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| Open reading frame (ORF) annotation in the exon skipping event |
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| Splicing Quantitative Trait Loci (sQTLs) in the skipped exons |
| Splicing Quantitative Trait Methylation (sQTM) in the skipped exon |
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Gene summary for SYT5 |
 Gene summary |
| Gene information | Gene symbol | SYT5 | Gene ID | 6861 |
| Gene name | synaptotagmin 5 | |
| Synonyms | - | |
| Cytomap | 19q13.42|11p | |
| Type of gene | protein-coding | |
| Description | synaptotagmin-5synaptotagmin VsytV | |
| Modification date | 20180523 | |
| UniProtAcc | O00445 | |
| Context | PubMed: SYT5 [Title/Abstract] AND exon [Title/Abstract] AND skip [Title/Abstract] - Title (PMID) |
| Gene ontology of each this gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Gene | GO ID | GO term | PubMed ID |
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Exon skipping events across known transcript of Ensembl for SYT5 from UCSC genome browser |
| Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure. * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Gene isoform structures and expression levels for SYT5 |
| Expression levels of gene isoforms across TCGA. |
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| Expression levels of gene isoforms across GTEx. |
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Exon skipping events with PSIs in TCGA for SYT5 |
| Information of exkip skipping event in TCGA. |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_322452 | 19 | 55687372:55687492:55689563:55689736:55690330:55690433 | 55689563:55689736 | ENSG00000129990.10 | ENST00000589172.1,ENST00000537500.1,ENST00000354308.3,ENST00000592470.1 |
| PSI values of skipped exons in TCGA. |
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Exon skipping events with PSIs in GTEx for SYT5 |
| Information of exkip skipping event in GTEx |
| Exon skip ID | chr | Exons involved in exon skipping | Skipped exon | ENSG | ENSTs |
| exon_skip_322452 | 19 | 55687372:55687492:55689563:55689736:55690330:55690433 | 55689563:55689736 | ENSG00000129990.10 | ENST00000354308.3,ENST00000537500.1,ENST00000589172.1,ENST00000592470.1 |
| PSI values of skipped exons in GTEx. |
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| * Skipped exon sequences. |
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Open reading frame (ORF) annotation in the exon skipping event for SYT5 |
| Open reading frame (ORF) of individual exon skipping events in TCGA based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000354308 | 55689563 | 55689736 | Frame-shift |
| ENST00000537500 | 55689563 | 55689736 | Frame-shift |
| Open reading frame (ORF) of individual exon skipping events in GTEx based on the Ensembl gene structure combined from isoforms. |
| ENST | Start of skipped exon | End of skipped exon | ORF |
| ENST00000354308 | 55689563 | 55689736 | Frame-shift |
| ENST00000537500 | 55689563 | 55689736 | Frame-shift |
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Infer the effects of exon skipping event on protein functional features for SYT5 |
| Exon skipping at the protein sequence level and followed lost functional features. * Click on the image to enlarge it in a new window. |
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| Loci of skipped exons in TCGA across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Loci of skipped exons in GTEx across genomic, transcript, and protein sequence levels of In-frame cases. |
| ENST | Length of mRNA | Length of AA seq. | Genomic start | Genomic end | mRNA start | mRNA end | AA start | AA end |
| Lost protein functional features of individual exon skipping events in TCGA. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
| Lost protein functional features of individual exon skipping events in GTEx. |
| UniProt acc. | Start of exon skipping (AA) | End of exon skipping (AA) | Protein feature start (AA) | Protein feature end (AA) | Category of protein feature | Description of feature |
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SNVs in the skipped exons for SYT5 |
| - Lollipop plot for presenting exon skipping associated SNVs. * Click on the image to enlarge it in a new window. |
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| - Differential PSIs between mutated versus non-mutated samples. |
| - Non-synonymous mutations located in the skipped exons in TCGA. |
| Cancer type | Sample | ESID | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| LIHC | TCGA-G3-A3CJ-01 | exon_skip_322452 | 55689564 | 55689736 | 55689645 | 55689645 | Frame_Shift_Del | C | - | p.R58fs |
| HNSC | TCGA-CN-4736-01 | exon_skip_322452 | 55689564 | 55689736 | 55689729 | 55689729 | Frame_Shift_Del | G | - | p.P29fs |
| PCPG | TCGA-W2-A7UY-01 | exon_skip_322452 | 55689564 | 55689736 | 55689729 | 55689729 | Frame_Shift_Del | G | - | p.P29fs |
| THCA | TCGA-DJ-A4UT-01 | exon_skip_322452 | 55689564 | 55689736 | 55689729 | 55689729 | Frame_Shift_Del | G | - | p.P29fs |
| CESC | TCGA-EK-A3GK-01 | exon_skip_322452 | 55689564 | 55689736 | 55689700 | 55689700 | Nonsense_Mutation | G | C | p.S39* |
| - Depth of coverage in the three exons composing exon skipping event |
| Depth of coverage in three exons | Mutation description |
| - Non-synonymous mutations located in the skipped exons in CCLE. |
| Sample | Skipped exon start | Skipped exon end | Mutation start | Mutation end | Mutation type | Reference seq | Mutation seq | AAchange |
| NCIH2286_LUNG | 55689564 | 55689736 | 55689695 | 55689695 | Missense_Mutation | G | A | p.L41F |
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Splicing Quantitative Trait Loci (sQTL) in the exon skipping event for SYT5 |
| sQTL information located at the skipped exons. |
| Exon skip ID | Chromosome | Three exons | Skippped exon | ENST | Cancer type | SNP id | Location | DNA change (ref/var) | P-value |
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Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SYT5 |
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Survival analysis of Splicing Quantitative Trait Methylation (sQTM) in the skipped exon for SYT5 |
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RelatedDrugs for SYT5 |
| Approved drugs targeting this gene. (DrugBank Version 5.1.0 2018-04-02) |
| Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SYT5 |
| Diseases associated with this gene. (DisGeNet 4.0) |
| Gene | Disease ID | Disease name | # pubmeds | Source |
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