ExonSkipDB: functional annotation of exon skipping event in human

Gene summary for TRAF5

Gene summary

Gene information	Gene symbol	TRAF5
	Gene ID	7188
	Gene name	TNF receptor associated factor 5
	Synonyms	MGC:39780\|RNF84
	Cytomap	1q32.3
	Type of gene	protein-coding
	Description	TNF receptor-associated factor 5RING finger protein 84
	Modification date	20180522
	UniProtAcc	O00463
	Context	PubMed: TRAF5 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID)

Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Gene

GO ID

GO term

PubMed ID

Top

Exon skipping events across known transcript of Ensembl for TRAF5 from UCSC genome browser

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Gene isoform structures and expression levels for TRAF5

Expression levels of gene isoforms across TCGA.

Expression levels of gene isoforms across GTEx.

Top

Exon skipping events with PSIs in TCGA for TRAF5

Information of exkip skipping event in TCGA.

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_17685	1	211500178:211500231:211526580:211526799:211527751:211527809	211526580:211526799	ENSG00000082512.10	ENST00000427925.2,ENST00000488428.1,ENST00000261464.5
exon_skip_17689	1	211527751:211527809:211529708:211529810:211533253:211533418	211529708:211529810	ENSG00000082512.10	ENST00000336184.2,ENST00000261464.5,ENST00000367004.3
exon_skip_17693	1	211529708:211529810:211533223:211533418:211534043:211534121	211533223:211533418	ENSG00000082512.10	ENST00000488428.1
exon_skip_17694	1	211529708:211529810:211533253:211533418:211534043:211534121	211533253:211533418	ENSG00000082512.10	ENST00000336184.2,ENST00000261464.5,ENST00000367004.3
exon_skip_17703	1	211534043:211534121:211534429:211534504:211538717:211538810	211534429:211534504	ENSG00000082512.10	ENST00000336184.2,ENST00000462410.1,ENST00000261464.5,ENST00000367004.3
exon_skip_17706	1	211534429:211534504:211538717:211538810:211542793:211542934	211538717:211538810	ENSG00000082512.10	ENST00000336184.2,ENST00000261464.5,ENST00000367004.3
exon_skip_17717	1	211538717:211538810:211542793:211542934:211544643:211544812	211542793:211542934	ENSG00000082512.10	ENST00000427925.2,ENST00000336184.2,ENST00000261464.5,ENST00000367004.3
exon_skip_17720	1	211542793:211542934:211544643:211544812:211545469:211546137	211544643:211544812	ENSG00000082512.10	ENST00000427925.2,ENST00000336184.2,ENST00000473385.1,ENST00000261464.5,ENST00000367004.3

PSI values of skipped exons in TCGA.

Top

Exon skipping events with PSIs in GTEx for TRAF5

Information of exkip skipping event in GTEx

Exon skip ID	chr	Exons involved in exon skipping	Skipped exon	ENSG	ENSTs
exon_skip_17685	1	211500178:211500231:211526580:211526799:211527751:211527809	211526580:211526799	ENSG00000082512.10	ENST00000488428.1,ENST00000427925.2,ENST00000261464.5
exon_skip_17689	1	211527751:211527809:211529708:211529810:211533253:211533418	211529708:211529810	ENSG00000082512.10	ENST00000336184.2,ENST00000261464.5,ENST00000367004.3
exon_skip_17693	1	211529708:211529810:211533223:211533418:211534043:211534121	211533223:211533418	ENSG00000082512.10	ENST00000488428.1
exon_skip_17694	1	211529708:211529810:211533253:211533418:211534043:211534121	211533253:211533418	ENSG00000082512.10	ENST00000336184.2,ENST00000261464.5,ENST00000367004.3
exon_skip_17703	1	211534043:211534121:211534429:211534504:211538717:211538810	211534429:211534504	ENSG00000082512.10	ENST00000462410.1,ENST00000336184.2,ENST00000261464.5,ENST00000367004.3
exon_skip_17706	1	211534429:211534504:211538717:211538810:211542793:211542934	211538717:211538810	ENSG00000082512.10	ENST00000336184.2,ENST00000261464.5,ENST00000367004.3
exon_skip_17717	1	211538717:211538810:211542793:211542934:211544643:211544812	211542793:211542934	ENSG00000082512.10	ENST00000336184.2,ENST00000427925.2,ENST00000261464.5,ENST00000367004.3
exon_skip_17720	1	211542793:211542934:211544643:211544812:211545469:211546137	211544643:211544812	ENSG00000082512.10	ENST00000336184.2,ENST00000427925.2,ENST00000261464.5,ENST00000367004.3,ENST00000473385.1

PSI values of skipped exons in GTEx.

* Skipped exon sequences.

Top

Open reading frame (ORF) annotation in the exon skipping event for TRAF5

Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000261464	211526580	211526799	5CDS-5UTR
ENST00000261464	211544643	211544812	Frame-shift
ENST00000336184	211544643	211544812	Frame-shift
ENST00000367004	211544643	211544812	Frame-shift
ENST00000261464	211529708	211529810	In-frame
ENST00000336184	211529708	211529810	In-frame
ENST00000367004	211529708	211529810	In-frame
ENST00000261464	211533253	211533418	In-frame
ENST00000336184	211533253	211533418	In-frame
ENST00000367004	211533253	211533418	In-frame
ENST00000261464	211534429	211534504	In-frame
ENST00000336184	211534429	211534504	In-frame
ENST00000367004	211534429	211534504	In-frame
ENST00000261464	211538717	211538810	In-frame
ENST00000336184	211538717	211538810	In-frame
ENST00000367004	211538717	211538810	In-frame
ENST00000261464	211542793	211542934	In-frame
ENST00000336184	211542793	211542934	In-frame
ENST00000367004	211542793	211542934	In-frame

Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.

ENST	Start of skipped exon	End of skipped exon	ORF
ENST00000261464	211526580	211526799	5CDS-5UTR
ENST00000261464	211544643	211544812	Frame-shift
ENST00000336184	211544643	211544812	Frame-shift
ENST00000367004	211544643	211544812	Frame-shift
ENST00000261464	211529708	211529810	In-frame
ENST00000336184	211529708	211529810	In-frame
ENST00000367004	211529708	211529810	In-frame
ENST00000261464	211533253	211533418	In-frame
ENST00000336184	211533253	211533418	In-frame
ENST00000367004	211533253	211533418	In-frame
ENST00000261464	211534429	211534504	In-frame
ENST00000336184	211534429	211534504	In-frame
ENST00000367004	211534429	211534504	In-frame
ENST00000261464	211538717	211538810	In-frame
ENST00000336184	211538717	211538810	In-frame
ENST00000367004	211538717	211538810	In-frame
ENST00000261464	211542793	211542934	In-frame
ENST00000336184	211542793	211542934	In-frame
ENST00000367004	211542793	211542934	In-frame

Top

Infer the effects of exon skipping event on protein functional features for TRAF5

Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.

Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000261464	3989	557	211529708	211529810	331	432	92	126
ENST00000336184	3989	557	211529708	211529810	337	438	92	126
ENST00000367004	1844	557	211529708	211529810	337	438	92	126
ENST00000261464	3989	557	211533253	211533418	433	597	126	181
ENST00000336184	3989	557	211533253	211533418	439	603	126	181
ENST00000367004	1844	557	211533253	211533418	439	603	126	181
ENST00000261464	3989	557	211534429	211534504	676	750	207	232
ENST00000336184	3989	557	211534429	211534504	682	756	207	232
ENST00000367004	1844	557	211534429	211534504	682	756	207	232
ENST00000261464	3989	557	211538717	211538810	751	843	232	263
ENST00000336184	3989	557	211538717	211538810	757	849	232	263
ENST00000367004	1844	557	211538717	211538810	757	849	232	263
ENST00000261464	3989	557	211542793	211542934	844	984	263	310
ENST00000336184	3989	557	211542793	211542934	850	990	263	310
ENST00000367004	1844	557	211542793	211542934	850	990	263	310

Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.

ENST	Length of mRNA	Length of AA seq.	Genomic start	Genomic end	mRNA start	mRNA end	AA start	AA end
ENST00000261464	3989	557	211529708	211529810	331	432	92	126
ENST00000336184	3989	557	211529708	211529810	337	438	92	126
ENST00000367004	1844	557	211529708	211529810	337	438	92	126
ENST00000261464	3989	557	211533253	211533418	433	597	126	181
ENST00000336184	3989	557	211533253	211533418	439	603	126	181
ENST00000367004	1844	557	211533253	211533418	439	603	126	181
ENST00000261464	3989	557	211534429	211534504	676	750	207	232
ENST00000336184	3989	557	211534429	211534504	682	756	207	232
ENST00000367004	1844	557	211534429	211534504	682	756	207	232
ENST00000261464	3989	557	211538717	211538810	751	843	232	263
ENST00000336184	3989	557	211538717	211538810	757	849	232	263
ENST00000367004	1844	557	211538717	211538810	757	849	232	263
ENST00000261464	3989	557	211542793	211542934	844	984	263	310
ENST00000336184	3989	557	211542793	211542934	850	990	263	310
ENST00000367004	1844	557	211542793	211542934	850	990	263	310

Lost protein functional features of individual exon skipping events in TCGA.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O00463	92	126	126	126	Alternative sequence	ID=VSP_055449;Note=In isoform 2. Q->QQVPLACCYLLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	92	126	126	126	Alternative sequence	ID=VSP_055449;Note=In isoform 2. Q->QQVPLACCYLLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	92	126	126	126	Alternative sequence	ID=VSP_055449;Note=In isoform 2. Q->QQVPLACCYLLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	92	126	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	92	126	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	92	126	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	92	126	120	120	Natural variant	ID=VAR_052151;Note=V->G;Dbxref=dbSNP:rs3946808
O00463	92	126	120	120	Natural variant	ID=VAR_052151;Note=V->G;Dbxref=dbSNP:rs3946808
O00463	92	126	120	120	Natural variant	ID=VAR_052151;Note=V->G;Dbxref=dbSNP:rs3946808
O00463	126	181	126	126	Alternative sequence	ID=VSP_055449;Note=In isoform 2. Q->QQVPLACCYLLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	126	181	126	126	Alternative sequence	ID=VSP_055449;Note=In isoform 2. Q->QQVPLACCYLLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	126	181	126	126	Alternative sequence	ID=VSP_055449;Note=In isoform 2. Q->QQVPLACCYLLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	126	181	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	126	181	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	126	181	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	126	181	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	126	181	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	126	181	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	126	181	127	181	Zinc finger	Note=TRAF-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00207
O00463	126	181	127	181	Zinc finger	Note=TRAF-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00207
O00463	126	181	127	181	Zinc finger	Note=TRAF-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00207
O00463	207	232	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	207	232	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	207	232	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	207	232	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	207	232	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	207	232	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	207	232	182	239	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00207
O00463	207	232	182	239	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00207
O00463	207	232	182	239	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00207
O00463	232	263	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	232	263	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	232	263	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	232	263	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	232	263	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	232	263	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	232	263	237	342	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O00463	232	263	237	342	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O00463	232	263	237	342	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O00463	232	263	182	239	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00207
O00463	232	263	182	239	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00207
O00463	232	263	182	239	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00207
O00463	263	310	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	263	310	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	263	310	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	263	310	237	342	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O00463	263	310	237	342	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O00463	263	310	237	342	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O00463	263	310	268	268	Natural variant	ID=VAR_071060;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14702039;Dbxref=dbSNP:rs200398415,PMID:14702039
O00463	263	310	268	268	Natural variant	ID=VAR_071060;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14702039;Dbxref=dbSNP:rs200398415,PMID:14702039
O00463	263	310	268	268	Natural variant	ID=VAR_071060;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14702039;Dbxref=dbSNP:rs200398415,PMID:14702039

Lost protein functional features of individual exon skipping events in GTEx.

UniProt acc.	Start of exon skipping (AA)	End of exon skipping (AA)	Protein feature start (AA)	Protein feature end (AA)	Category of protein feature	Description of feature
O00463	92	126	126	126	Alternative sequence	ID=VSP_055449;Note=In isoform 2. Q->QQVPLACCYLLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	92	126	126	126	Alternative sequence	ID=VSP_055449;Note=In isoform 2. Q->QQVPLACCYLLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	92	126	126	126	Alternative sequence	ID=VSP_055449;Note=In isoform 2. Q->QQVPLACCYLLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	92	126	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	92	126	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	92	126	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	92	126	120	120	Natural variant	ID=VAR_052151;Note=V->G;Dbxref=dbSNP:rs3946808
O00463	92	126	120	120	Natural variant	ID=VAR_052151;Note=V->G;Dbxref=dbSNP:rs3946808
O00463	92	126	120	120	Natural variant	ID=VAR_052151;Note=V->G;Dbxref=dbSNP:rs3946808
O00463	126	181	126	126	Alternative sequence	ID=VSP_055449;Note=In isoform 2. Q->QQVPLACCYLLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	126	181	126	126	Alternative sequence	ID=VSP_055449;Note=In isoform 2. Q->QQVPLACCYLLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	126	181	126	126	Alternative sequence	ID=VSP_055449;Note=In isoform 2. Q->QQVPLACCYLLQ;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	126	181	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	126	181	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	126	181	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	126	181	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	126	181	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	126	181	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	126	181	127	181	Zinc finger	Note=TRAF-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00207
O00463	126	181	127	181	Zinc finger	Note=TRAF-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00207
O00463	126	181	127	181	Zinc finger	Note=TRAF-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00207
O00463	207	232	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	207	232	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	207	232	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	207	232	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	207	232	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	207	232	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	207	232	182	239	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00207
O00463	207	232	182	239	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00207
O00463	207	232	182	239	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00207
O00463	232	263	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	232	263	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	232	263	127	232	Alternative sequence	ID=VSP_055450;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
O00463	232	263	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	232	263	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	232	263	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	232	263	237	342	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O00463	232	263	237	342	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O00463	232	263	237	342	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O00463	232	263	182	239	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00207
O00463	232	263	182	239	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00207
O00463	232	263	182	239	Zinc finger	Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00207
O00463	263	310	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	263	310	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	263	310	1	557	Chain	ID=PRO_0000056405;Note=TNF receptor-associated factor 5
O00463	263	310	237	342	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O00463	263	310	237	342	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O00463	263	310	237	342	Coiled coil	Ontology_term=ECO:0000255;evidence=ECO:0000255
O00463	263	310	268	268	Natural variant	ID=VAR_071060;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14702039;Dbxref=dbSNP:rs200398415,PMID:14702039
O00463	263	310	268	268	Natural variant	ID=VAR_071060;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14702039;Dbxref=dbSNP:rs200398415,PMID:14702039
O00463	263	310	268	268	Natural variant	ID=VAR_071060;Note=H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269\|PubMed:14702039;Dbxref=dbSNP:rs200398415,PMID:14702039

Top

SNVs in the skipped exons for TRAF5

- Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.

- Differential PSIs between mutated versus non-mutated samples.

- Non-synonymous mutations located in the skipped exons in TCGA.

Cancer type	Sample	ESID	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
LIHC	TCGA-DD-A3A0-01	exon_skip_17685	211526581	211526799	211526743	211526743	Frame_Shift_Del	C	-	p.N54fs
LIHC	TCGA-DD-A1EG-01	exon_skip_17693 exon_skip_17694	211533224	211533418	211533372	211533372	Frame_Shift_Del	A	-	p.E166fs
LIHC	TCGA-DD-A1EG-01	exon_skip_17693 exon_skip_17694	211533254	211533418	211533372	211533372	Frame_Shift_Del	A	-	p.E166fs
LIHC	TCGA-DD-A39Y-01	exon_skip_17693 exon_skip_17694	211533224	211533418	211533372	211533372	Frame_Shift_Del	A	-	p.E166fs
LIHC	TCGA-DD-A39Y-01	exon_skip_17693 exon_skip_17694	211533254	211533418	211533372	211533372	Frame_Shift_Del	A	-	p.E166fs
LIHC	TCGA-DD-A39Y-01	exon_skip_17703	211534430	211534504	211534477	211534477	Frame_Shift_Del	T	-	p.P223fs
LUAD	TCGA-69-7760-01	exon_skip_17685	211526581	211526799	211526711	211526711	Nonsense_Mutation	A	T	p.K44*
LUSC	TCGA-34-5231-01	exon_skip_17693 exon_skip_17694	211533224	211533418	211533358	211533358	Nonsense_Mutation	T	A	p.C172*
LUSC	TCGA-34-5231-01	exon_skip_17693 exon_skip_17694	211533254	211533418	211533358	211533358	Nonsense_Mutation	T	A	p.C172*
CHOL	TCGA-W5-AA2H-01	exon_skip_17693 exon_skip_17694	211533224	211533418	211533365	211533365	Nonsense_Mutation	C	T	p.R164X
CHOL	TCGA-W5-AA2H-01	exon_skip_17693 exon_skip_17694	211533254	211533418	211533365	211533365	Nonsense_Mutation	C	T	p.R164X
COAD	TCGA-AA-3510-01	exon_skip_17693 exon_skip_17694	211533224	211533418	211533365	211533365	Nonsense_Mutation	C	T	p.R164X
COAD	TCGA-AA-3510-01	exon_skip_17693 exon_skip_17694	211533254	211533418	211533365	211533365	Nonsense_Mutation	C	T	p.R164X
UCEC	TCGA-AP-A056-01	exon_skip_17693 exon_skip_17694	211533224	211533418	211533365	211533365	Nonsense_Mutation	C	T	p.R164*
UCEC	TCGA-AP-A056-01	exon_skip_17693 exon_skip_17694	211533254	211533418	211533365	211533365	Nonsense_Mutation	C	T	p.R164*
SKCM	TCGA-ER-A19M-06	exon_skip_17706	211538718	211538810	211538796	211538796	Nonsense_Mutation	C	T	p.Q259*
SKCM	TCGA-ER-A19M-06	exon_skip_17706	211538718	211538810	211538796	211538796	Nonsense_Mutation	C	T	p.Q259X

- Depth of coverage in the three exons composing exon skipping event

Depth of coverage in three exons

Mutation description

- Non-synonymous mutations located in the skipped exons in CCLE.

Sample	Skipped exon start	Skipped exon end	Mutation start	Mutation end	Mutation type	Reference seq	Mutation seq	AAchange
OCIM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	211538718	211538810	211538806	211538806	Frame_Shift_Del	A	-	p.E262fs
TTC442_SOFT_TISSUE	211526581	211526799	211526706	211526706	Missense_Mutation	G	A	p.R42H
TE14_OESOPHAGUS	211526581	211526799	211526730	211526730	Missense_Mutation	C	T	p.S50L
KYSE410_OESOPHAGUS	211526581	211526799	211526775	211526775	Missense_Mutation	G	C	p.C65S
DERL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	211529709	211529810	211529718	211529718	Missense_Mutation	G	T	p.D96Y
MS1_SKIN	211529709	211529810	211529751	211529751	Missense_Mutation	T	C	p.Y107H
MS1_LUNG	211529709	211529810	211529751	211529751	Missense_Mutation	T	C	p.Y107H
NCIH1836_LUNG	211529709	211529810	211529752	211529752	Missense_Mutation	A	G	p.Y107C
L33_PANCREAS	211529709	211529810	211529764	211529764	Missense_Mutation	G	T	p.S111I
NCIH2172_LUNG	211529709	211529810	211529779	211529779	Missense_Mutation	G	A	p.C116Y
OCIM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	211534430	211534504	211534465	211534465	Missense_Mutation	G	T	p.E219D
EFO21_OVARY	211534430	211534504	211534497	211534497	Missense_Mutation	C	T	p.A230V
JHUEM7_ENDOMETRIUM	211538718	211538810	211538722	211538722	Missense_Mutation	A	C	p.K234T
SNU1040_LARGE_INTESTINE	211538718	211538810	211538772	211538772	Missense_Mutation	C	T	p.R251C
HDLM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE	211538718	211538810	211538776	211538776	Missense_Mutation	T	C	p.L252S
JHUEM7_ENDOMETRIUM	211538718	211538810	211538789	211538789	Missense_Mutation	G	T	p.K256N
JHH2_LIVER	211542794	211542934	211542802	211542802	Missense_Mutation	C	G	p.D266E
NCIH1339_LUNG	211542794	211542934	211542805	211542805	Missense_Mutation	A	T	p.L267F
CAL39_VULVA	211542794	211542934	211542855	211542855	Missense_Mutation	C	G	p.T284S
SW156_KIDNEY	211542794	211542934	211542867	211542867	Missense_Mutation	T	C	p.L288P
HCC2998_LARGE_INTESTINE	211544644	211544812	211544791	211544791	Missense_Mutation	G	A	p.E360K
JHUEM7_ENDOMETRIUM	211533224	211533418	211533365	211533365	Nonsense_Mutation	C	T	p.R164*
JHUEM7_ENDOMETRIUM	211533254	211533418	211533365	211533365	Nonsense_Mutation	C	T	p.R164*
CW2_LARGE_INTESTINE	211544644	211544812	211544722	211544722	Nonsense_Mutation	C	T	p.Q337*
SNU466_CENTRAL_NERVOUS_SYSTEM	211542794	211542934	211542794	211542794	Splice_Site	A	T	p.I264F

Top

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRAF5

sQTL information located at the skipped exons.

Exon skip ID

Chromosome

Three exons

Skippped exon

ENST

Cancer type

SNP id

Location

DNA change (ref/var)

P-value

Top

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRAF5

Top

Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRAF5

Top

RelatedDrugs for TRAF5

Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

RelatedDiseases for TRAF5

Diseases associated with this gene.
(DisGeNet 4.0)

Gene

Disease ID

Disease name

# pubmeds

Source

	Gene summary
	Gene structures and expression levels
	Exon skipping events with PSIs in TCGA
	Exon skipping events with PSIs in GTEx
	Open reading frame (ORF) annotation in the exon skipping event
	Exon skipping events in the canonical protein sequence
	SNVs in the skipped exons with depth of coverage
	Splicing Quantitative Trait Loci (sQTLs) in the skipped exons
	Splicing Quantitative Trait Methylation (sQTM) in the skipped exon
	Related drugs with this gene
	Related diseases with this gene

Home

Download

Statistics

Landscape

Help

Contact

Gene summary for TRAF5

Exon skipping events across known transcript of Ensembl for TRAF5 from UCSC genome browser

Gene isoform structures and expression levels for TRAF5

Exon skipping events with PSIs in TCGA for TRAF5

Exon skipping events with PSIs in GTEx for TRAF5

Open reading frame (ORF) annotation in the exon skipping event for TRAF5

Infer the effects of exon skipping event on protein functional features for TRAF5

SNVs in the skipped exons for TRAF5

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRAF5

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRAF5

Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRAF5

RelatedDrugs for TRAF5

RelatedDiseases for TRAF5