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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ZNF75D |
 Gene summary |
| Gene information | Gene symbol | ZNF75D | Gene ID | 7626 |
| Gene name | zinc finger protein 75D | |
| Synonyms | D8C6|ZKSCAN24|ZNF75|ZNF82|ZSCAN28 | |
| Cytomap | Xq26.3 | |
| Type of gene | protein-coding | |
| Description | zinc finger protein 75Dzinc finger protein 75zinc finger protein 82 | |
| Modification date | 20180403 | |
| UniProtAcc | P51815 | |
| Context | PubMed: ZNF75D [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ZNF75D from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ZNF75D |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ZNF75D |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_516856 | X | 134424934:134425061:134425397:134425489:134426206:134426399 | 134425397:134425489 | ENSG00000186376.10 | ENST00000370766.3 |
| exon_skip_516875 | X | 134425397:134425489:134426206:134426399:134427655:134428184 | 134426206:134426399 | ENSG00000186376.10 | ENST00000370766.3 |
| exon_skip_516883 | X | 134426206:134426399:134427655:134428184:134429693:134429848 | 134427655:134428184 | ENSG00000186376.10 | ENST00000370766.3 |
| exon_skip_516894 | X | 134427655:134428184:134429693:134429965:134475692:134475879 | 134429693:134429965 | ENSG00000186376.10 | ENST00000370766.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ZNF75D |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_516856 | X | 134424934:134425061:134425397:134425489:134426206:134426399 | 134425397:134425489 | ENSG00000186376.10 | ENST00000370766.3 |
| exon_skip_516865 | X | 134424934:134425061:134427655:134428184:134429693:134429848 | 134427655:134428184 | ENSG00000186376.10 | ENST00000370764.1 |
| exon_skip_516875 | X | 134425397:134425489:134426206:134426399:134427655:134428184 | 134426206:134426399 | ENSG00000186376.10 | ENST00000370766.3 |
| exon_skip_516883 | X | 134426206:134426399:134427655:134428184:134429693:134429848 | 134427655:134428184 | ENSG00000186376.10 | ENST00000370766.3 |
| exon_skip_516894 | X | 134427655:134428184:134429693:134429965:134475692:134475879 | 134429693:134429965 | ENSG00000186376.10 | ENST00000370766.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF75D |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370766 | 134427655 | 134428184 | 3UTR-3CDS |
| ENST00000370766 | 134429693 | 134429965 | 3UTR-3UTR |
| ENST00000370766 | 134425397 | 134425489 | Frame-shift |
| ENST00000370766 | 134426206 | 134426399 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000370766 | 134427655 | 134428184 | 3UTR-3CDS |
| ENST00000370766 | 134429693 | 134429965 | 3UTR-3UTR |
| ENST00000370766 | 134425397 | 134425489 | Frame-shift |
| ENST00000370766 | 134426206 | 134426399 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for ZNF75D |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for ZNF75D |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_516856 | 134425398 | 134425489 | 134425448 | 134425448 | Frame_Shift_Del | T | - | p.R216fs |
| SARC | TCGA-DX-A7EU-01 | exon_skip_516883 | 134427656 | 134428184 | 134427799 | 134427799 | Frame_Shift_Del | C | - | p.E90fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_516883 | 134427656 | 134428184 | 134427844 | 134427844 | Frame_Shift_Del | G | - | p.H75fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_516883 | 134427656 | 134428184 | 134427886 | 134427886 | Frame_Shift_Del | T | - | p.T61fs |
| LIHC | TCGA-DD-A1EG-01 | exon_skip_516883 | 134427656 | 134428184 | 134427949 | 134427949 | Frame_Shift_Del | T | - | p.I40fs |
| LUAD | TCGA-69-A59K-01 | exon_skip_516875 | 134426207 | 134426399 | 134426224 | 134426225 | Frame_Shift_Ins | - | A | p.A196fs |
| LUAD | TCGA-O1-A52J-01 | exon_skip_516856 | 134425398 | 134425489 | 134425457 | 134425457 | Nonsense_Mutation | C | A | p.E213* |
| UCEC | TCGA-AP-A059-01 | exon_skip_516875 | 134426207 | 134426399 | 134426231 | 134426231 | Nonsense_Mutation | C | A | p.E194* |
| HNSC | TCGA-CR-7368-01 | exon_skip_516875 | 134426207 | 134426399 | 134426280 | 134426280 | Nonsense_Mutation | C | T | p.W177* |
| LIHC | TCGA-EP-A2KB-01 | exon_skip_516875 | 134426207 | 134426399 | 134426381 | 134426381 | Nonsense_Mutation | C | A | p.G144X |
| UCEC | TCGA-AP-A059-01 | exon_skip_516883 | 134427656 | 134428184 | 134427985 | 134427985 | Nonsense_Mutation | C | A | p.E28* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SW48_LARGE_INTESTINE | 134427656 | 134428184 | 134427949 | 134427949 | Frame_Shift_Del | T | - | p.I40fs |
| IOMMLEE_CENTRAL_NERVOUS_SYSTEM | 134426207 | 134426399 | 134426239 | 134426239 | Missense_Mutation | G | A | p.T191I |
| JHUEM7_ENDOMETRIUM | 134426207 | 134426399 | 134426324 | 134426324 | Missense_Mutation | G | A | p.P163S |
| HTCC3_THYROID | 134426207 | 134426399 | 134426336 | 134426336 | Missense_Mutation | A | C | p.F159V |
| SNU1040_LARGE_INTESTINE | 134426207 | 134426399 | 134426386 | 134426386 | Missense_Mutation | T | C | p.E142G |
| MIAPACA2_PANCREAS | 134427656 | 134428184 | 134427663 | 134427663 | Missense_Mutation | T | C | p.K135R |
| NCIH1563_LUNG | 134427656 | 134428184 | 134427749 | 134427749 | Missense_Mutation | C | G | p.Q106H |
| NCIH2030_LUNG | 134427656 | 134428184 | 134427874 | 134427874 | Missense_Mutation | C | T | p.E65K |
| SUPHD1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 134427656 | 134428184 | 134427882 | 134427882 | Missense_Mutation | C | T | p.G62E |
| L82_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 134427656 | 134428184 | 134427939 | 134427939 | Missense_Mutation | A | G | p.L43P |
| LNCAPCLONEFGC_PROSTATE | 134427656 | 134428184 | 134427946 | 134427946 | Missense_Mutation | C | T | p.E41K |
| KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 134427656 | 134428184 | 134427978 | 134427978 | Missense_Mutation | G | A | p.S30F |
| JHUEM7_ENDOMETRIUM | 134427656 | 134428184 | 134427981 | 134427981 | Missense_Mutation | T | C | p.N29S |
| HCC1569_BREAST | 134427656 | 134428184 | 134427981 | 134427981 | Missense_Mutation | T | C | p.N29S |
| HEC108_ENDOMETRIUM | 134427656 | 134428184 | 134428014 | 134428014 | Missense_Mutation | G | A | p.A18V |
| NCIH2110_LUNG | 134427656 | 134428184 | 134428019 | 134428019 | Missense_Mutation | C | A | p.M16I |
| NCIH1563_LUNG | 134427656 | 134428184 | 134428022 | 134428022 | Missense_Mutation | C | G | p.Q15H |
| CL34_LARGE_INTESTINE | 134427656 | 134428184 | 134428045 | 134428045 | Missense_Mutation | C | T | p.A8T |
| MCC13_SKIN | 134425398 | 134425489 | 134425434 | 134425434 | Nonsense_Mutation | C | T | p.W220* |
| GP2D_LARGE_INTESTINE | 134427656 | 134428184 | 134427836 | 134427836 | Nonsense_Mutation | C | T | p.W77* |
| GP5D_LARGE_INTESTINE | 134427656 | 134428184 | 134427836 | 134427836 | Nonsense_Mutation | C | T | p.W77* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF75D |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF75D |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF75D |
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RelatedDrugs for ZNF75D |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF75D |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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