | Frame_Shift_Del | G | - | p.P30fs |
| HNSC | TCGA-BA-7269-01 | exon_skip_346787 | 219510894 | 219511071 | 219510940 | 219510940 | Nonsense_Mutation | T | A | p.K469* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| KARPAS45_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 219510894 | 219511071 | 219510927 | 219510927 | Missense_Mutation | C | T | p.R473H |
| 5637_URINARY_TRACT | 219510894 | 219511071 | 219510941 | 219510941 | Missense_Mutation | C | G | p.W468C |
| FADU_UPPER_AERODIGESTIVE_TRACT | 219510894 | 219511071 | 219510957 | 219510957 | Missense_Mutation | C | A | p.G463V |
| SNU1040_LARGE_INTESTINE | 219520873 | 219521186 | 219520933 | 219520933 | Missense_Mutation | C | G | p.E74Q |
| DOK_UPPER_AERODIGESTIVE_TRACT | 219520873 | 219521186 | 219520944 | 219520944 | Missense_Mutation | G | T | p.P70Q |
| SNGM_ENDOMETRIUM | 219520873 | 219521186 | 219521143 | 219521143 | Missense_Mutation | G | A | p.P4S |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF142 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
| exon_skip_346808 | 2 | 219521109:219521186:219523423:219523599:219523702:219523758 | 219523423:219523599 | ENST00000450765.1,ENST00000432460.1,ENST00000449707.1 | ESCA | rs4674324 | chr2:219523433 | T/G | 4.10e-04 |
| exon_skip_346808 | 2 | 219521109:219521186:219523423:219523599:219523702:219523758 | 219523423:219523599 | ENST00000450765.1,ENST00000432460.1,ENST00000449707.1 | STAD | rs4674324 | chr2:219523433 | T/G | 2.70e-04 |
| exon_skip_346807 | 2 | 219521109:219521186:219523423:219523524:219523702:219523758 | 219523423:219523524 | ENST00000433921.1 | ESCA | rs4674324 | chr2:219523433 | T/G | 4.10e-04 |
| exon_skip_346807 | 2 | 219521109:219521186:219523423:219523524:219523702:219523758 | 219523423:219523524 | ENST00000433921.1 | STAD | rs4674324 | chr2:219523433 | T/G | 2.70e-04 |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF142 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF142 |
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RelatedDrugs for ZNF142 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF142 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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