ExonSkipDB Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Gene structures and expression levels

leaf

Exon skipping events with PSIs in TCGA

leaf

Exon skipping events with PSIs in GTEx

leaf

Open reading frame (ORF) annotation in the exon skipping event

leaf

Exon skipping events in the canonical protein sequence

leaf

SNVs in the skipped exons with depth of coverage

leaf

Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

leaf

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

leaf

Related drugs with this gene

leaf

Related diseases with this gene

Gene summary for XPO1

check button Gene summary
Gene informationGene symbol

XPO1

Gene ID

7514

Gene nameexportin 1
SynonymsCRM1|emb|exp1
Cytomap

2p15

Type of geneprotein-coding
Descriptionexportin-1chromosome region maintenance 1 homologchromosome region maintenance 1 protein homologexportin 1 (CRM1 homolog, yeast)exportin-1 (required for chromosome region maintenance)
Modification date20180523
UniProtAcc

O14980

ContextPubMed: XPO1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID
XPO1

GO:0006611

protein export from nucleus

22250199


Top

Exon skipping events across known transcript of Ensembl for XPO1 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

Top

Gene isoform structures and expression levels for XPO1

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


Top

Exon skipping events with PSIs in TCGA for XPO1

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_339465261705834:61706101:61708319:61708416:61709514:6170967461708319:61708416ENSG00000082898.12ENST00000428210.1,ENST00000481073.1,ENST00000406957.1,ENST00000401558.2,ENST00000404992.2
exon_skip_339470261708319:61708416:61709514:61709674:61710091:6171022661709514:61709674ENSG00000082898.12ENST00000428210.1,ENST00000481073.1,ENST00000406957.1,ENST00000401558.2,ENST00000404992.2
exon_skip_339471261709514:61709674:61710091:61710226:61711071:6171124061710091:61710226ENSG00000082898.12ENST00000428210.1,ENST00000481073.1,ENST00000406957.1,ENST00000401558.2,ENST00000404992.2
exon_skip_339472261711071:61711240:61712902:61713097:61715299:6171540661712902:61713097ENSG00000082898.12ENST00000428210.1,ENST00000481073.1,ENST00000406957.1,ENST00000401558.2,ENST00000404992.2
exon_skip_339481261715299:61715406:61715722:61715906:61717776:6171791161715722:61715906ENSG00000082898.12ENST00000428210.1,ENST00000481073.1,ENST00000406957.1,ENST00000401558.2,ENST00000404992.2
exon_skip_339482261715722:61715906:61717776:61717911:61719169:6171933161717776:61717911ENSG00000082898.12ENST00000428210.1,ENST00000481073.1,ENST00000406957.1,ENST00000401558.2,ENST00000404992.2
exon_skip_339483261719701:61719883:61720049:61720188:61721028:6172122661720049:61720188ENSG00000082898.12ENST00000481073.1,ENST00000406957.1,ENST00000401558.2,ENST00000404992.2
exon_skip_339485261720049:61720188:61721028:61721226:61722589:6172270861721028:61721226ENSG00000082898.12ENST00000406957.1,ENST00000401558.2,ENST00000404992.2
exon_skip_339486261722589:61722748:61724013:61724142:61725807:6172592761724013:61724142ENSG00000082898.12ENST00000428210.1,ENST00000406957.1,ENST00000401558.2,ENST00000404992.2
exon_skip_339488261724128:61724142:61725807:61725927:61725999:6172604861725807:61725927ENSG00000082898.12ENST00000428210.1,ENST00000406957.1,ENST00000437159.1,ENST00000401558.2,ENST00000404992.2
exon_skip_339491261725999:61726048:61726847:61727029:61749745:6174981861726847:61727029ENSG00000082898.12ENST00000437159.1
exon_skip_339493261726899:61727029:61729130:61729175:61729383:6172944561729130:61729175ENSG00000082898.12ENST00000428210.1,ENST00000406957.1,ENST00000451765.1,ENST00000401558.2,ENST00000404992.2,ENST00000489954.1
exon_skip_339497261729140:61729175:61729383:61729445:61749745:6174981861729383:61729445ENSG00000082898.12ENST00000443240.1,ENST00000428210.1,ENST00000406957.1,ENST00000451765.1,ENST00000401558.2,ENST00000404992.2
exon_skip_339500261749764:61749818:61752404:61752468:61752626:6175265661752404:61752468ENSG00000082898.12ENST00000428210.1
exon_skip_339511261749764:61749818:61753554:61753656:61760906:6176103861753554:61753656ENSG00000082898.12ENST00000443240.1,ENST00000457483.1,ENST00000406957.1,ENST00000422552.1,ENST00000451765.1,ENST00000401558.2,ENST00000404992.2,ENST00000420673.1
exon_skip_339520261753605:61753656:61760906:61761038:61764696:6176472261760906:61761038ENSG00000082898.12ENST00000443240.1,ENST00000428210.1,ENST00000406957.1,ENST00000481214.1
exon_skip_339524261760906:61761038:61761692:61761813:61764696:6176472261761692:61761813ENSG00000082898.12ENST00000457483.1
exon_skip_339527261760906:61761038:61764696:61764722:61765626:6176576161764696:61764722ENSG00000082898.12ENST00000443240.1

check button PSI values of skipped exons in TCGA.
psi tcga

Top

Exon skipping events with PSIs in GTEx for XPO1

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_339465261705834:61706101:61708319:61708416:61709514:6170967461708319:61708416ENSG00000082898.12ENST00000401558.2,ENST00000428210.1,ENST00000481073.1,ENST00000404992.2,ENST00000406957.1
exon_skip_339470261708319:61708416:61709514:61709674:61710091:6171022661709514:61709674ENSG00000082898.12ENST00000401558.2,ENST00000428210.1,ENST00000481073.1,ENST00000404992.2,ENST00000406957.1
exon_skip_339471261709514:61709674:61710091:61710226:61711071:6171124061710091:61710226ENSG00000082898.12ENST00000401558.2,ENST00000428210.1,ENST00000481073.1,ENST00000404992.2,ENST00000406957.1
exon_skip_339472261711071:61711240:61712902:61713097:61715299:6171540661712902:61713097ENSG00000082898.12ENST00000401558.2,ENST00000428210.1,ENST00000481073.1,ENST00000404992.2,ENST00000406957.1
exon_skip_339481261715299:61715406:61715722:61715906:61717776:6171791161715722:61715906ENSG00000082898.12ENST00000401558.2,ENST00000428210.1,ENST00000481073.1,ENST00000404992.2,ENST00000406957.1
exon_skip_339482261715722:61715906:61717776:61717911:61719169:6171933161717776:61717911ENSG00000082898.12ENST00000401558.2,ENST00000428210.1,ENST00000481073.1,ENST00000404992.2,ENST00000406957.1
exon_skip_339483261719701:61719883:61720049:61720188:61721028:6172122661720049:61720188ENSG00000082898.12ENST00000401558.2,ENST00000481073.1,ENST00000404992.2,ENST00000406957.1
exon_skip_339485261720049:61720188:61721028:61721226:61722589:6172270861721028:61721226ENSG00000082898.12ENST00000401558.2,ENST00000404992.2,ENST00000406957.1
exon_skip_339486261722589:61722748:61724013:61724142:61725807:6172592761724013:61724142ENSG00000082898.12ENST00000401558.2,ENST00000428210.1,ENST00000404992.2,ENST00000406957.1
exon_skip_339488261724128:61724142:61725807:61725927:61725999:6172604861725807:61725927ENSG00000082898.12ENST00000401558.2,ENST00000428210.1,ENST00000404992.2,ENST00000406957.1,ENST00000437159.1
exon_skip_339491261725999:61726048:61726847:61727029:61749745:6174981861726847:61727029ENSG00000082898.12ENST00000437159.1
exon_skip_339493261726899:61727029:61729130:61729175:61729383:6172944561729130:61729175ENSG00000082898.12ENST00000401558.2,ENST00000428210.1,ENST00000404992.2,ENST00000406957.1,ENST00000489954.1,ENST00000451765.1
exon_skip_339497261729140:61729175:61729383:61729445:61749745:6174981861729383:61729445ENSG00000082898.12ENST00000401558.2,ENST00000428210.1,ENST00000404992.2,ENST00000406957.1,ENST00000451765.1,ENST00000443240.1
exon_skip_339500261749764:61749818:61752404:61752468:61752626:6175265661752404:61752468ENSG00000082898.12ENST00000428210.1
exon_skip_339511261749764:61749818:61753554:61753656:61760906:6176103861753554:61753656ENSG00000082898.12ENST00000401558.2,ENST00000404992.2,ENST00000406957.1,ENST00000451765.1,ENST00000443240.1,ENST00000420673.1,ENST00000422552.1,ENST00000457483.1
exon_skip_339520261753605:61753656:61760906:61761038:61764696:6176472261760906:61761038ENSG00000082898.12ENST00000428210.1,ENST00000406957.1,ENST00000443240.1,ENST00000481214.1
exon_skip_339524261760906:61761038:61761692:61761813:61764696:6176472261761692:61761813ENSG00000082898.12ENST00000457483.1
exon_skip_339527261760906:61761038:61764696:61764722:61765626:6176576161764696:61764722ENSG00000082898.12ENST00000443240.1

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

Top

Open reading frame (ORF) annotation in the exon skipping event for XPO1

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000040695761760906617610383UTR-3CDS
ENST000004015586170831961708416Frame-shift
ENST000004049926170831961708416Frame-shift
ENST000004069576170831961708416Frame-shift
ENST000004015586170951461709674Frame-shift
ENST000004049926170951461709674Frame-shift
ENST000004069576170951461709674Frame-shift
ENST000004015586171572261715906Frame-shift
ENST000004049926171572261715906Frame-shift
ENST000004069576171572261715906Frame-shift
ENST000004015586172004961720188Frame-shift
ENST000004049926172004961720188Frame-shift
ENST000004069576172004961720188Frame-shift
ENST000004015586172938361729445Frame-shift
ENST000004049926172938361729445Frame-shift
ENST000004069576172938361729445Frame-shift
ENST000004015586171009161710226In-frame
ENST000004049926171009161710226In-frame
ENST000004069576171009161710226In-frame
ENST000004015586171290261713097In-frame
ENST000004049926171290261713097In-frame
ENST000004069576171290261713097In-frame
ENST000004015586171777661717911In-frame
ENST000004049926171777661717911In-frame
ENST000004069576171777661717911In-frame
ENST000004015586172102861721226In-frame
ENST000004049926172102861721226In-frame
ENST000004069576172102861721226In-frame
ENST000004015586172401361724142In-frame
ENST000004049926172401361724142In-frame
ENST000004069576172401361724142In-frame
ENST000004015586172580761725927In-frame
ENST000004049926172580761725927In-frame
ENST000004069576172580761725927In-frame
ENST000004015586172913061729175In-frame
ENST000004049926172913061729175In-frame
ENST000004069576172913061729175In-frame
ENST000004015586175355461753656In-frame
ENST000004049926175355461753656In-frame
ENST000004069576175355461753656In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST0000040695761760906617610383UTR-3CDS
ENST000004015586170831961708416Frame-shift
ENST000004049926170831961708416Frame-shift
ENST000004069576170831961708416Frame-shift
ENST000004015586170951461709674Frame-shift
ENST000004049926170951461709674Frame-shift
ENST000004069576170951461709674Frame-shift
ENST000004015586171572261715906Frame-shift
ENST000004049926171572261715906Frame-shift
ENST000004069576171572261715906Frame-shift
ENST000004015586172004961720188Frame-shift
ENST000004049926172004961720188Frame-shift
ENST000004069576172004961720188Frame-shift
ENST000004015586172938361729445Frame-shift
ENST000004049926172938361729445Frame-shift
ENST000004069576172938361729445Frame-shift
ENST000004015586171009161710226In-frame
ENST000004049926171009161710226In-frame
ENST000004069576171009161710226In-frame
ENST000004015586171290261713097In-frame
ENST000004049926171290261713097In-frame
ENST000004069576171290261713097In-frame
ENST000004015586171777661717911In-frame
ENST000004049926171777661717911In-frame
ENST000004069576171777661717911In-frame
ENST000004015586172102861721226In-frame
ENST000004049926172102861721226In-frame
ENST000004069576172102861721226In-frame
ENST000004015586172401361724142In-frame
ENST000004049926172401361724142In-frame
ENST000004069576172401361724142In-frame
ENST000004015586172580761725927In-frame
ENST000004049926172580761725927In-frame
ENST000004069576172580761725927In-frame
ENST000004015586172913061729175In-frame
ENST000004049926172913061729175In-frame
ENST000004069576172913061729175In-frame
ENST000004015586175355461753656In-frame
ENST000004049926175355461753656In-frame
ENST000004069576175355461753656In-frame

Top

Infer the effects of exon skipping event on protein functional features for XPO1

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000004015584932107161753554617536568559564276
ENST000004049924122107161753554617536565346354276
ENST000004069573496107161753554617536562703714276
ENST0000040155849321071617291306172917510921136121136
ENST00000404992412210716172913061729175771815121136
ENST00000406957349610716172913061729175507551121136
ENST0000040155849321071617258076172592713681487213253
ENST0000040499241221071617258076172592710471166213253
ENST00000406957349610716172580761725927783902213253
ENST0000040155849321071617240136172414214881616253296
ENST0000040499241221071617240136172414211671295253296
ENST000004069573496107161724013617241429031031253296
ENST0000040155849321071617210286172122617761973349415
ENST0000040499241221071617210286172122614551652349415
ENST0000040695734961071617210286172122611911388349415
ENST0000040155849321071617177766171791126162750629674
ENST0000040499241221071617177766171791122952429629674
ENST0000040695734961071617177766171791120312165629674
ENST0000040155849321071617129026171309730423236771836
ENST0000040499241221071617129026171309727212915771836
ENST0000040695734961071617129026171309724572651771836
ENST0000040155849321071617100916171022634063540892937
ENST0000040499241221071617100916171022630853219892937
ENST0000040695734961071617100916171022628212955892937

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST000004015584932107161753554617536568559564276
ENST000004049924122107161753554617536565346354276
ENST000004069573496107161753554617536562703714276
ENST0000040155849321071617291306172917510921136121136
ENST00000404992412210716172913061729175771815121136
ENST00000406957349610716172913061729175507551121136
ENST0000040155849321071617258076172592713681487213253
ENST0000040499241221071617258076172592710471166213253
ENST00000406957349610716172580761725927783902213253
ENST0000040155849321071617240136172414214881616253296
ENST0000040499241221071617240136172414211671295253296
ENST000004069573496107161724013617241429031031253296
ENST0000040155849321071617210286172122617761973349415
ENST0000040499241221071617210286172122614551652349415
ENST0000040695734961071617210286172122611911388349415
ENST0000040155849321071617177766171791126162750629674
ENST0000040499241221071617177766171791122952429629674
ENST0000040695734961071617177766171791120312165629674
ENST0000040155849321071617129026171309730423236771836
ENST0000040499241221071617129026171309727212915771836
ENST0000040695734961071617129026171309724572651771836
ENST0000040155849321071617100916171022634063540892937
ENST0000040499241221071617100916171022630853219892937
ENST0000040695734961071617100916171022628212955892937

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
O14980427611071ChainID=PRO_0000204705;Note=Exportin-1
O14980427611071ChainID=PRO_0000204705;Note=Exportin-1
O14980427611071ChainID=PRO_0000204705;Note=Exportin-1
O14980427646112DomainNote=Importin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00115
O14980427646112DomainNote=Importin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00115
O14980427646112DomainNote=Importin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00115
O1498042764055HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042764055HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042764055HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042766069HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042766069HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042766069HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042767390HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042767390HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042767390HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042761679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O1498042761679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O1498042761679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O1498042765759TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042765759TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042765759TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498012113611071ChainID=PRO_0000204705;Note=Exportin-1
O1498012113611071ChainID=PRO_0000204705;Note=Exportin-1
O1498012113611071ChainID=PRO_0000204705;Note=Exportin-1
O14980121136124141HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980121136124141HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980121136124141HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O149801211361679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O149801211361679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O149801211361679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O14980121136120123TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980121136120123TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980121136120123TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253243245Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253243245Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253243245Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498021325311071ChainID=PRO_0000204705;Note=Exportin-1
O1498021325311071ChainID=PRO_0000204705;Note=Exportin-1
O1498021325311071ChainID=PRO_0000204705;Note=Exportin-1
O14980213253202215HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253202215HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253202215HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253219235HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253219235HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253219235HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253239242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253239242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253239242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253246253HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253246253HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253246253HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O149802132531679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O149802132531679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O149802132531679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O14980213253217240RepeatNote=HEAT 1
O14980213253217240RepeatNote=HEAT 1
O14980213253217240RepeatNote=HEAT 1
O14980213253241277RepeatNote=HEAT 2
O14980213253241277RepeatNote=HEAT 2
O14980213253241277RepeatNote=HEAT 2
O14980253296255257Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296255257Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296255257Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498025329611071ChainID=PRO_0000204705;Note=Exportin-1
O1498025329611071ChainID=PRO_0000204705;Note=Exportin-1
O1498025329611071ChainID=PRO_0000204705;Note=Exportin-1
O14980253296246253HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296246253HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296246253HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296258273HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296258273HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296258273HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296277279HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296277279HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296277279HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296280297HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296280297HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296280297HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296284284MutagenesisNote=Does not abolish Rex-mediated mRNA export. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
O14980253296284284MutagenesisNote=Does not abolish Rex-mediated mRNA export. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
O14980253296284284MutagenesisNote=Does not abolish Rex-mediated mRNA export. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
O149802532961679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O149802532961679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O149802532961679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O14980253296241277RepeatNote=HEAT 2
O14980253296241277RepeatNote=HEAT 2
O14980253296241277RepeatNote=HEAT 2
O1498034941511071ChainID=PRO_0000204705;Note=Exportin-1
O1498034941511071ChainID=PRO_0000204705;Note=Exportin-1
O1498034941511071ChainID=PRO_0000204705;Note=Exportin-1
O14980349415344358HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980349415344358HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980349415344358HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980349415363383HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980349415363383HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980349415363383HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980349415404423HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980349415404423HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980349415404423HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980349415391391Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
O14980349415391391Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
O14980349415391391Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
O14980349415402402MutagenesisNote=Does not abolish Rex-mediated mRNA export. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
O14980349415402402MutagenesisNote=Does not abolish Rex-mediated mRNA export. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
O14980349415402402MutagenesisNote=Does not abolish Rex-mediated mRNA export. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
O14980349415411411MutagenesisNote=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with S-414. Abolishes Rex multimerization%3B when associated with S-414. P->T;Ontology_term=ECO:0000
O14980349415411411MutagenesisNote=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with S-414. Abolishes Rex multimerization%3B when associated with S-414. P->T;Ontology_term=ECO:0000
O14980349415411411MutagenesisNote=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with S-414. Abolishes Rex multimerization%3B when associated with S-414. P->T;Ontology_term=ECO:0000
O14980349415412412MutagenesisNote=Does not abolish interaction with Rex and RANBP3%2C and Rex-mediated mRNA export. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
O14980349415412412MutagenesisNote=Does not abolish interaction with Rex and RANBP3%2C and Rex-mediated mRNA export. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
O14980349415412412MutagenesisNote=Does not abolish interaction with Rex and RANBP3%2C and Rex-mediated mRNA export. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
O14980349415414414MutagenesisNote=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with T-411. Abolishes Rex multimerization%3B when associated with T-411. F->S;Ontology_term=ECO:0000
O14980349415414414MutagenesisNote=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with T-411. Abolishes Rex multimerization%3B when associated with T-411. F->S;Ontology_term=ECO:0000
O14980349415414414MutagenesisNote=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with T-411. Abolishes Rex multimerization%3B when associated with T-411. F->S;Ontology_term=ECO:0000
O149803494151679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O149803494151679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O149803494151679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O14980349415327450RegionNote=Interaction with Ran and nuclear export complex formation
O14980349415327450RegionNote=Interaction with Ran and nuclear export complex formation
O14980349415327450RegionNote=Interaction with Ran and nuclear export complex formation
O14980349415411481RegionNote=Interaction with RANBP3
O14980349415411481RegionNote=Interaction with RANBP3
O14980349415411481RegionNote=Interaction with RANBP3
O14980349415411414RegionNote=Necessary for HTLV-1 Rex multimerization
O14980349415411414RegionNote=Necessary for HTLV-1 Rex multimerization
O14980349415411414RegionNote=Necessary for HTLV-1 Rex multimerization
O14980349415354472RepeatNote=HEAT 3
O14980349415354472RepeatNote=HEAT 3
O14980349415354472RepeatNote=HEAT 3
O14980349415406406Sequence conflictNote=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O14980349415406406Sequence conflictNote=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O14980349415406406Sequence conflictNote=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O1498062967411071ChainID=PRO_0000204705;Note=Exportin-1
O1498062967411071ChainID=PRO_0000204705;Note=Exportin-1
O1498062967411071ChainID=PRO_0000204705;Note=Exportin-1
O14980629674627642HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980629674627642HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980629674627642HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980629674647657HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980629674647657HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980629674647657HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980629674659674HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980629674659674HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980629674659674HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O149806296741679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O149806296741679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O149806296741679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O14980629674602639RepeatNote=HEAT 6
O14980629674602639RepeatNote=HEAT 6
O14980629674602639RepeatNote=HEAT 6
O1498077183611071ChainID=PRO_0000204705;Note=Exportin-1
O1498077183611071ChainID=PRO_0000204705;Note=Exportin-1
O1498077183611071ChainID=PRO_0000204705;Note=Exportin-1
O14980771836769775HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836769775HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836769775HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836777789HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836777789HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836777789HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836793795HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836793795HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836793795HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836799811HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836799811HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836799811HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836812818HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836812818HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836812818HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836819834HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836819834HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836819834HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836800820RegionNote=Interaction with HIV-1 Rev
O14980771836800820RegionNote=Interaction with HIV-1 Rev
O14980771836800820RegionNote=Interaction with HIV-1 Rev
O14980771836775813RepeatNote=HEAT 7
O14980771836775813RepeatNote=HEAT 7
O14980771836775813RepeatNote=HEAT 7
O14980892937932934Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980892937932934Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980892937932934Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O1498089293711071ChainID=PRO_0000204705;Note=Exportin-1
O1498089293711071ChainID=PRO_0000204705;Note=Exportin-1
O1498089293711071ChainID=PRO_0000204705;Note=Exportin-1
O14980892937887906HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980892937887906HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980892937887906HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980892937908931HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980892937908931HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980892937908931HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980892937885916RepeatNote=HEAT 8
O14980892937885916RepeatNote=HEAT 8
O14980892937885916RepeatNote=HEAT 8
O14980892937917954RepeatNote=HEAT 9
O14980892937917954RepeatNote=HEAT 9
O14980892937917954RepeatNote=HEAT 9


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
O14980427611071ChainID=PRO_0000204705;Note=Exportin-1
O14980427611071ChainID=PRO_0000204705;Note=Exportin-1
O14980427611071ChainID=PRO_0000204705;Note=Exportin-1
O14980427646112DomainNote=Importin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00115
O14980427646112DomainNote=Importin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00115
O14980427646112DomainNote=Importin N-terminal;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00115
O1498042764055HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042764055HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042764055HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042766069HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042766069HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042766069HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042767390HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042767390HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042767390HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042761679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O1498042761679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O1498042761679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O1498042765759TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042765759TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498042765759TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498012113611071ChainID=PRO_0000204705;Note=Exportin-1
O1498012113611071ChainID=PRO_0000204705;Note=Exportin-1
O1498012113611071ChainID=PRO_0000204705;Note=Exportin-1
O14980121136124141HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980121136124141HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980121136124141HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O149801211361679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O149801211361679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O149801211361679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O14980121136120123TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980121136120123TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980121136120123TurnOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253243245Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253243245Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253243245Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498021325311071ChainID=PRO_0000204705;Note=Exportin-1
O1498021325311071ChainID=PRO_0000204705;Note=Exportin-1
O1498021325311071ChainID=PRO_0000204705;Note=Exportin-1
O14980213253202215HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253202215HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253202215HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253219235HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253219235HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253219235HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253239242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253239242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253239242HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253246253HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253246253HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980213253246253HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O149802132531679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O149802132531679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O149802132531679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O14980213253217240RepeatNote=HEAT 1
O14980213253217240RepeatNote=HEAT 1
O14980213253217240RepeatNote=HEAT 1
O14980213253241277RepeatNote=HEAT 2
O14980213253241277RepeatNote=HEAT 2
O14980213253241277RepeatNote=HEAT 2
O14980253296255257Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296255257Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296255257Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O1498025329611071ChainID=PRO_0000204705;Note=Exportin-1
O1498025329611071ChainID=PRO_0000204705;Note=Exportin-1
O1498025329611071ChainID=PRO_0000204705;Note=Exportin-1
O14980253296246253HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296246253HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296246253HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296258273HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296258273HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296258273HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296277279HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296277279HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296277279HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296280297HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296280297HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296280297HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980253296284284MutagenesisNote=Does not abolish Rex-mediated mRNA export. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
O14980253296284284MutagenesisNote=Does not abolish Rex-mediated mRNA export. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
O14980253296284284MutagenesisNote=Does not abolish Rex-mediated mRNA export. V->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
O149802532961679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O149802532961679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O149802532961679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O14980253296241277RepeatNote=HEAT 2
O14980253296241277RepeatNote=HEAT 2
O14980253296241277RepeatNote=HEAT 2
O1498034941511071ChainID=PRO_0000204705;Note=Exportin-1
O1498034941511071ChainID=PRO_0000204705;Note=Exportin-1
O1498034941511071ChainID=PRO_0000204705;Note=Exportin-1
O14980349415344358HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980349415344358HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980349415344358HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980349415363383HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980349415363383HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980349415363383HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980349415404423HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980349415404423HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980349415404423HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980349415391391Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
O14980349415391391Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
O14980349415391391Modified residueNote=Phosphoserine;Ontology_term=ECO:0000244,ECO:0000244;evidence=ECO:0000244|PubMed:20068231,ECO:0000244|PubMed:23186163;Dbxref=PMID:20068231,PMID:23186163
O14980349415402402MutagenesisNote=Does not abolish Rex-mediated mRNA export. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
O14980349415402402MutagenesisNote=Does not abolish Rex-mediated mRNA export. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
O14980349415402402MutagenesisNote=Does not abolish Rex-mediated mRNA export. V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
O14980349415411411MutagenesisNote=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with S-414. Abolishes Rex multimerization%3B when associated with S-414. P->T;Ontology_term=ECO:0000
O14980349415411411MutagenesisNote=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with S-414. Abolishes Rex multimerization%3B when associated with S-414. P->T;Ontology_term=ECO:0000
O14980349415411411MutagenesisNote=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with S-414. Abolishes Rex multimerization%3B when associated with S-414. P->T;Ontology_term=ECO:0000
O14980349415412412MutagenesisNote=Does not abolish interaction with Rex and RANBP3%2C and Rex-mediated mRNA export. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
O14980349415412412MutagenesisNote=Does not abolish interaction with Rex and RANBP3%2C and Rex-mediated mRNA export. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
O14980349415412412MutagenesisNote=Does not abolish interaction with Rex and RANBP3%2C and Rex-mediated mRNA export. M->V;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:14612415;Dbxref=PMID:14612415
O14980349415414414MutagenesisNote=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with T-411. Abolishes Rex multimerization%3B when associated with T-411. F->S;Ontology_term=ECO:0000
O14980349415414414MutagenesisNote=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with T-411. Abolishes Rex multimerization%3B when associated with T-411. F->S;Ontology_term=ECO:0000
O14980349415414414MutagenesisNote=Strongly abolishes interaction with Rex and RANBP3%2C abolishes Rex-mediated mRNA export. Does not abolish interaction with RANBP3%3B when associated with T-411. Abolishes Rex multimerization%3B when associated with T-411. F->S;Ontology_term=ECO:0000
O149803494151679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O149803494151679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O149803494151679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O14980349415327450RegionNote=Interaction with Ran and nuclear export complex formation
O14980349415327450RegionNote=Interaction with Ran and nuclear export complex formation
O14980349415327450RegionNote=Interaction with Ran and nuclear export complex formation
O14980349415411481RegionNote=Interaction with RANBP3
O14980349415411481RegionNote=Interaction with RANBP3
O14980349415411481RegionNote=Interaction with RANBP3
O14980349415411414RegionNote=Necessary for HTLV-1 Rex multimerization
O14980349415411414RegionNote=Necessary for HTLV-1 Rex multimerization
O14980349415411414RegionNote=Necessary for HTLV-1 Rex multimerization
O14980349415354472RepeatNote=HEAT 3
O14980349415354472RepeatNote=HEAT 3
O14980349415354472RepeatNote=HEAT 3
O14980349415406406Sequence conflictNote=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O14980349415406406Sequence conflictNote=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O14980349415406406Sequence conflictNote=R->G;Ontology_term=ECO:0000305;evidence=ECO:0000305
O1498062967411071ChainID=PRO_0000204705;Note=Exportin-1
O1498062967411071ChainID=PRO_0000204705;Note=Exportin-1
O1498062967411071ChainID=PRO_0000204705;Note=Exportin-1
O14980629674627642HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980629674627642HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980629674627642HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980629674647657HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980629674647657HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980629674647657HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980629674659674HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980629674659674HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O14980629674659674HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:5DIS
O149806296741679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O149806296741679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O149806296741679RegionNote=Necessary for HTLV-1 Rex-mediated mRNA export
O14980629674602639RepeatNote=HEAT 6
O14980629674602639RepeatNote=HEAT 6
O14980629674602639RepeatNote=HEAT 6
O1498077183611071ChainID=PRO_0000204705;Note=Exportin-1
O1498077183611071ChainID=PRO_0000204705;Note=Exportin-1
O1498077183611071ChainID=PRO_0000204705;Note=Exportin-1
O14980771836769775HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836769775HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836769775HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836777789HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836777789HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836777789HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836793795HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836793795HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836793795HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836799811HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836799811HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836799811HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836812818HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836812818HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836812818HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836819834HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836819834HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836819834HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980771836800820RegionNote=Interaction with HIV-1 Rev
O14980771836800820RegionNote=Interaction with HIV-1 Rev
O14980771836800820RegionNote=Interaction with HIV-1 Rev
O14980771836775813RepeatNote=HEAT 7
O14980771836775813RepeatNote=HEAT 7
O14980771836775813RepeatNote=HEAT 7
O14980892937932934Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980892937932934Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980892937932934Beta strandOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O1498089293711071ChainID=PRO_0000204705;Note=Exportin-1
O1498089293711071ChainID=PRO_0000204705;Note=Exportin-1
O1498089293711071ChainID=PRO_0000204705;Note=Exportin-1
O14980892937887906HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980892937887906HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980892937887906HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980892937908931HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980892937908931HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980892937908931HelixOntology_term=ECO:0000244;evidence=ECO:0000244|PDB:1W9C
O14980892937885916RepeatNote=HEAT 8
O14980892937885916RepeatNote=HEAT 8
O14980892937885916RepeatNote=HEAT 8
O14980892937917954RepeatNote=HEAT 9
O14980892937917954RepeatNote=HEAT 9
O14980892937917954RepeatNote=HEAT 9


Top

SNVs in the skipped exons for XPO1

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A39Y-01exon_skip_339470
61709515617096746170957361709573Frame_Shift_DelT-p.I972fs
LIHCTCGA-DD-A39Y-01exon_skip_339470
61709515617096746170963261709632Frame_Shift_DelA-p.L952fs
LIHCTCGA-DD-A3A0-01exon_skip_339471
61710092617102266171019661710196Frame_Shift_DelT-p.N903fs
LIHCTCGA-G3-A3CJ-01exon_skip_339482
61717777617179116171786661717866Frame_Shift_DelT-p.T645fs
LIHCTCGA-DD-A3A0-01exon_skip_339483
61720050617201886172011661720116Frame_Shift_DelC-p.V441fs
KIRCTCGA-DV-A4VX-01exon_skip_339486
61724014617241426172404161724041Frame_Shift_DelA-p.T288fs
LIHCTCGA-G3-A3CJ-01exon_skip_339488
61725808617259276172585561725855Frame_Shift_DelG-p.L238fs
LUADTCGA-44-7669-01exon_skip_339485
61721029617212266172108861721088Nonsense_MutationCAp.G396*
THYMTCGA-X7-A8M0-01exon_skip_339491
61726848617270296172684661726846Splice_SiteGT.

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
NB12_AUTONOMIC_GANGLIA61710092617102266171014661710146Frame_Shift_DelA-p.C920fs
MDAPCA2B_PROSTATE61708320617084166170839461708394Missense_MutationTAp.T999S
DAUDI_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61709515617096746170960661709606Missense_MutationAGp.S961P
JHH2_LIVER61710092617102266171016961710169Missense_MutationTCp.Q912R
HEC1_ENDOMETRIUM61712903617130976171293461712934Missense_MutationAGp.V826A
HEC1B_ENDOMETRIUM61712903617130976171293461712934Missense_MutationAGp.V826A
HCC2998_LARGE_INTESTINE61715723617159066171579461715794Missense_MutationCAp.R712I
RERFLCAD2_LUNG61715723617159066171585861715858Missense_MutationTCp.I691V
PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61720050617201886172013361720133Missense_MutationTCp.E434G
DMS114_LUNG61720050617201886172014661720146Missense_MutationCAp.V430L
NCIH2722_PLEURA61721029617212266172104661721046Missense_MutationACp.L410V
BICR22_UPPER_AERODIGESTIVE_TRACT61721029617212266172106661721066Missense_MutationGAp.P403L
HEC251_ENDOMETRIUM61721029617212266172119761721197Missense_MutationTGp.E359D
HN_UPPER_AERODIGESTIVE_TRACT61724014617241426172403761724037Missense_MutationGTp.L289M
TK_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61725808617259276172587961725879Missense_MutationGAp.L230F
SUDHL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61725808617259276172592261725922Missense_MutationACp.N215K
ESS1_ENDOMETRIUM61725808617259276172592561725925Missense_MutationTGp.E214D
NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61726848617270296172685561726855Missense_MutationTCp.K195E
EVSAT_BREAST61726848617270296172687461726874Missense_MutationTGp.Q188H
JHUEM7_ENDOMETRIUM61760907617610386176095461760954Missense_MutationACp.L27V
NCIH929_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE61760907617610386176102961761029Missense_MutationGCp.P2A
ASH3_THYROID61726848617270296172702061727020Nonsense_MutationGAp.Q140*

Top

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for XPO1

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value
exon_skip_339524261760906:61761038:61761692:61761813:61764696:6176472261761692:61761813ENST00000457483.1LUADrs9989775chr2:61761774A/G1.83e-03
exon_skip_339524261760906:61761038:61761692:61761813:61764696:6176472261761692:61761813ENST00000457483.1PCPGrs9989775chr2:61761774A/G1.43e-04

Top

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for XPO1


Top

Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for XPO1


Top

RelatedDrugs for XPO1

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for XPO1

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource