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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for MAP3K7 |
 Gene summary |
| Gene information | Gene symbol | MAP3K7 | Gene ID | 6885 |
| Gene name | mitogen-activated protein kinase kinase kinase 7 | |
| Synonyms | CSCF|FMD2|MEKK7|TAK1|TGF1a | |
| Cytomap | 6q15 | |
| Type of gene | protein-coding | |
| Description | mitogen-activated protein kinase kinase kinase 7TGF-beta activated kinase 1transforming growth factor-beta-activated kinase 1 | |
| Modification date | 20180523 | |
| UniProtAcc | O43318 | |
| Context | PubMed: MAP3K7 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
| MAP3K7 | GO:0000186 | activation of MAPKK activity | 8663074|9079627 |
| MAP3K7 | GO:0000187 | activation of MAPK activity | 9079627 |
| MAP3K7 | GO:0007252 | I-kappaB phosphorylation | 11460167 |
| MAP3K7 | GO:0007254 | JNK cascade | 9079627 |
| MAP3K7 | GO:0043507 | positive regulation of JUN kinase activity | 11460167 |
| MAP3K7 | GO:0043966 | histone H3 acetylation | 18838386 |
| MAP3K7 | GO:0051403 | stress-activated MAPK cascade | 9079627 |
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Exon skipping events across known transcript of Ensembl for MAP3K7 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for MAP3K7 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for MAP3K7 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_461106 | 6 | 91225626:91226400:91228165:91228281:91228976:91229038 | 91228165:91228281 | ENSG00000135341.13 | ENST00000369329.3,ENST00000369320.1,ENST00000479630.1,ENST00000369332.3 |
| exon_skip_461111 | 6 | 91246055:91246120:91254270:91254351:91256976:91257106 | 91254270:91254351 | ENSG00000135341.13 | ENST00000369329.3,ENST00000369325.3 |
| exon_skip_461116 | 6 | 91266218:91266343:91269794:91269933:91271340:91271386 | 91269794:91269933 | ENSG00000135341.13 | ENST00000369329.3,ENST00000369325.3,ENST00000369332.3,ENST00000369327.3 |
| exon_skip_461119 | 6 | 91269794:91269933:91271340:91271386:91278276:91278342 | 91271340:91271386 | ENSG00000135341.13 | ENST00000369329.3,ENST00000369325.3,ENST00000369332.3,ENST00000369327.3 |
| exon_skip_461121 | 6 | 91271340:91271386:91278276:91278342:91281415:91281526 | 91278276:91278342 | ENSG00000135341.13 | ENST00000369329.3,ENST00000369325.3,ENST00000369332.3,ENST00000369327.3 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for MAP3K7 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_461106 | 6 | 91225626:91226400:91228165:91228281:91228976:91229038 | 91228165:91228281 | ENSG00000135341.13 | ENST00000369332.3,ENST00000369329.3,ENST00000479630.1,ENST00000369320.1 |
| exon_skip_461111 | 6 | 91246055:91246120:91254270:91254351:91256976:91257106 | 91254270:91254351 | ENSG00000135341.13 | ENST00000369325.3,ENST00000369329.3 |
| exon_skip_461116 | 6 | 91266218:91266343:91269794:91269933:91271340:91271386 | 91269794:91269933 | ENSG00000135341.13 | ENST00000369325.3,ENST00000369327.3,ENST00000369332.3,ENST00000369329.3 |
| exon_skip_461119 | 6 | 91269794:91269933:91271340:91271386:91278276:91278342 | 91271340:91271386 | ENSG00000135341.13 | ENST00000369325.3,ENST00000369327.3,ENST00000369332.3,ENST00000369329.3 |
| exon_skip_461121 | 6 | 91271340:91271386:91278276:91278342:91281415:91281526 | 91278276:91278342 | ENSG00000135341.13 | ENST00000369325.3,ENST00000369327.3,ENST00000369332.3,ENST00000369329.3 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for MAP3K7 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000369329 | 91228165 | 91228281 | Frame-shift |
| ENST00000369329 | 91269794 | 91269933 | Frame-shift |
| ENST00000369329 | 91271340 | 91271386 | Frame-shift |
| ENST00000369329 | 91254270 | 91254351 | In-frame |
| ENST00000369329 | 91278276 | 91278342 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000369329 | 91228165 | 91228281 | Frame-shift |
| ENST00000369329 | 91269794 | 91269933 | Frame-shift |
| ENST00000369329 | 91271340 | 91271386 | Frame-shift |
| ENST00000369329 | 91254270 | 91254351 | In-frame |
| ENST00000369329 | 91278276 | 91278342 | In-frame |
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Infer the effects of exon skipping event on protein functional features for MAP3K7 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000369329 | 4928 | 606 | 91278276 | 91278342 | 394 | 459 | 77 | 99 |
| ENST00000369329 | 4928 | 606 | 91254270 | 91254351 | 1373 | 1453 | 403 | 430 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000369329 | 4928 | 606 | 91278276 | 91278342 | 394 | 459 | 77 | 99 |
| ENST00000369329 | 4928 | 606 | 91254270 | 91254351 | 1373 | 1453 | 403 | 430 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for MAP3K7 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| BLCA | TCGA-FD-A3N5-01 | exon_skip_461111 | 91254271 | 91254351 | 91254347 | 91254347 | Nonsense_Mutation | A | C | p.Y405* |
| THYM | TCGA-ZB-A963-01 | exon_skip_461116 | 91269795 | 91269933 | 91269835 | 91269835 | Nonsense_Mutation | G | A | p.Q148X |
| KIRC | TCGA-A3-3311-01 | exon_skip_461106 | 91228166 | 91228281 | 91228282 | 91228282 | Splice_Site | C | A | . |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| SW684_SOFT_TISSUE | 91228166 | 91228281 | 91228272 | 91228272 | Missense_Mutation | G | A | p.P512S |
| SNU1040_LARGE_INTESTINE | 91254271 | 91254351 | 91254324 | 91254324 | Missense_Mutation | C | T | p.R413H |
| A704_KIDNEY | 91254271 | 91254351 | 91254325 | 91254325 | Missense_Mutation | G | A | p.R413C |
| SKNFI_AUTONOMIC_GANGLIA | 91269795 | 91269933 | 91269886 | 91269886 | Missense_Mutation | T | C | p.M131V |
| NCIH446_LUNG | 91278277 | 91278342 | 91278335 | 91278335 | Missense_Mutation | T | A | p.Q80L |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for MAP3K7 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAP3K7 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for MAP3K7 |
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RelatedDrugs for MAP3K7 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for MAP3K7 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
| MAP3K7 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| MAP3K7 | C1834818 | Mitral Regurgitation, Conductive Deafness, and Fusion of Cervical Vertebrae and of Carpal and Tarsal Bones | 1 | ORPHANET;UNIPROT |
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