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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ZNF711 |
 Gene summary |
| Gene information | Gene symbol | ZNF711 | Gene ID | 7552 |
| Gene name | zinc finger protein 711 | |
| Synonyms | CMPX1|MRX97|ZNF4|ZNF5|ZNF6|Zfp711|dJ75N13.1 | |
| Cytomap | Xq21.1 | |
| Type of gene | protein-coding | |
| Description | zinc finger protein 711dJ75N13.1 (znf6-like)zinc finger protein 6 (CMPX1) | |
| Modification date | 20180523 | |
| UniProtAcc | Q9Y462 | |
| Context | PubMed: ZNF711 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ZNF711 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ZNF711 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ZNF711 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_511388 | X | 84499089:84499197:84500908:84501028:84501935:84502189 | 84500908:84501028 | ENSG00000147180.12 | ENST00000276123.3 |
| exon_skip_511389 | X | 84499089:84499197:84500908:84501028:84502552:84502657 | 84500908:84501028 | ENSG00000147180.12 | ENST00000373165.3 |
| exon_skip_511395 | X | 84500908:84501028:84501935:84502189:84502552:84502657 | 84501935:84502189 | ENSG00000147180.12 | ENST00000276123.3 |
| exon_skip_511398 | X | 84502552:84502657:84510264:84510807:84519280:84519436 | 84510264:84510807 | ENSG00000147180.12 | ENST00000395402.1,ENST00000276123.3,ENST00000373165.3,ENST00000360700.4 |
| exon_skip_511401 | X | 84520123:84520261:84522283:84522421:84523299:84523347 | 84522283:84522421 | ENSG00000147180.12 | ENST00000542798.1,ENST00000360700.4 |
| exon_skip_511402 | X | 84522283:84522421:84523299:84523347:84525008:84525152 | 84523299:84523347 | ENSG00000147180.12 | ENST00000542798.1,ENST00000360700.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ZNF711 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_511388 | X | 84499089:84499197:84500908:84501028:84501935:84502189 | 84500908:84501028 | ENSG00000147180.12 | ENST00000276123.3 |
| exon_skip_511389 | X | 84499089:84499197:84500908:84501028:84502552:84502657 | 84500908:84501028 | ENSG00000147180.12 | ENST00000373165.3 |
| exon_skip_511395 | X | 84500908:84501028:84501935:84502189:84502552:84502657 | 84501935:84502189 | ENSG00000147180.12 | ENST00000276123.3 |
| exon_skip_511398 | X | 84502552:84502657:84510264:84510807:84519280:84519436 | 84510264:84510807 | ENSG00000147180.12 | ENST00000395402.1,ENST00000373165.3,ENST00000276123.3,ENST00000360700.4 |
| exon_skip_511401 | X | 84520123:84520261:84522283:84522421:84523299:84523347 | 84522283:84522421 | ENSG00000147180.12 | ENST00000360700.4,ENST00000542798.1 |
| exon_skip_511402 | X | 84522283:84522421:84523299:84523347:84525008:84525152 | 84523299:84523347 | ENSG00000147180.12 | ENST00000360700.4,ENST00000542798.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ZNF711 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000276123 | 84500908 | 84501028 | 5UTR-5UTR |
| ENST00000373165 | 84500908 | 84501028 | 5UTR-5UTR |
| ENST00000276123 | 84501935 | 84502189 | 5UTR-5UTR |
| ENST00000276123 | 84510264 | 84510807 | In-frame |
| ENST00000373165 | 84510264 | 84510807 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000276123 | 84500908 | 84501028 | 5UTR-5UTR |
| ENST00000373165 | 84500908 | 84501028 | 5UTR-5UTR |
| ENST00000276123 | 84501935 | 84502189 | 5UTR-5UTR |
| ENST00000276123 | 84510264 | 84510807 | In-frame |
| ENST00000373165 | 84510264 | 84510807 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ZNF711 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000276123 | 2904 | 761 | 84510264 | 84510807 | 588 | 1130 | 26 | 207 |
| ENST00000373165 | 4141 | 761 | 84510264 | 84510807 | 386 | 928 | 26 | 207 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000276123 | 2904 | 761 | 84510264 | 84510807 | 588 | 1130 | 26 | 207 |
| ENST00000373165 | 4141 | 761 | 84510264 | 84510807 | 386 | 928 | 26 | 207 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y462 | 26 | 207 | 1 | 761 | Chain | ID=PRO_0000047329;Note=Zinc finger protein 711 |
| Q9Y462 | 26 | 207 | 1 | 761 | Chain | ID=PRO_0000047329;Note=Zinc finger protein 711 |
| Q9Y462 | 26 | 207 | 139 | 139 | Natural variant | ID=VAR_062990;Note=In MRX97%3B unknown pathological significance. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19377476;Dbxref=dbSNP:rs367654949,PMID:19377476 |
| Q9Y462 | 26 | 207 | 139 | 139 | Natural variant | ID=VAR_062990;Note=In MRX97%3B unknown pathological significance. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19377476;Dbxref=dbSNP:rs367654949,PMID:19377476 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9Y462 | 26 | 207 | 1 | 761 | Chain | ID=PRO_0000047329;Note=Zinc finger protein 711 |
| Q9Y462 | 26 | 207 | 1 | 761 | Chain | ID=PRO_0000047329;Note=Zinc finger protein 711 |
| Q9Y462 | 26 | 207 | 139 | 139 | Natural variant | ID=VAR_062990;Note=In MRX97%3B unknown pathological significance. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19377476;Dbxref=dbSNP:rs367654949,PMID:19377476 |
| Q9Y462 | 26 | 207 | 139 | 139 | Natural variant | ID=VAR_062990;Note=In MRX97%3B unknown pathological significance. G->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:19377476;Dbxref=dbSNP:rs367654949,PMID:19377476 |
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SNVs in the skipped exons for ZNF711 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_511398 | 84510265 | 84510807 | 84510360 | 84510360 | Frame_Shift_Del | G | - | p.G59fs |
| BLCA | TCGA-K4-A54R-01 | 84523300 | 84523347 | 84523329 | 84523329 | Nonsense_Mutation | G | T | p.E362* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SKN3_UPPER_AERODIGESTIVE_TRACT | 84510265 | 84510807 | 84510297 | 84510297 | Missense_Mutation | G | A | p.G38R |
| CW2_LARGE_INTESTINE | 84510265 | 84510807 | 84510481 | 84510481 | Missense_Mutation | C | T | p.A99V |
| HCC515_LUNG | 84510265 | 84510807 | 84510505 | 84510505 | Missense_Mutation | A | G | p.D107G |
| VMRCRCZ_KIDNEY | 84510265 | 84510807 | 84510507 | 84510507 | Missense_Mutation | G | A | p.D108N |
| M14_SKIN | 84510265 | 84510807 | 84510513 | 84510513 | Missense_Mutation | G | A | p.D110N |
| NCIH1930_LUNG | 84510265 | 84510807 | 84510558 | 84510558 | Missense_Mutation | C | T | p.P125S |
| RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 84510265 | 84510807 | 84510582 | 84510582 | Missense_Mutation | C | T | p.L133F |
| IM9_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 84510265 | 84510807 | 84510803 | 84510803 | Missense_Mutation | A | G | p.I206M |
| JHUEM7_ENDOMETRIUM | 84523300 | 84523347 | 84523309 | 84523309 | Missense_Mutation | G | T | p.R309I |
| HCC515_LUNG | 84510265 | 84510807 | 84510666 | 84510666 | Nonsense_Mutation | G | T | p.E161* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ZNF711 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF711 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ZNF711 |
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RelatedDrugs for ZNF711 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ZNF711 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| ZNF711 | C1136249 | Mental Retardation, X-Linked | 1 | CTD_human |
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