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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for WNT10B |
 Gene summary |
| Gene information | Gene symbol | WNT10B | Gene ID | 7480 |
| Gene name | Wnt family member 10B | |
| Synonyms | SHFM6|STHAG8|WNT-12 | |
| Cytomap | 12q13.12 | |
| Type of gene | protein-coding | |
| Description | protein Wnt-10bWNT-10B proteinwingless-type MMTV integration site family, member 10B | |
| Modification date | 20180527 | |
| UniProtAcc | O00744 | |
| Context | PubMed: WNT10B [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| WNT10B | GO:0045599 | negative regulation of fat cell differentiation | 10937998 |
| WNT10B | GO:0050821 | protein stabilization | 10937998 |
| WNT10B | GO:0060070 | canonical Wnt signaling pathway | 17761539 |
| WNT10B | GO:0071425 | hematopoietic stem cell proliferation | 9787155 |
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Exon skipping events across known transcript of Ensembl for WNT10B from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for WNT10B |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for WNT10B |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_91733 | 12 | 49359338:49360336:49361728:49361789:49361931:49362102 | 49361728:49361789 | ENSG00000169884.9 | ENST00000407467.1 |
| exon_skip_91735 | 12 | 49359338:49360336:49361728:49362102:49363871:49364134 | 49361728:49362102 | ENSG00000169884.9 | ENST00000301061.4 |
| exon_skip_91737 | 12 | 49361728:49361789:49361931:49362102:49363871:49364134 | 49361931:49362102 | ENSG00000169884.9 | ENST00000407467.1 |
| exon_skip_91740 | 12 | 49362078:49362102:49362892:49362927:49363871:49364134 | 49362892:49362927 | ENSG00000169884.9 | ENST00000413630.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for WNT10B |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_91733 | 12 | 49359338:49360336:49361728:49361789:49361931:49362102 | 49361728:49361789 | ENSG00000169884.9 | ENST00000407467.1 |
| exon_skip_91735 | 12 | 49359338:49360336:49361728:49362102:49363871:49364134 | 49361728:49362102 | ENSG00000169884.9 | ENST00000301061.4 |
| exon_skip_91737 | 12 | 49361728:49361789:49361931:49362102:49363871:49364134 | 49361931:49362102 | ENSG00000169884.9 | ENST00000407467.1 |
| exon_skip_91738 | 12 | 49361728:49361789:49361985:49362102:49363871:49364134 | 49361985:49362102 | ENSG00000169884.9 | ENST00000403957.1 |
| exon_skip_91740 | 12 | 49362078:49362102:49362892:49362927:49363871:49364134 | 49362892:49362927 | ENSG00000169884.9 | ENST00000413630.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for WNT10B |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000301061 | 49361728 | 49362102 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000301061 | 49361728 | 49362102 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for WNT10B |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for WNT10B |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| COAD | TCGA-CM-4750-01 | exon_skip_91733 | 49361729 | 49361789 | 49361758 | 49361758 | Nonsense_Mutation | G | A | p.R228X |
| COAD | TCGA-CM-4750-01 | exon_skip_91735 | 49361729 | 49362102 | 49361758 | 49361758 | Nonsense_Mutation | G | A | p.R228X |
| LUAD | TCGA-78-7150-01 | exon_skip_91735 | 49361729 | 49362102 | 49361889 | 49361889 | Nonsense_Mutation | G | C | p.S184* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| EN_ENDOMETRIUM | 49361729 | 49362102 | 49361917 | 49361917 | Frame_Shift_Del | G | - | p.H175fs |
| LN405_CENTRAL_NERVOUS_SYSTEM | 49361932 | 49362102 | 49361978 | 49361979 | Frame_Shift_Ins | - | TGCT | p.-154fs |
| LN405_CENTRAL_NERVOUS_SYSTEM | 49361729 | 49362102 | 49361978 | 49361979 | Frame_Shift_Ins | - | TGCT | p.-154fs |
| KOSC2_UPPER_AERODIGESTIVE_TRACT | 49361729 | 49361789 | 49361734 | 49361734 | Missense_Mutation | G | A | p.R236C |
| KOSC2_UPPER_AERODIGESTIVE_TRACT | 49361729 | 49362102 | 49361734 | 49361734 | Missense_Mutation | G | A | p.R236C |
| NB1_AUTONOMIC_GANGLIA | 49361729 | 49362102 | 49361871 | 49361871 | Missense_Mutation | G | C | p.P190R |
| RERFGC1B_STOMACH | 49361729 | 49362102 | 49361871 | 49361871 | Missense_Mutation | G | C | p.P190R |
| NCIN87_STOMACH | 49361729 | 49362102 | 49361884 | 49361884 | Missense_Mutation | G | A | p.P186S |
| MZ7MEL_SKIN | 49361932 | 49362102 | 49361973 | 49361973 | Missense_Mutation | C | T | p.R156Q |
| MZ7MEL_SKIN | 49361729 | 49362102 | 49361973 | 49361973 | Missense_Mutation | C | T | p.R156Q |
| WSUNHL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 49361932 | 49362102 | 49361973 | 49361973 | Missense_Mutation | C | T | p.R156Q |
| WSUNHL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 49361729 | 49362102 | 49361973 | 49361973 | Missense_Mutation | C | T | p.R156Q |
| HCC1569_BREAST | 49361932 | 49362102 | 49362084 | 49362084 | Missense_Mutation | A | G | p.F119S |
| HCC1569_BREAST | 49361729 | 49362102 | 49362084 | 49362084 | Missense_Mutation | A | G | p.F119S |
| HCT15_LARGE_INTESTINE | 49361729 | 49361789 | 49361758 | 49361758 | Nonsense_Mutation | G | A | p.R228* |
| HCT15_LARGE_INTESTINE | 49361729 | 49362102 | 49361758 | 49361758 | Nonsense_Mutation | G | A | p.R228* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for WNT10B |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for WNT10B |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for WNT10B |
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RelatedDrugs for WNT10B |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for WNT10B |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| WNT10B | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| WNT10B | C2749665 | SPLIT-HAND/FOOT MALFORMATION 6 (disorder) | 1 | CTD_human;UNIPROT |
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