ExonSkipDB Logo

Home

Download

Statistics

Landscape

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Gene structures and expression levels

leaf

Exon skipping events with PSIs in TCGA

leaf

Exon skipping events with PSIs in GTEx

leaf

Open reading frame (ORF) annotation in the exon skipping event

leaf

Exon skipping events in the canonical protein sequence

leaf

SNVs in the skipped exons with depth of coverage

leaf

Splicing Quantitative Trait Loci (sQTLs) in the skipped exons

leaf

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon

leaf

Related drugs with this gene

leaf

Related diseases with this gene

Gene summary for THBS3

check button Gene summary
Gene informationGene symbol

THBS3

Gene ID

7059

Gene namethrombospondin 3
SynonymsTSP3
Cytomap

1q22

Type of geneprotein-coding
Descriptionthrombospondin-3
Modification date20180519
UniProtAcc

P49746

ContextPubMed: THBS3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract]
- Title (PMID)

check button Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez
GeneGO IDGO termPubMed ID

Top

Exon skipping events across known transcript of Ensembl for THBS3 from UCSC genome browser

check buttonSkipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

Top

Gene isoform structures and expression levels for THBS3

check button Expression levels of gene isoforms across TCGA.
gencode gene structure

check button Expression levels of gene isoforms across GTEx.
gencode gene structure


Top

Exon skipping events with PSIs in TCGA for THBS3

check button Information of exkip skipping event in TCGA.
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_322441155165635:155165690:155165777:155165917:155166831:155167000155165777:155165917ENSG00000169231.9ENST00000457183.2,ENST00000541576.1,ENST00000368378.3,ENST00000541990.1,ENST00000469769.1
exon_skip_322451155166831:155167004:155167253:155167450:155167670:155167719155167253:155167450ENSG00000169231.9ENST00000457183.2,ENST00000541576.1,ENST00000368378.3,ENST00000541990.1
exon_skip_322491155169785:155169904:155170241:155170401:155170687:155170795155170241:155170401ENSG00000169231.9ENST00000457183.2,ENST00000541576.1,ENST00000368378.3,ENST00000541990.1
exon_skip_322501155170246:155170401:155170687:155170795:155170884:155170995155170687:155170795ENSG00000169231.9ENST00000486260.1,ENST00000457183.2,ENST00000368378.3,ENST00000541990.1
exon_skip_322511155170246:155170401:155170687:155170795:155171207:155171360155170687:155170795ENSG00000169231.9ENST00000541576.1
exon_skip_322551155170689:155170795:155170884:155170995:155171207:155171360155170884:155170995ENSG00000169231.9ENST00000486260.1,ENST00000457183.2,ENST00000368378.3,ENST00000460050.1,ENST00000541990.1,ENST00000428962.2
exon_skip_322591155172883:155172928:155173013:155173096:155173303:155173330155173013:155173096ENSG00000169231.9ENST00000486260.1,ENST00000457183.2,ENST00000368378.3,ENST00000541990.1
exon_skip_322681155173013:155173096:155173303:155173330:155174645:155174748155173303:155173330ENSG00000169231.9ENST00000486260.1,ENST00000368378.3
exon_skip_322691155173013:155173096:155173303:155173330:155174850:155175107155173303:155173330ENSG00000169231.9ENST00000541990.1
exon_skip_322701155173013:155173096:155173303:155173330:155175990:155176197155173303:155173330ENSG00000169231.9ENST00000457183.2
exon_skip_322771155173303:155173330:155174645:155174748:155174850:155175054155174645:155174748ENSG00000169231.9ENST00000486260.1,ENST00000368378.3
exon_skip_323051155174850:155175107:155175983:155176197:155177588:155177688155175983:155176197ENSG00000169231.9ENST00000541990.1
exon_skip_323091155174850:155175107:155175990:155176197:155177588:155177688155175990:155176197ENSG00000169231.9ENST00000368378.3

check button PSI values of skipped exons in TCGA.
psi tcga

Top

Exon skipping events with PSIs in GTEx for THBS3

check button Information of exkip skipping event in GTEx
Exon skip IDchrExons involved in exon skippingSkipped exonENSGENSTs
exon_skip_322441155165635:155165690:155165777:155165917:155166831:155167000155165777:155165917ENSG00000169231.9ENST00000368378.3,ENST00000541576.1,ENST00000457183.2,ENST00000541990.1,ENST00000469769.1
exon_skip_322451155166831:155167004:155167253:155167450:155167670:155167719155167253:155167450ENSG00000169231.9ENST00000368378.3,ENST00000541576.1,ENST00000457183.2,ENST00000541990.1
exon_skip_322491155169785:155169904:155170241:155170401:155170687:155170795155170241:155170401ENSG00000169231.9ENST00000368378.3,ENST00000541576.1,ENST00000457183.2,ENST00000541990.1
exon_skip_322501155170246:155170401:155170687:155170795:155170884:155170995155170687:155170795ENSG00000169231.9ENST00000368378.3,ENST00000457183.2,ENST00000541990.1,ENST00000486260.1
exon_skip_322511155170246:155170401:155170687:155170795:155171207:155171360155170687:155170795ENSG00000169231.9ENST00000541576.1
exon_skip_322551155170689:155170795:155170884:155170995:155171207:155171360155170884:155170995ENSG00000169231.9ENST00000368378.3,ENST00000457183.2,ENST00000541990.1,ENST00000428962.2,ENST00000486260.1,ENST00000460050.1
exon_skip_322591155172883:155172928:155173013:155173096:155173303:155173330155173013:155173096ENSG00000169231.9ENST00000368378.3,ENST00000457183.2,ENST00000541990.1,ENST00000486260.1
exon_skip_322681155173013:155173096:155173303:155173330:155174645:155174748155173303:155173330ENSG00000169231.9ENST00000368378.3,ENST00000486260.1
exon_skip_322691155173013:155173096:155173303:155173330:155174850:155175107155173303:155173330ENSG00000169231.9ENST00000541990.1
exon_skip_322701155173013:155173096:155173303:155173330:155175990:155176197155173303:155173330ENSG00000169231.9ENST00000457183.2
exon_skip_322771155173303:155173330:155174645:155174748:155174850:155175054155174645:155174748ENSG00000169231.9ENST00000368378.3,ENST00000486260.1
exon_skip_323051155174850:155175107:155175983:155176197:155177588:155177688155175983:155176197ENSG00000169231.9ENST00000541990.1
exon_skip_323091155174850:155175107:155175990:155176197:155177588:155177688155175990:155176197ENSG00000169231.9ENST00000368378.3

check button PSI values of skipped exons in GTEx.
psi gtex

* Skipped exon sequences.

Top

Open reading frame (ORF) annotation in the exon skipping event for THBS3

check button Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000368378155165777155165917Frame-shift
ENST00000368378155167253155167450Frame-shift
ENST00000368378155170241155170401Frame-shift
ENST00000368378155173013155173096Frame-shift
ENST00000368378155174645155174748Frame-shift
ENST00000368378155170687155170795In-frame
ENST00000368378155170884155170995In-frame
ENST00000368378155173303155173330In-frame
ENST00000368378155175990155176197In-frame

check button Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms.
ENSTStart of skipped exonEnd of skipped exonORF
ENST00000368378155165777155165917Frame-shift
ENST00000368378155167253155167450Frame-shift
ENST00000368378155170241155170401Frame-shift
ENST00000368378155173013155173096Frame-shift
ENST00000368378155174645155174748Frame-shift
ENST00000368378155170687155170795In-frame
ENST00000368378155170884155170995In-frame
ENST00000368378155173303155173330In-frame
ENST00000368378155175990155176197In-frame

Top

Infer the effects of exon skipping event on protein functional features for THBS3

check button Exon skipping at the protein sequence level and followed lost functional features.
* Click on the image to enlarge it in a new window.
prot feature distribution

check button Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000036837831629561551759901551761971013072695
ENST00000368378316295615517088415517099513511461443480
ENST00000368378316295615517068715517079514621569480516

check button Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases.
ENSTLength of mRNALength of AA seq.Genomic startGenomic endmRNA startmRNA endAA startAA end
ENST0000036837831629561551759901551761971013072695
ENST00000368378316295615517088415517099513511461443480
ENST00000368378316295615517068715517079514621569480516

check button Lost protein functional features of individual exon skipping events in TCGA.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P49746269523956ChainID=PRO_0000035849;Note=Thrombospondin-3
P49746269523193DomainNote=Laminin G-like
P4974644348023956ChainID=PRO_0000035849;Note=Thrombospondin-3
P49746443480444455Disulfide bondOntology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
P49746443480471478Disulfide bondOntology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
P49746443480414456DomainNote=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
P49746443480457491RepeatNote=TSP type-3 1
P4974648051623956ChainID=PRO_0000035849;Note=Thrombospondin-3
P49746480516483503Disulfide bondOntology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
P49746480516457491RepeatNote=TSP type-3 1
P49746480516492527RepeatNote=TSP type-3 2


check button Lost protein functional features of individual exon skipping events in GTEx.
UniProt acc.Start of exon skipping (AA)End of exon skipping (AA)Protein feature start (AA)Protein feature end (AA)Category of protein featureDescription of feature
P49746269523956ChainID=PRO_0000035849;Note=Thrombospondin-3
P49746269523193DomainNote=Laminin G-like
P4974644348023956ChainID=PRO_0000035849;Note=Thrombospondin-3
P49746443480444455Disulfide bondOntology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
P49746443480471478Disulfide bondOntology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
P49746443480414456DomainNote=EGF-like 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
P49746443480457491RepeatNote=TSP type-3 1
P4974648051623956ChainID=PRO_0000035849;Note=Thrombospondin-3
P49746480516483503Disulfide bondOntology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00076
P49746480516457491RepeatNote=TSP type-3 1
P49746480516492527RepeatNote=TSP type-3 2


Top

SNVs in the skipped exons for THBS3

check button - Lollipop plot for presenting exon skipping associated SNVs.
* Click on the image to enlarge it in a new window.
lollipop

check button - Differential PSIs between mutated versus non-mutated samples.

check button - Non-synonymous mutations located in the skipped exons in TCGA.
Cancer typeSampleESIDSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
LIHCTCGA-DD-A1EG-01exon_skip_32244
155165778155165917155165845155165845Frame_Shift_DelC-p.G915fs
LIHCTCGA-DD-A3A0-01exon_skip_32244
155165778155165917155165845155165845Frame_Shift_DelC-p.G915fs
LIHCTCGA-DD-A4NA-01exon_skip_32250
exon_skip_32251
155170688155170795155170766155170766Frame_Shift_DelC-p.G490fs
LIHCTCGA-DD-A4NA-01exon_skip_32250
exon_skip_32251
155170688155170795155170766155170766Frame_Shift_DelC-p.Q491fs
LIHCTCGA-DD-A1EG-01exon_skip_32305
exon_skip_32309
155175984155176197155176079155176079Frame_Shift_DelG-p.P66fs
LIHCTCGA-DD-A1EG-01exon_skip_32305
exon_skip_32309
155175991155176197155176079155176079Frame_Shift_DelG-p.P66fs
LIHCTCGA-DD-A39Y-01exon_skip_32305
exon_skip_32309
155175984155176197155176079155176079Frame_Shift_DelG-p.P66fs
LIHCTCGA-DD-A39Y-01exon_skip_32305
exon_skip_32309
155175991155176197155176079155176079Frame_Shift_DelG-p.P66fs
LIHCTCGA-G3-A3CJ-01exon_skip_32305
exon_skip_32309
155175984155176197155176079155176079Frame_Shift_DelG-p.P66fs
LIHCTCGA-G3-A3CJ-01exon_skip_32305
exon_skip_32309
155175991155176197155176079155176079Frame_Shift_DelG-p.P66fs
LIHCTCGA-G3-A3CG-01exon_skip_32245
155167254155167450155167449155167450Frame_Shift_Ins-Ap.G768fs
BLCATCGA-ZF-AA4X-01exon_skip_32244
155165778155165917155165787155165787Nonsense_MutationGAp.R935*
LIHCTCGA-G3-A3CG-01exon_skip_32245
155167254155167450155167451155167451Splice_SiteCT.
STADTCGA-HF-A5NB-01exon_skip_32305
exon_skip_32309
155175991155176197155175989155175989Splice_SiteAG.

check button - Depth of coverage in the three exons composing exon skipping event
Depth of coverage in three exonsMutation description

check button - Non-synonymous mutations located in the skipped exons in CCLE.
SampleSkipped exon startSkipped exon endMutation startMutation endMutation typeReference seqMutation seqAAchange
MERO48A_LUNG155165778155165917155165845155165845Frame_Shift_DelC-p.G915fs
SNGM_ENDOMETRIUM155165778155165917155165845155165845Frame_Shift_DelC-p.G915fs
LS411N_LARGE_INTESTINE155165778155165917155165845155165845Frame_Shift_DelC-p.G915fs
MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE155170242155170401155170259155170263Frame_Shift_DelTTGTC-p.DN563fs
CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE155170242155170401155170278155170278Frame_Shift_DelC-p.E558fs
MDAPCA2B_PROSTATE155167254155167450155167268155167268Missense_MutationCTp.G829R
UW228_CENTRAL_NERVOUS_SYSTEM155167254155167450155167286155167286Missense_MutationGAp.R823W
HEC6_ENDOMETRIUM155167254155167450155167345155167345Missense_MutationCTp.R803H
GI1_CENTRAL_NERVOUS_SYSTEM155167254155167450155167345155167345Missense_MutationCTp.R803H
HEC50B_ENDOMETRIUM155167254155167450155167346155167346Missense_MutationGTp.R803S
SNU520_STOMACH155167254155167450155167415155167415Missense_MutationTCp.T780A
HCC202_BREAST155167254155167450155167430155167430Missense_MutationCTp.V775M
LOVO_LARGE_INTESTINE155167254155167450155167432155167432Missense_MutationCTp.G774D
NCC021_KIDNEY155170242155170401155170358155170358Missense_MutationTCp.D531G
GP2D_LARGE_INTESTINE155170242155170401155170364155170364Missense_MutationTCp.N529S
GP5D_LARGE_INTESTINE155170242155170401155170364155170364Missense_MutationTCp.N529S
RPMI8402_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE155170242155170401155170369155170369Missense_MutationCAp.Q527H
MDAMB453_BREAST155170688155170795155170720155170720Missense_MutationCTp.D506N
NCIH1930_LUNG155170688155170795155170791155170791Missense_MutationTGp.N482T
REH_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE155173014155173096155173019155173019Missense_MutationCTp.D251N
CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE155173014155173096155173021155173021Missense_MutationCTp.R250Q
DND41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE155173014155173096155173061155173061Missense_MutationGTp.L237I
BICR18_UPPER_AERODIGESTIVE_TRACT155173304155173330155173324155173324Missense_MutationTCp.N218S
MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE155174646155174748155174679155174679Missense_MutationGAp.P205S
MM415_SKIN155175984155176197155176044155176044Missense_MutationCTp.R78H
MM415_SKIN155175991155176197155176044155176044Missense_MutationCTp.R78H
JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE155175984155176197155176132155176132Missense_MutationCTp.A49T
JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE155175991155176197155176132155176132Missense_MutationCTp.A49T
NUGC3_STOMACH155175984155176197155176167155176167Missense_MutationCAp.R37L
NUGC3_STOMACH155175991155176197155176167155176167Missense_MutationCAp.R37L
ES7_BONE155173014155173096155173022155173022Nonsense_MutationGAp.R250*

Top

Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for THBS3

check button sQTL information located at the skipped exons.
Exon skip IDChromosomeThree exonsSkippped exonENSTCancer typeSNP idLocationDNA change (ref/var)P-value

Top

Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for THBS3


Top

Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for THBS3


Top

RelatedDrugs for THBS3

check button Approved drugs targeting this gene.
(DrugBank Version 5.1.0 2018-04-02)
GeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for THBS3

check button Diseases associated with this gene.
(DisGeNet 4.0)
GeneDisease IDDisease name# pubmedsSource