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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for ICAM5 |
 Gene summary |
| Gene information | Gene symbol | ICAM5 | Gene ID | 7087 |
| Gene name | intercellular adhesion molecule 5 | |
| Synonyms | TLCN|TLN | |
| Cytomap | 19p13.2 | |
| Type of gene | protein-coding | |
| Description | intercellular adhesion molecule 5ICAM-5intercellular adhesion molecule 5, telencephalintelencephalin | |
| Modification date | 20180523 | |
| UniProtAcc | Q9UMF0 | |
| Context | PubMed: ICAM5 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for ICAM5 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for ICAM5 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for ICAM5 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_302068 | 19 | 10400699:10400801:10401747:10401992:10402164:10402384 | 10401747:10401992 | ENSG00000105376.4 | ENST00000586004.1 |
| exon_skip_302070 | 19 | 10402164:10402485:10402710:10402998:10403287:10403542 | 10402710:10402998 | ENSG00000105376.4 | ENST00000586480.1,ENST00000221980.4 |
| exon_skip_302072 | 19 | 10403287:10403542:10403673:10403922:10404373:10404619 | 10403673:10403922 | ENSG00000105376.4 | ENST00000586480.1,ENST00000221980.4 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for ICAM5 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_302068 | 19 | 10400699:10400801:10401747:10401992:10402164:10402384 | 10401747:10401992 | ENSG00000105376.4 | ENST00000586004.1 |
| exon_skip_302070 | 19 | 10402164:10402485:10402710:10402998:10403287:10403542 | 10402710:10402998 | ENSG00000105376.4 | ENST00000221980.4,ENST00000586480.1 |
| exon_skip_302072 | 19 | 10403287:10403542:10403673:10403922:10404373:10404619 | 10403673:10403922 | ENSG00000105376.4 | ENST00000221980.4,ENST00000586480.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for ICAM5 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000221980 | 10402710 | 10402998 | In-frame |
| ENST00000221980 | 10403673 | 10403922 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000221980 | 10402710 | 10402998 | In-frame |
| ENST00000221980 | 10403673 | 10403922 | In-frame |
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Infer the effects of exon skipping event on protein functional features for ICAM5 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000221980 | 3017 | 924 | 10402710 | 10402998 | 737 | 1024 | 224 | 320 |
| ENST00000221980 | 3017 | 924 | 10403673 | 10403922 | 1280 | 1528 | 405 | 488 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000221980 | 3017 | 924 | 10402710 | 10402998 | 737 | 1024 | 224 | 320 |
| ENST00000221980 | 3017 | 924 | 10403673 | 10403922 | 1280 | 1528 | 405 | 488 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UMF0 | 224 | 320 | 223 | 226 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 232 | 234 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 237 | 241 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 245 | 251 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 253 | 256 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 261 | 271 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 274 | 278 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 281 | 288 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 295 | 306 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 309 | 320 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 32 | 924 | Chain | ID=PRO_0000014799;Note=Intercellular adhesion molecule 5 |
| Q9UMF0 | 224 | 320 | 249 | 302 | Disulfide bond | Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 |
| Q9UMF0 | 224 | 320 | 135 | 235 | Domain | Note=Ig-like C2-type 2 |
| Q9UMF0 | 224 | 320 | 242 | 329 | Domain | Note=Ig-like C2-type 3 |
| Q9UMF0 | 224 | 320 | 303 | 303 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UMF0 | 224 | 320 | 316 | 316 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UMF0 | 224 | 320 | 257 | 259 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 301 | 301 | Natural variant | ID=VAR_056046;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8995416;Dbxref=dbSNP:rs1056538,PMID:8995416 |
| Q9UMF0 | 224 | 320 | 32 | 835 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UMF0 | 405 | 488 | 392 | 405 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 405 | 488 | 32 | 924 | Chain | ID=PRO_0000014799;Note=Intercellular adhesion molecule 5 |
| Q9UMF0 | 405 | 488 | 415 | 470 | Disulfide bond | Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 |
| Q9UMF0 | 405 | 488 | 408 | 486 | Domain | Note=Ig-like C2-type 5 |
| Q9UMF0 | 405 | 488 | 488 | 488 | Natural variant | ID=VAR_035517;Note=In a breast cancer sample%3B somatic mutation. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 |
| Q9UMF0 | 405 | 488 | 32 | 835 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Q9UMF0 | 224 | 320 | 223 | 226 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 232 | 234 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 237 | 241 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 245 | 251 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 253 | 256 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 261 | 271 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 274 | 278 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 281 | 288 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 295 | 306 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 309 | 320 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 32 | 924 | Chain | ID=PRO_0000014799;Note=Intercellular adhesion molecule 5 |
| Q9UMF0 | 224 | 320 | 249 | 302 | Disulfide bond | Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 |
| Q9UMF0 | 224 | 320 | 135 | 235 | Domain | Note=Ig-like C2-type 2 |
| Q9UMF0 | 224 | 320 | 242 | 329 | Domain | Note=Ig-like C2-type 3 |
| Q9UMF0 | 224 | 320 | 303 | 303 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UMF0 | 224 | 320 | 316 | 316 | Glycosylation | Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UMF0 | 224 | 320 | 257 | 259 | Helix | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 224 | 320 | 301 | 301 | Natural variant | ID=VAR_056046;Note=V->I;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:8995416;Dbxref=dbSNP:rs1056538,PMID:8995416 |
| Q9UMF0 | 224 | 320 | 32 | 835 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
| Q9UMF0 | 405 | 488 | 392 | 405 | Beta strand | Ontology_term=ECO:0000244;evidence=ECO:0000244|PDB:4OI9 |
| Q9UMF0 | 405 | 488 | 32 | 924 | Chain | ID=PRO_0000014799;Note=Intercellular adhesion molecule 5 |
| Q9UMF0 | 405 | 488 | 415 | 470 | Disulfide bond | Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 |
| Q9UMF0 | 405 | 488 | 408 | 486 | Domain | Note=Ig-like C2-type 5 |
| Q9UMF0 | 405 | 488 | 488 | 488 | Natural variant | ID=VAR_035517;Note=In a breast cancer sample%3B somatic mutation. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 |
| Q9UMF0 | 405 | 488 | 32 | 835 | Topological domain | Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 |
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SNVs in the skipped exons for ICAM5 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-DD-A39Y-01 | exon_skip_302070 | 10402711 | 10402998 | 10402835 | 10402835 | Frame_Shift_Del | G | - | p.L266fs |
| COAD | TCGA-D5-6540-01 | exon_skip_302070 | 10402711 | 10402998 | 10402955 | 10402955 | Frame_Shift_Del | G | - | p.L306fs |
| READ | TCGA-EI-6507-01 | exon_skip_302070 | 10402711 | 10402998 | 10402955 | 10402955 | Frame_Shift_Del | G | - | p.L306fs |
| UCEC | TCGA-B5-A0K6-01 | exon_skip_302070 | 10402711 | 10402998 | 10402955 | 10402955 | Frame_Shift_Del | G | - | p.L306fs |
| BLCA | TCGA-FD-A6TC-01 | exon_skip_302072 | 10403674 | 10403922 | 10403751 | 10403751 | Nonsense_Mutation | G | T | p.E432* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| OVK18_OVARY | 10402711 | 10402998 | 10402955 | 10402955 | Frame_Shift_Del | G | - | p.L306fs |
| EW1_BONE | 10403674 | 10403922 | 10403889 | 10403889 | Frame_Shift_Del | G | - | p.E478fs |
| HCC2998_LARGE_INTESTINE | 10401748 | 10401992 | 10401765 | 10401765 | Missense_Mutation | T | G | p.F34V |
| SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 10401748 | 10401992 | 10401807 | 10401807 | Missense_Mutation | G | A | p.G48R |
| 5637_URINARY_TRACT | 10401748 | 10401992 | 10401874 | 10401874 | Missense_Mutation | C | T | p.S70L |
| PLCPRF5_LIVER | 10401748 | 10401992 | 10401976 | 10401976 | Missense_Mutation | C | A | p.A104E |
| LS411N_LARGE_INTESTINE | 10401748 | 10401992 | 10401976 | 10401976 | Missense_Mutation | C | T | p.A104V |
| MOLT13_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 10402711 | 10402998 | 10402731 | 10402731 | Missense_Mutation | C | T | p.R232C |
| HCT15_LARGE_INTESTINE | 10402711 | 10402998 | 10402820 | 10402820 | Missense_Mutation | G | T | p.R261S |
| TASK1_CENTRAL_NERVOUS_SYSTEM | 10402711 | 10402998 | 10402900 | 10402900 | Missense_Mutation | C | A | p.A288D |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 10402711 | 10402998 | 10402969 | 10402969 | Missense_Mutation | G | A | p.R311Q |
| OACP4C_OESOPHAGUS | 10403674 | 10403922 | 10403676 | 10403676 | Missense_Mutation | G | T | p.A407S |
| MDAMB361_BREAST | 10403674 | 10403922 | 10403751 | 10403751 | Missense_Mutation | G | A | p.E432K |
| WSUNHL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 10403674 | 10403922 | 10403758 | 10403758 | Missense_Mutation | G | A | p.R434H |
| SNU1040_LARGE_INTESTINE | 10403674 | 10403922 | 10403862 | 10403862 | Missense_Mutation | C | T | p.R469C |
| MOLT3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 10403674 | 10403922 | 10403871 | 10403871 | Missense_Mutation | G | A | p.A472T |
| HCT15_LARGE_INTESTINE | 10403674 | 10403922 | 10403891 | 10403891 | Missense_Mutation | G | T | p.E478D |
| HCC2157_BREAST | 10403674 | 10403922 | 10403919 | 10403919 | Missense_Mutation | G | C | p.E488Q |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for ICAM5 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ICAM5 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for ICAM5 |
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RelatedDrugs for ICAM5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ICAM5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| ICAM5 | C0009404 | Colorectal Neoplasms | 2 | CTD_human |
| ICAM5 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
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