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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TCF3 |
 Gene summary |
| Gene information | Gene symbol | TCF3 | Gene ID | 6929 |
| Gene name | transcription factor 3 | |
| Synonyms | AGM8|E2A|E47|ITF1|TCF-3|VDIR|bHLHb21|p75 | |
| Cytomap | 19p13.3 | |
| Type of gene | protein-coding | |
| Description | transcription factor E2-alphaNOL1-TCF3 fusionVDR interacting repressorclass B basic helix-loop-helix protein 21helix-loop-helix protein HE47immunoglobulin transcription factor 1kappa-E2-binding factornegative vitamin D response element-binding prot | |
| Modification date | 20180523 | |
| UniProtAcc | P15923 | |
| Context | PubMed: TCF3 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TCF3 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 14576336 |
| TCF3 | GO:0006351 | transcription, DNA-templated | 10775504 |
| TCF3 | GO:0033152 | immunoglobulin V(D)J recombination | 16428437 |
| TCF3 | GO:0045893 | positive regulation of transcription, DNA-templated | 2105528 |
| TCF3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16428437|19362560 |
| TCF3 | GO:0051091 | positive regulation of DNA binding transcription factor activity | 14752053 |
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Exon skipping events across known transcript of Ensembl for TCF3 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TCF3 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TCF3 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_312596 | 19 | 1611804:1611848:1612205:1612429:1615684:1615740 | 1612205:1612429 | ENSG00000071564.10 | ENST00000453954.2,ENST00000590684.1 |
| exon_skip_312597 | 19 | 1611804:1611848:1612205:1612432:1615283:1615323 | 1612205:1612432 | ENSG00000071564.10 | ENST00000585855.1,ENST00000592395.1 |
| exon_skip_312599 | 19 | 1611804:1611848:1612205:1612432:1615684:1615740 | 1612205:1612432 | ENSG00000071564.10 | ENST00000585731.1,ENST00000588136.1,ENST00000344749.5 |
| exon_skip_312611 | 19 | 1611804:1611848:1615283:1615484:1615684:1615740 | 1615283:1615484 | ENSG00000071564.10 | ENST00000586164.1 |
| exon_skip_312613 | 19 | 1611804:1611848:1615283:1615519:1615684:1615740 | 1615283:1615519 | ENSG00000071564.10 | ENST00000593064.1,ENST00000262965.5,ENST00000592628.1,ENST00000587425.1 |
| exon_skip_312641 | 19 | 1612419:1612432:1615283:1615514:1615684:1615740 | 1615283:1615514 | ENSG00000071564.10 | ENST00000585855.1 |
| exon_skip_312652 | 19 | 1619109:1619233:1619314:1619473:1619778:1619852 | 1619314:1619473 | ENSG00000071564.10 | ENST00000262965.5,ENST00000588136.1,ENST00000453954.2,ENST00000395423.3,ENST00000344749.5 |
| exon_skip_312654 | 19 | 1620966:1621045:1621131:1621190:1621836:1621969 | 1621131:1621190 | ENSG00000071564.10 | ENST00000262965.5,ENST00000588136.1,ENST00000453954.2,ENST00000395423.3,ENST00000344749.5 |
| exon_skip_312656 | 19 | 1621836:1621969:1622052:1622222:1622311:1622414 | 1622052:1622222 | ENSG00000071564.10 | ENST00000262965.5,ENST00000588136.1,ENST00000453954.2,ENST00000395423.3,ENST00000344749.5 |
| exon_skip_312658 | 19 | 1622311:1622414:1623949:1623999:1625574:1625707 | 1623949:1623999 | ENSG00000071564.10 | ENST00000262965.5,ENST00000588136.1,ENST00000453954.2,ENST00000395423.3,ENST00000344749.5 |
| exon_skip_312664 | 19 | 1627357:1627425:1631949:1632115:1632330:1632404 | 1631949:1632115 | ENSG00000071564.10 | ENST00000587235.1 |
| exon_skip_312666 | 19 | 1627357:1627425:1632036:1632115:1632330:1632404 | 1632036:1632115 | ENSG00000071564.10 | ENST00000262965.5,ENST00000588136.1,ENST00000344749.5 |
| exon_skip_312670 | 19 | 1627357:1627425:1646353:1646426:1650175:1650275 | 1646353:1646426 | ENSG00000071564.10 | ENST00000395423.3 |
| exon_skip_312671 | 19 | 1632049:1632115:1632330:1632404:1646353:1646426 | 1632330:1632404 | ENSG00000071564.10 | ENST00000262965.5,ENST00000588136.1,ENST00000586318.1,ENST00000344749.5,ENST00000587235.1 |
| exon_skip_312672 | 19 | 1632330:1632404:1646353:1646426:1650175:1650275 | 1646353:1646426 | ENSG00000071564.10 | ENST00000262965.5,ENST00000588136.1,ENST00000586318.1,ENST00000344749.5,ENST00000587235.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TCF3 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_312596 | 19 | 1611804:1611848:1612205:1612429:1615684:1615740 | 1612205:1612429 | ENSG00000071564.10 | ENST00000453954.2,ENST00000590684.1 |
| exon_skip_312597 | 19 | 1611804:1611848:1612205:1612432:1615283:1615323 | 1612205:1612432 | ENSG00000071564.10 | ENST00000592395.1,ENST00000585855.1 |
| exon_skip_312599 | 19 | 1611804:1611848:1612205:1612432:1615684:1615740 | 1612205:1612432 | ENSG00000071564.10 | ENST00000344749.5,ENST00000585731.1,ENST00000588136.1 |
| exon_skip_312611 | 19 | 1611804:1611848:1615283:1615484:1615684:1615740 | 1615283:1615484 | ENSG00000071564.10 | ENST00000586164.1 |
| exon_skip_312613 | 19 | 1611804:1611848:1615283:1615519:1615684:1615740 | 1615283:1615519 | ENSG00000071564.10 | ENST00000262965.5,ENST00000587425.1,ENST00000592628.1,ENST00000593064.1 |
| exon_skip_312641 | 19 | 1612419:1612432:1615283:1615514:1615684:1615740 | 1615283:1615514 | ENSG00000071564.10 | ENST00000585855.1 |
| exon_skip_312652 | 19 | 1619109:1619233:1619314:1619473:1619778:1619852 | 1619314:1619473 | ENSG00000071564.10 | ENST00000262965.5,ENST00000344749.5,ENST00000453954.2,ENST00000395423.3,ENST00000588136.1 |
| exon_skip_312654 | 19 | 1620966:1621045:1621131:1621190:1621836:1621969 | 1621131:1621190 | ENSG00000071564.10 | ENST00000262965.5,ENST00000344749.5,ENST00000453954.2,ENST00000395423.3,ENST00000588136.1 |
| exon_skip_312656 | 19 | 1621836:1621969:1622052:1622222:1622311:1622414 | 1622052:1622222 | ENSG00000071564.10 | ENST00000262965.5,ENST00000344749.5,ENST00000453954.2,ENST00000395423.3,ENST00000588136.1 |
| exon_skip_312658 | 19 | 1622311:1622414:1623949:1623999:1625574:1625707 | 1623949:1623999 | ENSG00000071564.10 | ENST00000262965.5,ENST00000344749.5,ENST00000453954.2,ENST00000395423.3,ENST00000588136.1 |
| exon_skip_312664 | 19 | 1627357:1627425:1631949:1632115:1632330:1632404 | 1631949:1632115 | ENSG00000071564.10 | ENST00000587235.1 |
| exon_skip_312666 | 19 | 1627357:1627425:1632036:1632115:1632330:1632404 | 1632036:1632115 | ENSG00000071564.10 | ENST00000262965.5,ENST00000344749.5,ENST00000588136.1 |
| exon_skip_312670 | 19 | 1627357:1627425:1646353:1646426:1650175:1650275 | 1646353:1646426 | ENSG00000071564.10 | ENST00000395423.3 |
| exon_skip_312671 | 19 | 1632049:1632115:1632330:1632404:1646353:1646426 | 1632330:1632404 | ENSG00000071564.10 | ENST00000262965.5,ENST00000344749.5,ENST00000588136.1,ENST00000587235.1,ENST00000586318.1 |
| exon_skip_312672 | 19 | 1632330:1632404:1646353:1646426:1650175:1650275 | 1646353:1646426 | ENSG00000071564.10 | ENST00000262965.5,ENST00000344749.5,ENST00000588136.1,ENST00000587235.1,ENST00000586318.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TCF3 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000262965 | 1615283 | 1615519 | Frame-shift |
| ENST00000262965 | 1621131 | 1621190 | Frame-shift |
| ENST00000262965 | 1622052 | 1622222 | Frame-shift |
| ENST00000262965 | 1623949 | 1623999 | Frame-shift |
| ENST00000262965 | 1632036 | 1632115 | Frame-shift |
| ENST00000262965 | 1632330 | 1632404 | Frame-shift |
| ENST00000262965 | 1646353 | 1646426 | Frame-shift |
| ENST00000262965 | 1619314 | 1619473 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000262965 | 1615283 | 1615519 | Frame-shift |
| ENST00000262965 | 1621131 | 1621190 | Frame-shift |
| ENST00000262965 | 1622052 | 1622222 | Frame-shift |
| ENST00000262965 | 1623949 | 1623999 | Frame-shift |
| ENST00000262965 | 1632036 | 1632115 | Frame-shift |
| ENST00000262965 | 1632330 | 1632404 | Frame-shift |
| ENST00000262965 | 1646353 | 1646426 | Frame-shift |
| ENST00000262965 | 1619314 | 1619473 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TCF3 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000262965 | 4740 | 654 | 1619314 | 1619473 | 1513 | 1671 | 389 | 442 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000262965 | 4740 | 654 | 1619314 | 1619473 | 1513 | 1671 | 389 | 442 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P15923 | 389 | 442 | 1 | 654 | Chain | ID=PRO_0000127466;Note=Transcription factor E2-alpha |
| P15923 | 389 | 442 | 431 | 431 | Natural variant | ID=VAR_049554;Note=G->S;Dbxref=dbSNP:rs1052692 |
| P15923 | 389 | 442 | 389 | 425 | Region | Note=Leucine-zipper |
| P15923 | 389 | 442 | 390 | 390 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| P15923 | 389 | 442 | 1 | 654 | Chain | ID=PRO_0000127466;Note=Transcription factor E2-alpha |
| P15923 | 389 | 442 | 431 | 431 | Natural variant | ID=VAR_049554;Note=G->S;Dbxref=dbSNP:rs1052692 |
| P15923 | 389 | 442 | 389 | 425 | Region | Note=Leucine-zipper |
| P15923 | 389 | 442 | 390 | 390 | Sequence conflict | Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 |
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SNVs in the skipped exons for TCF3 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
TCF3_PRAD_exon_skip_312596_psi_boxplot.png |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SKCM | TCGA-YG-AA3N-01 | exon_skip_312656 | 1622053 | 1622222 | 1622191 | 1622191 | Frame_Shift_Del | C | - | p.W228fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_312670 exon_skip_312672 | 1646354 | 1646426 | 1646395 | 1646395 | Frame_Shift_Del | C | - | p.G35fs |
| PRAD | TCGA-XK-AAIW-01 | exon_skip_312596 | 1612206 | 1612429 | 1612209 | 1612209 | Nonsense_Mutation | G | A | p.R604* |
| PRAD | TCGA-XK-AAIW-01 | exon_skip_312599 exon_skip_312597 | 1612206 | 1612432 | 1612209 | 1612209 | Nonsense_Mutation | G | A | p.R604* |
| UCEC | TCGA-B5-A11E-01 | exon_skip_312611 | 1615284 | 1615484 | 1615287 | 1615287 | Nonsense_Mutation | G | A | p.R607* |
| UCEC | TCGA-B5-A11E-01 | exon_skip_312641 | 1615284 | 1615514 | 1615287 | 1615287 | Nonsense_Mutation | G | A | p.R607* |
| UCEC | TCGA-B5-A11E-01 | exon_skip_312613 | 1615284 | 1615519 | 1615287 | 1615287 | Nonsense_Mutation | G | A | p.R607* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
 | Sample: TCGA-B5-A11E-01 |
| Cancer type: UCEC | |
| ESID: exon_skip_312613 | |
| Skipped exon start: 1615284 | |
| Skipped exon end: 1615519 | |
| Mutation start: 1615287 | |
| Mutation end: 1615287 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R607* | |
| Sample: TCGA-B5-A11E-01 |
| Cancer type: UCEC | |
| ESID: exon_skip_312611 | |
| Skipped exon start: 1615284 | |
| Skipped exon end: 1615484 | |
| Mutation start: 1615287 | |
| Mutation end: 1615287 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R607* | |
| Sample: TCGA-B5-A11E-01 |
| Cancer type: UCEC | |
| ESID: exon_skip_312641 | |
| Skipped exon start: 1615284 | |
| Skipped exon end: 1615514 | |
| Mutation start: 1615287 | |
| Mutation end: 1615287 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R607* | |
exon_skip_104037_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_106242_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_108777_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_108778_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_121584_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_121649_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_131821_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_133126_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_23327_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_27874_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_312611_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_312613_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_312641_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_313540_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_326446_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_326448_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_330038_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_340150_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_348004_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_348005_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_377858_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_380242_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_433438_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_489645_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_500396_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_62223_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_97620_UCEC_TCGA-B5-A11E-01.png | |
exon_skip_97655_UCEC_TCGA-B5-A11E-01.png | |
 | Sample: TCGA-B5-A11E-01 |
| Cancer type: UCEC | |
| ESID: exon_skip_312613 | |
| Skipped exon start: 1615284 | |
| Skipped exon end: 1615519 | |
| Mutation start: 1615287 | |
| Mutation end: 1615287 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R607* | |
| Sample: TCGA-B5-A11E-01 |
| Cancer type: UCEC | |
| ESID: exon_skip_312611 | |
| Skipped exon start: 1615284 | |
| Skipped exon end: 1615484 | |
| Mutation start: 1615287 | |
| Mutation end: 1615287 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R607* | |
| Sample: TCGA-B5-A11E-01 |
| Cancer type: UCEC | |
| ESID: exon_skip_312641 | |
| Skipped exon start: 1615284 | |
| Skipped exon end: 1615514 | |
| Mutation start: 1615287 | |
| Mutation end: 1615287 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R607* | |
| exon_skip_104037_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_106242_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_108777_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_108778_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_121584_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_121649_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_131821_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_133126_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_23327_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_27874_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_312611_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_312613_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_312641_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_313540_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_326446_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_326448_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_330038_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_340150_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_348004_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_348005_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_377858_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_380242_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_433438_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_489645_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_500396_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_62223_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_97620_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_97655_UCEC_TCGA-B5-A11E-01.png | |
 | Sample: TCGA-B5-A11E-01 |
| Cancer type: UCEC | |
| ESID: exon_skip_312613 | |
| Skipped exon start: 1615284 | |
| Skipped exon end: 1615519 | |
| Mutation start: 1615287 | |
| Mutation end: 1615287 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R607* | |
| Sample: TCGA-B5-A11E-01 |
| Cancer type: UCEC | |
| ESID: exon_skip_312611 | |
| Skipped exon start: 1615284 | |
| Skipped exon end: 1615484 | |
| Mutation start: 1615287 | |
| Mutation end: 1615287 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R607* | |
| Sample: TCGA-B5-A11E-01 |
| Cancer type: UCEC | |
| ESID: exon_skip_312641 | |
| Skipped exon start: 1615284 | |
| Skipped exon end: 1615514 | |
| Mutation start: 1615287 | |
| Mutation end: 1615287 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R607* | |
| exon_skip_104037_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_106242_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_108777_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_108778_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_121584_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_121649_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_131821_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_133126_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_23327_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_27874_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_312611_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_312613_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_312641_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_313540_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_326446_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_326448_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_330038_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_340150_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_348004_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_348005_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_377858_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_380242_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_433438_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_489645_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_500396_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_62223_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_97620_UCEC_TCGA-B5-A11E-01.png | |
| exon_skip_97655_UCEC_TCGA-B5-A11E-01.png | |
 | Sample: TCGA-XK-AAIW-01 |
| Cancer type: PRAD | |
| ESID: exon_skip_312597 | |
| Skipped exon start: 1612206 | |
| Skipped exon end: 1612432 | |
| Mutation start: 1612209 | |
| Mutation end: 1612209 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R604* | |
| Sample: TCGA-XK-AAIW-01 |
| Cancer type: PRAD | |
| ESID: exon_skip_312596 | |
| Skipped exon start: 1612206 | |
| Skipped exon end: 1612429 | |
| Mutation start: 1612209 | |
| Mutation end: 1612209 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R604* | |
exon_skip_101989_PRAD_TCGA-XK-AAIW-01.png | |
exon_skip_123519_PRAD_TCGA-XK-AAIW-01.png | |
exon_skip_141370_PRAD_TCGA-XK-AAIW-01.png | |
exon_skip_307491_PRAD_TCGA-XK-AAIW-01.png | |
exon_skip_312596_PRAD_TCGA-XK-AAIW-01.png | |
exon_skip_312597_PRAD_TCGA-XK-AAIW-01.png | |
exon_skip_312599_PRAD_TCGA-XK-AAIW-01.png | |
exon_skip_382100_PRAD_TCGA-XK-AAIW-01.png | |
exon_skip_500520_PRAD_TCGA-XK-AAIW-01.png | |
exon_skip_66767_PRAD_TCGA-XK-AAIW-01.png | |
exon_skip_74728_PRAD_TCGA-XK-AAIW-01.png | |
 | Sample: TCGA-XK-AAIW-01 |
| Cancer type: PRAD | |
| ESID: exon_skip_312597 | |
| Skipped exon start: 1612206 | |
| Skipped exon end: 1612432 | |
| Mutation start: 1612209 | |
| Mutation end: 1612209 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R604* | |
| Sample: TCGA-XK-AAIW-01 |
| Cancer type: PRAD | |
| ESID: exon_skip_312596 | |
| Skipped exon start: 1612206 | |
| Skipped exon end: 1612429 | |
| Mutation start: 1612209 | |
| Mutation end: 1612209 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R604* | |
| exon_skip_101989_PRAD_TCGA-XK-AAIW-01.png | |
| exon_skip_123519_PRAD_TCGA-XK-AAIW-01.png | |
| exon_skip_141370_PRAD_TCGA-XK-AAIW-01.png | |
| exon_skip_307491_PRAD_TCGA-XK-AAIW-01.png | |
| exon_skip_312596_PRAD_TCGA-XK-AAIW-01.png | |
| exon_skip_312597_PRAD_TCGA-XK-AAIW-01.png | |
| exon_skip_312599_PRAD_TCGA-XK-AAIW-01.png | |
| exon_skip_382100_PRAD_TCGA-XK-AAIW-01.png | |
| exon_skip_500520_PRAD_TCGA-XK-AAIW-01.png | |
| exon_skip_66767_PRAD_TCGA-XK-AAIW-01.png | |
| exon_skip_74728_PRAD_TCGA-XK-AAIW-01.png | |
 | Sample: TCGA-XK-AAIW-01 |
| Cancer type: PRAD | |
| ESID: exon_skip_312597 | |
| Skipped exon start: 1612206 | |
| Skipped exon end: 1612432 | |
| Mutation start: 1612209 | |
| Mutation end: 1612209 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R604* | |
| Sample: TCGA-XK-AAIW-01 |
| Cancer type: PRAD | |
| ESID: exon_skip_312596 | |
| Skipped exon start: 1612206 | |
| Skipped exon end: 1612429 | |
| Mutation start: 1612209 | |
| Mutation end: 1612209 | |
| Mutation type: Nonsense_Mutation | |
| Reference seq: G | |
| Mutation seq: A | |
| AAchange: p.R604* | |
| exon_skip_101989_PRAD_TCGA-XK-AAIW-01.png | |
| exon_skip_123519_PRAD_TCGA-XK-AAIW-01.png | |
| exon_skip_141370_PRAD_TCGA-XK-AAIW-01.png | |
| exon_skip_307491_PRAD_TCGA-XK-AAIW-01.png | |
| exon_skip_312596_PRAD_TCGA-XK-AAIW-01.png | |
| exon_skip_312597_PRAD_TCGA-XK-AAIW-01.png | |
| exon_skip_312599_PRAD_TCGA-XK-AAIW-01.png | |
| exon_skip_382100_PRAD_TCGA-XK-AAIW-01.png | |
| exon_skip_500520_PRAD_TCGA-XK-AAIW-01.png | |
| exon_skip_66767_PRAD_TCGA-XK-AAIW-01.png | |
| exon_skip_74728_PRAD_TCGA-XK-AAIW-01.png | |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LS180_LARGE_INTESTINE | 1615284 | 1615519 | 1615487 | 1615487 | Frame_Shift_Del | G | - | p.P540fs |
| LS180_LARGE_INTESTINE | 1615284 | 1615484 | 1615487 | 1615487 | Frame_Shift_Del | G | - | p.P540fs |
| LS180_LARGE_INTESTINE | 1615284 | 1615514 | 1615487 | 1615487 | Frame_Shift_Del | G | - | p.P540fs |
| COLO684_ENDOMETRIUM | 1612206 | 1612432 | 1612328 | 1612328 | Missense_Mutation | T | C | p.E564G |
| COLO684_ENDOMETRIUM | 1612206 | 1612429 | 1612328 | 1612328 | Missense_Mutation | T | C | p.E564G |
| RAMOS2G64C10_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1612206 | 1612432 | 1612336 | 1612336 | Missense_Mutation | A | C | p.D561E |
| RAMOS2G64C10_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1612206 | 1612429 | 1612336 | 1612336 | Missense_Mutation | A | C | p.D561E |
| DG75_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1612206 | 1612432 | 1612337 | 1612337 | Missense_Mutation | T | A | p.D561V |
| DG75_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1612206 | 1612429 | 1612337 | 1612337 | Missense_Mutation | T | A | p.D561V |
| RL952_ENDOMETRIUM | 1612206 | 1612432 | 1612361 | 1612361 | Missense_Mutation | G | A | p.A553V |
| RL952_ENDOMETRIUM | 1612206 | 1612429 | 1612361 | 1612361 | Missense_Mutation | G | A | p.A553V |
| SUPHD1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1612206 | 1612432 | 1612366 | 1612366 | Missense_Mutation | A | C | p.N551K |
| SUPHD1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1612206 | 1612429 | 1612366 | 1612366 | Missense_Mutation | A | C | p.N551K |
| EB3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1612206 | 1612432 | 1612366 | 1612366 | Missense_Mutation | A | T | p.N551K |
| EB3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1612206 | 1612429 | 1612366 | 1612366 | Missense_Mutation | A | T | p.N551K |
| MHHPREB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1612206 | 1612432 | 1612366 | 1612366 | Missense_Mutation | A | C | p.N551K |
| MHHPREB1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1612206 | 1612429 | 1612366 | 1612366 | Missense_Mutation | A | C | p.N551K |
| SC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1612206 | 1612432 | 1612366 | 1612366 | Missense_Mutation | A | C | p.N551K |
| SC1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1612206 | 1612429 | 1612366 | 1612366 | Missense_Mutation | A | C | p.N551K |
| VAL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1612206 | 1612432 | 1612366 | 1612366 | Missense_Mutation | A | C | p.N551K |
| VAL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1612206 | 1612429 | 1612366 | 1612366 | Missense_Mutation | A | C | p.N551K |
| SCI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1612206 | 1612432 | 1612366 | 1612366 | Missense_Mutation | A | C | p.N551K |
| SCI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1612206 | 1612429 | 1612366 | 1612366 | Missense_Mutation | A | C | p.N551K |
| KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1612206 | 1612432 | 1612406 | 1612406 | Missense_Mutation | T | A | p.E538V |
| KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1612206 | 1612429 | 1612406 | 1612406 | Missense_Mutation | T | A | p.E538V |
| KM12_LARGE_INTESTINE | 1612206 | 1612432 | 1612409 | 1612409 | Missense_Mutation | A | C | p.L537R |
| KM12_LARGE_INTESTINE | 1612206 | 1612429 | 1612409 | 1612409 | Missense_Mutation | A | C | p.L537R |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1615284 | 1615519 | 1615314 | 1615314 | Missense_Mutation | C | T | p.V598I |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1615284 | 1615484 | 1615314 | 1615314 | Missense_Mutation | C | T | p.V598I |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1615284 | 1615514 | 1615314 | 1615314 | Missense_Mutation | C | T | p.V598I |
| JHH6_LIVER | 1615284 | 1615519 | 1615316 | 1615316 | Missense_Mutation | G | A | p.S597L |
| JHH6_LIVER | 1615284 | 1615484 | 1615316 | 1615316 | Missense_Mutation | G | A | p.S597L |
| JHH6_LIVER | 1615284 | 1615514 | 1615316 | 1615316 | Missense_Mutation | G | A | p.S597L |
| HCT15_LARGE_INTESTINE | 1615284 | 1615519 | 1615359 | 1615359 | Missense_Mutation | C | T | p.E583K |
| HCT15_LARGE_INTESTINE | 1615284 | 1615484 | 1615359 | 1615359 | Missense_Mutation | C | T | p.E583K |
| HCT15_LARGE_INTESTINE | 1615284 | 1615514 | 1615359 | 1615359 | Missense_Mutation | C | T | p.E583K |
| HRT18_LARGE_INTESTINE | 1615284 | 1615519 | 1615359 | 1615359 | Missense_Mutation | C | T | p.E583K |
| HRT18_LARGE_INTESTINE | 1615284 | 1615484 | 1615359 | 1615359 | Missense_Mutation | C | T | p.E583K |
| HRT18_LARGE_INTESTINE | 1615284 | 1615514 | 1615359 | 1615359 | Missense_Mutation | C | T | p.E583K |
| 2313287_STOMACH | 1615284 | 1615519 | 1615430 | 1615430 | Missense_Mutation | C | T | p.R559Q |
| 2313287_STOMACH | 1615284 | 1615484 | 1615430 | 1615430 | Missense_Mutation | C | T | p.R559Q |
| 2313287_STOMACH | 1615284 | 1615514 | 1615430 | 1615430 | Missense_Mutation | C | T | p.R559Q |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1615284 | 1615519 | 1615431 | 1615431 | Missense_Mutation | G | A | p.R559W |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1615284 | 1615484 | 1615431 | 1615431 | Missense_Mutation | G | A | p.R559W |
| MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1615284 | 1615514 | 1615431 | 1615431 | Missense_Mutation | G | A | p.R559W |
| HEC108_ENDOMETRIUM | 1615284 | 1615519 | 1615473 | 1615473 | Missense_Mutation | C | T | p.E545K |
| HEC108_ENDOMETRIUM | 1615284 | 1615484 | 1615473 | 1615473 | Missense_Mutation | C | T | p.E545K |
| HEC108_ENDOMETRIUM | 1615284 | 1615514 | 1615473 | 1615473 | Missense_Mutation | C | T | p.E545K |
| KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1615284 | 1615519 | 1615512 | 1615512 | Missense_Mutation | C | T | p.E532K |
| KCL22_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1615284 | 1615514 | 1615512 | 1615512 | Missense_Mutation | C | T | p.E532K |
| LS411N_LARGE_INTESTINE | 1615284 | 1615519 | 1615517 | 1615517 | Missense_Mutation | G | C | p.P530R |
| LS411N_LARGE_INTESTINE | 1615284 | 1615514 | 1615517 | 1615517 | Missense_Mutation | G | C | p.P530R |
| MINO_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1615284 | 1615519 | 1615520 | 1615520 | Missense_Mutation | C | T | p.S533N |
| MINO_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1615284 | 1615514 | 1615520 | 1615520 | Missense_Mutation | C | T | p.S533N |
| TE8_OESOPHAGUS | 1619315 | 1619473 | 1619458 | 1619458 | Missense_Mutation | C | T | p.D395N |
| OVTOKO_OVARY | 1622053 | 1622222 | 1622057 | 1622057 | Missense_Mutation | C | T | p.R273H |
| PANC0213_PANCREAS | 1622053 | 1622222 | 1622061 | 1622061 | Missense_Mutation | C | T | p.E272K |
| NCIH358_LUNG | 1622053 | 1622222 | 1622115 | 1622115 | Missense_Mutation | C | T | p.G254S |
| HEC6_ENDOMETRIUM | 1622053 | 1622222 | 1622163 | 1622163 | Missense_Mutation | G | T | p.P238T |
| HEC265_ENDOMETRIUM | 1623950 | 1623999 | 1623966 | 1623966 | Missense_Mutation | G | A | p.P178L |
| 2313287_STOMACH | 1631950 | 1632115 | 1631962 | 1631962 | Missense_Mutation | G | A | p.T12M |
| MOT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1632331 | 1632404 | 1632336 | 1632336 | Missense_Mutation | T | A | p.S72C |
| MOLP2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1632331 | 1632404 | 1632402 | 1632402 | Missense_Mutation | G | A | p.L50F |
| LN340_CENTRAL_NERVOUS_SYSTEM | 1646354 | 1646426 | 1646375 | 1646375 | Missense_Mutation | C | T | p.G42R |
| MM370_SKIN | 1646354 | 1646426 | 1646385 | 1646386 | Missense_Mutation | GG | AA | p.A38V |
| HCC2108_LUNG | 1646354 | 1646426 | 1646419 | 1646419 | Missense_Mutation | G | T | p.P27Q |
| NCIH1105_LUNG | 1612206 | 1612432 | 1612317 | 1612317 | Nonsense_Mutation | C | A | p.E568* |
| NCIH1105_LUNG | 1612206 | 1612429 | 1612317 | 1612317 | Nonsense_Mutation | C | A | p.E568* |
| FEPD_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 1621132 | 1621190 | 1621185 | 1621185 | Nonsense_Mutation | G | A | p.R321* |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TCF3 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
Top |
Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TCF3 |
Top |
Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TCF3 |
Top |
RelatedDrugs for TCF3 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for TCF3 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TCF3 | C0006413 | Burkitt Lymphoma | 2 | CTD_human |
| TCF3 | C0023485 | Precursor B-Cell Lymphoblastic Leukemia-Lymphoma | 1 | CTD_human |
| TCF3 | C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | CTD_human |
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