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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TP73 |
 Gene summary |
| Gene information | Gene symbol | TP73 | Gene ID | 7161 |
| Gene name | tumor protein p73 | |
| Synonyms | P73 | |
| Cytomap | 1p36.32 | |
| Type of gene | protein-coding | |
| Description | tumor protein p73p53-like transcription factorp53-related protein | |
| Modification date | 20180522 | |
| UniProtAcc | O15350 | |
| Context | PubMed: TP73 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TP73 | GO:0006974 | cellular response to DNA damage stimulus | 18174154 |
| TP73 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 18174154|19490146 |
| TP73 | GO:0045893 | positive regulation of transcription, DNA-templated | 15678106|16343436 |
| TP73 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16343436|18174154|18421303|19490146|24652652 |
| TP73 | GO:0071158 | positive regulation of cell cycle arrest | 18421303 |
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Exon skipping events across known transcript of Ensembl for TP73 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TP73 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TP73 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_562 | 1 | 3569128:3569205:3598896:3598994:3599623:3599744 | 3598896:3598994 | ENSG00000078900.10 | ENST00000604074.1,ENST00000354437.4,ENST00000357733.3,ENST00000346387.4 |
| exon_skip_566 | 1 | 3638584:3638771:3639917:3640033:3643678:3643788 | 3639917:3640033 | ENSG00000078900.10 | ENST00000378290.4,ENST00000378295.4,ENST00000603364.1,ENST00000604074.1,ENST00000354437.4,ENST00000357733.3,ENST00000346387.4,ENST00000378285.1,ENST00000604479.1,ENST00000378288.4,ENST00000603362.1,ENST00000378280.1 |
| exon_skip_568 | 1 | 3645890:3646012:3646563:3646712:3647490:3647629 | 3646563:3646712 | ENSG00000078900.10 | ENST00000378290.4,ENST00000378295.4,ENST00000354437.4,ENST00000378285.1,ENST00000378288.4 |
| exon_skip_569 | 1 | 3645890:3646012:3647490:3647629:3648026:3648120 | 3647490:3647629 | ENSG00000078900.10 | ENST00000604566.1,ENST00000378280.1 |
| exon_skip_571 | 1 | 3645890:3646012:3647490:3647629:3649310:3649643 | 3647490:3647629 | ENSG00000078900.10 | ENST00000357733.3,ENST00000603362.1 |
| exon_skip_572 | 1 | 3645890:3646012:3648026:3648120:3649310:3649643 | 3648026:3648120 | ENSG00000078900.10 | ENST00000346387.4,ENST00000604479.1 |
| exon_skip_574 | 1 | 3647490:3647629:3648026:3648120:3649310:3649643 | 3648026:3648120 | ENSG00000078900.10 | ENST00000378290.4,ENST00000378295.4,ENST00000604566.1,ENST00000378288.4,ENST00000378280.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TP73 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_562 | 1 | 3569128:3569205:3598896:3598994:3599623:3599744 | 3598896:3598994 | ENSG00000078900.10 | ENST00000604074.1,ENST00000354437.4,ENST00000357733.3,ENST00000346387.4 |
| exon_skip_566 | 1 | 3638584:3638771:3639917:3640033:3643678:3643788 | 3639917:3640033 | ENSG00000078900.10 | ENST00000378295.4,ENST00000604074.1,ENST00000354437.4,ENST00000357733.3,ENST00000346387.4,ENST00000603362.1,ENST00000604479.1,ENST00000378285.1,ENST00000378280.1,ENST00000378288.4,ENST00000603364.1,ENST00000378290.4 |
| exon_skip_568 | 1 | 3645890:3646012:3646563:3646712:3647490:3647629 | 3646563:3646712 | ENSG00000078900.10 | ENST00000378295.4,ENST00000354437.4,ENST00000378285.1,ENST00000378288.4,ENST00000378290.4 |
| exon_skip_569 | 1 | 3645890:3646012:3647490:3647629:3648026:3648120 | 3647490:3647629 | ENSG00000078900.10 | ENST00000378280.1,ENST00000604566.1 |
| exon_skip_571 | 1 | 3645890:3646012:3647490:3647629:3649310:3649643 | 3647490:3647629 | ENSG00000078900.10 | ENST00000357733.3,ENST00000603362.1 |
| exon_skip_572 | 1 | 3645890:3646012:3648026:3648120:3649310:3649643 | 3648026:3648120 | ENSG00000078900.10 | ENST00000346387.4,ENST00000604479.1 |
| exon_skip_574 | 1 | 3647490:3647629:3648026:3648120:3649310:3649643 | 3648026:3648120 | ENSG00000078900.10 | ENST00000378295.4,ENST00000378280.1,ENST00000378288.4,ENST00000378290.4,ENST00000604566.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TP73 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000378295 | 3639917 | 3640033 | Frame-shift |
| ENST00000378295 | 3646563 | 3646712 | Frame-shift |
| ENST00000378295 | 3648026 | 3648120 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000378295 | 3639917 | 3640033 | Frame-shift |
| ENST00000378295 | 3646563 | 3646712 | Frame-shift |
| ENST00000378295 | 3648026 | 3648120 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for TP73 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for TP73 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| COAD | TCGA-CM-4743-01 | exon_skip_568 | 3646564 | 3646712 | 3646622 | 3646622 | Frame_Shift_Del | G | - | p.H369fs |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_568 | 3646564 | 3646712 | 3646670 | 3646670 | Frame_Shift_Del | C | - | p.P436fs |
| COAD | TCGA-CM-6674-01 | exon_skip_571 exon_skip_569 | 3647491 | 3647629 | 3647598 | 3647598 | Frame_Shift_Del | C | - | p.T386fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_571 exon_skip_569 | 3647491 | 3647629 | 3647598 | 3647598 | Frame_Shift_Del | C | - | p.P486fs |
| CESC | TCGA-Q1-A73R-01 | exon_skip_566 | 3639918 | 3640033 | 3639972 | 3639973 | Frame_Shift_Ins | - | GTAT | p.D227fs |
| UCEC | TCGA-D1-A16F-01 | exon_skip_571 exon_skip_569 | 3647491 | 3647629 | 3647612 | 3647612 | Nonsense_Mutation | C | T | p.R391* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| HEC59_ENDOMETRIUM | 3647491 | 3647629 | 3647598 | 3647598 | Frame_Shift_Del | C | - | p.P486fs |
| RERFLCKJ_LUNG | 3639918 | 3640033 | 3639930 | 3639930 | Missense_Mutation | C | T | p.P210L |
| SUPHD1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 3639918 | 3640033 | 3639942 | 3639942 | Missense_Mutation | T | G | p.L214R |
| MINO_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 3639918 | 3640033 | 3639948 | 3639948 | Missense_Mutation | G | A | p.R216H |
| NCIH187_LUNG | 3639918 | 3640033 | 3640005 | 3640005 | Missense_Mutation | G | C | p.S235T |
| GSS_STOMACH | 3646564 | 3646712 | 3646641 | 3646641 | Missense_Mutation | C | T | p.P425L |
| SKUT1_SOFT_TISSUE | 3646564 | 3646712 | 3646646 | 3646646 | Missense_Mutation | G | A | p.V427I |
| SNU407_LARGE_INTESTINE | 3646564 | 3646712 | 3646662 | 3646662 | Missense_Mutation | G | A | p.G432D |
| MKN74_STOMACH | 3646564 | 3646712 | 3646670 | 3646670 | Missense_Mutation | C | T | p.P435S |
| DMS454_LUNG | 3647491 | 3647629 | 3647559 | 3647559 | Missense_Mutation | G | A | p.A472T |
| SKNMC_BONE | 3647491 | 3647629 | 3647559 | 3647559 | Missense_Mutation | G | A | p.A472T |
| SNU175_LARGE_INTESTINE | 3647491 | 3647629 | 3647559 | 3647559 | Missense_Mutation | G | A | p.A472T |
| MCIXC_AUTONOMIC_GANGLIA | 3647491 | 3647629 | 3647559 | 3647559 | Missense_Mutation | G | A | p.A472T |
| JHUEM7_ENDOMETRIUM | 3647491 | 3647629 | 3647575 | 3647575 | Missense_Mutation | C | T | p.S477L |
| SNUC4_LARGE_INTESTINE | 3647491 | 3647629 | 3647577 | 3647577 | Missense_Mutation | G | A | p.G478R |
| LNCAPCLONEFGC_PROSTATE | 3647491 | 3647629 | 3647604 | 3647604 | Missense_Mutation | T | C | p.Y487H |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TP73 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TP73 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TP73 |
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RelatedDrugs for TP73 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| O15350 | DB01593 | Zinc | Tumor protein p73 | small molecule | approved|investigational | |
| O15350 | DB14487 | Zinc acetate | Tumor protein p73 | small molecule | approved|investigational | |
| O15350 | DB14533 | Zinc chloride | Tumor protein p73 | small molecule | approved|investigational |
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RelatedDiseases for TP73 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TP73 | C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | CTD_human |
| TP73 | C0206655 | Alveolar rhabdomyosarcoma | 1 | CTD_human |
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