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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for TACC1 |
 Gene summary |
| Gene information | Gene symbol | TACC1 | Gene ID | 6867 |
| Gene name | transforming acidic coiled-coil containing protein 1 | |
| Synonyms | Ga55 | |
| Cytomap | 8p11.22 | |
| Type of gene | protein-coding | |
| Description | transforming acidic coiled-coil-containing protein 1gastric cancer antigen Ga55taxin-1 | |
| Modification date | 20180523 | |
| UniProtAcc | O75410 | |
| Context | PubMed: TACC1 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for TACC1 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for TACC1 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for TACC1 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_482867 | 8 | 38586157:38586189:38599868:38599969:38602412:38602719 | 38599868:38599969 | ENSG00000147526.15 | ENST00000518415.1 |
| exon_skip_482870 | 8 | 38586157:38586189:38599868:38599969:38645074:38645261 | 38599868:38599969 | ENSG00000147526.15 | ENST00000443286.2 |
| exon_skip_482871 | 8 | 38586157:38586189:38599868:38599969:38646221:38646337 | 38599868:38599969 | ENSG00000147526.15 | ENST00000520340.1 |
| exon_skip_482881 | 8 | 38586157:38586189:38646221:38646337:38677039:38677140 | 38646221:38646337 | ENSG00000147526.15 | ENST00000520615.1 |
| exon_skip_482887 | 8 | 38599868:38599969:38602412:38603011:38646221:38646337 | 38602412:38603011 | ENSG00000147526.15 | ENST00000518415.1 |
| exon_skip_482892 | 8 | 38599868:38599969:38645074:38645261:38646221:38646337 | 38645074:38645261 | ENSG00000147526.15 | ENST00000443286.2 |
| exon_skip_482894 | 8 | 38599868:38599969:38646221:38646337:38677039:38677140 | 38646221:38646337 | ENSG00000147526.15 | ENST00000520340.1 |
| exon_skip_482903 | 8 | 38614850:38614927:38646221:38646337:38677039:38677140 | 38646221:38646337 | ENSG00000147526.15 | ENST00000522904.1 |
| exon_skip_482907 | 8 | 38614850:38614927:38681507:38681543:38682825:38682886 | 38681507:38681543 | ENSG00000147526.15 | ENST00000330691.6,ENST00000521050.1 |
| exon_skip_482908 | 8 | 38643193:38643254:38645074:38645261:38646221:38646337 | 38645074:38645261 | ENSG00000147526.15 | ENST00000524354.1 |
| exon_skip_482910 | 8 | 38646221:38646337:38677039:38678153:38682825:38682886 | 38677039:38678153 | ENSG00000147526.15 | ENST00000522904.1,ENST00000520973.1,ENST00000518415.1,ENST00000520615.1,ENST00000317827.4,ENST00000443286.2,ENST00000520340.1 |
| exon_skip_482911 | 8 | 38678064:38678153:38681507:38681543:38682825:38682886 | 38681507:38681543 | ENSG00000147526.15 | ENST00000521866.1,ENST00000518809.1,ENST00000379931.3 |
| exon_skip_482912 | 8 | 38678064:38678153:38682825:38682886:38684685:38684893 | 38682825:38682886 | ENSG00000147526.15 | ENST00000522904.1,ENST00000520973.1,ENST00000518415.1,ENST00000520615.1,ENST00000317827.4,ENST00000443286.2,ENST00000520340.1,ENST00000522955.1 |
| exon_skip_482913 | 8 | 38678064:38678153:38682828:38682886:38684685:38684893 | 38682828:38682886 | ENSG00000147526.15 | ENST00000519416.1 |
| exon_skip_482915 | 8 | 38688642:38688695:38693679:38693805:38695987:38696025 | 38693679:38693805 | ENSG00000147526.15 | ENST00000348567.4,ENST00000520973.1,ENST00000523239.1,ENST00000521866.1,ENST00000518809.1,ENST00000518415.1,ENST00000520615.1,ENST00000317827.4,ENST00000379931.3,ENST00000522752.1,ENST00000443286.2,ENST00000276520.8,ENST00000519416.1,ENST00000520611.1,ENS |
| exon_skip_482916 | 8 | 38695987:38696064:38697741:38697785:38699804:38699965 | 38697741:38697785 | ENSG00000147526.15 | ENST00000348567.4,ENST00000520973.1,ENST00000518415.1,ENST00000520615.1,ENST00000317827.4,ENST00000379931.3,ENST00000443286.2,ENST00000276520.8,ENST00000519416.1,ENST00000330691.6 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for TACC1 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_482867 | 8 | 38586157:38586189:38599868:38599969:38602412:38602719 | 38599868:38599969 | ENSG00000147526.15 | ENST00000518415.1 |
| exon_skip_482870 | 8 | 38586157:38586189:38599868:38599969:38645074:38645261 | 38599868:38599969 | ENSG00000147526.15 | ENST00000443286.2 |
| exon_skip_482871 | 8 | 38586157:38586189:38599868:38599969:38646221:38646337 | 38599868:38599969 | ENSG00000147526.15 | ENST00000520340.1 |
| exon_skip_482881 | 8 | 38586157:38586189:38646221:38646337:38677039:38677140 | 38646221:38646337 | ENSG00000147526.15 | ENST00000520615.1 |
| exon_skip_482887 | 8 | 38599868:38599969:38602412:38603011:38646221:38646337 | 38602412:38603011 | ENSG00000147526.15 | ENST00000518415.1 |
| exon_skip_482892 | 8 | 38599868:38599969:38645074:38645261:38646221:38646337 | 38645074:38645261 | ENSG00000147526.15 | ENST00000443286.2 |
| exon_skip_482894 | 8 | 38599868:38599969:38646221:38646337:38677039:38677140 | 38646221:38646337 | ENSG00000147526.15 | ENST00000520340.1 |
| exon_skip_482903 | 8 | 38614850:38614927:38646221:38646337:38677039:38677140 | 38646221:38646337 | ENSG00000147526.15 | ENST00000522904.1 |
| exon_skip_482907 | 8 | 38614850:38614927:38681507:38681543:38682825:38682886 | 38681507:38681543 | ENSG00000147526.15 | ENST00000521050.1,ENST00000330691.6 |
| exon_skip_482908 | 8 | 38643193:38643254:38645074:38645261:38646221:38646337 | 38645074:38645261 | ENSG00000147526.15 | ENST00000524354.1 |
| exon_skip_482910 | 8 | 38646221:38646337:38677039:38678153:38682825:38682886 | 38677039:38678153 | ENSG00000147526.15 | ENST00000520615.1,ENST00000443286.2,ENST00000520340.1,ENST00000518415.1,ENST00000522904.1,ENST00000317827.4,ENST00000520973.1 |
| exon_skip_482911 | 8 | 38678064:38678153:38681507:38681543:38682825:38682886 | 38681507:38681543 | ENSG00000147526.15 | ENST00000379931.3,ENST00000521866.1,ENST00000518809.1 |
| exon_skip_482912 | 8 | 38678064:38678153:38682825:38682886:38684685:38684893 | 38682825:38682886 | ENSG00000147526.15 | ENST00000520615.1,ENST00000443286.2,ENST00000520340.1,ENST00000518415.1,ENST00000522904.1,ENST00000317827.4,ENST00000520973.1,ENST00000522955.1 |
| exon_skip_482913 | 8 | 38678064:38678153:38682828:38682886:38684685:38684893 | 38682828:38682886 | ENSG00000147526.15 | ENST00000519416.1 |
| exon_skip_482915 | 8 | 38688642:38688695:38693679:38693805:38695987:38696025 | 38693679:38693805 | ENSG00000147526.15 | ENST00000519416.1,ENST00000520615.1,ENST00000443286.2,ENST00000520340.1,ENST00000518415.1,ENST00000522752.1,ENST00000330691.6,ENST00000348567.4,ENST00000523239.1,ENST00000317827.4,ENST00000379931.3,ENST00000276520.8,ENST00000520973.1,ENST00000521866.1,ENS |
| exon_skip_482916 | 8 | 38695987:38696064:38697741:38697785:38699804:38699965 | 38697741:38697785 | ENSG00000147526.15 | ENST00000519416.1,ENST00000520615.1,ENST00000443286.2,ENST00000518415.1,ENST00000330691.6,ENST00000348567.4,ENST00000317827.4,ENST00000379931.3,ENST00000276520.8,ENST00000520973.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for TACC1 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000317827 | 38677039 | 38678153 | Frame-shift |
| ENST00000317827 | 38682825 | 38682886 | Frame-shift |
| ENST00000317827 | 38697741 | 38697785 | Frame-shift |
| ENST00000317827 | 38693679 | 38693805 | In-frame |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000317827 | 38677039 | 38678153 | Frame-shift |
| ENST00000317827 | 38682825 | 38682886 | Frame-shift |
| ENST00000317827 | 38697741 | 38697785 | Frame-shift |
| ENST00000317827 | 38693679 | 38693805 | In-frame |
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Infer the effects of exon skipping event on protein functional features for TACC1 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000317827 | 7819 | 805 | 38693679 | 38693805 | 2093 | 2218 | 571 | 613 |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| ENST00000317827 | 7819 | 805 | 38693679 | 38693805 | 2093 | 2218 | 571 | 613 |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for TACC1 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_482892 exon_skip_482908 | 38645075 | 38645261 | 38645146 | 38645146 | Frame_Shift_Del | A | - | p.K16fs |
| LIHC | TCGA-DD-A3A0-01 | exon_skip_482910 | 38677040 | 38678153 | 38677928 | 38677928 | Frame_Shift_Del | G | - | p.W389fs |
| STAD | TCGA-CG-4440-01 | exon_skip_482910 | 38677040 | 38678153 | 38677319 | 38677320 | Frame_Shift_Ins | - | GCCCGCCAGAC | p.S186fs |
| ESCA | TCGA-L5-A8NM-01 | exon_skip_482910 | 38677040 | 38678153 | 38677720 | 38677721 | Frame_Shift_Ins | - | T | p.E321fs |
| LGG | TCGA-WY-A85E-01 | exon_skip_482894 exon_skip_482881 exon_skip_482903 | 38646222 | 38646337 | 38646271 | 38646271 | Nonsense_Mutation | C | T | p.R71* |
| READ | TCGA-EI-6917-01 | exon_skip_482910 | 38677040 | 38678153 | 38677639 | 38677639 | Nonsense_Mutation | G | T | p.E293X |
| UCEC | TCGA-BS-A0UV-01 | exon_skip_482910 | 38677040 | 38678153 | 38677639 | 38677639 | Nonsense_Mutation | G | T | p.E293* |
| UCEC | TCGA-D1-A17Q-01 | exon_skip_482910 | 38677040 | 38678153 | 38677639 | 38677639 | Nonsense_Mutation | G | T | p.E293* |
| BLCA | TCGA-GC-A3YS-01 | exon_skip_482910 | 38677040 | 38678153 | 38677879 | 38677879 | Nonsense_Mutation | C | T | p.R373* |
| SKCM | TCGA-D3-A8GL-06 | exon_skip_482915 | 38693680 | 38693805 | 38693689 | 38693689 | Nonsense_Mutation | G | T | p.E587* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| TGBC11TKB_STOMACH | 38677040 | 38678153 | 38677470 | 38677470 | Frame_Shift_Del | C | - | p.V236fs |
| TGBC11TKB_STOMACH | 38677040 | 38678153 | 38677624 | 38677624 | Frame_Shift_Del | C | - | p.P289fs |
| SNU1040_LARGE_INTESTINE | 38645075 | 38645261 | 38645144 | 38645144 | Missense_Mutation | C | T | p.A15V |
| NCIH1650_LUNG | 38646222 | 38646337 | 38646290 | 38646290 | Missense_Mutation | C | T | p.S77F |
| SW780_URINARY_TRACT | 38646222 | 38646337 | 38646325 | 38646325 | Missense_Mutation | G | A | p.A89T |
| SNU449_LIVER | 38677040 | 38678153 | 38677151 | 38677151 | Missense_Mutation | A | G | p.H130R |
| IGR1_SKIN | 38677040 | 38678153 | 38677321 | 38677321 | Missense_Mutation | C | T | p.P187S |
| SNU503_LARGE_INTESTINE | 38677040 | 38678153 | 38677331 | 38677331 | Missense_Mutation | C | T | p.A190V |
| SLVL_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 38677040 | 38678153 | 38677342 | 38677342 | Missense_Mutation | G | A | p.E194K |
| COGN305_AUTONOMIC_GANGLIA | 38677040 | 38678153 | 38677346 | 38677346 | Missense_Mutation | C | T | p.A195V |
| LB1047EBV_MATCHED_NORMAL_TISSUE | 38677040 | 38678153 | 38677346 | 38677346 | Missense_Mutation | C | T | p.A195V |
| LB1047RCC_KIDNEY | 38677040 | 38678153 | 38677346 | 38677346 | Missense_Mutation | C | T | p.A195V |
| EN_ENDOMETRIUM | 38677040 | 38678153 | 38677472 | 38677472 | Missense_Mutation | C | G | p.P237R |
| TGBC24TKB_BILIARY_TRACT | 38677040 | 38678153 | 38677482 | 38677482 | Missense_Mutation | G | C | p.K240N |
| EN_ENDOMETRIUM | 38677040 | 38678153 | 38677545 | 38677545 | Missense_Mutation | G | T | p.K261N |
| HEPG2_LIVER | 38677040 | 38678153 | 38677553 | 38677553 | Missense_Mutation | A | G | p.Y264C |
| C3A_LIVER | 38677040 | 38678153 | 38677553 | 38677553 | Missense_Mutation | A | G | p.Y264C |
| NCIH187_LUNG | 38677040 | 38678153 | 38677622 | 38677622 | Missense_Mutation | C | G | p.S287C |
| SNU1197_LARGE_INTESTINE | 38677040 | 38678153 | 38677661 | 38677661 | Missense_Mutation | G | A | p.S300N |
| ISHIKAWAHERAKLIO02ER_ENDOMETRIUM | 38677040 | 38678153 | 38677755 | 38677755 | Missense_Mutation | A | G | p.I331M |
| SARC9371_BONE | 38677040 | 38678153 | 38677774 | 38677774 | Missense_Mutation | C | T | p.P338S |
| WM2664_SKIN | 38677040 | 38678153 | 38677808 | 38677808 | Missense_Mutation | T | C | p.L349P |
| WM115_SKIN | 38677040 | 38678153 | 38677808 | 38677808 | Missense_Mutation | T | C | p.L349P |
| COV362_OVARY | 38677040 | 38678153 | 38677822 | 38677822 | Missense_Mutation | C | G | p.Q354E |
| L1236_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 38677040 | 38678153 | 38677828 | 38677828 | Missense_Mutation | G | C | p.D356H |
| LNCAPCLONEFGC_PROSTATE | 38677040 | 38678153 | 38677874 | 38677874 | Missense_Mutation | T | C | p.V371A |
| NCIH2110_LUNG | 38677040 | 38678153 | 38677885 | 38677885 | Missense_Mutation | G | T | p.G375W |
| HCT15_LARGE_INTESTINE | 38677040 | 38678153 | 38677911 | 38677911 | Missense_Mutation | G | T | p.K383N |
| MFE319_ENDOMETRIUM | 38677040 | 38678153 | 38677954 | 38677954 | Missense_Mutation | G | A | p.G398R |
| KYSE270_OESOPHAGUS | 38677040 | 38678153 | 38677979 | 38677979 | Missense_Mutation | C | T | p.S406F |
| KYSE270_OESOPHAGUS | 38677040 | 38678153 | 38677979 | 38677980 | Missense_Mutation | CC | TT | p.S406F |
| SUPHD1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 38677040 | 38678153 | 38678032 | 38678032 | Missense_Mutation | G | A | p.E424K |
| RKO_LARGE_INTESTINE | 38677040 | 38678153 | 38678068 | 38678068 | Missense_Mutation | A | G | p.T436A |
| OC316_OVARY | 38677040 | 38678153 | 38678134 | 38678134 | Missense_Mutation | G | A | p.A458T |
| OC314_OVARY | 38677040 | 38678153 | 38678134 | 38678134 | Missense_Mutation | G | A | p.A458T |
| DAOY_CENTRAL_NERVOUS_SYSTEM | 38677040 | 38678153 | 38678149 | 38678149 | Missense_Mutation | A | G | p.I463V |
| NCIH2795_PLEURA | 38677040 | 38678153 | 38678149 | 38678149 | Missense_Mutation | A | G | p.I463V |
| NCIH345_LUNG | 38693680 | 38693805 | 38693729 | 38693729 | Missense_Mutation | G | T | p.G588V |
| WIL2NS_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE | 38677040 | 38678153 | 38677041 | 38677041 | Splice_Site | A | G | p.E93E |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for TACC1 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TACC1 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for TACC1 |
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RelatedDrugs for TACC1 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for TACC1 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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