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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TRAF3 |
 Gene summary |
| Gene information | Gene symbol | TRAF3 | Gene ID | 7187 |
| Gene name | TNF receptor associated factor 3 | |
| Synonyms | CAP-1|CAP1|CD40bp|CRAF1|IIAE5|LAP1|RNF118 | |
| Cytomap | 14q32.32 | |
| Type of gene | protein-coding | |
| Description | TNF receptor-associated factor 3CD40 associated protein 1CD40 binding proteinCD40 receptor associated factor 1LMP1-associated protein 1RING-type E3 ubiquitin transferase TRAF3 | |
| Modification date | 20180527 | |
| UniProtAcc | Q13114 | |
| Context | PubMed: TRAF3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for TRAF3 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TRAF3 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TRAF3 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_110231 | 14 | 103243954:103244012:103296670:103296809:103336521:103336783 | 103296670:103296809 | ENSG00000131323.10 | ENST00000347662.4,ENST00000392745.2 |
| exon_skip_110233 | 14 | 103342694:103342862:103352525:103352606:103355896:103355971 | 103352525:103352606 | ENSG00000131323.10 | ENST00000560371.1,ENST00000558700.1,ENST00000392745.2 |
| exon_skip_110234 | 14 | 103342694:103342862:103352525:103352606:103357661:103357754 | 103352525:103352606 | ENSG00000131323.10 | ENST00000351691.5,ENST00000347662.4 |
| exon_skip_110238 | 14 | 103342694:103342862:103357661:103357754:103363597:103363644 | 103357661:103357754 | ENSG00000131323.10 | ENST00000559734.1 |
| exon_skip_110240 | 14 | 103342694:103342862:103363597:103363738:103369591:103369766 | 103363597:103363738 | ENSG00000131323.10 | ENST00000539721.1 |
| exon_skip_110241 | 14 | 103352525:103352606:103355896:103355971:103357661:103357754 | 103355896:103355971 | ENSG00000131323.10 | ENST00000560371.1,ENST00000558700.1,ENST00000392745.2 |
| exon_skip_110242 | 14 | 103352525:103352606:103357661:103357754:103363597:103363644 | 103357661:103357754 | ENSG00000131323.10 | ENST00000351691.5,ENST00000347662.4 |
| exon_skip_110245 | 14 | 103357661:103357754:103361409:103361536:103363597:103363644 | 103361409:103361536 | ENSG00000131323.10 | ENST00000558700.1 |
| exon_skip_110249 | 14 | 103357661:103357754:103363597:103363738:103369591:103369766 | 103363597:103363738 | ENSG00000131323.10 | ENST00000351691.5,ENST00000560371.1,ENST00000347662.4,ENST00000559734.1,ENST00000392745.2 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TRAF3 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_110231 | 14 | 103243954:103244012:103296670:103296809:103336521:103336783 | 103296670:103296809 | ENSG00000131323.10 | ENST00000347662.4,ENST00000392745.2 |
| exon_skip_110233 | 14 | 103342694:103342862:103352525:103352606:103355896:103355971 | 103352525:103352606 | ENSG00000131323.10 | ENST00000560371.1,ENST00000392745.2,ENST00000558700.1 |
| exon_skip_110234 | 14 | 103342694:103342862:103352525:103352606:103357661:103357754 | 103352525:103352606 | ENSG00000131323.10 | ENST00000347662.4,ENST00000351691.5 |
| exon_skip_110238 | 14 | 103342694:103342862:103357661:103357754:103363597:103363644 | 103357661:103357754 | ENSG00000131323.10 | ENST00000559734.1 |
| exon_skip_110240 | 14 | 103342694:103342862:103363597:103363738:103369591:103369766 | 103363597:103363738 | ENSG00000131323.10 | ENST00000539721.1 |
| exon_skip_110241 | 14 | 103352525:103352606:103355896:103355971:103357661:103357754 | 103355896:103355971 | ENSG00000131323.10 | ENST00000560371.1,ENST00000392745.2,ENST00000558700.1 |
| exon_skip_110242 | 14 | 103352525:103352606:103357661:103357754:103363597:103363644 | 103357661:103357754 | ENSG00000131323.10 | ENST00000347662.4,ENST00000351691.5 |
| exon_skip_110245 | 14 | 103357661:103357754:103361409:103361536:103363597:103363644 | 103361409:103361536 | ENSG00000131323.10 | ENST00000558700.1 |
| exon_skip_110249 | 14 | 103357661:103357754:103363597:103363738:103369591:103369766 | 103363597:103363738 | ENSG00000131323.10 | ENST00000560371.1,ENST00000347662.4,ENST00000392745.2,ENST00000351691.5,ENST00000559734.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TRAF3 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000392745 | 103296670 | 103296809 | 5UTR-5UTR |
| ENST00000392745 | 103352525 | 103352606 | In-frame |
| ENST00000560371 | 103352525 | 103352606 | In-frame |
| ENST00000392745 | 103355896 | 103355971 | In-frame |
| ENST00000560371 | 103355896 | 103355971 | In-frame |
| ENST00000392745 | 103363597 | 103363738 | In-frame |
| ENST00000560371 | 103363597 | 103363738 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000392745 | 103296670 | 103296809 | 5UTR-5UTR |
| ENST00000392745 | 103352525 | 103352606 | In-frame |
| ENST00000560371 | 103352525 | 103352606 | In-frame |
| ENST00000392745 | 103355896 | 103355971 | In-frame |
| ENST00000560371 | 103355896 | 103355971 | In-frame |
| ENST00000392745 | 103363597 | 103363738 | In-frame |
| ENST00000560371 | 103363597 | 103363738 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TRAF3 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000392745 | 2476 | 568 | 103352525 | 103352606 | 846 | 926 | 190 | 217 |
| ENST00000560371 | 7657 | 568 | 103352525 | 103352606 | 788 | 868 | 190 | 217 |
| ENST00000392745 | 2476 | 568 | 103355896 | 103355971 | 927 | 1001 | 217 | 242 |
| ENST00000560371 | 7657 | 568 | 103355896 | 103355971 | 869 | 943 | 217 | 242 |
| ENST00000392745 | 2476 | 568 | 103363597 | 103363738 | 1095 | 1235 | 273 | 320 |
| ENST00000560371 | 7657 | 568 | 103363597 | 103363738 | 1037 | 1177 | 273 | 320 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000392745 | 2476 | 568 | 103352525 | 103352606 | 846 | 926 | 190 | 217 |
| ENST00000560371 | 7657 | 568 | 103352525 | 103352606 | 788 | 868 | 190 | 217 |
| ENST00000392745 | 2476 | 568 | 103355896 | 103355971 | 927 | 1001 | 217 | 242 |
| ENST00000560371 | 7657 | 568 | 103355896 | 103355971 | 869 | 943 | 217 | 242 |
| ENST00000392745 | 2476 | 568 | 103363597 | 103363738 | 1095 | 1235 | 273 | 320 |
| ENST00000560371 | 7657 | 568 | 103363597 | 103363738 | 1037 | 1177 | 273 | 320 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13114 | 190 | 217 | 191 | 273 | Alternative sequence | ID=VSP_040040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q13114 | 190 | 217 | 191 | 273 | Alternative sequence | ID=VSP_040040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q13114 | 190 | 217 | 1 | 568 | Chain | ID=PRO_0000056401;Note=TNF receptor-associated factor 3 |
| Q13114 | 190 | 217 | 1 | 568 | Chain | ID=PRO_0000056401;Note=TNF receptor-associated factor 3 |
| Q13114 | 190 | 217 | 135 | 190 | Zinc finger | Note=TRAF-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207 |
| Q13114 | 190 | 217 | 135 | 190 | Zinc finger | Note=TRAF-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207 |
| Q13114 | 190 | 217 | 191 | 249 | Zinc finger | Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207 |
| Q13114 | 190 | 217 | 191 | 249 | Zinc finger | Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207 |
| Q13114 | 217 | 242 | 191 | 273 | Alternative sequence | ID=VSP_040040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q13114 | 217 | 242 | 191 | 273 | Alternative sequence | ID=VSP_040040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q13114 | 217 | 242 | 1 | 568 | Chain | ID=PRO_0000056401;Note=TNF receptor-associated factor 3 |
| Q13114 | 217 | 242 | 1 | 568 | Chain | ID=PRO_0000056401;Note=TNF receptor-associated factor 3 |
| Q13114 | 217 | 242 | 218 | 242 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q13114 | 217 | 242 | 218 | 242 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q13114 | 217 | 242 | 191 | 249 | Zinc finger | Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207 |
| Q13114 | 217 | 242 | 191 | 249 | Zinc finger | Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207 |
| Q13114 | 273 | 320 | 191 | 273 | Alternative sequence | ID=VSP_040040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q13114 | 273 | 320 | 191 | 273 | Alternative sequence | ID=VSP_040040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q13114 | 273 | 320 | 1 | 568 | Chain | ID=PRO_0000056401;Note=TNF receptor-associated factor 3 |
| Q13114 | 273 | 320 | 1 | 568 | Chain | ID=PRO_0000056401;Note=TNF receptor-associated factor 3 |
| Q13114 | 273 | 320 | 267 | 338 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q13114 | 273 | 320 | 267 | 338 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q13114 | 190 | 217 | 191 | 273 | Alternative sequence | ID=VSP_040040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q13114 | 190 | 217 | 191 | 273 | Alternative sequence | ID=VSP_040040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q13114 | 190 | 217 | 1 | 568 | Chain | ID=PRO_0000056401;Note=TNF receptor-associated factor 3 |
| Q13114 | 190 | 217 | 1 | 568 | Chain | ID=PRO_0000056401;Note=TNF receptor-associated factor 3 |
| Q13114 | 190 | 217 | 135 | 190 | Zinc finger | Note=TRAF-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207 |
| Q13114 | 190 | 217 | 135 | 190 | Zinc finger | Note=TRAF-type 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207 |
| Q13114 | 190 | 217 | 191 | 249 | Zinc finger | Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207 |
| Q13114 | 190 | 217 | 191 | 249 | Zinc finger | Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207 |
| Q13114 | 217 | 242 | 191 | 273 | Alternative sequence | ID=VSP_040040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q13114 | 217 | 242 | 191 | 273 | Alternative sequence | ID=VSP_040040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q13114 | 217 | 242 | 1 | 568 | Chain | ID=PRO_0000056401;Note=TNF receptor-associated factor 3 |
| Q13114 | 217 | 242 | 1 | 568 | Chain | ID=PRO_0000056401;Note=TNF receptor-associated factor 3 |
| Q13114 | 217 | 242 | 218 | 242 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q13114 | 217 | 242 | 218 | 242 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Q13114 | 217 | 242 | 191 | 249 | Zinc finger | Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207 |
| Q13114 | 217 | 242 | 191 | 249 | Zinc finger | Note=TRAF-type 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00207 |
| Q13114 | 273 | 320 | 191 | 273 | Alternative sequence | ID=VSP_040040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q13114 | 273 | 320 | 191 | 273 | Alternative sequence | ID=VSP_040040;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 |
| Q13114 | 273 | 320 | 1 | 568 | Chain | ID=PRO_0000056401;Note=TNF receptor-associated factor 3 |
| Q13114 | 273 | 320 | 1 | 568 | Chain | ID=PRO_0000056401;Note=TNF receptor-associated factor 3 |
| Q13114 | 273 | 320 | 267 | 338 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q13114 | 273 | 320 | 267 | 338 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for TRAF3 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HNSC | TCGA-CR-5250-01 | exon_skip_110233 exon_skip_110234 | 103352526 | 103352606 | 103352585 | 103352585 | Frame_Shift_Del | C | - | p.V210fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_110241 | 103355897 | 103355971 | 103355928 | 103355928 | Frame_Shift_Del | C | - | p.A228fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_110240 exon_skip_110249 | 103363598 | 103363738 | 103363648 | 103363648 | Frame_Shift_Del | T | - | p.S290fs |
| BRCA | TCGA-C8-A274-01 | exon_skip_110240 exon_skip_110249 | 103363598 | 103363738 | 103363658 | 103363658 | Nonsense_Mutation | C | T | p.Q294* |
| HNSC | TCGA-BB-4228-01 | exon_skip_110240 exon_skip_110249 | 103363598 | 103363738 | 103363706 | 103363706 | Nonsense_Mutation | C | T | p.R310* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LP1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 103363598 | 103363738 | 103363635 | 103363648 | Frame_Shift_Del | AGAGCATACAAAGT | - | p.KSIQS286fs |
| MFE319_ENDOMETRIUM | 103363598 | 103363738 | 103363625 | 103363626 | Frame_Shift_Ins | - | A | p.E283fs |
| RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 103352526 | 103352606 | 103352541 | 103352541 | Missense_Mutation | G | A | p.D196N |
| A2058_SKIN | 103352526 | 103352606 | 103352556 | 103352556 | Missense_Mutation | G | A | p.V201M |
| NBSUSSR_AUTONOMIC_GANGLIA | 103352526 | 103352606 | 103352563 | 103352563 | Missense_Mutation | C | A | p.S203Y |
| JSC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 103352526 | 103352606 | 103352592 | 103352592 | Missense_Mutation | C | T | p.L213F |
| CAL27_UPPER_AERODIGESTIVE_TRACT | 103355897 | 103355971 | 103355913 | 103355913 | Missense_Mutation | C | T | p.S223L |
| DMS53_LUNG | 103355897 | 103355971 | 103355937 | 103355937 | Missense_Mutation | C | G | p.T231S |
| MYLA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 103355897 | 103355971 | 103355943 | 103355943 | Missense_Mutation | G | A | p.S233N |
| CCRFCEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 103355897 | 103355971 | 103355952 | 103355952 | Missense_Mutation | G | A | p.R236H |
| DJM1_SKIN | 103357662 | 103357754 | 103357699 | 103357699 | Missense_Mutation | C | G | p.S255C |
| CAL27_UPPER_AERODIGESTIVE_TRACT | 103363598 | 103363738 | 103363616 | 103363616 | Missense_Mutation | G | A | p.E280K |
| IM95_STOMACH | 103363598 | 103363738 | 103363651 | 103363651 | Missense_Mutation | G | T | p.L291F |
| SNU81_LARGE_INTESTINE | 103363598 | 103363738 | 103363706 | 103363706 | Nonsense_Mutation | C | T | p.R310* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TRAF3 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRAF3 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TRAF3 |
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RelatedDrugs for TRAF3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TRAF3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TRAF3 | C3553868 | HERPES SIMPLEX ENCEPHALITIS, SUSCEPTIBILITY TO, 3 | 1 | UNIPROT |
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