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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TAL1 |
 Gene summary |
| Gene information | Gene symbol | TAL1 | Gene ID | 6886 |
| Gene name | TAL bHLH transcription factor 1, erythroid differentiation factor | |
| Synonyms | SCL|TCL5|bHLHa17|tal-1 | |
| Cytomap | 1p33 | |
| Type of gene | protein-coding | |
| Description | T-cell acute lymphocytic leukemia protein 1T-cell acute lymphocytic leukemia 1T-cell leukemia/lymphoma protein 5class A basic helix-loop-helix protein 17stem cell proteintal-1 product | |
| Modification date | 20180523 | |
| UniProtAcc | P17542 | |
| Context | PubMed: TAL1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| TAL1 | GO:0031334 | positive regulation of protein complex assembly | 20855495 |
| TAL1 | GO:0045648 | positive regulation of erythrocyte differentiation | 20028976 |
| TAL1 | GO:0045893 | positive regulation of transcription, DNA-templated | 20028976 |
| TAL1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20855495 |
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Exon skipping events across known transcript of Ensembl for TAL1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TAL1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TAL1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_26570 | 1 | 47685618:47685846:47689055:47689291:47689675:47689748 | 47689055:47689291 | ENSG00000162367.7 | ENST00000459729.1 |
| exon_skip_26571 | 1 | 47689743:47689770:47691114:47691561:47694867:47695023 | 47691114:47691561 | ENSG00000162367.7 | ENST00000371884.2,ENST00000294339.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TAL1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_26570 | 1 | 47685618:47685846:47689055:47689291:47689675:47689748 | 47689055:47689291 | ENSG00000162367.7 | ENST00000459729.1 |
| exon_skip_26571 | 1 | 47689743:47689770:47691114:47691561:47694867:47695023 | 47691114:47691561 | ENSG00000162367.7 | ENST00000371884.2,ENST00000294339.3 |
| exon_skip_26572 | 1 | 47689743:47689770:47694867:47695023:47697838:47697892 | 47694867:47695023 | ENSG00000162367.7 | ENST00000464796.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TAL1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000294339 | 47691114 | 47691561 | 3UTR-3CDS |
| ENST00000371884 | 47691114 | 47691561 | 3UTR-3CDS |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000294339 | 47691114 | 47691561 | 3UTR-3CDS |
| ENST00000371884 | 47691114 | 47691561 | 3UTR-3CDS |
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Infer the effects of exon skipping event on protein functional features for TAL1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for TAL1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LUAD | TCGA-17-Z015-01 | exon_skip_26571 | 47691115 | 47691561 | 47691474 | 47691475 | Frame_Shift_Ins | - | G | p.P29fs |
| STAD | TCGA-BR-7707-01 | exon_skip_26571 | 47691115 | 47691561 | 47691474 | 47691475 | Frame_Shift_Ins | - | G | p.P29fs |
| STAD | TCGA-D7-A4YV-01 | exon_skip_26571 | 47691115 | 47691561 | 47691474 | 47691475 | Frame_Shift_Ins | - | G | p.P29fs |
| STAD | TCGA-BR-7707-01 | exon_skip_26571 | 47691115 | 47691561 | 47691475 | 47691476 | Frame_Shift_Ins | - | G | p.P29fs |
| STAD | TCGA-D7-A4YV-01 | exon_skip_26571 | 47691115 | 47691561 | 47691475 | 47691476 | Frame_Shift_Ins | - | G | p.P29fs |
| LUSC | TCGA-66-2768-01 | exon_skip_26571 | 47691115 | 47691561 | 47691494 | 47691494 | Nonsense_Mutation | C | A | p.E23* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| CTV1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 47691115 | 47691561 | 47691389 | 47691390 | Frame_Shift_Del | CG | - | p.G59fs |
| SNU1040_LARGE_INTESTINE | 47691115 | 47691561 | 47691475 | 47691475 | Frame_Shift_Del | G | - | p.P29fs |
| SNU1040_LARGE_INTESTINE | 47691115 | 47691561 | 47691411 | 47691412 | Frame_Shift_Ins | - | G | p.P50fs |
| OCIM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 47691115 | 47691561 | 47691125 | 47691125 | Missense_Mutation | A | T | p.S146T |
| 8305C_THYROID | 47691115 | 47691561 | 47691191 | 47691191 | Missense_Mutation | G | A | p.P124S |
| T84_LARGE_INTESTINE | 47691115 | 47691561 | 47691215 | 47691215 | Missense_Mutation | C | T | p.G116S |
| IGR39_SKIN | 47691115 | 47691561 | 47691364 | 47691364 | Missense_Mutation | C | A | p.G66V |
| JURKAT_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 47691115 | 47691561 | 47691368 | 47691368 | Missense_Mutation | C | T | p.A65T |
| RMGI_OVARY | 47691115 | 47691561 | 47691520 | 47691520 | Missense_Mutation | G | T | p.P14H |
| KASUMI2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 47691115 | 47691561 | 47691544 | 47691544 | Missense_Mutation | G | A | p.P6L |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TAL1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TAL1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TAL1 |
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RelatedDrugs for TAL1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TAL1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| TAL1 | C1961099 | Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | 2 | CTD_human |
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