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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TPR |
 Gene summary |
| Gene information | Gene symbol | TPR | Gene ID | 7175 |
| Gene name | translocated promoter region, nuclear basket protein | |
| Synonyms | - | |
| Cytomap | 1q31.1 | |
| Type of gene | protein-coding | |
| Description | nucleoprotein TPRNPC-associated intranuclear proteinmegatornuclear pore complex-associated protein TPRtranslocated promoter region (to activated MET oncogene)translocated promoter region proteintumor potentiating region | |
| Modification date | 20180523 | |
| UniProtAcc | P12270 | |
| Context | PubMed: TPR [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TPR | GO:0006404 | RNA import into nucleus | 9864356 |
| TPR | GO:0006606 | protein import into nucleus | 9864356 |
| TPR | GO:0031990 | mRNA export from nucleus in response to heat stress | 17897941 |
| TPR | GO:0034605 | cellular response to heat | 17897941 |
| TPR | GO:0046832 | negative regulation of RNA export from nucleus | 22253824 |
| TPR | GO:0070849 | response to epidermal growth factor | 18794356 |
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Exon skipping events across known transcript of Ensembl for TPR from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TPR |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TPR |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_35092 | 1 | 186280783:186283158:186283760:186283856:186286613:186286732 | 186283760:186283856 | ENSG00000047410.9 | ENST00000367478.4 |
| exon_skip_35095 | 1 | 186283760:186283856:186286613:186286732:186287578:186287735 | 186286613:186286732 | ENSG00000047410.9 | ENST00000367478.4 |
| exon_skip_35099 | 1 | 186287636:186287735:186287864:186287960:186289443:186289550 | 186287864:186287960 | ENSG00000047410.9 | ENST00000367478.4,ENST00000467810.1 |
| exon_skip_35101 | 1 | 186292817:186293002:186294895:186294986:186295235:186295352 | 186294895:186294986 | ENSG00000047410.9 | ENST00000367478.4 |
| exon_skip_35104 | 1 | 186294928:186294986:186295235:186295367:186296591:186296792 | 186295235:186295367 | ENSG00000047410.9 | ENST00000367478.4 |
| exon_skip_35106 | 1 | 186296591:186296792:186300629:186300713:186301326:186301475 | 186300629:186300713 | ENSG00000047410.9 | ENST00000367478.4 |
| exon_skip_35108 | 1 | 186303456:186303665:186304199:186304261:186304469:186304675 | 186304199:186304261 | ENSG00000047410.9 | ENST00000367478.4 |
| exon_skip_35109 | 1 | 186307318:186307375:186308773:186308904:186310159:186310291 | 186308773:186308904 | ENSG00000047410.9 | ENST00000367478.4,ENST00000481347.1 |
| exon_skip_35110 | 1 | 186310159:186310291:186310383:186310521:186312457:186312605 | 186310383:186310521 | ENSG00000047410.9 | ENST00000367478.4 |
| exon_skip_35113 | 1 | 186321146:186321242:186322819:186322982:186324541:186324684 | 186322819:186322982 | ENSG00000047410.9 | ENST00000367478.4,ENST00000491783.1 |
| exon_skip_35115 | 1 | 186321146:186321242:186322819:186323012:186324541:186324684 | 186322819:186323012 | ENSG00000047410.9 | ENST00000474852.1 |
| exon_skip_35118 | 1 | 186332473:186332577:186337017:186337114:186340101:186340175 | 186337017:186337114 | ENSG00000047410.9 | ENST00000474852.1,ENST00000367478.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TPR |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_35092 | 1 | 186280783:186283158:186283760:186283856:186286613:186286732 | 186283760:186283856 | ENSG00000047410.9 | ENST00000367478.4 |
| exon_skip_35095 | 1 | 186283760:186283856:186286613:186286732:186287578:186287735 | 186286613:186286732 | ENSG00000047410.9 | ENST00000367478.4 |
| exon_skip_35099 | 1 | 186287636:186287735:186287864:186287960:186289443:186289550 | 186287864:186287960 | ENSG00000047410.9 | ENST00000367478.4,ENST00000467810.1 |
| exon_skip_35101 | 1 | 186292817:186293002:186294895:186294986:186295235:186295352 | 186294895:186294986 | ENSG00000047410.9 | ENST00000367478.4 |
| exon_skip_35104 | 1 | 186294928:186294986:186295235:186295367:186296591:186296792 | 186295235:186295367 | ENSG00000047410.9 | ENST00000367478.4 |
| exon_skip_35106 | 1 | 186296591:186296792:186300629:186300713:186301326:186301475 | 186300629:186300713 | ENSG00000047410.9 | ENST00000367478.4 |
| exon_skip_35108 | 1 | 186303456:186303665:186304199:186304261:186304469:186304675 | 186304199:186304261 | ENSG00000047410.9 | ENST00000367478.4 |
| exon_skip_35109 | 1 | 186307318:186307375:186308773:186308904:186310159:186310291 | 186308773:186308904 | ENSG00000047410.9 | ENST00000367478.4,ENST00000481347.1 |
| exon_skip_35110 | 1 | 186310159:186310291:186310383:186310521:186312457:186312605 | 186310383:186310521 | ENSG00000047410.9 | ENST00000367478.4 |
| exon_skip_35113 | 1 | 186321146:186321242:186322819:186322982:186324541:186324684 | 186322819:186322982 | ENSG00000047410.9 | ENST00000367478.4,ENST00000491783.1 |
| exon_skip_35115 | 1 | 186321146:186321242:186322819:186323012:186324541:186324684 | 186322819:186323012 | ENSG00000047410.9 | ENST00000474852.1 |
| exon_skip_35118 | 1 | 186332473:186332577:186337017:186337114:186340101:186340175 | 186337017:186337114 | ENSG00000047410.9 | ENST00000367478.4,ENST00000474852.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TPR |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000367478 | 186286613 | 186286732 | Frame-shift |
| ENST00000367478 | 186294895 | 186294986 | Frame-shift |
| ENST00000367478 | 186304199 | 186304261 | Frame-shift |
| ENST00000367478 | 186308773 | 186308904 | Frame-shift |
| ENST00000367478 | 186322819 | 186322982 | Frame-shift |
| ENST00000367478 | 186337017 | 186337114 | Frame-shift |
| ENST00000367478 | 186283760 | 186283856 | In-frame |
| ENST00000367478 | 186287864 | 186287960 | In-frame |
| ENST00000367478 | 186295235 | 186295367 | In-frame |
| ENST00000367478 | 186300629 | 186300713 | In-frame |
| ENST00000367478 | 186310383 | 186310521 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000367478 | 186286613 | 186286732 | Frame-shift |
| ENST00000367478 | 186294895 | 186294986 | Frame-shift |
| ENST00000367478 | 186304199 | 186304261 | Frame-shift |
| ENST00000367478 | 186308773 | 186308904 | Frame-shift |
| ENST00000367478 | 186322819 | 186322982 | Frame-shift |
| ENST00000367478 | 186337017 | 186337114 | Frame-shift |
| ENST00000367478 | 186283760 | 186283856 | In-frame |
| ENST00000367478 | 186287864 | 186287960 | In-frame |
| ENST00000367478 | 186295235 | 186295367 | In-frame |
| ENST00000367478 | 186300629 | 186300713 | In-frame |
| ENST00000367478 | 186310383 | 186310521 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TPR |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000367478 | 9725 | 2363 | 186310383 | 186310521 | 4048 | 4185 | 1250 | 1296 |
| ENST00000367478 | 9725 | 2363 | 186300629 | 186300713 | 5902 | 5985 | 1868 | 1896 |
| ENST00000367478 | 9725 | 2363 | 186295235 | 186295367 | 6187 | 6318 | 1963 | 2007 |
| ENST00000367478 | 9725 | 2363 | 186287864 | 186287960 | 6866 | 6961 | 2189 | 2221 |
| ENST00000367478 | 9725 | 2363 | 186283760 | 186283856 | 7238 | 7333 | 2313 | 2345 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000367478 | 9725 | 2363 | 186310383 | 186310521 | 4048 | 4185 | 1250 | 1296 |
| ENST00000367478 | 9725 | 2363 | 186300629 | 186300713 | 5902 | 5985 | 1868 | 1896 |
| ENST00000367478 | 9725 | 2363 | 186295235 | 186295367 | 6187 | 6318 | 1963 | 2007 |
| ENST00000367478 | 9725 | 2363 | 186287864 | 186287960 | 6866 | 6961 | 2189 | 2221 |
| ENST00000367478 | 9725 | 2363 | 186283760 | 186283856 | 7238 | 7333 | 2313 | 2345 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P12270 | 1250 | 1296 | 727 | 2363 | Alternative sequence | ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355 |
| P12270 | 1250 | 1296 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| P12270 | 1250 | 1296 | 1215 | 1630 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P12270 | 1250 | 1296 | 1218 | 1320 | Region | Note=Necessary for interaction with HSF1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17897941;Dbxref=PMID:17897941 |
| P12270 | 1868 | 1896 | 727 | 2363 | Alternative sequence | ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355 |
| P12270 | 1868 | 1896 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| P12270 | 1868 | 1896 | 1893 | 1893 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569 |
| P12270 | 1963 | 2007 | 727 | 2363 | Alternative sequence | ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355 |
| P12270 | 1963 | 2007 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| P12270 | 1963 | 2007 | 1971 | 1978 | Compositional bias | Note=Poly-Asp |
| P12270 | 1963 | 2007 | 1952 | 1965 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P12270 | 2189 | 2221 | 727 | 2363 | Alternative sequence | ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355 |
| P12270 | 2189 | 2221 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| P12270 | 2313 | 2345 | 727 | 2363 | Alternative sequence | ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355 |
| P12270 | 2313 | 2345 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| P12270 | 2313 | 2345 | 2343 | 2343 | Modified residue | Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F6ZDS4 |
| P12270 | 2313 | 2345 | 2345 | 2345 | Modified residue | Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F6ZDS4 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P12270 | 1250 | 1296 | 727 | 2363 | Alternative sequence | ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355 |
| P12270 | 1250 | 1296 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| P12270 | 1250 | 1296 | 1215 | 1630 | Coiled coil | Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| P12270 | 1250 | 1296 | 1218 | 1320 | Region | Note=Necessary for interaction with HSF1;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17897941;Dbxref=PMID:17897941 |
| P12270 | 1868 | 1896 | 727 | 2363 | Alternative sequence | ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355 |
| P12270 | 1868 | 1896 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| P12270 | 1868 | 1896 | 1893 | 1893 | Modified residue | Note=Phosphoserine;Ontology_term=ECO:0000244;evidence=ECO:0000244|PubMed:24275569;Dbxref=PMID:24275569 |
| P12270 | 1963 | 2007 | 727 | 2363 | Alternative sequence | ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355 |
| P12270 | 1963 | 2007 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| P12270 | 1963 | 2007 | 1971 | 1978 | Compositional bias | Note=Poly-Asp |
| P12270 | 1963 | 2007 | 1952 | 1965 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| P12270 | 2189 | 2221 | 727 | 2363 | Alternative sequence | ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355 |
| P12270 | 2189 | 2221 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| P12270 | 2313 | 2345 | 727 | 2363 | Alternative sequence | ID=VSP_057407;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1549355;Dbxref=PMID:1549355 |
| P12270 | 2313 | 2345 | 2 | 2363 | Chain | ID=PRO_0000204920;Note=Nucleoprotein TPR |
| P12270 | 2313 | 2345 | 2343 | 2343 | Modified residue | Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F6ZDS4 |
| P12270 | 2313 | 2345 | 2345 | 2345 | Modified residue | Note=Asymmetric dimethylarginine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:F6ZDS4 |
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SNVs in the skipped exons for TPR |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_35099 | 186287865 | 186287960 | 186287943 | 186287943 | Frame_Shift_Del | T | - | p.T2196fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_35101 | 186294896 | 186294986 | 186294963 | 186294963 | Frame_Shift_Del | A | - | p.G2015fs |
| BLCA | TCGA-ZF-A9R0-01 | exon_skip_35104 | 186295236 | 186295367 | 186295316 | 186295316 | Frame_Shift_Del | T | - | p.M1981fs |
| LIHC | TCGA-G3-A3CJ-01 | 186304200 | 186304261 | 186304228 | 186304228 | Frame_Shift_Del | T | - | p.T1650fs | |
| BLCA | TCGA-XF-A9T6-01 | exon_skip_35118 | 186337018 | 186337114 | 186337095 | 186337105 | Frame_Shift_Del | TTTGTTCTTGT | - | p.TRTK114fs |
| BLCA | TCGA-GC-A3OO-01 | exon_skip_35092 | 186283761 | 186283856 | 186283842 | 186283842 | Nonsense_Mutation | G | A | p.Q2319* |
| STAD | TCGA-D7-A4YV-01 | exon_skip_35110 | 186310384 | 186310521 | 186310500 | 186310500 | Nonsense_Mutation | G | A | p.Q1258* |
| STAD | TCGA-D7-A4YV-01 | exon_skip_35110 | 186310384 | 186310521 | 186310500 | 186310500 | Nonsense_Mutation | G | A | p.Q1258X |
| UCEC | TCGA-AP-A0LM-01 | exon_skip_35113 | 186322820 | 186322982 | 186322945 | 186322945 | Nonsense_Mutation | G | A | p.R737* |
| UCEC | TCGA-AP-A0LM-01 | exon_skip_35115 | 186322820 | 186323012 | 186322945 | 186322945 | Nonsense_Mutation | G | A | p.R737* |
| UCEC | TCGA-BS-A0UV-01 | exon_skip_35113 | 186322820 | 186322982 | 186322945 | 186322945 | Nonsense_Mutation | G | A | p.R737* |
| UCEC | TCGA-BS-A0UV-01 | exon_skip_35115 | 186322820 | 186323012 | 186322945 | 186322945 | Nonsense_Mutation | G | A | p.R737* |
| READ | TCGA-F5-6814-01 | exon_skip_35118 | 186337018 | 186337114 | 186337090 | 186337090 | Nonsense_Mutation | C | A | p.E119X |
| LUSC | TCGA-18-3409-01 | exon_skip_35106 | 186300630 | 186300713 | 186300714 | 186300714 | Splice_Site | C | T | p.E1869_splice |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SW48_LARGE_INTESTINE | 186337018 | 186337114 | 186337050 | 186337053 | Frame_Shift_Del | TCAT | - | p.NE131fs |
| LOVO_LARGE_INTESTINE | 186283761 | 186283856 | 186283802 | 186283802 | Missense_Mutation | A | G | p.L2332S |
| A704_KIDNEY | 186283761 | 186283856 | 186283803 | 186283803 | Missense_Mutation | A | C | p.L2332V |
| GP2D_LARGE_INTESTINE | 186283761 | 186283856 | 186283854 | 186283854 | Missense_Mutation | T | C | p.T2315A |
| REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 186283761 | 186283856 | 186283854 | 186283854 | Missense_Mutation | T | C | p.T2315A |
| HEC108_ENDOMETRIUM | 186287865 | 186287960 | 186287870 | 186287870 | Missense_Mutation | G | A | p.A2220V |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 186294896 | 186294986 | 186294921 | 186294921 | Missense_Mutation | G | C | p.H2029Q |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 186294896 | 186294986 | 186294929 | 186294929 | Missense_Mutation | C | T | p.G2027S |
| BICR18_UPPER_AERODIGESTIVE_TRACT | 186294896 | 186294986 | 186294934 | 186294934 | Missense_Mutation | C | G | p.G2025A |
| MHHCALL4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 186294896 | 186294986 | 186294935 | 186294935 | Missense_Mutation | C | A | p.G2025C |
| MZ7MEL_SKIN | 186294896 | 186294986 | 186294964 | 186294964 | Missense_Mutation | C | T | p.G2015D |
| ISHIKAWAHERAKLIO02ER_ENDOMETRIUM | 186295236 | 186295367 | 186295259 | 186295259 | Missense_Mutation | C | A | p.G2000C |
| DMS153_LUNG | 186295236 | 186295367 | 186295262 | 186295262 | Missense_Mutation | C | A | p.D1999Y |
| LNCAPCLONEFGC_PROSTATE | 186295236 | 186295367 | 186295294 | 186295294 | Missense_Mutation | C | A | p.S1988I |
| AN3CA_ENDOMETRIUM | 186295236 | 186295367 | 186295322 | 186295322 | Missense_Mutation | T | G | p.T1979P |
| NCIH1838_LUNG | 186295236 | 186295367 | 186295330 | 186295330 | Missense_Mutation | T | C | p.E1976G |
| BT483_BREAST | 186295236 | 186295367 | 186295337 | 186295337 | Missense_Mutation | C | T | p.D1974N |
| HEC108_ENDOMETRIUM | 186300630 | 186300713 | 186300646 | 186300646 | Missense_Mutation | T | C | p.Q1891R |
| HELA_CERVIX | 186310384 | 186310521 | 186310393 | 186310393 | Missense_Mutation | C | T | p.M1293I |
| HCC2998_LARGE_INTESTINE | 186310384 | 186310521 | 186310407 | 186310407 | Missense_Mutation | C | T | p.D1289N |
| NCIH2052_PLEURA | 186310384 | 186310521 | 186310431 | 186310431 | Missense_Mutation | C | T | p.E1281K |
| COLO775_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 186310384 | 186310521 | 186310480 | 186310480 | Missense_Mutation | C | A | p.K1264N |
| NCIH2023_LUNG | 186310384 | 186310521 | 186310504 | 186310504 | Missense_Mutation | C | A | p.M1256I |
| EFO21_OVARY | 186322820 | 186322982 | 186322853 | 186322853 | Missense_Mutation | C | G | p.L767F |
| EFO21_OVARY | 186322820 | 186323012 | 186322853 | 186322853 | Missense_Mutation | C | G | p.L767F |
| MFE319_ENDOMETRIUM | 186322820 | 186322982 | 186322906 | 186322906 | Missense_Mutation | T | C | p.T750A |
| MFE319_ENDOMETRIUM | 186322820 | 186323012 | 186322906 | 186322906 | Missense_Mutation | T | C | p.T750A |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TPR |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TPR |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TPR |
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RelatedDrugs for TPR |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TPR |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TPR | C0040136 | Thyroid Neoplasm | 1 | CTD_human |
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